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  1. Artikel ; Online: Selective Genome Packaging Mechanisms of Influenza A Viruses.

    Noda, Takeshi

    Cold Spring Harbor perspectives in medicine

    2021  Band 11, Heft 7

    Abstract: The genome of influenza A virus (IAV) comprises eight segmented, single-stranded, negative-sense RNAs. The genome packaging mechanism of IAV was a long-standing enigma, but it is now widely accepted that IAV packages one copy of each of the eight viral ... ...

    Abstract The genome of influenza A virus (IAV) comprises eight segmented, single-stranded, negative-sense RNAs. The genome packaging mechanism of IAV was a long-standing enigma, but it is now widely accepted that IAV packages one copy of each of the eight viral RNA (vRNA) segments in a selective manner. Accumulating evidence over the last decade suggests that the eight unique vRNAs are selected via intersegment interactions mediated by their segment-specific genome packaging signals; however, the characteristics of these RNA-based interactions largely remain unknown. This review summarizes our current knowledge of IAV selective genome packaging and the possible mechanisms underlying the selection of the eight unique vRNAs.
    Mesh-Begriff(e) Genome, Viral ; Influenza A virus/genetics ; RNA, Viral/genetics ; Virus Assembly
    Chemische Substanzen RNA, Viral
    Sprache Englisch
    Erscheinungsdatum 2021-07-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2157-1422
    ISSN (online) 2157-1422
    DOI 10.1101/cshperspect.a038497
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Foreword- A Decade of Cross-Boundary Cooperation: UICC-ARO and the University of Tokyo.

    Noda, Tetsuo

    Japanese journal of clinical oncology

    2021  Band 51, Heft 12 Suppl 2, Seite(n) i1

    Mesh-Begriff(e) Humans ; International Cooperation ; Neoplasms ; Tokyo
    Sprache Englisch
    Erscheinungsdatum 2021-05-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 190978-2
    ISSN 1465-3621 ; 0368-2811
    ISSN (online) 1465-3621
    ISSN 0368-2811
    DOI 10.1093/jjco/hyab016
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Response to the Letter to the editor - 'Labeling sarcopenia in cardiovascular patients with SARC-F? A definite faux pas' by Abdulsalam et al.

    Noda, Takumi / Kamiya, Kentaro

    European journal of cardiovascular nursing

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-05-24
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2151245-0
    ISSN 1873-1953 ; 1474-5151
    ISSN (online) 1873-1953
    ISSN 1474-5151
    DOI 10.1093/eurjcn/zvae079
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Stochastic resonance in sparse neuronal network: functional role of ongoing activity to detect weak sensory input in awake auditory cortex of rat.

    Noda, Takahiro / Takahashi, Hirokazu

    Cerebral cortex (New York, N.Y. : 1991)

    2023  Band 34, Heft 1

    Abstract: The awake cortex is characterized by a higher level of ongoing spontaneous activity, but it has a better detectability of weak sensory inputs than the anesthetized cortex. However, the computational mechanism underlying this paradoxical nature of awake ... ...

    Abstract The awake cortex is characterized by a higher level of ongoing spontaneous activity, but it has a better detectability of weak sensory inputs than the anesthetized cortex. However, the computational mechanism underlying this paradoxical nature of awake neuronal activity remains to be elucidated. Here, we propose a hypothetical stochastic resonance, which improves the signal-to-noise ratio (SNR) of weak sensory inputs through nonlinear relations between ongoing spontaneous activities and sensory-evoked activities. Prestimulus and tone-evoked activities were investigated via in vivo extracellular recording with a dense microelectrode array covering the entire auditory cortex in rats in both awake and anesthetized states. We found that tone-evoked activities increased supralinearly with the prestimulus activity level in the awake state and that the SNR of weak stimulus representation was optimized at an intermediate level of prestimulus ongoing activity. Furthermore, the temporally intermittent firing pattern, but not the trial-by-trial reliability or the fluctuation of local field potential, was identified as a relevant factor for SNR improvement. Since ongoing activity differs among neurons, hypothetical stochastic resonance or "sparse network stochastic resonance" might offer beneficial SNR improvement at the single-neuron level, which is compatible with the sparse representation in the sensory cortex.
    Mesh-Begriff(e) Rats ; Animals ; Auditory Cortex/physiology ; Wakefulness/physiology ; Reproducibility of Results ; Neurons/physiology ; Vibration
    Sprache Englisch
    Erscheinungsdatum 2023-11-13
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1077450-6
    ISSN 1460-2199 ; 1047-3211
    ISSN (online) 1460-2199
    ISSN 1047-3211
    DOI 10.1093/cercor/bhad428
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Filovirus helical nucleocapsid structures.

    Hu, Shangfan / Noda, Takeshi

    Microscopy (Oxford, England)

    2022  Band 72, Heft 3, Seite(n) 178–190

    Abstract: Filoviruses are filamentous enveloped viruses belonging to the family Filoviridae, in the order Mononegavirales. Some filovirus members, such as Ebola virus and Marburg virus, cause severe hemorrhagic fever in humans and non-human primates. The filovirus ...

    Abstract Filoviruses are filamentous enveloped viruses belonging to the family Filoviridae, in the order Mononegavirales. Some filovirus members, such as Ebola virus and Marburg virus, cause severe hemorrhagic fever in humans and non-human primates. The filovirus ribonucleoprotein complex, called the nucleocapsid, forms a double-layered helical structure in which a non-segmented, single-stranded, negative-sense RNA genome is encapsidated by the nucleoprotein (NP), viral protein 35 (VP35), VP24, VP30 and RNA-dependent RNA polymerase (L). The inner layer consists of the helical NP-RNA complex, acting as a scaffold for the binding of VP35 and VP24 that constitute the outer layer. Recent structural studies using cryo-electron microscopy have advanced our understanding of the molecular mechanism of filovirus nucleocapsid formation. Here, we review the key characteristics of the Ebola virus and Marburg virus nucleocapsid structures, highlighting the similarities and differences between the two viruses. In particular, we focus on the structure of the helical NP-RNA complex, the RNA binding mechanism and the NP-NP interactions in the helix. The structural analyses reveal a possible mechanism of nucleocapsid assembly and provide potential targets for the anti-filovirus drug design.
    Mesh-Begriff(e) Animals ; Cryoelectron Microscopy ; Nucleocapsid/chemistry ; Nucleocapsid/metabolism ; Ebolavirus/chemistry ; Ebolavirus/metabolism ; Marburgvirus/chemistry ; Marburgvirus/metabolism ; Viral Proteins/analysis ; Viral Proteins/chemistry ; Viral Proteins/metabolism ; RNA/analysis ; RNA/metabolism
    Chemische Substanzen Viral Proteins ; RNA (63231-63-0)
    Sprache Englisch
    Erscheinungsdatum 2022-10-14
    Erscheinungsland England
    Dokumenttyp Review ; Journal Article
    ZDB-ID 2707496-1
    ISSN 2050-5701 ; 2050-5698
    ISSN (online) 2050-5701
    ISSN 2050-5698
    DOI 10.1093/jmicro/dfac049
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Unsaturated polyurethanes degradable by conjugate substitution reactions with amines and carboxylate anions.

    Noda, Takumi / Tanaka, Anri / Akae, Yosuke / Kohsaka, Yasuhiro

    RSC advances

    2023  Band 13, Heft 29, Seite(n) 20336–20341

    Abstract: Main-chain scission of polymers induces a significant decrease in molecular weight and accompanying changes in physical properties and is important for applications in materials engineering, such as in photoresists and adhesive dismantling. In this study, ...

    Abstract Main-chain scission of polymers induces a significant decrease in molecular weight and accompanying changes in physical properties and is important for applications in materials engineering, such as in photoresists and adhesive dismantling. In this study, we focused on methacrylates substituted with carbamate groups at the allylic positions for the purpose of developing a mechanism that efficiently cleaves the main chain in response to chemical stimuli. Dimethacrylates substituted with hydroxy groups at the allylic positions were synthesized by the Morita-Baylis-Hillman reaction of diacrylates and aldehydes. The polyaddition with diisocyanates afforded a series of poly(conjugated ester-urethane)s. These polymers underwent a conjugate substitution reaction with diethylamine or acetate anion at 25 °C, resulting in main-chain scission accompanied by decarboxylation. A side reaction by the re-attack of the liberated amine end to the methacrylate skeleton proceeded, whereas it was suppressed for the polymers with an allylic substitute of the phenyl group. Therefore, the methacrylate skeleton substituted with phenyl and carbamate groups at the allylic position is an excellent decomposition point that induces selective and quantitative main-chain scission with weak nucleophiles, such as carboxylate anions.
    Sprache Englisch
    Erscheinungsdatum 2023-07-07
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra03461e
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Regulation of Autophagy through TORC1 and mTORC1.

    Noda, Takeshi

    Biomolecules

    2017  Band 7, Heft 3

    Abstract: Autophagy is an intracellular protein-degradation process that is conserved across eukaryotes including yeast and humans. Under nutrient starvation conditions, intracellular proteins are transported to lysosomes and vacuoles via membranous structures ... ...

    Abstract Autophagy is an intracellular protein-degradation process that is conserved across eukaryotes including yeast and humans. Under nutrient starvation conditions, intracellular proteins are transported to lysosomes and vacuoles via membranous structures known as autophagosomes, and are degraded. The various steps of autophagy are regulated by the target of rapamycin complex 1 (TORC1/mTORC1). In this review, a history of this regulation and recent advances in such regulation both in yeast and mammals will be discussed. Recently, the mechanism of autophagy initiation in yeast has been deduced. The autophagy-related gene 13 (Atg13) and the unc-51 like autophagy activating kinase 1 (Ulk1) are the most crucial substrates of TORC1 in autophagy, and by its dephosphorylation, autophagosome formation is initiated. Phosphorylation/dephosphorylation of Atg13 is regulated spatially inside the cell. Another TORC1-dependent regulation lies in the expression of autophagy genes and vacuolar/lysosomal hydrolases. Several transcriptional and post-transcriptional regulations are controlled by TORC1, which affects autophagy activity in yeast and mammals.
    Mesh-Begriff(e) Animals ; Autophagy ; Autophagy-Related Protein-1 Homolog/metabolism ; Autophagy-Related Proteins/metabolism ; Gene Expression Regulation ; Humans ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Phosphorylation ; Protein Transport
    Chemische Substanzen Autophagy-Related Proteins ; Autophagy-Related Protein-1 Homolog (EC 2.7.11.1) ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1)
    Sprache Englisch
    Erscheinungsdatum 2017-07-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom7030052
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Interactive effects of two rodent species on the seed dispersal of Japanese walnut.

    Okawa, Ryunosuke / Saitoh, Takashi / Noda, Takashi

    Scientific reports

    2023  Band 13, Heft 1, Seite(n) 18098

    Abstract: The effects of seed dispersers on plant fitness (seed dispersal effectiveness, SDE) have been evaluated based on the number (quantity) and recruitment probability (quality) of dispersed seeds. Although seeds of most zoochorous species are dispersed by ... ...

    Abstract The effects of seed dispersers on plant fitness (seed dispersal effectiveness, SDE) have been evaluated based on the number (quantity) and recruitment probability (quality) of dispersed seeds. Although seeds of most zoochorous species are dispersed by two or more animal species, which may interact with each other, SDE has often been studied assuming a one-plant and one-animal species system. We compared the SDE of Japanese walnut (Juglans ailanthifolia) between squirrel-only and squirrel-mouse sites in natural forests of Hokkaido, Japan, and found that the SDE from the red squirrel (Sciurus vulgaris), considered a primary seed disperser, was altered by an alternative seed disperser species, the Japanese wood mouse (Apodemus speciosus). Seed removal rates at the squirrel-mouse site were significantly higher than those at the squirrel-only site, and both dispersed seeds and seedlings were less aggregated, with a strongly repulsive relationship with adult conspecific trees at the squirrel-mouse site. Seedlings established themselves at a location with fewer medium-sized trees (< 10 cm DBH) at the squirrel-mouse site. These results suggest that the interactive effect of the rodent species affects the SDE of Japanese walnut.
    Mesh-Begriff(e) Animals ; Mice ; Feeding Behavior ; Juglans ; Sciuridae ; Seed Dispersal ; Seedlings ; Seeds ; Japan ; Behavior, Animal
    Sprache Englisch
    Erscheinungsdatum 2023-10-23
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-44513-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Molecular characterization of Satsuma mandarin (

    Hasan, Nazmul / Tokuhara, Naoki / Noda, Takayuki / Kotoda, Nobuhiro

    Plant biotechnology (Tokyo, Japan)

    2023  Band 40, Heft 1, Seite(n) 51–62

    Abstract: Shortening the juvenility is a burning issue in breeding fruit trees such as Satsuma mandarin ( ...

    Abstract Shortening the juvenility is a burning issue in breeding fruit trees such as Satsuma mandarin (
    Sprache Englisch
    Erscheinungsdatum 2023-12-27
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 2210142-1
    ISSN 1347-6114 ; 1342-4580
    ISSN (online) 1347-6114
    ISSN 1342-4580
    DOI 10.5511/plantbiotechnology.23.0122a
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Tartary Buckwheat Bran: A Review of Its Chemical Composition, Processing Methods and Food Uses.

    Noda, Takahiro / Ishiguro, Koji / Suzuki, Tatsuro / Morishita, Toshikazu

    Plants (Basel, Switzerland)

    2023  Band 12, Heft 10

    Abstract: Tartary buckwheat ( ...

    Abstract Tartary buckwheat (
    Sprache Englisch
    Erscheinungsdatum 2023-05-12
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12101965
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