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  1. AU="Panse, R"
  2. TI=The impact of national culture on the increase of COVID 19: A cross country analysis of European countries

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  1. Buch ; Online: Zur vergleichenden Anatomie und Physiologie des Gleichgewichts- und Gehörorganes

    Panse, Rudolf

    (Bibliothek niederrheinischer Verein - Gesundheitspflege)

    2020  

    Verfasserangabe von Dr. Rudolf Panse, Ohrenarzt in Dresden-Neustadt, Oberarzt am Diakonissenhaus
    Serientitel Bibliothek niederrheinischer Verein - Gesundheitspflege
    Sprache Deutsch
    Umfang 1 Online-Ressource (Seite [185]- 236), Illustrationen
    Verlag ZB MED - Informationszentrum Lebenswissenschaften
    Erscheinungsort Köln
    Erscheinungsland XA-DXDE
    Dokumenttyp Buch ; Online
    HBZ-ID CT002017697
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Buch ; Online: Die sogenannte Sklerose des Mittelohres

    Panse, Rudolf

    (Bibliothek niederrheinischer Verein - Gesundheitspflege)

    2020  

    Verfasserangabe von Dr. Rudolf Panse, Ohrenarzt in Dresden-Neustadt
    Serientitel Bibliothek niederrheinischer Verein - Gesundheitspflege
    Sprache Deutsch
    Umfang 1 Online-Ressource (Seite [407]-432)
    Verlag ZB MED - Informationszentrum Lebenswissenschaften
    Erscheinungsort Köln
    Erscheinungsland XA-DXDE
    Dokumenttyp Buch ; Online
    HBZ-ID CT002017691
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

    Kategorien

  3. Buch ; Online: Das Cholesteatom des Ohres

    Panse, Rudolf

    (Bibliothek niederrheinischer Verein - Gesundheitspflege)

    2020  

    Verfasserangabe von Dr. Rudolf Panse, Ohrenarzt in Dresden-Neustadt
    Serientitel Bibliothek niederrheinischer Verein - Gesundheitspflege
    Sprache Deutsch
    Umfang 1 Online-Ressource (Seite [75]-94)
    Verlag ZB MED - Informationszentrum Lebenswissenschaften
    Erscheinungsort Köln
    Erscheinungsland XA-DXDE
    Dokumenttyp Buch ; Online
    HBZ-ID CT002017683
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

    Kategorien

  4. Buch ; Online: Advances in Autoimmune Myasthenia Gravis

    Le Panse, Rozen / Kusner, Linda L. / Berrih-Aknin, Sonia / Rostedt Punga, Anna

    2020  

    Schlagwörter Medicine ; Immunology ; autoantibodies ; CD4 T cells ; thymus ; therapy ; miRNA
    Umfang 1 electronic resource (205 pages)
    Verlag Frontiers Media SA
    Dokumenttyp Buch ; Online
    Anmerkung English ; Open Access
    HBZ-ID HT021230922
    ISBN 9782889661077 ; 2889661075
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  5. Artikel ; Online: Does Surgical Removal of the Thymus Have Deleterious Consequences?

    Kaminski, Henry J / Kusner, Linda L / Cutter, Gary R / Le Panse, Rozen / Wright, Cameron D / Perry, Yaron / Wolfe, Gil I

    Neurology

    2024  Band 102, Heft 12, Seite(n) e209482

    Abstract: The role of immunosenescence, particularly the natural process of thymic involution during aging, is increasingly acknowledged as a factor contributing to the development of autoimmune diseases and cancer. Recently, a concern has been raised about ... ...

    Abstract The role of immunosenescence, particularly the natural process of thymic involution during aging, is increasingly acknowledged as a factor contributing to the development of autoimmune diseases and cancer. Recently, a concern has been raised about deleterious consequences of the surgical removal of thymic tissue, including for patients who undergo thymectomy for myasthenia gravis (MG) or resection of a thymoma. This review adopts a multidisciplinary approach to scrutinize the evidence concerning the long-term risks of cancer and autoimmunity postthymectomy. We conclude that for patients with acetylcholine receptor antibody-positive MG and those diagnosed with thymoma, the removal of the thymus offers prominent benefits that well outweigh the potential risks. However, incidental removal of thymic tissue during other thoracic surgeries should be minimized whenever feasible.
    Mesh-Begriff(e) Humans ; Thymectomy/adverse effects ; Thymectomy/methods ; Myasthenia Gravis/surgery ; Thymus Gland/surgery ; Thymus Neoplasms/surgery ; Thymus Neoplasms/complications ; Thymoma/surgery ; Thymoma/complications ; Postoperative Complications/etiology ; Autoimmune Diseases/surgery
    Sprache Englisch
    Erscheinungsdatum 2024-05-23
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000209482
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Comment on "Detecting Key Genes Regulated by miRNAs in Dysfunctional Crosstalk Pathway of Myasthenia Gravis".

    Le Panse, Rozen

    BioMed research international

    2017  Band 2017, Seite(n) 6950308

    Mesh-Begriff(e) Cell Physiological Phenomena ; Humans ; MicroRNAs/genetics ; Myasthenia Gravis
    Chemische Substanzen MicroRNAs
    Sprache Englisch
    Erscheinungsdatum 2017-02-08
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2017/6950308
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: New Pathways and Therapeutic Targets in Autoimmune Myasthenia Gravis.

    Behin, Anthony / Le Panse, Rozen

    Journal of neuromuscular diseases

    2018  Band 5, Heft 3, Seite(n) 265–277

    Abstract: Acquired Myasthenia Gravis (MG) is a neuromuscular disease caused by autoantibodies against components of the neuromuscular junction. It is a prototype organ-specific autoimmune disease with well-defined antigenic targets mainly the nicotinic ... ...

    Abstract Acquired Myasthenia Gravis (MG) is a neuromuscular disease caused by autoantibodies against components of the neuromuscular junction. It is a prototype organ-specific autoimmune disease with well-defined antigenic targets mainly the nicotinic acetylcholine receptor (AChR). Patients suffer from fluctuating, fatigable muscle weakness that worsens with activity and improves with rest.Various therapeutic strategies have been used over the years to alleviate MG symptoms. These strategies aim at improving the transmission of the nerve impulse to muscle or at lowering the immune system with steroids or immunosuppressant drugs. Nevertheless, MG remains a chronic disease and symptoms tend to persist in many patients, some being or becoming refractory over time. In this review, based on recent experimental data on MG or based on results from clinical trials for other autoimmune diseases, we explore new potential therapeutic approaches for MG patients, going from non-specific approaches with the use of stem cells with their anti-inflammatory and immunosuppressive properties to targeted therapies using monoclonal antibodies specific for cell-surface antigens or circulating molecules.
    Mesh-Begriff(e) Animals ; Autoimmune Diseases/drug therapy ; Autoimmune Diseases/physiopathology ; Autoimmune Diseases/therapy ; Humans ; Myasthenia Gravis/drug therapy ; Myasthenia Gravis/physiopathology ; Myasthenia Gravis/therapy ; Receptors, Nicotinic/drug effects ; Synaptic Transmission
    Chemische Substanzen Receptors, Nicotinic
    Sprache Englisch
    Erscheinungsdatum 2018-07-16
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ISSN 2214-3599
    ISSN 2214-3599
    DOI 10.3233/JND-170294
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Advances in the understanding of disease mechanisms of autoimmune neuromuscular junction disorders.

    Huijbers, Maartje G / Marx, Alexander / Plomp, Jaap J / Le Panse, Rozen / Phillips, William D

    The Lancet. Neurology

    2022  Band 21, Heft 2, Seite(n) 163–175

    Abstract: Muscle weakness and fatigue are the hallmarks of autoimmune neuromuscular junction disorders. Although a plethora of immunosuppressive treatments exist, no cure is available to date and many patients are left with debilitating muscle weakness. Recent ... ...

    Abstract Muscle weakness and fatigue are the hallmarks of autoimmune neuromuscular junction disorders. Although a plethora of immunosuppressive treatments exist, no cure is available to date and many patients are left with debilitating muscle weakness. Recent advances in the understanding of the structure and function of the neuromuscular junction, and the development of novel in vitro and in vivo models, have been instrumental in unravelling the pathophysiology of these autoimmune diseases. These advances are providing the rationale for the development of new therapeutic strategies. Restoration of the immune imbalance in these diseases, in parallel with symptomatic therapeutic approaches at the neuromuscular junction, will be crucial to obtain long-term remission or even cure.
    Mesh-Begriff(e) Humans ; Neuromuscular Junction ; Neuromuscular Junction Diseases
    Sprache Englisch
    Erscheinungsdatum 2022-01-21
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(21)00357-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Thymectomy in myasthenia gravis: when, why, and how?

    Berrih-Aknin, Sonia / Le Panse, Rozen

    The Lancet. Neurology

    2019  Band 18, Heft 3, Seite(n) 225–226

    Mesh-Begriff(e) Humans ; Myasthenia Gravis ; Prednisone ; Scorpion Venoms ; Thymectomy
    Chemische Substanzen Scorpion Venoms ; margatoxin (6197NL836C) ; Prednisone (VB0R961HZT)
    Sprache Englisch
    Erscheinungsdatum 2019-01-25
    Erscheinungsland England
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 2079704-7
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(18)30467-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Role of miRNAs in Normal and Myasthenia Gravis Thymus.

    Cron, Mélanie A / Guillochon, Émilie / Kusner, Linda / Le Panse, Rozen

    Frontiers in immunology

    2020  Band 11, Seite(n) 1074

    Abstract: The thymus, a primary lymphoid organ, provides a complex environment essential for the generation of the T-cell repertoire. Thymic alterations occur during life either in the context of thymic involution upon aging or the pathophysiological context of ... ...

    Abstract The thymus, a primary lymphoid organ, provides a complex environment essential for the generation of the T-cell repertoire. Thymic alterations occur during life either in the context of thymic involution upon aging or the pathophysiological context of Myasthenia Gravis (MG). These changes involve complicated regulatory networks, in which microRNAs (miRNAs) are key players. Here, we analyzed the role of miRNAs in thymocyte maturation and differentiation sustained by thymic epithelial cells. We compared data from the literature regarding the role of mouse thymic miRNAs and original data obtained from a human thymic miRnome study. We identified a set of highly expressed miRNAs defined as ThymiRs and investigated miRNA expression in infants as compared to adults to determine those associated with human thymic involution. Thymic changes are also frequently observed in MG, an autoimmune disease which results in the production of anti-acetylcholine receptor (AChR) antibodies that lead to muscle weaknesses. Alterations such as thymoma in late-onset MG patients and hyperplasia with ectopic germinal centers (GCs) in early-onset (EOMG) patients are found. Thymic miRNA expression has been studied in AChR-MG patients both in thymoma-associated MG (TAMG) and EOMG, and their function through their mRNA targets investigated. Most of the dysregulated thymic miRNAs in EOMG are associated with GC development, such as miR-7, miR-24, miR-139, miR-143, miR-145, miR-146, miR-150, miR-452, miR-548 or thymic inflammation, such as miR-125b, miR-146, or miR-29. Understanding these pathways may provide therapeutic targets or biomarkers of disease manifestations.
    Mesh-Begriff(e) Aging/genetics ; Aging/immunology ; Animals ; Cell Differentiation/genetics ; Cell Differentiation/immunology ; Epithelial Cells/immunology ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Gene Expression Profiling ; Humans ; Mice ; MicroRNAs/genetics ; MicroRNAs/immunology ; Myasthenia Gravis/genetics ; Myasthenia Gravis/immunology ; Myasthenia Gravis/pathology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; T-Lymphocytes/pathology ; Thymoma/genetics ; Thymoma/immunology ; Thymoma/pathology ; Thymus Gland/immunology ; Thymus Gland/metabolism ; Thymus Gland/pathology ; Thymus Neoplasms/genetics ; Thymus Neoplasms/immunology ; Thymus Neoplasms/pathology
    Chemische Substanzen MicroRNAs
    Sprache Englisch
    Erscheinungsdatum 2020-06-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.01074
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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