Artikel ; Online: Delineating the Spectrum of Pituitary Adenoma Based on the WHO 2017 Classification.
2024 Band 72, Heft 1, Seite(n) 96–101
Abstract: Background: The WHO 2017 classification of endocrine tumors incorporates lineage-specific transcription factors (TF) and hormone expression for the classification of pituitary adenoma (PA). There is paucity of reports describing the spectrum of PA based ...
Abstract | Background: The WHO 2017 classification of endocrine tumors incorporates lineage-specific transcription factors (TF) and hormone expression for the classification of pituitary adenoma (PA). There is paucity of reports describing the spectrum of PA based on this classification. Objective: The aim of this study was to delineate the spectrum of PA based on WHO 2017 classification of endocrine tumors. Materials and methods: PA diagnosed in the year 2018 were studied. H and E and hormonal immunohistochemistry (IHC) for GH, PRL, ACTH, TSH, FSH, LH, CK, T-Pit and MIB-1 were performed and the results were analyzed. Results: The cohort included 88 cases. M: F ratio was 2:1. Clinically, 22 (25%) were functional and 66 (75%) were non-functional adenomas. Amongst the clinically functional adenomas, GH secreting adenomas were the commonest (68%). Majority (83%) of non-functional adenomas were hormone positive with gonadotroph adenomas being the commonest (72.7%). Eleven (12.5%) PA were clinically and hormonally silent. Three of these showed intense nuclear T-Pit positivity, classifying them under silent corticotroph adenoma. Lineage of the remaining eight adenomas remained undetermined, since, IHC for Pit-1 and SF-1 was not performed. The aggressive adenomas identified by IHC included sparsely granulated somatotroph adenoma, Crooke cell adenoma, silent corticotroph adenoma, densely granulated lactotroph adenoma in men and constituted 17% of the PA. Four (4/88) cases were clinically invasive. Conclusion: A large majority of PA including aggressive adenomas can be identified by IHC. Addition of T-Pit helped to identify silent corticotroph adenoma. Pit -1 and SF-1 TF would help identify plurihormonal Pit-1 PA and null cell adenomas. |
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Mesh-Begriff(e) | Male ; Humans ; Pituitary Neoplasms/diagnosis ; ACTH-Secreting Pituitary Adenoma ; Adenoma/diagnosis ; Hormones ; Organic Chemicals |
Chemische Substanzen | OMS 2017 ; Hormones ; Organic Chemicals |
Sprache | Englisch |
Erscheinungsdatum | 2024-02-29 |
Erscheinungsland | India |
Dokumenttyp | Journal Article |
ZDB-ID | 415522-1 |
ISSN | 1998-4022 ; 0028-3886 |
ISSN (online) | 1998-4022 |
ISSN | 0028-3886 |
DOI | 10.4103/neuroindia.NI_913_20 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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