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  1. Artikel ; Online: Functional opsin patterning for Drosophila color vision is established through signaling pathways in adjacent object-detection neurons.

    Kitamata, Manabu / Otake, Yoshiaki / Kitagori, Hideaki / Zhang, Xuanshuo / Maki, Yusuke / Boku, Rika / Takeuchi, Masato / Nakagoshi, Hideki

    Development (Cambridge, England)

    2024  Band 151, Heft 6

    Abstract: Vision is mainly based on two different tasks, object detection and color discrimination, carried out by photoreceptor (PR) cells. The Drosophila compound eye consists of ∼800 ommatidia. Every ommatidium contains eight PR cells, six outer cells (R1-R6) ... ...

    Abstract Vision is mainly based on two different tasks, object detection and color discrimination, carried out by photoreceptor (PR) cells. The Drosophila compound eye consists of ∼800 ommatidia. Every ommatidium contains eight PR cells, six outer cells (R1-R6) and two inner cells (R7 and R8), by which object detection and color vision are achieved, respectively. Expression of opsin genes in R7 and R8 is highly coordinated through the instructive signal from R7 to R8, and two major ommatidial subtypes are distributed stochastically; pale type expresses Rh3/Rh5 and yellow type expresses Rh4/Rh6 in R7/R8. The homeodomain protein Defective proventriculus (Dve) is expressed in yellow-type R7 and in six outer PRs, and it is involved in Rh3 repression to specify the yellow-type R7. dve mutant eyes exhibited atypical coupling, Rh3/Rh6 and Rh4/Rh5, indicating that Dve activity is required for proper opsin coupling. Surprisingly, Dve activity in R1 is required for the instructive signal, whereas activity in R6 and R7 blocks the signal. Our results indicate that functional coupling of two different neurons is established through signaling pathways from adjacent neurons that are functionally different.
    Mesh-Begriff(e) Animals ; Drosophila/genetics ; Drosophila/metabolism ; Opsins/genetics ; Opsins/metabolism ; Color Vision/genetics ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Neurons/metabolism ; Signal Transduction/genetics ; Photoreceptor Cells, Invertebrate/physiology ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism
    Chemische Substanzen Opsins ; Drosophila Proteins
    Sprache Englisch
    Erscheinungsdatum 2024-03-15
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.202388
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Interlocked feedforward loops control cell-type-specific Rhodopsin expression in the Drosophila eye.

    Johnston, Robert J / Otake, Yoshiaki / Sood, Pranidhi / Vogt, Nina / Behnia, Rudy / Vasiliauskas, Daniel / McDonald, Elizabeth / Xie, Baotong / Koenig, Sebastian / Wolf, Reinhard / Cook, Tiffany / Gebelein, Brian / Kussell, Edo / Nakagoshi, Hideki / Desplan, Claude

    Cell

    2011  Band 145, Heft 6, Seite(n) 956–968

    Abstract: How complex networks of activators and repressors lead to exquisitely specific cell-type determination during development is poorly understood. In the Drosophila eye, expression patterns of Rhodopsins define at least eight functionally distinct though ... ...

    Abstract How complex networks of activators and repressors lead to exquisitely specific cell-type determination during development is poorly understood. In the Drosophila eye, expression patterns of Rhodopsins define at least eight functionally distinct though related subtypes of photoreceptors. Here, we describe a role for the transcription factor gene defective proventriculus (dve) as a critical node in the network regulating Rhodopsin expression. dve is a shared component of two opposing, interlocked feedforward loops (FFLs). Orthodenticle and Dve interact in an incoherent FFL to repress Rhodopsin expression throughout the eye. In R7 and R8 photoreceptors, a coherent FFL relieves repression by Dve while activating Rhodopsin expression. Therefore, this network uses repression to restrict and combinatorial activation to induce cell-type-specific expression. Furthermore, Dve levels are finely tuned to yield cell-type- and region-specific repression or activation outcomes. This interlocked FFL motif may be a general mechanism to control terminal cell-fate specification.
    Mesh-Begriff(e) Animals ; Drosophila/cytology ; Drosophila/embryology ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Eye/embryology ; Feedback, Physiological ; Gene Expression Regulation, Developmental ; Gene Regulatory Networks ; Homeodomain Proteins/metabolism ; Photoreceptor Cells, Invertebrate/metabolism ; Rhodopsin/genetics ; Transcription Factors/metabolism
    Chemische Substanzen Drosophila Proteins ; Homeodomain Proteins ; Transcription Factors ; dve protein, Drosophila ; oc protein, Drosophila ; salm protein, Drosophila ; Rhodopsin (9009-81-8)
    Sprache Englisch
    Erscheinungsdatum 2011-05-24
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2011.05.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Interlocked Feedforward Loops Control Cell-Type-Specific Rhodopsin Expression in the Drosophila Eye

    Johnston, Robert J., Jr. / Otake, Yoshiaki / Sood, Pranidhi / Vogt, Nina / Behnia, Rudy / Vasiliauskas, Daniel / McDonald, Elizabeth / Xie, Baotong / Koenig, Sebastian / Wolf, Reinhard / Cook, Tiffany / Gebelein, Brian / Kussell, Edo / Nakagoshi, Hideki / Desplan, Claude

    Cell

    Band v. 145,, Heft no. 6

    Abstract: How complex networks of activators and repressors lead to exquisitely specific cell-type determination during development is poorly understood. In the Drosophila eye, expression patterns of Rhodopsins define at least eight functionally distinct though ... ...

    Abstract How complex networks of activators and repressors lead to exquisitely specific cell-type determination during development is poorly understood. In the Drosophila eye, expression patterns of Rhodopsins define at least eight functionally distinct though related subtypes of photoreceptors. Here, we describe a role for the transcription factor gene defective proventriculus (dve) as a critical node in the network regulating Rhodopsin expression. dve is a shared component of two opposing, interlocked feedforward loops (FFLs). Orthodenticle and Dve interact in an incoherent FFL to repress Rhodopsin expression throughout the eye. In R7 and R8 photoreceptors, a coherent FFL relieves repression by Dve while activating Rhodopsin expression. Therefore, this network uses repression to restrict and combinatorial activation to induce cell-type-specific expression. Furthermore, Dve levels are finely tuned to yield cell-type- and region-specific repression or activation outcomes. This interlocked FFL motif may be a general mechanism to control terminal cell-fate specification.
    Schlagwörter cells ; photoreceptors ; rhodopsin ; genes ; transcription factors ; proventriculus ; Drosophila ; eyes
    Sprache Englisch
    Dokumenttyp Artikel
    ISSN 0092-8674
    Datenquelle AGRIS - International Information System for the Agricultural Sciences and Technology

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