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  1. Artikel: Gene Transcription, Metabolite and Lipid Profiling in Eco-Indicator Daphnia magna Indicate Diverse Mechanisms of Toxicity by Legacy and Emerging Flame-Retardants

    Scanlan, LeonaD / Loguinov, Alexandre V / Teng, Quincy / Antczak, Philipp / Dailey, KathleenP / Nowinski, Daniel T / Kornbluh, Jonah / Lin, Xin Xin / Lachenauer, Erica / Arai, Audrey / Douglas, Nora K / Falciani, Francesco / Stapleton, Heather M / Vulpe, Chris D

    Environmental Science & Technology. 2015 June 16, v. 49, no. 12

    2015  

    Abstract: The use of chemical flame-retardants (FR) in consumer products has steadily increased over the last 30 years. Toxicity data exist for legacy FRs such as pentabromodiphenyl ether (pentaBDE), but less is known about effects of new formulations. To address ... ...

    Abstract The use of chemical flame-retardants (FR) in consumer products has steadily increased over the last 30 years. Toxicity data exist for legacy FRs such as pentabromodiphenyl ether (pentaBDE), but less is known about effects of new formulations. To address this issue, the toxicity of seven FR chemicals and formulations was assessed on the freshwater crustacean Daphnia magna. Acute 48-h nominal LC50 values for penta- and octabromodiphenyl ether (pentaBDE, octaBDE), Firemaster 550 (FM550), Firemaster BZ-54 (BZ54), bis(2-ethylhexyl) tetrabromophthalate (BEH-TEBP), triphenyl phosphate (TPhP), and nonbrominated BEH-TEBP analog bis(2-ethylhexyl) phthalate (BEHP) ranged from 0.058 mg/L (pentaBDE) to 3.96 mg/L (octaBDE). mRNA expression, 1H NMR-based metabolomic and lipidomic profiling at 1/10 LC50 revealed distinct patterns of molecular response for each exposure, suggesting pentaPBDE affects transcription and translation, octaBDE and BEH-TEBP affect glycosphingolipid biosynthesis and BZ54 affects Wnt and Hedgehog signal pathways as well as glycosaminoglycan degradation. Brominated components of FM550 (i.e., BZ54) were significantly higher in Daphnia after 48 h following 1/10 LC50 exposure. FM550 elicited significant mRNA changes at five concentrations across a range from 1/106 LC50 to 1/2 LC50. Analyses suggest FM550 impairs nutrient utilization or uptake in Daphnia.
    Schlagwörter Daphnia magna ; biosynthesis ; flame retardants ; freshwater crustaceans ; gene expression ; glycosaminoglycans ; lethal concentration 50 ; lipid composition ; messenger RNA ; metabolites ; metabolomics ; nutrient utilization ; phosphates ; phthalates ; signal transduction ; toxicity ; transcription (genetics) ; translation (genetics)
    Sprache Englisch
    Erscheinungsverlauf 2015-0616
    Umfang p. 7400-7410.
    Erscheinungsort American Chemical Society
    Dokumenttyp Artikel
    ISSN 1520-5851
    DOI 10.1021%2Facs.est.5b00977
    Datenquelle NAL Katalog (AGRICOLA)

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  2. Artikel ; Online: Gene transcription, metabolite and lipid profiling in eco-indicator daphnia magna indicate diverse mechanisms of toxicity by legacy and emerging flame-retardants.

    Scanlan, Leona D / Loguinov, Alexandre V / Teng, Quincy / Antczak, Philipp / Dailey, Kathleen P / Nowinski, Daniel T / Kornbluh, Jonah / Lin, Xin Xin / Lachenauer, Erica / Arai, Audrey / Douglas, Nora K / Falciani, Francesco / Stapleton, Heather M / Vulpe, Chris D

    Environmental science & technology

    2015  Band 49, Heft 12, Seite(n) 7400–7410

    Abstract: The use of chemical flame-retardants (FR) in consumer products has steadily increased over the last 30 years. Toxicity data exist for legacy FRs such as pentabromodiphenyl ether (pentaBDE), but less is known about effects of new formulations. To address ... ...

    Abstract The use of chemical flame-retardants (FR) in consumer products has steadily increased over the last 30 years. Toxicity data exist for legacy FRs such as pentabromodiphenyl ether (pentaBDE), but less is known about effects of new formulations. To address this issue, the toxicity of seven FR chemicals and formulations was assessed on the freshwater crustacean Daphnia magna. Acute 48-h nominal LC50 values for penta- and octabromodiphenyl ether (pentaBDE, octaBDE), Firemaster 550 (FM550), Firemaster BZ-54 (BZ54), bis(2-ethylhexyl) tetrabromophthalate (BEH-TEBP), triphenyl phosphate (TPhP), and nonbrominated BEH-TEBP analog bis(2-ethylhexyl) phthalate (BEHP) ranged from 0.058 mg/L (pentaBDE) to 3.96 mg/L (octaBDE). mRNA expression, (1)H NMR-based metabolomic and lipidomic profiling at 1/10 LC50 revealed distinct patterns of molecular response for each exposure, suggesting pentaPBDE affects transcription and translation, octaBDE and BEH-TEBP affect glycosphingolipid biosynthesis and BZ54 affects Wnt and Hedgehog signal pathways as well as glycosaminoglycan degradation. Brominated components of FM550 (i.e., BZ54) were significantly higher in Daphnia after 48 h following 1/10 LC50 exposure. FM550 elicited significant mRNA changes at five concentrations across a range from 1/10(6) LC50 to 1/2 LC50. Analyses suggest FM550 impairs nutrient utilization or uptake in Daphnia.
    Mesh-Begriff(e) Animals ; Biomarkers/metabolism ; Cluster Analysis ; Daphnia/drug effects ; Daphnia/genetics ; Daphnia/metabolism ; Environmental Exposure/analysis ; Flame Retardants/toxicity ; Gene Expression Profiling ; Lipid Metabolism/drug effects ; Lipid Metabolism/genetics ; Metabolome/drug effects ; Metabolome/genetics ; Metabolomics ; Proton Magnetic Resonance Spectroscopy ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Transcription, Genetic/drug effects
    Chemische Substanzen Biomarkers ; Flame Retardants ; RNA, Messenger
    Sprache Englisch
    Erscheinungsdatum 2015-06-16
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.5b00977
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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