Artikel ; Online: Abrogation of neutrophil inflammatory pathways and potential reduction of neutrophil-related factors in COVID-19 by intravenous immunoglobulin.
2022 Band 13, Seite(n) 993720
Abstract: Pathogenesis of lung injury in COVID-19 is not completely understood, leaving gaps in understanding how current treatments modulate the course of COVID-19. Neutrophil numbers and activation state in circulation have been found to correlate with COVID-19 ... ...
Abstract | Pathogenesis of lung injury in COVID-19 is not completely understood, leaving gaps in understanding how current treatments modulate the course of COVID-19. Neutrophil numbers and activation state in circulation have been found to correlate with COVID-19 severity, and neutrophil extracellular traps (NETs) have been found in the lung parenchyma of patients with acute respiratory distress syndrome (ARDS) in COVID-19. Targeting the pro-inflammatory functions of neutrophils may diminish lung injury in COVID-19 and ARDS. Neutrophils were isolated from peripheral blood of healthy donors, treated |
---|---|
Mesh-Begriff(e) | Humans ; Neutrophils/metabolism ; Immunoglobulins, Intravenous/therapeutic use ; Immunoglobulins, Intravenous/pharmacology ; Leukocyte Elastase/metabolism ; Lung Injury/metabolism ; Respiratory Distress Syndrome ; Cell-Free Nucleic Acids/metabolism ; Dexamethasone ; COVID-19 Drug Treatment |
Chemische Substanzen | Immunoglobulins, Intravenous ; Leukocyte Elastase (EC 3.4.21.37) ; Cell-Free Nucleic Acids ; Dexamethasone (7S5I7G3JQL) |
Sprache | Englisch |
Erscheinungsdatum | 2022-10-20 |
Erscheinungsland | Switzerland |
Dokumenttyp | Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural |
ZDB-ID | 2606827-8 |
ISSN | 1664-3224 ; 1664-3224 |
ISSN (online) | 1664-3224 |
ISSN | 1664-3224 |
DOI | 10.3389/fimmu.2022.993720 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Zusatzmaterialien
Kategorien
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.