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  1. Artikel ; Online: Photovoltaic Stimulation Induces Overdrive Suppression in Embryonic Chicken Cardiomyocytes

    Polz Mathias / Ziesel Daniel / Shrestha Niroj / Pelzmann Brigitte / Lang Petra / Scherübel Susanne / Üçal Muammer / Kornmüller Karin / Schröttner Jörg / Đerek Vedran / Opančar Aleksandar / Głowacki Eric Daniel / Baumgartner Christian / Rienmüller Theresa

    Current Directions in Biomedical Engineering, Vol 9, Iss 2, Pp 12-

    2023  Band 15

    Abstract: In this study, we employed calcium imaging to investigate the dynamics of intracellular calcium levels in embryonic chicken cardiomyocytes upon extracellular, optoelectronic stimulation. A photovoltaic layer of donoracceptor pigments on a flexible PET ... ...

    Abstract In this study, we employed calcium imaging to investigate the dynamics of intracellular calcium levels in embryonic chicken cardiomyocytes upon extracellular, optoelectronic stimulation. A photovoltaic layer of donoracceptor pigments on a flexible PET substrate was used as a wireless stimulation electrode. Our findings revealed a distinct change in their spontaneous activity pattern in cardiac cells following asynchronous light stimulation. A short pause in cellular activity, indicative of overdrive suppression, was observed in recordings from several different cells. The pause in activity signifies a transient refractory period induced by stimulation of the photovoltaic device with red light. These findings suggest that photovoltaic electrodes can be used to effectively modulate the electrical activity of cardiac cells in a wireless, non-pharmacological manner. This opens new avenues for non-invasive and precise light-modulated control of cellular electrophysiology as well as potential therapeutic applications for cardiac rhythm disorders.
    Schlagwörter extracellular stimulation ; arrhythmia ; optoelectronics ; oepc ; photocapacitor ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag De Gruyter
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Micropyramid structured photo capacitive interfaces.

    Nikić, Marta / Opančar, Aleksandar / Hartmann, Florian / Migliaccio, Ludovico / Jakešová, Marie / Głowacki, Eric Daniel / Đerek, Vedran

    Nanotechnology

    2022  Band 33, Heft 24

    Abstract: Optically driven electronic neuromodulation devices are a novel tool in basic research and offer new prospects in medical therapeutic applications. Optimal operation of such devices requires efficient light capture and charge generation, effective ... ...

    Abstract Optically driven electronic neuromodulation devices are a novel tool in basic research and offer new prospects in medical therapeutic applications. Optimal operation of such devices requires efficient light capture and charge generation, effective electrical communication across the device's bioelectronic interface, conformal adhesion to the target tissue, and mechanical stability of the device during the lifetime of the implant-all of which can be tuned by spatial structuring of the device. We demonstrate a 3D structured opto-bioelectronic device-an organic electrolytic photocapacitor spatially designed by depositing the active device layers on an inverted micropyramid-shaped substrate. Ultrathin, transparent, and flexible micropyramid-shaped foil was fabricated by chemical vapour deposition of parylene C on silicon moulds containing arrays of inverted micropyramids, followed by a peel-off procedure. The capacitive current delivered by the devices showed a strong dependency on the underlying spatial structure. The device performance was evaluated by numerical modelling. We propose that the developed numerical model can be used as a basis for the design of future functional 3D design of opto-bioelectronic devices and electrodes.
    Sprache Englisch
    Erscheinungsdatum 2022-03-23
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/ac5927
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Shedding Light on Cardiac Excitation: In Vitro and In Silico Analysis of Native Ca

    Rienmuller, Theresa / Shrestha, Niroj / Polz, Mathias / Stoppacher, Sara / Ziesel, Daniel / Migliaccio, Ludovico / Pelzmann, Brigitte / Lang, Petra / Zorn-Pauly, Klaus / Langthaler, Sonja / Opancar, Aleksandar / Baumgartner, Christian / Ucal, Muammer / Schindl, Rainer / Derek, Vedran / Scheruebel, Susanne

    IEEE transactions on bio-medical engineering

    2024  Band 71, Heft 6, Seite(n) 1980–1992

    Abstract: Objective: This study aims to explore the potential of organic electrolytic photocapacitors (OEPCs), an innovative photovoltaic device, in mediating the activation of native voltage-gated Cav1.2 channels (I: Methods: Whole-cell patch-clamp recordings ...

    Abstract Objective: This study aims to explore the potential of organic electrolytic photocapacitors (OEPCs), an innovative photovoltaic device, in mediating the activation of native voltage-gated Cav1.2 channels (I
    Methods: Whole-cell patch-clamp recordings were employed to examine light-triggered OEPC mediated I
    Results: Light pulses activated I
    Conclusion: OEPC-mediated activation of I
    Significance: Treating cardiac conduction disorders by minimal-invasive means without genetic modifications could advance therapeutic approaches increasing patients' quality of life compared with conventional methods employing electronic devices.
    Mesh-Begriff(e) Animals ; Guinea Pigs ; Myocytes, Cardiac/physiology ; Calcium Channels, L-Type/metabolism ; Computer Simulation ; Patch-Clamp Techniques ; Models, Cardiovascular ; Action Potentials/physiology ; Action Potentials/radiation effects ; Light
    Sprache Englisch
    Erscheinungsdatum 2024-05-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 160429-6
    ISSN 1558-2531 ; 0018-9294
    ISSN (online) 1558-2531
    ISSN 0018-9294
    DOI 10.1109/TBME.2024.3358240
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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