Artikel ; Online: Computational modeling to predict the micromechanical environment in tissue engineering scaffolds.
2021 Band 120, Seite(n) 110355
Abstract: Cell fate in tissue engineering (TE) strategies is paramount to regenerate healthy, functional organs. The mechanical loads experienced by cells play an important role in cell fate. However, in TE scaffolds with a cell-laden hydrogel matrix, it is ... ...
Abstract | Cell fate in tissue engineering (TE) strategies is paramount to regenerate healthy, functional organs. The mechanical loads experienced by cells play an important role in cell fate. However, in TE scaffolds with a cell-laden hydrogel matrix, it is prohibitively complex to prescribe and measure this cellular micromechanical environment (CME). Accordingly, this study aimed to develop a finite element (FE) model of a TE scaffold unit cell that can be subsequently implemented to predict the CME and cell fates under prescribed loading. The compressible hyperelastic mechanics of a fibrin hydrogel were characterized by fitting unconfined compression and confined compression experimental data. This material model was implemented in a unit cell FE model of a TE scaffold. The FE mesh and boundary conditions were evaluated with respect to the mechanical response of a region of interest (ROI). A compressible second-order reduced polynomial hyperelastic model gave the best fit to the experimental data (C |
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Mesh-Begriff(e) | Finite Element Analysis ; Hydrogels ; Stress, Mechanical ; Tissue Engineering ; Tissue Scaffolds |
Chemische Substanzen | Hydrogels |
Sprache | Englisch |
Erscheinungsdatum | 2021-03-02 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 218076-5 |
ISSN | 1873-2380 ; 0021-9290 |
ISSN (online) | 1873-2380 |
ISSN | 0021-9290 |
DOI | 10.1016/j.jbiomech.2021.110355 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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