Article ; Online: Increased risk of type 3c diabetes mellitus after acute pancreatitis warrants a personalized approach including diabetes screening.
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2022 Volume 6, Issue 6
Abstract: Background: Acute pancreatitis (AP) is a frequent cause of hospitalization with long-term health consequences, including type 3c diabetes mellitus (DM). The incidence and risk factors for new-onset morbidities after AP need to be clarified to inform a ... ...
Abstract | Background: Acute pancreatitis (AP) is a frequent cause of hospitalization with long-term health consequences, including type 3c diabetes mellitus (DM). The incidence and risk factors for new-onset morbidities after AP need to be clarified to inform a personalized medicine approach. Methods: Using a longitudinal electronic healthcare record-linkage analysis, all patients admitted to hospital in Scotland with a first episode of AP between 1 April 2009 and 31 March 2012 and followed for a minimum of 5 years after their index AP admission were identified. All new-onset morbidity with specific focus on type 3c DM were analysed and, using time-split multiple regression. Results: A total of 2047 patients were included. AP requiring critical care was followed by 2 years of heightened risk (HR 5.24) of developing type 3c DM, increased risk of new-onset cardiac disease (HR 1.61), and renal disease (HR 2.96). The additional risk conferred by critical care AP had a negative interaction with time, whereas additional risk associated with male sex and a non-gallstone aetiology was long lasting. Conclusion: Based on these findings, a personalized approach to include type 3c DM screening for a minimum of 2 years for individuals who required critical care when hospitalized with AP is recommended. |
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MeSH term(s) | Humans ; Male ; Pancreatitis/diagnosis ; Pancreatitis/etiology ; Pancreatitis/therapy ; Acute Disease ; Risk Factors ; Incidence ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/etiology |
Language | English |
Publishing date | 2022-12-13 |
Publishing country | England |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ISSN | 2474-9842 |
ISSN (online) | 2474-9842 |
DOI | 10.1093/bjsopen/zrac148 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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