Artikel ; Online: A Simple-to-Use R Package for Mimicking Study Data by Simulations.
Methods of information in medicine
2023 Band 62, Heft 3-04, Seite(n) 119–129
Abstract: Background: Data protection policies might prohibit the transfer of existing study data to interested research groups. To overcome legal restrictions, simulated data can be transferred that mimic the structure but are different from the existing study ... ...
Abstract | Background: Data protection policies might prohibit the transfer of existing study data to interested research groups. To overcome legal restrictions, simulated data can be transferred that mimic the structure but are different from the existing study data. Objectives: The aim of this work is to introduce the simple-to-use R package Mock Data Generation (modgo) that may be used for simulating data from existing study data for continuous, ordinal categorical, and dichotomous variables. Methods: The core is to combine rank inverse normal transformation with the calculation of a correlation matrix for all variables. Data can then be simulated from a multivariate normal and transferred back to the original scale of the variables. Unique features of modgo are that it allows to change the correlation between variables, to perform perturbation analysis, to handle multicenter data, and to change inclusion/exclusion criteria by selecting specific values of one or a set of variables. Simulation studies on real data demonstrate the validity and flexibility of modgo. Results: modgo mimicked the structure of the original study data. Results of modgo were similar with those from two other existing packages in standard simulation scenarios. modgo's flexibility was demonstrated on several expansions. Conclusion: The R package modgo is useful when existing study data may not be shared. Its perturbation expansion permits to simulate truly anonymized subjects. The expansion to multicenter studies can be used for validating prediction models. Additional expansions can support the unraveling of associations even in large study data and can be useful in power calculations. |
---|---|
Mesh-Begriff(e) | Computer Simulation ; Computer Security |
Sprache | Englisch |
Erscheinungsdatum | 2023-03-07 |
Erscheinungsland | Germany |
Dokumenttyp | Journal Article |
ZDB-ID | 3500-2 |
ISSN | 2511-705X ; 0026-1270 |
ISSN (online) | 2511-705X |
ISSN | 0026-1270 |
DOI | 10.1055/a-2048-7692 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Volltext online
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
Zs.A 126: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.