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Artikel ; Online: Animal model for in-vivo Nuclear Cataract. Lens hardness and elasticity assessment.

Caixinha, Miguel / Santos, Jaime / Santos, Mário / Nunes, Sandrina

Journal of the mechanical behavior of biomedical materials

2024 Band 157, Seite(n) 106610

Abstract: Age-related cataract is the most frequent cause of blindness in the world being responsible for 48% of blindness and affecting more than 10% of the working population. Currently there is no objective data of the lens biomechanical properties so the ... ...

Abstract	Age-related cataract is the most frequent cause of blindness in the world being responsible for 48% of blindness and affecting more than 10% of the working population. Currently there is no objective data of the lens biomechanical properties so the process by which the cataract affects the lens's properties (e.g. hardness and elasticity) is still unclear. A modified animal model was produced to create different severities of nuclear cataract. Different doses of sodium selenite were injected in two different moments of the rat' eyes maturation resulting in 12, 13 and 11 rats with incipient, moderate and severe cataract, respectively. The nucleus and cortex's hardness and the stiffness were measured using NanoTest™. Statistically significant differences were found between healthy and cataractous lenses. Statistically significant differences were also found between the different nuclear cataract degrees (p = 0.016), showing that the lens' hardness increases with cataract formation. The nucleus shows a higher hardness increase with cataract formation (p = 0.049). The animal model used in this study allowed for the first time the characterization of the lens's hardness and elasticity in two regions of the lens, in healthy and cataractous lenses.
Sprache	Englisch
Erscheinungsdatum	2024-06-02
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	2378381-3
ISSN	1878-0180 ; 1751-6161
ISSN (online)	1878-0180
ISSN	1751-6161
DOI	10.1016/j.jmbbm.2024.106610
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Machine Learning Techniques in Clinical Vision Sciences.

Caixinha, Miguel / Nunes, Sandrina

Current eye research

2017 Band 42, Heft 1, Seite(n) 1–15

Abstract: This review presents and discusses the contribution of machine learning techniques for diagnosis and disease monitoring in the context of clinical vision science. Many ocular diseases leading to blindness can be halted or delayed when detected and ... ...

Abstract	This review presents and discusses the contribution of machine learning techniques for diagnosis and disease monitoring in the context of clinical vision science. Many ocular diseases leading to blindness can be halted or delayed when detected and treated at its earliest stages. With the recent developments in diagnostic devices, imaging and genomics, new sources of data for early disease detection and patients' management are now available. Machine learning techniques emerged in the biomedical sciences as clinical decision-support techniques to improve sensitivity and specificity of disease detection and monitoring, increasing objectively the clinical decision-making process. This manuscript presents a review in multimodal ocular disease diagnosis and monitoring based on machine learning approaches. In the first section, the technical issues related to the different machine learning approaches will be present. Machine learning techniques are used to automatically recognize complex patterns in a given dataset. These techniques allows creating homogeneous groups (unsupervised learning), or creating a classifier predicting group membership of new cases (supervised learning), when a group label is available for each case. To ensure a good performance of the machine learning techniques in a given dataset, all possible sources of bias should be removed or minimized. For that, the representativeness of the input dataset for the true population should be confirmed, the noise should be removed, the missing data should be treated and the data dimensionally (i.e., the number of parameters/features and the number of cases in the dataset) should be adjusted. The application of machine learning techniques in ocular disease diagnosis and monitoring will be presented and discussed in the second section of this manuscript. To show the clinical benefits of machine learning in clinical vision sciences, several examples will be presented in glaucoma, age-related macular degeneration, and diabetic retinopathy, these ocular pathologies being the major causes of irreversible visual impairment.
Mesh-Begriff(e)	Algorithms ; Diagnostic Techniques, Ophthalmological ; Eye Diseases/diagnosis ; Eye Diseases/physiopathology ; Humans ; Machine Learning ; Monitoring, Physiologic ; Multimodal Imaging ; Sensitivity and Specificity ; Vision, Ocular/physiology
Sprache	Englisch
Erscheinungsdatum	2017-01
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review
ZDB-ID	82079-9
ISSN	1460-2202 ; 0271-3683
ISSN (online)	1460-2202
ISSN	0271-3683
DOI	10.1080/02713683.2016.1175019
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Feasibility assessment of the Eye Scan Ultrasound System for cataract characterization and optimal phacoemulsification energy estimation: protocol for a pilot, nonblinded and monocentre study.

Petrella, Lorena / Nunes, Sandrina / Perdigão, Fernando / Gomes, Marco / Santos, Mário / Pinto, Carlos / Morgado, Miguel / Travassos, António / Santos, Jaime / Caixinha, Miguel

Pilot and feasibility studies

2022 Band 8, Heft 1, Seite(n) 219

Abstract: Background: Cataracts are lens opacifications that are responsible for more than half of blindness cases worldwide, and the only treatment is surgical intervention. Phacoemulsification surgery, the most frequently performed cataract surgery in developed ...

Abstract	Background: Cataracts are lens opacifications that are responsible for more than half of blindness cases worldwide, and the only treatment is surgical intervention. Phacoemulsification surgery, the most frequently performed cataract surgery in developed countries, has associated risks, some of which are related to excessive phacoemulsification energy levels and times. The protocol proposed in herein will be used to evaluate the feasibility of a new experimental medical device, the Eye Scan Ultrasound System (ESUS), for the automatic classification of cataract type and severity and quantitative estimation of the optimal phacoemulsification energy. Methods: The pilot study protocol will be used to evaluate the feasibility and safety of the ESUS in clinical practice. The study will be conducted in subjects with age-related cataracts and on healthy subjects as controls. The procedures include data acquisition with the experimental ESUS, classification based on the Lens Opacity Classification System III (LOCS III, comparator) using a slit lamp, contrast sensitivity test, optical coherence tomography, specular microscopy and surgical parameters. ESUS works in A-scan pulse-echo mode, with a central frequency of 20 MHz. From the collected signals, acoustic parameters will be extracted and used for automatic cataract characterization and optimal phacoemulsification energy estimation. The study includes two phases. The data collected in the first phase (40 patients, 2 eyes per patient) will be used to train the ESUS algorithms, while the data collected in the second phase (10 patients, 2 eyes per patient) will be used to assess the classification performance. System safety will be monitored during the study. Discussion: The present pilot study protocol will evaluate the feasibility and safety of the ESUS for use in clinical practice, and the results will support a larger clinical study for the efficacy assessment of the ESUS as a diagnostic tool. Ultimately, the ESUS is expected to represent a valuable tool for surgical planning by reducing complications associated with excessive levels of phacoemulsification energy and surgical times, which will have a positive impact on healthcare systems and society. The study is not yet recruiting. Trial registration: ClinicalTrials.gov identifier NCT04461912 , registered on July 8, 2020.
Sprache	Englisch
Erscheinungsdatum	2022-09-29
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2809935-7
ISSN	2055-5784
ISSN	2055-5784
DOI	10.1186/s40814-022-01173-2
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Safety Assessment of an A-Scan Ultrasonic System for Ophthalmic Use.

Petrella, Lorena / Fernandes, Paulo / Santos, Mário / Caixinha, Miguel / Nunes, Sandrina / Pinto, Carlos / Morgado, Miguel / Santos, Jaime / Perdigão, Fernando / Gomes, Marco

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

2020 Band 39, Heft 11, Seite(n) 2143–2150

Abstract: Objectives: This study describes the safety assessment of an A-scan ultrasonic system for ophthalmic use. The system is an investigational medical device for automatic cataract detection and classification.: Methods: The risk management was based on ... ...

Abstract	Objectives: This study describes the safety assessment of an A-scan ultrasonic system for ophthalmic use. The system is an investigational medical device for automatic cataract detection and classification. Methods: The risk management was based on the International Organization for Standardization (ISO) standard DIN EN ISO 14971:2009-10 and International Electrotechnical Commission (IEC) standard IEC 60601-2-37. The calibration of the ultrasonic field was conducted according to the standards IEC 62127-1:2007 and IEC 62359:2010. The uncertainty on measurements was delineated in agreement with the guide JCGM 100:2008. Results: After risk management, all risks were qualitatively classified as acceptable. The mechanical index (0.08 ± 0.05), soft tissue thermal index (0.08 ± 0.08) and spatial-peak temporal-average intensity (0.56 ± 0.59 mW/cm Conclusions: This study presents a practical approach for the safety assessment of A-scan ultrasonic systems for ophthalmic use. The safety evaluation of a medical device is mandatory before its use in clinical practice. However, the safety monitoring throughout its life cycle should also be considered, since many device components may deteriorate over time and use.
Mesh-Begriff(e)	Humans ; Reference Standards ; Transducers ; Ultrasonics ; Ultrasonography ; United States ; United States Food and Drug Administration
Sprache	Englisch
Erscheinungsdatum	2020-05-08
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	604829-8
ISSN	1550-9613 ; 0278-4297
ISSN (online)	1550-9613
ISSN	0278-4297
DOI	10.1002/jum.15323
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Protocol for a randomised, double-masked, sham-controlled phase 4 study on the efficacy, safety and tolerability of intravitreal aflibercept monotherapy compared with aflibercept with adjunctive photodynamic therapy in polypoidal choroidal vasculopathy: the ATLANTIC study.

Marques, João Pedro / Farinha, Cláudia / Costa, Miguel Ângelo / Ferrão, Ângela / Nunes, Sandrina / Silva, Rufino

BMJ open

2017 Band 7, Heft 8, Seite(n) e015785

Abstract: Purpose: The purpose of this study is to compare the efficacy and safety of intravitreal aflibercept (IVA) with sham photodynamic therapy (sPDT) versus IVA with verteporfin PDT (vPDT) in a Caucasian population with treatment-naive polypoidal choroidal ... ...

Abstract	Purpose: The purpose of this study is to compare the efficacy and safety of intravitreal aflibercept (IVA) with sham photodynamic therapy (sPDT) versus IVA with verteporfin PDT (vPDT) in a Caucasian population with treatment-naive polypoidal choroidal vasculopathy (PCV), enrolling into a treat and extend (T&E) regimen. Methods and analysis: Randomised, double-masked, sham-controlled, multicentre phase 4 investigator-driven clinical trial. The primary outcomes are (1) change in best-corrected visual acuity (BCVA) from baseline and (2) polyp regression at week 52, assessed by indocyanine green angiography (ICGA). Fifty patients with treatment-naive PCV will be recruited from Portuguese and Spanish clinical sites. Eligible patients will receive monthly IVA for 3 months (week 0, week 4 and week 8). At week 16, all patients will repeat ICGA and undergo central randomisation (1:1 ratio) into one of the following groups: Group 1-IVA T&E + vPDT; Group 2-IVA T&E + sPDT. PDT will be performed at week 16, week 28 and week 40 in the presence of active polyps. After week 16, the presence of macular fluid on optical coherence tomography will determine the schedule of observations. When present, the interval between visits/injections will decrease 2 weeks (minimum 6 weeks). When not, the interval between visits/injections will increase 2 weeks (maximum 12 weeks). Efficacy will be evaluated based on BCVA, central retinal thickness and polyp regression. Safety parameters will include assessment of intraocular pressure, adverse events and serious adverse events. Ethics and dissemination: This study was designed and shall be implemented and reported in accordance with the International Conference on Harmonisation (ICH) Harmonised Tripartite Guidelines for Good Clinical Practice, with applicable local regulations and with the ethical principles laid down in the Declaration of Helsinki. The study received approval from Comissão de Ética para a Investigação Clínica and Comité Ético de investigación Clínica del Hospital Universitari de Bellvitge. Trial registration number: This study is registered under the EudraCT number: 2015-001368-20 and the ClinicalTrials.gov Identifier: NCT02495181.
Mesh-Begriff(e)	Aged ; Choroid/drug effects ; Choroid/pathology ; Choroidal Neovascularization/drug therapy ; Female ; Humans ; Intravitreal Injections ; Male ; Middle Aged ; Photochemotherapy ; Photosensitizing Agents/therapeutic use ; Polyps ; Porphyrins/therapeutic use ; Receptors, Vascular Endothelial Growth Factor/administration & dosage ; Receptors, Vascular Endothelial Growth Factor/therapeutic use ; Recombinant Fusion Proteins/administration & dosage ; Recombinant Fusion Proteins/adverse effects ; Recombinant Fusion Proteins/therapeutic use ; Research Design ; Treatment Outcome ; Verteporfin ; Visual Acuity
Chemische Substanzen	Photosensitizing Agents ; Porphyrins ; Recombinant Fusion Proteins ; Verteporfin (0X9PA28K43) ; aflibercept (15C2VL427D) ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1)
Sprache	Englisch
Erscheinungsdatum	2017-08-28
Erscheinungsland	England
Dokumenttyp	Comparative Study ; Journal Article ; Randomized Controlled Trial
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2016-015785
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Polypoidal Choroidal Vasculopathy in Caucasians: Morphological Findings from Multimodal Retinal Imaging.

Simão, Jorge M / Farinha, Cláudia V / Marques, João P / Nunes, Sandrina / Pires, Isabel M / Cachulo, Maria L / Figueira, João P / Murta, Joaquim N / Silva, Rufino M

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde

2021 Band 244, Heft 4, Seite(n) 315–325

Abstract: Purpose: The aim of the study was to characterize the morphological features of polypoidal choroidal vasculopathy (PCV) in a large Caucasian population.: Methods: We conducteda multicenter, cross-sectional study of treatment-naïve patients with PCV. ... ...

Abstract	Purpose: The aim of the study was to characterize the morphological features of polypoidal choroidal vasculopathy (PCV) in a large Caucasian population. Methods: We conducteda multicenter, cross-sectional study of treatment-naïve patients with PCV. Baseline fundus photography, spectral-domain optical coherence tomography (SD-OCT), fluorescein angiography (FA), and indocyanine green angiography (ICGA) were assessed by trained medical graders. Typical PCV features were explored, and retinal thickness (RT) and choroidal thickness (CT) measurements were performed. Results: Seventy-nine eyes of 73 patients (mean age, 72.6 ± 11.9 years) were included. ICGA identified macular polyps in 89.9% of cases. SD-OCT revealed mostly subretinal fluid (93.6%) and a retinal pigment epithelium (RPE) detachment in 91.4%, with sharp protrusion in 67.0% of cases. Polyp-like structures were seen in 74.3% of cases, mostly adherent to an elevated RPE (69.6%). Type 1 neovascularization (NV) was identified in 74.7% of patients, while 16.5% had a mixed NV. The mean macular CT was 220.9 ± 83.2 μm (range, 67.9-403.6). Diffuse and focal pachychoroid were observed in 26.6 and 30.4% of patients, respectively. Soft drusen were reported in 62.0% of cases, but retinal hemorrhage occurred in only 19.0% of cases. Conclusion: The morphological features of PCV in Caucasians are similar to those reported in Asians. Pachychoroid signs were found in nearly half of our cohort. However, the mean age at presentation, high prevalence of soft drusen, and low prevalence of large subretinal hemorrhages make PCV closer to age-related macular degeneration in this ethnic group.
Mesh-Begriff(e)	Aged ; Aged, 80 and over ; Choroid/pathology ; Choroidal Neovascularization/pathology ; Coloring Agents ; Cross-Sectional Studies ; Fluorescein Angiography ; Humans ; Indocyanine Green ; Middle Aged ; Polyps/diagnosis ; Retrospective Studies ; Tomography, Optical Coherence
Chemische Substanzen	Coloring Agents ; Indocyanine Green (IX6J1063HV)
Sprache	Englisch
Erscheinungsdatum	2021-02-17
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Multicenter Study
ZDB-ID	209735-7
ISSN	1423-0267 ; 0030-3755
ISSN (online)	1423-0267
ISSN	0030-3755
DOI	10.1159/000515295
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Retinal layer thicknesses and neurodegeneration in early age-related macular degeneration: insights from the Coimbra Eye Study.

Farinha, Cláudia / Silva, Ana Luísa / Coimbra, Rita / Nunes, Sandrina / Cachulo, Maria Luz / Marques, João Pedro / Pires, Isabel / Cunha-Vaz, José / Silva, Rufino

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

2021 Band 259, Heft 9, Seite(n) 2545–2557

Abstract: Purpose: This study aims to analyze the retinal layers and choroidal thickness in a large set of eyes with early age-related macular degeneration (AMD), in order to detect differences by stage suggestive of early neurodegeneration, and to explore ... ...

Abstract	Purpose: This study aims to analyze the retinal layers and choroidal thickness in a large set of eyes with early age-related macular degeneration (AMD), in order to detect differences by stage suggestive of early neurodegeneration, and to explore biomarkers of different phenotypes. Methods: This study is a population-based, cross-sectional study. Patients from the incidence AMD study (NCT02748824) with early AMD (Rotterdam 2a, 2b, 3) were included. All performed spectral-domain optical coherence tomography (SD-OCT) (Spectralis, Heidelberg Engineering, Germany) and automatic segmentation of all retinal layers was obtained with built-in software. Manual correction was performed whenever necessary. The mean thicknesses (ETDRS grid) and volume of each layer were recorded. Subfoveal choroidal thickness was manually measured. Estimates for each layer thickness were calculated with linear mixed models and tested for pairwise differences between stages. Associations between layer thickness and microstructural findings were assessed by multivariate regression analysis. Results: The final cohort comprised 346 eyes (233 patients): 82.66% (n = 286) in stage 2a, 5.49% (n = 19) in stage 2b, and 11.85% (n = 41) in stage 3. A global tendency for lower/inferior thickness of the neuroretinal layers was found comparing stage 3 to 2a: retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL) were inferior in the inner/outer ETDRS circles and the outer nuclear layer (ONL) and photoreceptors' segments layer in the central circle (p ≤ 0.002). The retinal pigment epithelium-Bruch's membrane (RPE/BrM) layer was thicker in stage 3 (p ≤ 0.001). Subretinal drusenoid deposits (SDD) were associated with thinner neuroretinal layers and choroid (p < 0.05). Conclusions: Our results showed in a large population-based dataset that several inner and outer neuroretinal layers were thinner with a higher stage in early AMD. These findings support the existence of early and progressive neurodegeneration. Neuronal retinal layer thicknesses might thus be used as quantitative biomarkers of disease progression in AMD. The presence of SDD is possibly associated to more prominent and faster neurodegeneration.
Mesh-Begriff(e)	Cross-Sectional Studies ; Humans ; Macular Degeneration/diagnosis ; Retina/diagnostic imaging ; Retinal Ganglion Cells ; Tomography, Optical Coherence
Sprache	Englisch
Erscheinungsdatum	2021-03-18
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	8435-9
ISSN	1435-702X ; 0721-832X
ISSN (online)	1435-702X
ISSN	0721-832X
DOI	10.1007/s00417-021-05140-0
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: T and genetic variations between Asian and Caucasian polypoidal choroidal vasculopathy.

Jordan-Yu, Janice Marie / Teo, Kelvin / Fan, Qiao / Gana, Jose Carlos / Leopando, Anna Karina / Nunes, Sandrina / Farinha, Cláudia / Barreto, Patricia / Melo, Joana Barbosa / Carreira, Isabel / Murta, Joaquim Neto / Silva, Rufino / Cheung, Chui Ming Gemmy

The British journal of ophthalmology

2020 Band 105, Heft 12, Seite(n) 1716–1723

Abstract: Purpose: To compare phenotypic and genetic variations in polypoidal choroidal vasculopathy (PCV) between Caucasian and Asian patients.: Methods: We analysed phenotypic and genotypic data from two sites, Association for Innovation and Biomedical ... ...

Abstract	Purpose: To compare phenotypic and genetic variations in polypoidal choroidal vasculopathy (PCV) between Caucasian and Asian patients. Methods: We analysed phenotypic and genotypic data from two sites, Association for Innovation and Biomedical Research on Light and Image, Portugal and Singapore National Eye Centre, Singapore. Baseline fundus photography, spectral domain-optical coherence tomography, indocyanine green and fluorescein angiography scans were analysed by respective reading centres using a standardised grading protocol. Single nucleotide polymorphisms across 8 PCV loci were compared between cases and controls selected from each population. Results: One hundred and forty treatment-naïve PCV participants (35 Portuguese and 105 Singaporean) were included. The Portuguese cohort were older (72.33±8.44 vs 68.71±9.40 years, p=0.043) and were comprised of a lower proportion of males (43% vs 71%, p=0.005) compared with the Singaporean cohort. Differences in imaging features include higher prevalence of soft drusen (66% vs 30%, p=0.004), lower prevalence of subretinal haemorrhage (14% vs 67%, p<0.001), smaller polypoidal lesion (PL) area (0.09±0.09 vs 0.76±0.93 mm Conclusion: Among Asian and Caucasian patients with PCV, there are significant differences in the expression of phenotype. We also identified different polymorphisms associated with PCV in the two populations.
Mesh-Begriff(e)	Choroid/pathology ; Choroidal Neovascularization/diagnosis ; Choroidal Neovascularization/genetics ; Choroidal Neovascularization/pathology ; Coloring Agents ; Eye Diseases/pathology ; Fluorescein Angiography/methods ; Genetic Variation ; Humans ; Indocyanine Green ; Male ; Polyps/diagnosis ; Polyps/genetics ; Tomography, Optical Coherence/methods
Chemische Substanzen	Coloring Agents ; Indocyanine Green (IX6J1063HV)
Sprache	Englisch
Erscheinungsdatum	2020-10-09
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80078-8
ISSN	1468-2079 ; 0007-1161
ISSN (online)	1468-2079
ISSN	0007-1161
DOI	10.1136/bjophthalmol-2020-317537
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Three different phenotypes of mild nonproliferative diabetic retinopathy with different risks for development of clinically significant macular edema.

Nunes, Sandrina / Ribeiro, Luisa / Lobo, Conceição / Cunha-Vaz, José

Investigative ophthalmology & visual science

2013 Band 54, Heft 7, Seite(n) 4595–4604

Abstract: Purpose: To identify different phenotypes of nonproliferative diabetic retinopathy (NPDR) and their progression to clinically significant macular edema (CSME).: Methods: A prospective observational study was designed to follow eyes/patients with ... ...

Abstract	Purpose: To identify different phenotypes of nonproliferative diabetic retinopathy (NPDR) and their progression to clinically significant macular edema (CSME). Methods: A prospective observational study was designed to follow eyes/patients with diabetes type 2 and NPDR with no prior laser treatment for 2 years or until development of CSME. A total of 410 patients, one eye per patient, fulfilled the inclusion/exclusion criteria and were included in the study. Ophthalmological examinations, including BCVA, fundus photography with Retmarker analysis, and optical coherence tomography (OCT), were performed at baseline, month 6 and month 24, or before laser treatment. Hierarchical cluster analysis was used to identify homogeneous subgroups and clinically significant thresholds of the data collected. Results: A total of 376 eyes/patients performed the 6-month visit and were considered for cluster analysis. This mathematical method identified three different phenotypes based on statistically significant differences for the microaneurysm (MA) turnover and for the central retinal thickness (RT): phenotype A (low MA turnover and normal RT, 48.1%); phenotype B (low MA turnover and increased central RT, 23.2%); and phenotype C (high MA turnover, 28.7%). From the 348 eyes/patients that reached the study end point or completed the 24-month visit, 26 developed CSME: 3 from phenotype A (1.8%), 7 from phenotype B (8.5%), and 16 from phenotype C (16.2%). Eyes/patients from phenotype C showed a higher risk for CSME development (OR = 3.536; P < 0.001). Conclusions: Hierarchical cluster analysis identifies three different phenotypes of NPDR based on MA turnover and central macular thickness. Eyes/patients from phenotype C show a higher risk for the development of CSME. (ClinicalTrials.gov number, NCT00763802.)
Mesh-Begriff(e)	Aged ; Cluster Analysis ; Diabetes Mellitus, Type 2/complications ; Diabetic Retinopathy/classification ; Diabetic Retinopathy/pathology ; Diabetic Retinopathy/physiopathology ; Disease Progression ; Female ; Humans ; Macular Edema/classification ; Macular Edema/pathology ; Macular Edema/physiopathology ; Male ; Middle Aged ; Phenotype ; Prospective Studies ; Risk Factors ; Tomography, Optical Coherence ; Visual Acuity/physiology
Sprache	Englisch
Erscheinungsdatum	2013-07-10
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391794-0
ISSN	1552-5783 ; 0146-0404
ISSN (online)	1552-5783
ISSN	0146-0404
DOI	10.1167/iovs.13-11895
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Macular thickness measured by stratus optical coherence tomography in patients with diabetes type 2 and mild nonproliferative retinopathy without clinical evidence of macular edema.

Pires, Isabel / Santos, Ana Rita / Nunes, Sandrina / Lobo, Conceição

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde

2013 Band 229, Heft 4, Seite(n) 181–186

Abstract: To evaluate macular thickness in eyes with mild nonproliferative diabetic retinopathy (NPDR), patients with diabetes type 2, NPDR level 20 or 35, and without evidence of clinical macular edema underwent best-corrected visual acuity assessment, color ... ...

Abstract	To evaluate macular thickness in eyes with mild nonproliferative diabetic retinopathy (NPDR), patients with diabetes type 2, NPDR level 20 or 35, and without evidence of clinical macular edema underwent best-corrected visual acuity assessment, color fundus photography and Stratus optical coherence tomography. Mean center point thickness (CPT) and mean central subfield (CSF) thickness were compared with those of a healthy control population. 410 eyes/patients aged 61.2 ± 8.3 years, and with glycosylated hemoglobin of 7.9 ± 1.5% were included. Mean CPT and CSF were 186.6 ± 28.4 and 215.2 ± 25 µm, respectively, significantly increased compared to healthy subjects (p < 0.001). CSF thickness was abnormally increased in 17.6% of the patients, with values within the normal range in 79.5%, and abnormally decreased in 2.9%. CPT and CSF thickness were significantly thicker in men. No systemic factors showed a significant association. A significant increase in the macular thickness was found in eyes/patients with mild NPDR without clinical macular edema; however, only 17.6% of the eyes/patients had abnormally increased values and less than 3% abnormally decreased values.
Mesh-Begriff(e)	Adult ; Aged ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Diabetic Retinopathy/diagnosis ; Female ; Glycated Hemoglobin A/metabolism ; Humans ; Macula Lutea/pathology ; Macular Edema/diagnosis ; Male ; Middle Aged ; Severity of Illness Index ; Tomography, Optical Coherence/methods
Chemische Substanzen	Glycated Hemoglobin A
Sprache	Englisch
Erscheinungsdatum	2013
Erscheinungsland	Switzerland
Dokumenttyp	Clinical Trial ; Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209735-7
ISSN	1423-0267 ; 0030-3755
ISSN (online)	1423-0267
ISSN	0030-3755
DOI	10.1159/000350593
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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