Artikel ; Online: Extracellular Vesicles
International Journal of Molecular Sciences, Vol 24, Iss 1920, p
New Players in the Mechanisms of Sepsis- and COVID-19-Related Thromboinflammation
2023 Band 1920
Abstract: Sepsis and COVID-19 patients often manifest an imbalance in inflammation and coagulation, a complex pathological mechanism also named thromboinflammation, which strongly affects patient prognosis. Extracellular vesicles (EVs) are nanoparticles released ... ...
Abstract | Sepsis and COVID-19 patients often manifest an imbalance in inflammation and coagulation, a complex pathological mechanism also named thromboinflammation, which strongly affects patient prognosis. Extracellular vesicles (EVs) are nanoparticles released by cells into extracellular space that have a relevant role in cell-to-cell communication. Recently, EVs have been shown to act as important players in a variety of pathologies, including cancer and cardiovascular disease. The biological properties of EVs in the mechanisms of thromboinflammation during sepsis and COVID-19 are still only partially known. Herein, we summarize the current experimental evidence on the role of EVs in thromboinflammation, both in bacterial sepsis and in COVID-19. A better understanding of EV involvement in these processes could be useful in describing novel diagnostic and therapeutic applications of EVs in these diseases. |
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Schlagwörter | extracellular vesicles ; sepsis ; COVID-19 ; thromboinflammation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999 |
Thema/Rubrik (Code) | 610 |
Sprache | Englisch |
Erscheinungsdatum | 2023-01-01T00:00:00Z |
Verlag | MDPI AG |
Dokumenttyp | Artikel ; Online |
Datenquelle | BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl) |
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