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  1. Article ; Online: Comparative serologic profiles of hepatitis B Virus (HBV) between HIV/HBV co-infected and Hbv mono-infected patients in Ile-Ife, Nigeria.

    Osasona, Oluwadamilola Gideon / Adewale-Fashoro, Opeoluwa / Olumade, Testimony J / Oguzie, Judith / George, Uwem / Ariyo, Olumuyiwa Elijah / Oguntoye, Oluwatosin Oluwagbenga

    Journal of immunoassay & immunochemistry

    2021  Volume 42, Issue 6, Page(s) 633–647

    Abstract: Hepatitis B virus (HBV) infects about 2 billion people globally and accounts for mortality of about 800,000 from liver cirrhosis and hepatocellular carcinoma. Sub-Saharan Africa accounts for 70% of the Human Immunodeficiency Virus (HIV) global burden. ... ...

    Abstract Hepatitis B virus (HBV) infects about 2 billion people globally and accounts for mortality of about 800,000 from liver cirrhosis and hepatocellular carcinoma. Sub-Saharan Africa accounts for 70% of the Human Immunodeficiency Virus (HIV) global burden. HIV/HBV co-infection results in the early development of HBV complications, alterations of serological biomarkers of HBV. Two hundred and fifty patients with HIV/AIDS were screened for HBV and 20 (8%) were identified. The same number of HBV mono-infected individuals were recruited into the study and subsequently, HBV serological profiles which include HBsAg, HBsAb, HBeAg, HBeAb, HBcAbIgM, and HBcAbIgG were assayed using HBV ELISA kits. Mean age of patients in the HBV/HIV cohort was 45.5 years while the HBV mono-infected infected cohort was 30.5 years. The majority of the HBV/HIV co-infected individuals were females (85%). The frequency of HBeAg among HIV/HBV co-infected cohort was 25% and 15% for HBV mono-infected, while the frequency of HBeAb was higher (60%) among the cohort of HBV/HIV co-infected patients in comparison with the HBV mono-infected cohorts (50%). Two patients among the HIV/HBV co-infected cohort have the isolated anti-HBcAg serologic pattern. The study broadened the available evidence of comparative serologic profiles of Hepatitis B virus between cohorts of HBV/HIV co-infected individuals and HBV mono-infected patients in Nigeria.
    MeSH term(s) Coinfection ; Female ; HIV Infections/complications ; Hepatitis B/complications ; Hepatitis B Antibodies ; Hepatitis B Surface Antigens ; Hepatitis B e Antigens ; Hepatitis B virus/immunology ; Humans ; Liver Neoplasms ; Male ; Middle Aged ; Nigeria
    Chemical Substances Hepatitis B Antibodies ; Hepatitis B Surface Antigens ; Hepatitis B e Antigens
    Language English
    Publishing date 2021-05-24
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 2050610-7
    ISSN 1532-4230 ; 1532-1819
    ISSN (online) 1532-4230
    ISSN 1532-1819
    DOI 10.1080/15321819.2021.1924197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Infectious disease outbreak preparedness and response in Nigeria: history, limitations and recommendations for global health policy and practice.

    Olumade, Testimony J / Adesanya, Oluwafolajimi A / Fred-Akintunwa, Iyanuoluwa J / Babalola, David O / Oguzie, Judith U / Ogunsanya, Olusola A / George, Uwem E / Akin-Ajani, Oluwawapelumi D / Osasona, Damilola G

    AIMS public health

    2020  Volume 7, Issue 4, Page(s) 736–757

    Abstract: Effective disease outbreak response has historically been a challenging accomplishment for the Nigerian health system due to an array of hurdles not unique to Nigeria but also found in other African nations which share its large size and complexity. ... ...

    Abstract Effective disease outbreak response has historically been a challenging accomplishment for the Nigerian health system due to an array of hurdles not unique to Nigeria but also found in other African nations which share its large size and complexity. However, the efficiency of the response mounted against the Ebola Virus Disease (EVD) outbreak of 2014 proved that indeed, though challenging, proactive and effective outbreak response is not impossible. With over 20 public health emergencies and infectious disease outbreaks between 2016 and 2018 alone, Nigeria is one of only five members of the World Health Organization (WHO) African Region to report five or more public health events per annum. There are many lessons that can be drawn from Nigeria's experience in handling outbreaks of infectious diseases. In this review, we discuss the history of emerging and re-emerging infectious disease outbreaks in Nigeria and explore the response strategies mounted towards each. We also highlight the significant successes and note-worthy limitations, which we have then utilized to proffer policy recommendations to strengthen the Nigerian public health emergency response systems.
    Language English
    Publishing date 2020-09-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2777115-5
    ISSN 2327-8994 ; 2327-8994
    ISSN (online) 2327-8994
    ISSN 2327-8994
    DOI 10.3934/publichealth.2020057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Increased Prevalence of Lassa Fever Virus-Positive Rodents and Diversity of Infected Species Found during Human Lassa Fever Epidemics in Nigeria.

    Happi, Anise N / Olumade, Testimony J / Ogunsanya, Olusola A / Sijuwola, Ayotunde E / Ogunleye, Seto C / Oguzie, Judith U / Nwofoke, Cecilia / Ugwu, Chinedu A / Okoro, Samuel J / Otuh, Patricia I / Ngele, Louis N / Ojo, Oluwafemi O / Adelabu, Ademola / Adeleye, Roseline F / Oyejide, Nicholas E / Njaka, Clinton S / Heeney, Jonathan L / Happi, Christian T

    Microbiology spectrum

    2022  Volume 10, Issue 4, Page(s) e0036622

    Abstract: The dynamics of Lassa virus (LASV) infections in rodent reservoirs and their endemic human caseloads remain poorly understood. During the endemic period, human infections are believed to be associated with the seasonal migration of Mastomys natalensis, ... ...

    Abstract The dynamics of Lassa virus (LASV) infections in rodent reservoirs and their endemic human caseloads remain poorly understood. During the endemic period, human infections are believed to be associated with the seasonal migration of Mastomys natalensis, thought to be the primary reservoir that triggers multiple spillovers of LASV to humans. It has become imperative to improve LASV diagnosis in rodents while updating their prevalence in two regions of Lassa fever endemicity in Nigeria. Rodents (total, 942) were trapped in Ondo (531) and Ebonyi (411) states between October 2018 and April 2020 for detection of LASV using various tissues. Overall, the LASV prevalence was 53.6%. The outbreak area sampled in Ondo had three and two times higher capture success and LASV prevalence, respectively, than Ebonyi State. This correlated with the higher number of annual cases of Lassa fever (LF) in Ondo State versus Ebonyi State. All rodent genera (
    MeSH term(s) Animals ; Epidemics ; Humans ; Lassa Fever/epidemiology ; Lassa Fever/prevention & control ; Lassa Fever/veterinary ; Lassa virus ; Murinae ; Nigeria/epidemiology ; Prevalence ; Rats
    Language English
    Publishing date 2022-08-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.00366-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Metagenomic sequencing characterizes a wide diversity of viruses in field mosquito samples in Nigeria.

    Oguzie, Judith U / Nwangwu, Udoka C / Oluniyi, Paul E / Olumade, Testimony J / George, Uwem E / Kazeem, Akano / Bankole, Bolajoko E / Brimmo, Farida O / Asadu, Chukwuemeka C / Chukwuekezie, Okechukwu C / Ochu, Josephine C / Makwe, Catherine O / Dogunro, Festus A / Onwude, Cosmas O / Nwachukwu, William E / Ezihe, Ebuka K / Okonkwo, Gilkenny K / Umazi, Ndubuisi E / Maikere, Jacob /
    Agashi, Nneka O / Eloy, Emelda I / Anokwu, Stephen O / Okoronkwo, Angela I / Nwosu, Ebuka M / Etiki, Sandra O / Ngwu, Ifeoma M / Ihekweazu, Chikwe / Folarin, Onikepe A / Komolafe, Isaac O O / Happi, Christian T

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 7616

    Abstract: Mosquito vectors are a tremendous public health threat. One in six diseases worldwide is vector-borne transmitted mainly by mosquitoes. In the last couple of years, there have been active Yellow fever virus (YFV) outbreaks in many settings in Nigeria, ... ...

    Abstract Mosquito vectors are a tremendous public health threat. One in six diseases worldwide is vector-borne transmitted mainly by mosquitoes. In the last couple of years, there have been active Yellow fever virus (YFV) outbreaks in many settings in Nigeria, and nationwide, entomological surveillance has been a significant effort geared towards understanding these outbreaks. In this study, we used a metagenomic sequencing approach to characterize viruses present in vector samples collected during various outbreaks of Yellow fever (YF) in Nigeria between 2017 and 2020. Mosquito samples were grouped into pools of 1 to 50 mosquitoes, each based on species, sex and location. Twenty-five pools of Aedes spp and one pool of Anopheles spp collected from nine states were sequenced and metagenomic analysis was carried out. We identified a wide diversity of viruses belonging to various families in this sample set. Seven different viruses detected included: Fako virus, Phasi Charoen-like virus, Verdadero virus, Chaq like-virus, Aedes aegypti totivirus, cell fusing agent virus and Tesano Aedes virus. Although there are no reports of these viruses being pathogenic, they are an understudied group in the same families and closely related to known pathogenic arboviruses. Our study highlights the power of next generation sequencing in identifying Insect specific viruses (ISVs), and provide insight into mosquito vectors virome in Nigeria.
    MeSH term(s) Aedes ; Animals ; Arboviruses ; Humans ; Insect Viruses ; Mosquito Vectors ; Nigeria/epidemiology ; RNA Viruses
    Language English
    Publishing date 2022-05-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-11797-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: CLINICAL AND DEMOGRAPHIC CHARACTERISTICS OF COVID-19 PATIENTS IN LAGOS, NIGERIA: A DESCRIPTIVE STUDY

    Otuonye, Ngozi Mirabel / Olumade, Testimony J. / Ojetunde, Mercy Mayowa / Holdbrooke, Susan Abba / Ayoola, Joy Boluwatife / Nyam, Itse Yusuf / Iwalokun, Bamidele / Onwuamah, Chika / Uwandu, Mabel / Salako, Babatunde Lawal / Abayomi, Akinola / Osibogun, Akin / Bowale, Abimbola / Osikomaiya, Bodunrin / Thomas, Babafemi / Mutiu, Bamidele / Odunukwe, Nkiruka Nnonyelum

    medRxiv

    Abstract: Introduction: COVID-19 is an emerging, rapidly evolving global situation, infecting over 25 million people and causing more than 850,000 deaths. Several signs and symptoms have been described to be characteristic of the disease. However, there is a ... ...

    Abstract Introduction: COVID-19 is an emerging, rapidly evolving global situation, infecting over 25 million people and causing more than 850,000 deaths. Several signs and symptoms have been described to be characteristic of the disease. However, there is a dearth of report on the description of the clinical characteristics of the disease in patients from Nigeria. This study was designed to provide a description of the clinical and demographic characteristics of COVID-19 patients in Nigeria. Methods: This study is a case series that includes patients that are evaluated between June and August 30, 2020, and diagnosed with COVID-19. Patient health records were reviewed and evaluated to describe the clinical characteristics on presentation. Results: A total of 154 COVID-19 patients were included in this study, with a mean age (S.D.) of 46.16 (13.701). Most of the patients survived (mortality rate of 2.6%), and were symptomatic (89.6%). There were more males (74.7%) than females, and the most common symptoms were fever, breathing difficulty, dry cough and malaise. Co-morbidities were also present in almost half of the study participants (49.4%). Conclusion: This study presents the most extensive description, to date, on the clinical and demographic characteristics of COVID-19 patients in Nigeria. Males are more likely than females to be infected with COVID-19 and the most occurring symptoms are fever, breathing difficulty, malaise, dry cough and chest pain. Old age and the presence of co-morbidities may also be associated with developing the severe disease. Key words: COVID-19, SARS-CoV-2, Signs, Symptoms, Nigeria.
    Keywords covid19
    Language English
    Publishing date 2020-09-24
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.09.15.20195412
    Database COVID19

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  6. Article: The Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Response

    Botti-Lodovico, Yolanda / Nair, Parvathy / Nosamiefan, Dolo / Stremlau, Matthew / Schaffner, Stephen / Agignoae, Sebastian V. / Aiyepada, John Oke / Ajogbasile, Fehintola V. / Akpede, George O. / Alhasan, Foday / Andersen, Kristian G. / Asogun, Danny A. / Ayodeji, Oladele Oluwafemi / Badiane, Aida S. / Barnes, Kayla / Bauer, Matthew R. / Bell-Kareem, Antoinette / Benard, Muoebonam Ekene / Benevolence, Ebo Ohomoime /
    Blessing, Osiemi / Boehm, Chloe K. / Boisen, Matthew L. / Bond, Nell G. / Branco, Luis M. / Butts, Michael J. / Carter, Amber / Colubri, Andres / Deme, Awa B. / DeRuff, Katherine C. / Diédhiou, Younousse / Edamhande, Akhilomen Patience / Elhamoumi, Siham / Engel, Emily J. / Eromon, Philomena / Fallah, Mosoka / Folarin, Onikepe A. / Fry, Ben / Garry, Robert / Gaye, Amy / Gbakie, Michael / Gevao, Sahr M. / Gionet, Gabrielle / Gladden-Young, Adrianne / Goba, Augustine / Gomis, Jules Francois / Happi, Anise N. / Houghton, Mary / Ihekwuazu, Chikwe / Iruolagbe, Christopher Ojemiega / Jackson, Jonathan / Jalloh, Simbirie / Johnson, Jeremy / Kanneh, Lansana / Kayode, Adeyemi / Kemball, Molly / Kingsley, Ojide Chiedozie / Koroma, Veronica / Kotliar, Dylan / Mehta, Samar / Metsky, Hayden C. / Michael, Airende / Mirhashemi, Marzieh Ezzaty / Modjarrad, Kayvon / Momoh, Mambu / Myhrvold, Cameron A. / Naregose, Okonofua Grace / Ndiaye, Tolla / Ndiaye, Mouhamadou / Ndiaye, Aliou / Normandin, Erica / Odia, Ikponmwosa / Oguzie, Judith Uche / Okogbenin, Sylvanus A. / Okokhere, Peter O. / Okolie, Johnson / Olawoye, Idowu B. / Olumade, Testimony J. / Oluniyi, Paul E. / Omoregie, Omigie / Park, Daniel J. / Paye, Mariétou Faye / Petros, Brittany / Philippakis, Anthony A. / Priscilla, Abechi / Ricks, Alan / Rimoin, Anne / Sandi, John Demby / Schieffelin, John S. / Schreiber, Monica / Seck, Mame Cheikh / Siddiqui, Sameed / Siddle, Katherine / Smither, Allison R. / Sy, Mouhamad / Sy, Ngayo / Tomkins-Tinch, Christopher H. / Tomori, Oyewale / Ugwu, Chinedu / Uwanibe, Jessica N. / Uyigue, Eghosasere Anthonia / Victoria, Dada Ireti / Vinzé, Anika / Vodzak, Megan E. / Welch, Nicole / Wurie, Haja Isatta / Zoumarou, Daba / Grant, Donald S. / Ndiaye, Daouda / MacInnis, Bronwyn / Sabeti, Pardis C. / Happi, Christian

    Viruses. 2021 Aug. 13, v. 13, no. 8

    2021  

    Abstract: While investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in Lassa virus binding and entry. This led us to pursue field work to test our ... ...

    Abstract While investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in Lassa virus binding and entry. This led us to pursue field work to test our hypothesis that natural selection acting on LARGE—detected in the Yoruba population of Nigeria—conferred resistance to Lassa Fever in some West African populations. As we delved further, we conjectured that the “emerging” nature of recently discovered diseases like Lassa fever is related to a newfound capacity for detection, rather than a novel viral presence, and that humans have in fact been exposed to the viruses that cause such diseases for much longer than previously suspected. Dr. Stefan Kunz’s critical efforts not only laid the groundwork for this discovery, but also inspired and catalyzed a series of events that birthed Sentinel, an ambitious and large-scale pandemic prevention effort in West Africa. Sentinel aims to detect and characterize deadly pathogens before they spread across the globe, through implementation of its three fundamental pillars: Detect, Connect, and Empower. More specifically, Sentinel is designed to detect known and novel infections rapidly, connect and share information in real time to identify emerging threats, and empower the public health community to improve pandemic preparedness and response anywhere in the world. We are proud to dedicate this work to Stefan Kunz, and eagerly invite new collaborators, experts, and others to join us in our efforts.
    Keywords Lassa mammarenavirus ; Lassa virus fever ; early warning systems ; evolutionary adaptation ; genes ; natural selection ; pandemic ; public health ; Western Africa
    Language English
    Dates of publication 2021-0813
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13081605
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria.

    Olawoye, Idowu B / Oluniyi, Paul E / Oguzie, Judith U / Uwanibe, Jessica N / Kayode, Tolulope A / Olumade, Testimony J / Ajogbasile, Fehintola V / Parker, Edyth / Eromon, Philomena E / Abechi, Priscilla / Sobajo, Tope A / Ugwu, Chinedu A / George, Uwem E / Ayoade, Femi / Akano, Kazeem / Oyejide, Nicholas E / Nosamiefan, Iguosadolo / Fred-Akintunwa, Iyanuoluwa / Adedotun-Sulaiman, Kemi /
    Brimmo, Farida B / Adegboyega, Babatunde B / Philip, Courage / Adeleke, Richard A / Chukwu, Grace C / Ahmed, Muhammad I / Ope-Ewe, Oludayo O / Otitoola, Shobi G / Ogunsanya, Olusola A / Saibu, Mudasiru F / Sijuwola, Ayotunde E / Ezekiel, Grace O / John, Oluwagboadurami G / Akin-John, Julie O / Akinlo, Oluwasemilogo O / Fayemi, Olanrewaju O / Ipaye, Testimony O / Nwodo, Deborah C / Omoniyi, Abolade E / Omwanghe, Iyobosa B / Terkuma, Christabel A / Okolie, Johnson / Ayo-Ale, Olubukola / Ikponmwosa, Odia / Benevolence, Ebo / Naregose, Grace O / Patience, Akhilomen E / Blessing, Osiemi / Micheal, Airende / Jacqueline, Agbukor / Aiyepada, John O / Ebhodaghe, Paulson / Racheal, Omiunu / Rita, Esumeh / Rosemary, Giwa E / Solomon, Ehikhametalor / Anieno, Ekanem / Edna, Yerumoh / Chris, Aire O / Donatus, Adomeh I / Ogbaini-Emovon, Ephraim / Tatfeng, Mirabeau Y / Omunakwe, Hannah E / Bob-Manuel, Mienye / Ahmed, Rahaman A / Onwuamah, Chika K / Shaibu, Joseph O / Okwuraiwe, Azuka / Ataga, Anthony E / Bock-Oruma, Andrew / Daramola, Funmi / Yusuf, Ibrahim F / Fajola, Akinwumi / Ntia, Nsikak-Abasi / Ekpo, Julie J / Moses, Anietie E / Moore-Igwe, Beatrice W / Fakayode, Oluwatosin E / Akinola, Monilade / Kida, Ibrahim M / Oderinde, Bamidele S / Wudiri, Zara W / Adeyemi, Oluwapelumi O / Akanbi, Olusola A / Ahumibe, Anthony / Akinpelu, Afolabi / Ayansola, Oyeronke / Babatunde, Olajumoke / Omoare, Adesuyi A / Chukwu, Chimaobi / Mba, Nwando G / Omoruyi, Ewean C / Olisa, Olasunkanmi / Akande, Olatunji K / Nwafor, Ifeanyi E / Ekeh, Matthew A / Ndoma, Erim / Ewah, Richard L / Duruihuoma, Rosemary O / Abu, Augustine / Odeh, Elizabeth / Onyia, Venatius / Ojide, Chiedozie K / Okoro, Sylvanus / Igwe, Daniel / Ogah, Emeka O / Khan, Kamran / Ajayi, Nnennaya A / Ugwu, Collins N / Ukwaja, Kingsley N / Ugwu, Ngozi I / Abejegah, Chukwuyem / Adedosu, Nelson / Ayodeji, Olufemi / Liasu, Ahmed A / Isamotu, Rafiu O / Gadzama, Galadima / Petros, Brittany A / Siddle, Katherine J / Schaffner, Stephen F / Akpede, George / Erameh, Cyril Oshomah / Baba, Marycelin M / Oladiji, Femi / Audu, Rosemary / Ndodo, Nnaemeka / Fowotade, Adeola / Okogbenin, Sylvanus / Okokhere, Peter O / Park, Danny J / Mcannis, Bronwyn L / Adetifa, Ifedayo M / Ihekweazu, Chikwe / Salako, Babatunde L / Tomori, Oyewale / Happi, Anise N / Folarin, Onikepe A / Andersen, Kristian G / Sabeti, Pardis C / Happi, Christian T

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 811

    Abstract: Identifying the dissemination patterns and impacts of a virus of economic or health importance during a pandemic is crucial, as it informs the public on policies for containment in order to reduce the spread of the virus. In this study, we integrated ... ...

    Abstract Identifying the dissemination patterns and impacts of a virus of economic or health importance during a pandemic is crucial, as it informs the public on policies for containment in order to reduce the spread of the virus. In this study, we integrated genomic and travel data to investigate the emergence and spread of the SARS-CoV-2 B.1.1.318 and B.1.525 (Eta) variants of interest in Nigeria and the wider Africa region. By integrating travel data and phylogeographic reconstructions, we find that these two variants that arose during the second wave in Nigeria emerged from within Africa, with the B.1.525 from Nigeria, and then spread to other parts of the world. Data from this study show how regional connectivity of Nigeria drove the spread of these variants of interest to surrounding countries and those connected by air-traffic. Our findings demonstrate the power of genomic analysis when combined with mobility and epidemiological data to identify the drivers of transmission, as bidirectional transmission within and between African nations are grossly underestimated as seen in our import risk index estimates.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Nigeria/epidemiology ; SARS-CoV-2/genetics
    Language English
    Publishing date 2023-02-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-36449-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Response.

    Botti-Lodovico, Yolanda / Nair, Parvathy / Nosamiefan, Dolo / Stremlau, Matthew / Schaffner, Stephen / Agignoae, Sebastian V / Aiyepada, John Oke / Ajogbasile, Fehintola V / Akpede, George O / Alhasan, Foday / Andersen, Kristian G / Asogun, Danny A / Ayodeji, Oladele Oluwafemi / Badiane, Aida S / Barnes, Kayla / Bauer, Matthew R / Bell-Kareem, Antoinette / Benard, Muoebonam Ekene / Benevolence, Ebo Ohomoime /
    Blessing, Osiemi / Boehm, Chloe K / Boisen, Matthew L / Bond, Nell G / Branco, Luis M / Butts, Michael J / Carter, Amber / Colubri, Andres / Deme, Awa B / DeRuff, Katherine C / Diédhiou, Younousse / Edamhande, Akhilomen Patience / Elhamoumi, Siham / Engel, Emily J / Eromon, Philomena / Fallah, Mosoka / Folarin, Onikepe A / Fry, Ben / Garry, Robert / Gaye, Amy / Gbakie, Michael / Gevao, Sahr M / Gionet, Gabrielle / Gladden-Young, Adrianne / Goba, Augustine / Gomis, Jules Francois / Happi, Anise N / Houghton, Mary / Ihekwuazu, Chikwe / Iruolagbe, Christopher Ojemiega / Jackson, Jonathan / Jalloh, Simbirie / Johnson, Jeremy / Kanneh, Lansana / Kayode, Adeyemi / Kemball, Molly / Kingsley, Ojide Chiedozie / Koroma, Veronica / Kotliar, Dylan / Mehta, Samar / Metsky, Hayden C / Michael, Airende / Mirhashemi, Marzieh Ezzaty / Modjarrad, Kayvon / Momoh, Mambu / Myhrvold, Cameron A / Naregose, Okonofua Grace / Ndiaye, Tolla / Ndiaye, Mouhamadou / Ndiaye, Aliou / Normandin, Erica / Odia, Ikponmwosa / Oguzie, Judith Uche / Okogbenin, Sylvanus A / Okokhere, Peter O / Okolie, Johnson / Olawoye, Idowu B / Olumade, Testimony J / Oluniyi, Paul E / Omoregie, Omigie / Park, Daniel J / Paye, Mariétou Faye / Petros, Brittany / Philippakis, Anthony A / Priscilla, Abechi / Ricks, Alan / Rimoin, Anne / Sandi, John Demby / Schieffelin, John S / Schreiber, Monica / Seck, Mame Cheikh / Siddiqui, Sameed / Siddle, Katherine / Smither, Allison R / Sy, Mouhamad / Sy, Ngayo / Tomkins-Tinch, Christopher H / Tomori, Oyewale / Ugwu, Chinedu / Uwanibe, Jessica N / Uyigue, Eghosasere Anthonia / Victoria, Dada Ireti / Vinzé, Anika / Vodzak, Megan E / Welch, Nicole / Wurie, Haja Isatta / Zoumarou, Daba / Grant, Donald S / Ndiaye, Daouda / MacInnis, Bronwyn / Sabeti, Pardis C / Happi, Christian

    Viruses

    2021  Volume 13, Issue 8

    Abstract: While investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in Lassa virus binding and entry. This led us to pursue field work to test our ... ...

    Abstract While investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in Lassa virus binding and entry. This led us to pursue field work to test our hypothesis that natural selection acting on LARGE-detected in the Yoruba population of Nigeria-conferred resistance to Lassa Fever in some West African populations. As we delved further, we conjectured that the "emerging" nature of recently discovered diseases like Lassa fever is related to a newfound capacity for detection, rather than a novel viral presence, and that humans have in fact been exposed to the viruses that cause such diseases for much longer than previously suspected. Dr. Stefan Kunz's critical efforts not only laid the groundwork for this discovery, but also inspired and catalyzed a series of events that birthed Sentinel, an ambitious and large-scale pandemic prevention effort in West Africa. Sentinel aims to detect and characterize deadly pathogens before they spread across the globe, through implementation of its three fundamental pillars: Detect, Connect, and Empower. More specifically, Sentinel is designed to detect known and novel infections rapidly, connect and share information in real time to identify emerging threats, and empower the public health community to improve pandemic preparedness and response anywhere in the world. We are proud to dedicate this work to Stefan Kunz, and eagerly invite new collaborators, experts, and others to join us in our efforts.
    MeSH term(s) Africa, Western/epidemiology ; Disaster Planning/methods ; Humans ; Lassa Fever/epidemiology ; Lassa Fever/genetics ; Lassa Fever/prevention & control ; Lassa Fever/virology ; Lassa virus/genetics ; Lassa virus/physiology ; N-Acetylglucosaminyltransferases/genetics ; N-Acetylglucosaminyltransferases/immunology ; Nigeria/epidemiology ; Pandemics ; Polymorphism, Genetic ; Receptors, Virus/genetics ; Receptors, Virus/immunology
    Chemical Substances Receptors, Virus ; LARGE1 protein, human (EC 2.4.1.-) ; N-Acetylglucosaminyltransferases (EC 2.4.1.-)
    Language English
    Publishing date 2021-08-13
    Publishing country Switzerland
    Document type Consensus Development Conference ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13081605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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