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  1. Artikel ; Online: Response to: Author's reply to: Effect of adjuvant treatment on survival in 2023 FIGO stage IIC endometrial cancer.

    Akgor, Utku / Ozgul, Nejat / Ayhan, Ali

    Journal of gynecologic oncology

    2024  Band 35, Heft 3, Seite(n) e92

    Mesh-Begriff(e) Humans ; Endometrial Neoplasms/pathology ; Endometrial Neoplasms/drug therapy ; Endometrial Neoplasms/therapy ; Endometrial Neoplasms/mortality ; Female ; Chemotherapy, Adjuvant ; Neoplasm Staging
    Sprache Englisch
    Erscheinungsdatum 2024-04-11
    Erscheinungsland Korea (South)
    Dokumenttyp Letter ; Comment
    ZDB-ID 2478405-9
    ISSN 2005-0399 ; 2005-0380
    ISSN (online) 2005-0399
    ISSN 2005-0380
    DOI 10.3802/jgo.2024.35.e92
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Recurrent mucinous neoplasm arising in cesarean scar: A case report and review of literature.

    Gundogdu, Fatma / Orhan, Nazlı / Ozgul, Nejat / Usubutun, Alp

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2021  Band 157, Heft 3, Seite(n) 564–567

    Abstract: Ovarian mucinous tumors are one of the common epithelial tumors in the ovary, but their recurrence is extremely rare. In a 37-year-old female patient who had had five operations in 7 years due to recurrent mucinous neoplasms, a mass extending to the ... ...

    Abstract Ovarian mucinous tumors are one of the common epithelial tumors in the ovary, but their recurrence is extremely rare. In a 37-year-old female patient who had had five operations in 7 years due to recurrent mucinous neoplasms, a mass extending to the umbilicus was recently detected during a routine examination. With this finding the patient underwent cystectomy, total abdominal hysterectomy, and left salpingo-oophorectomy. Two of the five operations were performed during cesarean delivery. In the recent surgical procedure, two cysts were removed. A 20 cm cyst in the pelvic region was diagnosed as a mucinous cystadenoma. The other cyst located in the myometrium was a mucinous cystadenoma with focal borderline change and arose in the previous cesarean scar. The authors present what is believed to be the first case of recurrent mucinous neoplasm arising within a cesarean scar. A review of the literature concerning the topic is also presented.
    Mesh-Begriff(e) Adult ; Cicatrix/complications ; Cicatrix/pathology ; Cystadenoma, Mucinous/diagnosis ; Cystadenoma, Mucinous/pathology ; Cystadenoma, Mucinous/surgery ; Cysts ; Female ; Humans ; Ovarian Neoplasms/pathology ; Pregnancy ; Salpingo-oophorectomy
    Sprache Englisch
    Erscheinungsdatum 2021-09-21
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article ; Review
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.13924
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: The simple right ventricle contraction pressure index: A novel method for echocardiographic assessment of right ventricle dysfunction in acute pulmonary embolism.

    Acar, Emrah / Ozgul, Neryan / Izci, Servet

    Journal of clinical ultrasound : JCU

    2020  Band 49, Heft 5, Seite(n) 466–471

    Abstract: Purpose: The simple right ventricular contraction pressure index (sRVCPI) is a new echocardiographic variable for estimating the right ventricular systolic function. Our aim was to investigate the association between the sRVCPI, the pulmonary embolism ... ...

    Abstract Purpose: The simple right ventricular contraction pressure index (sRVCPI) is a new echocardiographic variable for estimating the right ventricular systolic function. Our aim was to investigate the association between the sRVCPI, the pulmonary embolism severity index (PESI), and mortality rate in acute pulmonary embolism (APE).
    Methods: We included in this study 116 patients diagnosed with APE by pulmonary computed tomography angiography or ventilation/perfusion scintigraphy. They were divided into two groups based on the simplified PESI < or >1. Tricuspid regurgitation velocity and TAPSE were measured and used for sRVCPI calculation.
    Results: Mortality was higher in patients with a higher sRVCPI (P < .001). In receiver operating characteristic (ROC) curve analysis using a cut-off level of 312.8 mm Hg mm, sRVCPI predicted mortality with a sensitivity of 86.8% and specificity of 69.5% (ROC area under curve: 0.712; 95%CI 0.597-0.882; P < .001). The sRVCPI was lower in the sPESI >1 than in the sPESI <1 group (364.3 ± 31.9 vs 511.6 ± 26.1; P < .001). There was an inverse correlation between sRVCPI and the sPESI score (-0.784; P < .001).
    Conclusion: The sRVCPI correlated with the sPESI score and was associated with mortality in patients with APE. This easily measurable variable may be used to predict short-term mortality in APE patients.
    Mesh-Begriff(e) Acute Disease ; Aged ; Echocardiography ; Humans ; Male ; Middle Aged ; Myocardial Contraction ; Pressure ; Pulmonary Embolism/physiopathology ; ROC Curve ; Ventricular Dysfunction, Right/diagnosis ; Ventricular Dysfunction, Right/physiopathology
    Sprache Englisch
    Erscheinungsdatum 2020-12-17
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 189393-2
    ISSN 1097-0096 ; 0091-2751
    ISSN (online) 1097-0096
    ISSN 0091-2751
    DOI 10.1002/jcu.22970
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Evaluation of colposcopy after the addition of human papillomavirus testing to the Turkish cervical cancer screening program.

    Gunes, Ali Can / Ozgul, Nejat / Turkyılmaz, Murat / Kara, Fatih / Unlu, Fahriye / Ayhan, Ali / Gultekin, Murat

    Cancer medicine

    2023  Band 12, Heft 24, Seite(n) 21751–21760

    Abstract: Objective: To evaluate colposcopy performance following the human papillomavirus (HPV) DNA screening program in Turkey.: Methods: Women aged 30-65 years are screened for cervical cancer every 5 years, with individuals positive for HPV 16 and/or 18 or ...

    Abstract Objective: To evaluate colposcopy performance following the human papillomavirus (HPV) DNA screening program in Turkey.
    Methods: Women aged 30-65 years are screened for cervical cancer every 5 years, with individuals positive for HPV 16 and/or 18 or other high-risk HPV types with abnormal cytology referred for colposcopy. Both HPV test and cytology are obtained at the same visit. If HPV is negative, cytology will not be assessed. However, if HPV is positive, both cytology and HPV genotyping will be performed. Colposcopy-require was defined as HPV 16/18 positivity or abnormal smear results with any hrHPV positivity, and the remaining patients (normal smear with hrHPV positivity other than HPV 16/18) were grouped as colposcopy non-required. National data on colposcopy outcomes and unnecessary performance rates in February 2018-2019 were evaluated via a questionnaire.
    Results: A total of 9808 patients were included, divided based on colposcopy requirement: 5751 (58.6%) patients required colposcopy and 4057 (41.4%) did not. Unnecessary colposcopy was performed on 90.1% of the non-required group (3657 of 4057 patients). In the colposcopy-required group, 4455 patients (79.9%) underwent punch biopsy; 3194 (57.1%), endocervical curettage (ECC); and 421 (7.5%), "see and treat" in the non-required group, the results were 2790 (76.3%), 1957 (53.2%), and 211 (5.7%), respectively. A total of 746 cervical intraepithelial neoplasia (CIN)-3 isolates were detected, including 702 using existing screening and triage with 94.1% sensitivity (702/746). Multiple biopsies were taken in 69.8% (n = 3110) of patients from the colposcopy-required group and 63.7% (n = 1777) from the non-required group. The ECC samples included 19 cervical cancers and 212 ≥CIN-3 lesions in the colposcopy-required group, and four cancers and 41 ≥CIN-3 lesions in the non-required group. The proportion of ≥CIN-3 lesions detected by ECC only was 4.7% (35 of 746 ≥CIN-3 lesions).
    Conclusion: Our results showed high rates of unnecessary colposcopies, and a high percentage of multiple and random punch biopsies and ECC.
    Mesh-Begriff(e) Pregnancy ; Humans ; Female ; Uterine Cervical Neoplasms/pathology ; Colposcopy ; Human papillomavirus 16/genetics ; Papillomavirus Infections ; Early Detection of Cancer/methods ; Turkey ; Human papillomavirus 18/genetics ; Uterine Cervical Dysplasia ; Mass Screening/methods ; Papillomaviridae/genetics ; Vaginal Smears/methods
    Sprache Englisch
    Erscheinungsdatum 2023-11-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.6740
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Psychometric Properties and Cutoff Value of the Turkish Overactive Bladder Symptom Score.

    Baran, Emine / Gürşen, Ceren / Ozgul, Serap / Çinar, Gamze Nalan / Nakip, Gulbala / Üzelpasaci, Esra / Ozgul, Nejat / Beksaç, Mehmet Sinan / Akbayrak, Türkan

    Urogynecology (Philadelphia, Pa.)

    2023  

    Abstract: Importance: The Overactive Bladder Symptom Score (OABSS) measures all overactive bladder (OAB) symptoms with graded answers, evaluates urgency symptoms, and reveals the subjective bladder control. However, the Turkish version and the cutoff value of the ...

    Abstract Importance: The Overactive Bladder Symptom Score (OABSS) measures all overactive bladder (OAB) symptoms with graded answers, evaluates urgency symptoms, and reveals the subjective bladder control. However, the Turkish version and the cutoff value of the questionnaire have not yet been studied.
    Objective: The aims of this study were to determine the psychometric properties of the 7-item OABSS and to estimate the cutoff value of the scale.
    Study design: This was an observational study. The internal consistency (Cronbach α) and test-retest reliability were analyzed, and exploratory factor analysis was performed. For the criterion validity, the correlations between the OABSS, the Overactive Bladder Questionnaire, the Bristol Female Lower Urinary Tract Symptoms questionnaire, and outcomes of a bladder diary were used. The cutoff value of the OABSS was analyzed by the receiver operating characteristics curve analysis.
    Results: Participants with (n = 49) and without (n = 38) OAB were included. The internal consistency was very strong (Cronbach α = 0.95). The test-retest reliability was very strong (intraclass correlation coefficients = 0.93-0.95, P = 0.001). The percentage of explanation of the total variance was calculated as 78%. There was a strong to very strong correlation between the OABSS and the Overactive Bladder Questionnaire and Bristol Female Lower Urinary Tract Symptoms scores and outcomes of the bladder diary. The cutoff value for the OABSS was determined as 10.5.
    Conclusions: The Turkish OABSS was found to be a valid and reliable scale to determine OAB symptoms and severity. Those who score more than 10.5 on the questionnaire can be considered as at risk of OAB syndrome.
    Sprache Englisch
    Erscheinungsdatum 2023-12-28
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2771-1897
    ISSN (online) 2771-1897
    DOI 10.1097/SPV.0000000000001446
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Herlyn-Werner-Wunderlich Syndrome; laparoscopic treatment of obstructing longitudinal vaginal septum in patients with hematocolpos - a different technique for virgin patients

    Boyraz, Gökhan / Karalok, Alper / Turan, Taner / Özgül, Nejat

    Journal of the Turkish German Gynecological Association

    2019  Band 21, Heft 4, Seite(n) 303–304

    Abstract: We aimed to define a new laparoscopic treatment approach for patients with hematocolpos and obstructed hemi-vagina due to longitudinal obstructing vaginal septum. This technique is particularly useful for patients who desire to preserve virginity. To the ...

    Abstract We aimed to define a new laparoscopic treatment approach for patients with hematocolpos and obstructed hemi-vagina due to longitudinal obstructing vaginal septum. This technique is particularly useful for patients who desire to preserve virginity. To the best of our knowledge this is the first case reporting laparoscopic resection of vaginal septum with an obstructed hemivagina and hematocolpos.
    Sprache Englisch
    Erscheinungsdatum 2019-08-27
    Erscheinungsland Turkey
    Dokumenttyp Journal Article
    ZDB-ID 2425806-4
    ISSN 1309-0380 ; 1303-9695 ; 1309-0399
    ISSN (online) 1309-0380 ; 1303-9695
    ISSN 1309-0399
    DOI 10.4274/jtgga.galenos.2019.2019.0046
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  7. Artikel ; Online: Endocervical polyps in high risk human papillomavirus infections.

    Kucukyıldız, Irem / Karaca, Mujdegul / Akgor, Utku / Turkyılmaz, Murat / Keskinkılıc, Bekir / Kara, Fatih / Ozgul, Nejat / Gultekin, Murat

    Ginekologia polska

    2022  Band 93, Heft 1, Seite(n) 7–10

    Abstract: Objectives: Human papillomavirus (HPV) positive patients with and without endocervical polyps is compared with respect to HPV genotypes and presence of pre-invasive diseases. To our knowledge, this is the first and largest report in the literature ... ...

    Abstract Objectives: Human papillomavirus (HPV) positive patients with and without endocervical polyps is compared with respect to HPV genotypes and presence of pre-invasive diseases. To our knowledge, this is the first and largest report in the literature examining the endocervical polyps in HPV positive cases.
    Material and methods: Clinicopathological data for the first one million screening patients (n = 1060 992) from around the entire country during 2015 and 2016 were targeted for this research. Colposcopy, colposcopic surgical diagnostic procedures and final pathology results of 3499 patients with high-risk (HR) HPV-positive were obtained from reference colposcopy centers. Patients with endocervical polyps (n = 243 [6.9 %]) were accepted as experimental arm while patients without any endocervical polyp (n = 3256 [93.1%]) were regarded as the control group. Age, HPV genotype, Pap smear abnormality, and final pathological results were compared between two groups using Student's t-test and cross-tabulation chi-square test.
    Results: The incidence of endocervical polyp was found to be 6.9 % in HR HPV-positive women. The most common HPV genotypes observed in both groups were HPV 16 or 18. Abnormal cytology reports (≥ ASC-US) were not significantly different between both groups. However, with respect to final pathological diagnosis, patients with endocervical polyp had significantly lower numbers of pre-invasive diseases (31.3% vs 44.2%; p < 0.10).
    Conclusions: Endocervical polyps may be more common in patients with HR HPV infections. HPV 18 is observed significantly more, in the HR HPV positive endocervical polyp group. Patients with endocervical polyps do not have increased risk for preinvasive cervical diseases.
    Mesh-Begriff(e) Humans ; Female ; Pregnancy ; Human Papillomavirus Viruses ; Papillomavirus Infections/complications ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/epidemiology ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/pathology ; Colposcopy ; Papanicolaou Test ; Papillomaviridae/genetics
    Sprache Englisch
    Erscheinungsdatum 2022-01-24
    Erscheinungsland Poland
    Dokumenttyp Journal Article
    ZDB-ID 130894-4
    ISSN 2543-6767 ; 0017-0011
    ISSN (online) 2543-6767
    ISSN 0017-0011
    DOI 10.5603/GP.a2021.0207
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Tumor apelin immunoreactivity is correlated with body mass index in ovarian high grade serous carcinoma.

    Unal, I / Khiavi, I R / Tasar, G E / Goksuluk, D / Boyraz, G / Ozgul, N / Usubutun, A / Yuruker, S / Zeybek, N D

    Biotechnic & histochemistry : official publication of the Biological Stain Commission

    2019  Band 95, Heft 1, Seite(n) 27–36

    Abstract: Ovarian cancer has a high mortality rate. Serous carcinoma is the most common subtype and can be detected by distant or lymph node metastasis in advanced stages. Apelin, an adipokine associated with obesity, and its receptor, APJ, participate in ... ...

    Abstract Ovarian cancer has a high mortality rate. Serous carcinoma is the most common subtype and can be detected by distant or lymph node metastasis in advanced stages. Apelin, an adipokine associated with obesity, and its receptor, APJ, participate in lymphatic invasion. Angiogenesis also can affect lymph node involvement in serous ovarian carcinomas. We investigated apelin/APJ receptor immunoreactivity in stages III and IV ovarian cancer with or without lymph node involvement and correlated the results with body mass index (BMI) to determine whether the potential relation of the two affects the outcome of the cancer. We investigated 30 patients diagnosed between 2014 and 2016 with high grade serous ovarian cancer. Tumor:stroma ratio, indirect immunoperoxidase method, H-score and MATLAB analysis were performed. In obese and pre-obese patients, tumor apelin immunoreactivity was stronger than for patients with normal BMI. Tumor:stroma ratio was correlated with survival and lymph node involvement. Strong apelin and moderate APJ immunoreactivity was detected in both lymph node negative and positive patients. BMI was related to both survival outcome and apelin immunoreactivity. BMI, adipokines such as apelin, and the stromal compartment play critical roles in advanced stage serous carcinomas.
    Mesh-Begriff(e) Adult ; Aged ; Apelin/genetics ; Apelin/metabolism ; Body Mass Index ; Carcinoma/classification ; Carcinoma/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Middle Aged ; Ovarian Neoplasms/classification ; Ovarian Neoplasms/metabolism
    Chemische Substanzen APLN protein, human ; Apelin
    Sprache Englisch
    Erscheinungsdatum 2019-07-02
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1069349-x
    ISSN 1473-7760 ; 1052-0295
    ISSN (online) 1473-7760
    ISSN 1052-0295
    DOI 10.1080/10520295.2019.1627419
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  9. Artikel: Synchronous Ovarian and Endometrial Endometrioid Adenocarcinoma Presenting with Nonbacterial Thrombotic Endocarditis and Pulmonary Thromboembolism: Adenocarcinoma with Thrombotic Events.

    Erturk, N K / Erturk, A / Basaran, D / Ozgul, N

    Case reports in obstetrics and gynecology

    2015  Band 2015, Seite(n) 825404

    Abstract: Introduction. Nonbacterial thrombotic endocarditis (NBTE) is a rare manifestation of hypercoagulability in patients with malignant neoplasms. Case Report. A fifty-six-year-old woman presented to the emergency service; the clinical workup revealed deep ... ...

    Abstract Introduction. Nonbacterial thrombotic endocarditis (NBTE) is a rare manifestation of hypercoagulability in patients with malignant neoplasms. Case Report. A fifty-six-year-old woman presented to the emergency service; the clinical workup revealed deep vein thrombosis in right leg and bilateral massive PTE. As the abdominal sections on the spiral CT revealed a giant pelvic mass of ovarian origin, she was referred to our hospital's gynecologic oncology department. She was scheduled for surgery under enoxaparin. She described numbness on one side of her face. Cranial imaging findings revealed acute ischemic cerebral lesions and transesophageal echocardiogram showed vegetation on the aortic cusp. Under anticoagulation treatment, she underwent hysterectomy with bilateral salpingo-oophorectomy and infracolic omentectomy. After tumor resection, her neurological symptoms dissolved with aggressive anticoagulant treatment. Pathology result was synchronous endometrial and ovarian adenocarcinoma. Discussion. NBTE is a rare condition often associated with advanced malignancies. Peripheral embolism and venous thrombosis are complications that have been associated with NBTE due to hypercoagulable state. These disorders could be resistant to routine anticoagulant treatment. In case of a thrombotic complication due to ovarian malignancy, surgical resection of the primary tumor may increase the effect of anticoagulant treatment.
    Sprache Englisch
    Erscheinungsdatum 2015-10-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2627654-9
    ISSN 2090-6692 ; 2090-6684
    ISSN (online) 2090-6692
    ISSN 2090-6684
    DOI 10.1155/2015/825404
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: The

    Acar, Emrah / Izci, Servet / Donmez, Ibrahim / Yilmaz, Mehmet Fatih / Ozgul, Neryan / Kayabası, Oguz / Gokce, Mustafa / Güneş, Yilmaz / Izgi, Ibrahim Akin / Kirma, Cevat

    Angiology

    2023  Band 75, Heft 5, Seite(n) 425–433

    Abstract: Transradial Access (TRA) is the suggested method when performing coronary procedures. TRA has several advantages over the transfemoral approach, but also some restrictions. The present study compared the efficacy and safety of the traditional proximal ... ...

    Abstract Transradial Access (TRA) is the suggested method when performing coronary procedures. TRA has several advantages over the transfemoral approach, but also some restrictions. The present study compared the efficacy and safety of the traditional proximal transradial approach (pTRA) with a newer technique known as the distal transradial approach (dTRA) for performing a coronary angiography (CAG) and percutaneous coronary intervention (PCI). Patients (n = 700) were placed into one of two categories (dTRA or pTRA) based on a random technique. The primary endpoint was RAO at follow-up. The secondary endpoints included the time required for sheath insertion, the rate of successful sheath insertion, rate of successful completion of CAG and PCI, total procedure time, total fluoroscopy time, total radiation dose, total contrast volume used, pain perception (visual analog scale 0-10), and hemostasis duration. dTRA patients had more skin punctures, failed punctures, failed wiring, overlap of access sites, sheath insertion time, and pain evaluation scale, while the pTRA group had more hemostasis time and first-time cannulation. RAO and pseudoaneurysm (PseA) were lower in the dTRA group. In this randomized study, dTRA had lower RAO and PseA than pTRA. However, multicenter, larger-patient trials are needed to provide definitive evidence.
    Mesh-Begriff(e) Humans ; Catheterization ; Coronary Angiography/adverse effects ; Coronary Angiography/methods ; Heart ; Pain ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/methods ; Radial Artery ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2023-06-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 80040-5
    ISSN 1940-1574 ; 0003-3197
    ISSN (online) 1940-1574
    ISSN 0003-3197
    DOI 10.1177/00033197231183226
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