Artikel ; Online: Two Onnamide Analogs from the Marine Sponge Theonella conica
Molecules, Vol 28, Iss 2524, p
Evaluation of Geometric Effects in the Polyene Systems on Biological Activity
2023 Band 2524
Abstract: Two previously unreported onnamide analogs, 2 Z - and 6 Z -onnamides A ( 1 and 2 ), were isolated from the marine sponge Theonella conica collected at Amami-Oshima Is., Kagoshima Prefecture, Japan. Structures of compounds 1 and 2 were elucidated by ... ...
Abstract | Two previously unreported onnamide analogs, 2 Z - and 6 Z -onnamides A ( 1 and 2 ), were isolated from the marine sponge Theonella conica collected at Amami-Oshima Is., Kagoshima Prefecture, Japan. Structures of compounds 1 and 2 were elucidated by spectral analysis. Structure–activity relationships (SARs) for effects on histone modifications and cytotoxicity against HeLa and P388 cells were characterized. The geometry in the polyene systems of onnamides affected the histone modification levels and cytotoxicity. |
---|---|
Schlagwörter | onnamides ; Theonella sp ; marine sponges ; histone modifications ; cytotoxicity ; marine natural products ; Organic chemistry ; QD241-441 |
Sprache | Englisch |
Erscheinungsdatum | 2023-03-01T00:00:00Z |
Verlag | MDPI AG |
Dokumenttyp | Artikel ; Online |
Datenquelle | BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl) |
Volltext online
Zusatzmaterialien
Kategorien
Fernleihe an ZB MED
Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.