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  1. Buch ; Online ; E-Book: Nutrition and Diet in Health

    Oladiji, Adenike Temidayo / Oladele, Johnson Olaleye / Ajayi, Ebenezer I. O.

    Principles and Applications

    2024  

    Abstract: Nutrition and Diet in Health: Principles and Applications reviews and discusses the issues related to the roles of nutrition and diet in human health and diseases. ...

    Verfasserangabe edited by Adenike Temidayo Oladiji, Johnson Olaleye Oladele, and Ebenezer I. O. Ajayi
    Abstract Nutrition and Diet in Health: Principles and Applications reviews and discusses the issues related to the roles of nutrition and diet in human health and diseases.
    Schlagwörter Diet in disease ; Diet therapy ; Nutrition
    Thema/Rubrik (Code) 615.854
    Sprache Englisch
    Umfang 1 online resource (289 pages)
    Ausgabenhinweis First edition.
    Verlag CRC Press
    Erscheinungsort Boca Raton, FL
    Dokumenttyp Buch ; Online ; E-Book
    Anmerkung Includes index.
    Bemerkung Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-003-85840-6 ; 1-003-36149-8 ; 9781032421711 ; 978-1-003-85840-9 ; 978-1-003-36149-7 ; 1032421711
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Artikel ; Online: Kaempferol from Moringa oleifera demonstrated potent antivenom activities via inhibition of metalloproteinase and attenuation of Bitis arietans venom-induced toxicities.

    Ajisebiola, Babafemi Siji / Oladele, Johnson Olaleye / Adeyi, Akindele Oluwatosin

    Toxicon : official journal of the International Society on Toxinology

    2023  Band 233, Seite(n) 107242

    Abstract: Bitis arietans venom (BAV) can induce severe pathophysiological disorders after envenoming. However, studies have shown that the Moringa oleifera fraction is effective against BAV toxicities and contains bioactive compounds with significant antivenom ... ...

    Abstract Bitis arietans venom (BAV) can induce severe pathophysiological disorders after envenoming. However, studies have shown that the Moringa oleifera fraction is effective against BAV toxicities and contains bioactive compounds with significant antivenom potency. This research aimed to identify the main active antivenom compound in the M. oleifera fraction responsible for neutralizing the toxicities induced by BAV. The compounds identified from M. oleifera fraction were docked in silico against the catalytic site of the Snake Venom Metalloproteinase (SVMP) to determine the lead inhibitor compound. The antivenom potency of the lead inhibitor compound was tested against BAV toxicities and metalloproteinase isolated from BAV using in vitro and in vivo methods, while EchiTab-Plus polyvalent antivenom served as a standard drug. The in silico prediction revealed kaempferol as the lead inhibitor compound with a docking score of -7.0 kcal/mol. Kaempferol effectively inhibited metalloproteinase activity at 0.2 mg/ml, compared to antivenom (0.4 mg/ml) and demonstrated significant antihaemorrhagic, antihaemolytic and coagulant effects against BAV activities. Furthermore, kaempferol showed a significant dose-dependent effect on altered haematological indices observed in rats challenged with LD
    Mesh-Begriff(e) Animals ; Rats ; Antivenins/pharmacology ; Antivenins/therapeutic use ; Moringa oleifera ; Kaempferols/pharmacology ; Kaempferols/therapeutic use ; Snake Venoms ; Snake Bites/drug therapy ; Metalloproteases/therapeutic use
    Chemische Substanzen Antivenins ; Kaempferols ; Snake Venoms ; Metalloproteases (EC 3.4.-)
    Sprache Englisch
    Erscheinungsdatum 2023-08-08
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 204479-1
    ISSN 1879-3150 ; 0041-0101
    ISSN (online) 1879-3150
    ISSN 0041-0101
    DOI 10.1016/j.toxicon.2023.107242
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Kaempferol from Moringa oleifera demonstrated potent antivenom activities via inhibition of metalloproteinase and attenuation of Bitis arietans venom–induced toxicities

    Ajisebiola, Babafemi Siji / Oladele, Johnson Olaleye / Adeyi, Akindele Oluwatosin

    Toxicon. 2023 Aug. 08, p.107242-

    2023  , Seite(n) 107242–

    Abstract: Bitis arietans venom (BAV) can induce severe pathophysiological disorders after envenoming. However, studies have shown that the Moringa oleifera fraction is effective against BAV toxicities and contains bioactive compounds with significant antivenom ... ...

    Abstract Bitis arietans venom (BAV) can induce severe pathophysiological disorders after envenoming. However, studies have shown that the Moringa oleifera fraction is effective against BAV toxicities and contains bioactive compounds with significant antivenom potency. This research aimed to identify the main active antivenom compound in the M. oleifera fraction responsible for neutralizing the toxicities induced by BAV. The compounds identified from M. oleifera fraction were docked in silico against the catalytic site of the Snake Venom Metalloproteinase (SVMP) to determine the lead inhibitor compound. The antivenom potency of the lead inhibitor compound was tested against BAV toxicities and metalloproteinase isolated from BAV using in vitro and in vivo methods, while EchiTab-Plus polyvalent antivenom served as a standard drug. The in silico prediction revealed kaempferol as the lead inhibitor compound with a docking score of −7.0 kcal/mol. Kaempferol effectively inhibited metalloproteinase activity at 0.2 mg/ml, compared to antivenom (0.4 mg/ml) and demonstrated significant antihaemorrhagic, antihaemolytic and coagulant effects against BAV activities. Furthermore, kaempferol showed a significant dose-dependent effect on altered haematological indices observed in rats challenged with LD₅₀ of BAV. Envenomed rats also showed an increase in oxidative stress biomarkers and antioxidant enzyme activity in the heart and kidney. However, treatment with kaempferol significantly (P < 0.05) decreased malondialdehyde levels and SOD activity with concomitant enhancement of glutathione levels. Severe histopathological defects noticed in the organ tissues of envenomed rats were ameliorated after kaempferol treatment. Kaempferol is identified as the main active antivenom compound in M. oleifera, and this research highlights the potential of the compound as an effective alternative to snakebite treatment.
    Schlagwörter Bitis arietans ; Moringa oleifera ; active sites ; antioxidant enzymes ; antivenoms ; biomarkers ; coagulants ; computer simulation ; dose response ; enzyme activity ; glutathione ; heart ; histopathology ; kaempferol ; kidneys ; lead ; malondialdehyde ; metalloproteinases ; oxidative stress ; prediction ; snake bites ; snake venoms ; Envenomation ; Natural inhibitor ; Metalloproteinase
    Sprache Englisch
    Erscheinungsverlauf 2023-0808
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel ; Online
    Anmerkung Pre-press version
    ZDB-ID 204479-1
    ISSN 1879-3150 ; 0041-0101
    ISSN (online) 1879-3150
    ISSN 0041-0101
    DOI 10.1016/j.toxicon.2023.107242
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel: Functional Bioactivities of Soluble Seed Proteins from Two Leguminous Seeds.

    Adewole, Taiwo Scholes / Dudu, Boluwatife Bolanle / Oladele, Johnson Olaleye / Oyeleke, Oyedotun Moses / Kuku, Adenike

    Preventive nutrition and food science

    2023  Band 28, Heft 2, Seite(n) 160–169

    Abstract: Storage proteins ... ...

    Abstract Storage proteins from
    Sprache Englisch
    Erscheinungsdatum 2023-06-12
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2668373-8
    ISSN 2287-8602 ; 2287-1098
    ISSN (online) 2287-8602
    ISSN 2287-1098
    DOI 10.3746/pnf.2023.28.2.160
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Kaempferol mitigates reproductive dysfunctions induced by Naja nigricollis venom through antioxidant system and anti-inflammatory response in male rats.

    Adeyi, Akindele Oluwatosin / Ajisebiola, Babafemi Siji / Sanni, Akanni Abubakar / Oladele, Johnson Olaleye / Mustapha, Abdur-Rahman Kolawole / Oyedara, Omotayo Opemipo / Fagbenro, Olukunle Silas

    Scientific reports

    2024  Band 14, Heft 1, Seite(n) 3933

    Abstract: Naja nigricollis Venom (NnV) contains complex toxins that affects various vital systems functions after envenoming. The venom toxins have been reported to induce male reproductive disorders in envenomed rats. This present study explored the ameliorative ... ...

    Abstract Naja nigricollis Venom (NnV) contains complex toxins that affects various vital systems functions after envenoming. The venom toxins have been reported to induce male reproductive disorders in envenomed rats. This present study explored the ameliorative potential of kaempferol on NnV-induced male reproductive toxicity. Fifty male wistar rats were sorted randomly into five groups (n = 10) for this study. Group 1 were noted as the control, while rats in groups 2 to 5 were injected with LD
    Mesh-Begriff(e) Rats ; Male ; Animals ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Kaempferols/pharmacology ; Kaempferols/metabolism ; Sperm Motility ; Semen/metabolism ; Testis/metabolism ; Epididymis/metabolism ; Spermatozoa/metabolism ; Rats, Wistar ; Testosterone/metabolism ; Oxidative Stress ; Anti-Inflammatory Agents/pharmacology ; Naja
    Chemische Substanzen Antioxidants ; Kaempferols ; Testosterone (3XMK78S47O) ; Anti-Inflammatory Agents
    Sprache Englisch
    Erscheinungsdatum 2024-02-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-54523-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Water-soluble phenolics from

    Adewale, Omowumi Oyeronke / Oyelola, Roseline Fadera / Adetuyi, Oluwatosin Adefunke / Adebisi, Oluwaseun Abraham / Adekomi, Damilare Adedayo / Oladele, Johnson Olaleye

    Drug and chemical toxicology

    2024  , Seite(n) 1–14

    Abstract: Nephrotoxicity is the major side effect of cisplatin, an effective platinum-based chemotherapeutic drug that is applicable in the treatment of several solid-tissue cancers. Studies have indicated that certain water-soluble phenolics offer renal ... ...

    Abstract Nephrotoxicity is the major side effect of cisplatin, an effective platinum-based chemotherapeutic drug that is applicable in the treatment of several solid-tissue cancers. Studies have indicated that certain water-soluble phenolics offer renal protection. Thus, this study investigates the role of pre and post-treatment of rats with water-soluble phenolics from
    Sprache Englisch
    Erscheinungsdatum 2024-03-26
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 548368-2
    ISSN 1525-6014 ; 0148-0545
    ISSN (online) 1525-6014
    ISSN 0148-0545
    DOI 10.1080/01480545.2024.2329762
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  7. Artikel ; Online: Efficacy of selected Nigerian tropical plants in the treatment of COVID-19: in silico and in vitro investigations

    Oladele, Johnson Olaleye / Adewole, Taiwo Scholes / Ogundepo, Gbenga Emmanuel / Oyeleke, Oyedotun Moses / Kuku, Adenike

    Environ Sci Pollut Res. 2022 Dec., v. 29, no. 59 p.89295-89339

    2022  

    Abstract: The whole world is still challenged with COVID-19 pandemic caused by Coronavirus-2 (SARS-CoV-2) which has affected millions of individuals around the globe. Although there are prophylactic vaccines being used, till now, there is ongoing research into ... ...

    Abstract The whole world is still challenged with COVID-19 pandemic caused by Coronavirus-2 (SARS-CoV-2) which has affected millions of individuals around the globe. Although there are prophylactic vaccines being used, till now, there is ongoing research into discovery of drug candidates for total eradication of all types of coronaviruses. In this context, this study sought to investigate the inhibitory effects of six selected tropical plants against four pathogenic proteins of Coronavirus-2. The medicinal plants used in this study were selected based on their traditional applications in herbal medicine to treat COVID-19 and related symptoms. The biological activities (antioxidant, free radical scavenging, and anti-inflammatory activities) of the extracts of the plants were assessed using different standard procedures. The phytochemicals present in the extracts were identified using GCMS and further screened via in silico molecular docking. The data from this study demonstrated that the phytochemicals of the selected tropical medicinal plants displayed substantial binding affinity to the binding pockets of the four main pathogenic proteins of Coronavirus-2 indicating them as putative inhibitors of Coronavirus-2 and as potential anti-coronavirus drug candidates. The reaction between these phytocompounds and proteins of Coronavirus-2 could alter the pathophysiology of COVID-19, thus mitigating its pathogenic reactions/activities. In conclusion, phytocompounds of these plants exhibited promising binding efficiency with target proteins of SARS-COV-2. Nevertheless, in vitro and in vivo studies are important to potentiate these findings. Other drug techniques or models are vital to elucidate their compatibility and usage as adjuvants in vaccine development against the highly contagious COVID-19 infection.
    Schlagwörter COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; antioxidants ; computer simulation ; free radicals ; herbal medicines ; pathophysiology ; phytochemicals ; vaccine development
    Sprache Englisch
    Erscheinungsverlauf 2022-12
    Umfang p. 89295-89339.
    Erscheinungsort Springer Berlin Heidelberg
    Dokumenttyp Artikel ; Online
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-22025-9
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  8. Artikel: Covid-19 treatment: Investigation on the phytochemical constituents of

    Oladele, Johnson Olaleye / Oyeleke, Oyedotun Moses / Oladele, Oluwaseun Titilope / Oladiji, Adenike Temidayo

    Computational toxicology (Amsterdam, Netherlands)

    2021  Band 18, Seite(n) 100161

    Abstract: The upsurge in the current cases of COVID-19 poses a major threat on human health and population all over the globe. The emergence of new infectious diseases and increase in frequency of drug resistant viruses demand effective and novel therapeutic ... ...

    Abstract The upsurge in the current cases of COVID-19 poses a major threat on human health and population all over the globe. The emergence of new infectious diseases and increase in frequency of drug resistant viruses demand effective and novel therapeutic agents. In this study, we used bioinformatics approach to investigate the possible inhibitory potentials of phytochemical constituents of
    Sprache Englisch
    Erscheinungsdatum 2021-02-18
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ISSN 2468-1113
    ISSN 2468-1113
    DOI 10.1016/j.comtox.2021.100161
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  9. Artikel ; Online: Efficacy of selected Nigerian tropical plants in the treatment of COVID-19: in silico and in vitro investigations.

    Oladele, Johnson Olaleye / Adewole, Taiwo Scholes / Ogundepo, Gbenga Emmanuel / Oyeleke, Oyedotun Moses / Kuku, Adenike

    Environmental science and pollution research international

    2022  Band 29, Heft 59, Seite(n) 89295–89339

    Abstract: The whole world is still challenged with COVID-19 pandemic caused by Coronavirus-2 (SARS-CoV-2) which has affected millions of individuals around the globe. Although there are prophylactic vaccines being used, till now, there is ongoing research into ... ...

    Abstract The whole world is still challenged with COVID-19 pandemic caused by Coronavirus-2 (SARS-CoV-2) which has affected millions of individuals around the globe. Although there are prophylactic vaccines being used, till now, there is ongoing research into discovery of drug candidates for total eradication of all types of coronaviruses. In this context, this study sought to investigate the inhibitory effects of six selected tropical plants against four pathogenic proteins of Coronavirus-2. The medicinal plants used in this study were selected based on their traditional applications in herbal medicine to treat COVID-19 and related symptoms. The biological activities (antioxidant, free radical scavenging, and anti-inflammatory activities) of the extracts of the plants were assessed using different standard procedures. The phytochemicals present in the extracts were identified using GCMS and further screened via in silico molecular docking. The data from this study demonstrated that the phytochemicals of the selected tropical medicinal plants displayed substantial binding affinity to the binding pockets of the four main pathogenic proteins of Coronavirus-2 indicating them as putative inhibitors of Coronavirus-2 and as potential anti-coronavirus drug candidates. The reaction between these phytocompounds and proteins of Coronavirus-2 could alter the pathophysiology of COVID-19, thus mitigating its pathogenic reactions/activities. In conclusion, phytocompounds of these plants exhibited promising binding efficiency with target proteins of SARS-COV-2. Nevertheless, in vitro and in vivo studies are important to potentiate these findings. Other drug techniques or models are vital to elucidate their compatibility and usage as adjuvants in vaccine development against the highly contagious COVID-19 infection.
    Mesh-Begriff(e) Humans ; COVID-19 ; SARS-CoV-2 ; Pandemics ; Molecular Docking Simulation ; Nigeria ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; Phytochemicals/pharmacology ; Phytochemicals/chemistry
    Chemische Substanzen Antiviral Agents ; Phytochemicals
    Sprache Englisch
    Erscheinungsdatum 2022-07-18
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-22025-9
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  10. Artikel ; Online: Bitter Leaf (Vernonia Amygdalina) Modulates Nitrobenzene-Induced Renal Damage in Rats Via Suppression of Oxido-Inflammatory Activities

    Oladele Johnson Olaleye / Oyeleke Oyedotun Moses / Olowookere Boyede Dele / Babatope Oluwafeyisayo Doyinsola / Olaniyan Monisola Dorcas / Akindolie Blessing Oluwadunsin / Oladele Oluwaseun Titilope

    Serbian Journal of Experimental and Clinical Research, Vol 22, Iss 4, Pp 317-

    2021  Band 324

    Abstract: Renal diseases have been documented as one of the massive health challenges, ranked as the 12th most common cause of death globally. This study was carried out to assess the chemopreventive effects of Vernonia amydalina on nitrobenzene mediated renal ... ...

    Abstract Renal diseases have been documented as one of the massive health challenges, ranked as the 12th most common cause of death globally. This study was carried out to assess the chemopreventive effects of Vernonia amydalina on nitrobenzene mediated renal damage in rats. Rats were exposed to 100 mg/kg body weight of nitrobenzene via oral administration and treated with 200 mg/kg body weight (BW) and 400 mg/kg BW of methanol leaf extract of Vernonia amydalina (MLVA) and Vitamin E for 14 consecutive days. Nitrobenzene significantly induced a renal injury with a significant increase in the serum levels of urea and creatinine with the concomitant altered serum electrolyte profile. Also, nitrobenzene mediated the oxidative stress and lipid peroxidation with a significant increase in the renal level of malondialdehyde (MDA), hydrogen peroxide (H2O2), with a concomitant decrease in the level of reduced glutathione (GSH), Catalase (CAT) and Superoxide dismutase (SOD). Furthermore, an inflammation was observed in the nitrobenzene-treated rats with the elevated level of nitric oxide (NO) and myeloperoxidase (MPO). However, the treatment with methanol leaf extract of Vernonia amydalina reversed all the nitrobenzene-associated renal damage, electrolyte imbalance, oxidative stress, lipid peroxidation, inflammation and altered antioxidant defence system. Taken together, methanol leaf extract of Vernonia amydalina offers protection which may be beneficial for the treatment and management of kidney diseases or other related disorders via enhancing the serum electrolyte homeostasis, protecting the structural integrity of the kidney, antioxidant, anti-inflammatory mechanisms.
    Schlagwörter renal damage ; nitrobenzene ; oxidative stress ; vernonia amydalina ; inflammation ; electrolyte imbalance ; Medicine ; R
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag Sciendo
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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