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  1. Artikel ; Online: Quality improvement project to improve adherence to lung protective ventilation guidelines.

    Harriman, Adam / Butler, Katrina / Parekh, Dhruv / Weblin, Jonathan

    BMJ open quality

    2024  Band 13, Heft 2

    Abstract: Introduction: Lung protective ventilation (LPV) is advocated for all patients requiring mechanical ventilation (MV), for any duration of time, to prevent worsening lung injury. Previous studies proved simple interventions can increase awareness of LPV ... ...

    Abstract Introduction: Lung protective ventilation (LPV) is advocated for all patients requiring mechanical ventilation (MV), for any duration of time, to prevent worsening lung injury. Previous studies proved simple interventions can increase awareness of LPV and disease pathophysiology as well as improve adherence to LPV guidelines.
    Objective: To assess the impact of a multi-component LPV quality improvement project (QIP) on adherence to LPV guidelines.
    Methods: Tidal volume data for all patients requiring MV at a large, tertiary UK critical care unit were collected retrospectively over 3, 6 months, Plan-Do-Study-Act cycles between September 2019 and August 2022. These cycles included the sequential implementation of LPV reports, bedside whiteboards and targeted education led by a multispecialty working group.
    Main outcome measure: Adherence against predetermined targets of <5% of MV hours spent at >10 mL/kg predicted body weight (PBW) and >75% of MV hours spent <8 mL/kg PBW for all patients requiring MV.
    Results: 408 949 hours (17 040 days) of MV data were analysed. Improved LPV adherence was demonstrated throughout the QIP. During mandated MV, time spent >10 mL/kg PBW reduced from 7.65% of MV hours to 4.04% and time spent <8 mL/kg PBW improved from 68.86% of MV hours to 71.87% following the QIP. During spontaneous MV, adherence improved with a reduction in time spent >10 mL/kg PBW from baseline to completion (13.2% vs 6.75%) with increased time spent <8 mL/kg PBW (62.74% vs 72.25%). Despite demonstrating improvements in adherence, we were unable to achieve success in all our predetermined targets.
    Conclusion: This multicomponent intervention including the use of LPV reports, bedside whiteboards and education improves adherence to LPV guidelines. More robust data analysis of reasons for non-adherence to our predetermined targets is required to guide future interventions that may allow further improvement in adherence to LPV guidelines.
    Mesh-Begriff(e) Humans ; Quality Improvement ; Guideline Adherence/statistics & numerical data ; Guideline Adherence/standards ; Respiration, Artificial/methods ; Respiration, Artificial/standards ; Respiration, Artificial/statistics & numerical data ; Retrospective Studies ; United Kingdom ; Female ; Male ; Middle Aged ; Intensive Care Units/organization & administration ; Intensive Care Units/statistics & numerical data ; Aged
    Sprache Englisch
    Erscheinungsdatum 2024-05-24
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2399-6641
    ISSN (online) 2399-6641
    DOI 10.1136/bmjoq-2023-002638
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Practices to prevent non-ventilator hospital acquired pneumonia: a narrative review.

    Livesey, Alana / Quarton, Samuel / Pittaway, Harriet / Adiga, Aditya / Grudzinska, Frances / Dosanjh, Davinder / Parekh, Dhruv

    The Journal of hospital infection

    2024  

    Abstract: Nosocomial infection has significant consequences in healthcare, at the individual level driving increased morbidity and mortality, but also at the organisational level due to increased costs. Hospital acquired pneumonia(HAP) is the most common ... ...

    Abstract Nosocomial infection has significant consequences in healthcare, at the individual level driving increased morbidity and mortality, but also at the organisational level due to increased costs. Hospital acquired pneumonia(HAP) is the most common nosocomial infection and is associated with high excess mortality, frequent use of broad spectrum anti-microbials and increased length of stay. In this review we explore the preventative strategies that have been examined in non-ventilator acquired hospital associated pneumonia (NVHAP). We discuss management of aspiration risk, interventions for oral hygiene, the role of mobilisation and physiotherapy, modification of environmental factors, and vaccination. Many of these interventions are low risk, acceptable to patients and have good cost-benefit ratios. However, the evidence base for prevention of NVHAP is weak. We identify lack of a unified research definition, under-recruitment to studies, and variation in intervention and outcome measures as limitations in the existing literature. Given the core risk factors for acquisition of NVHAP are increasing there is an urgent need for research to address the prevention of NVHAP. In this review we call for a unified definition, identification of a core outcome set for studies in NVHAP and suggest future directions for research in NVHAP. Improving care for people with NVHAP will reduce morbidity, mortality, and healthcare costs significantly.
    Sprache Englisch
    Erscheinungsdatum 2024-04-23
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 779366-2
    ISSN 1532-2939 ; 0195-6701
    ISSN (online) 1532-2939
    ISSN 0195-6701
    DOI 10.1016/j.jhin.2024.03.019
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Cardiovascular Subphenotypes in ARDS: Diagnostic and Therapeutic Implications and Overlap with Other ARDS Subphenotypes.

    Chotalia, Minesh / Patel, Jaimin M / Bangash, Mansoor N / Parekh, Dhruv

    Journal of clinical medicine

    2023  Band 12, Heft 11

    Abstract: Acute respiratory distress syndrome (ARDS) is a highly heterogeneous clinical condition. Shock is a poor prognostic sign in ARDS, and heterogeneity in its pathophysiology may be a barrier to its effective treatment. Although right ventricular dysfunction ...

    Abstract Acute respiratory distress syndrome (ARDS) is a highly heterogeneous clinical condition. Shock is a poor prognostic sign in ARDS, and heterogeneity in its pathophysiology may be a barrier to its effective treatment. Although right ventricular dysfunction is commonly implicated, there is no consensus definition for its diagnosis, and left ventricular function is neglected. There is a need to identify the homogenous subgroups within ARDS, that have a similar pathobiology, which can then be treated with targeted therapies. Haemodynamic clustering analyses in patients with ARDS have identified two subphenotypes of increasingly severe right ventricular injury, and a further subphenotype of hyperdynamic left ventricular function. In this review, we discuss how phenotyping the cardiovascular system in ARDS may align with haemodynamic pathophysiology, can aid in optimally defining right ventricular dysfunction and can identify tailored therapeutic targets for shock in ARDS. Additionally, clustering analyses of inflammatory, clinical and radiographic data describe other subphenotypes in ARDS. We detail the potential overlap between these and the cardiovascular phenotypes.
    Sprache Englisch
    Erscheinungsdatum 2023-05-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12113695
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: The authors reply.

    Chotalia, Minesh / Patel, Jaimin M / Parekh, Dhruv / Bangash, Mansoor N

    Critical care medicine

    2023  Band 51, Heft 2, Seite(n) e66–e67

    Sprache Englisch
    Erscheinungsdatum 2023-01-20
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005761
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Characterising right ventricular dysfunction in acute respiratory distress syndrome due to COVID-19: which measurements are best?

    Chotalia, Minesh / Patel, Jaimin / Parekh, Dhruv / Bangash, Mansoor

    Intensive care medicine

    2022  Band 48, Heft 8, Seite(n) 1104–1105

    Mesh-Begriff(e) COVID-19/complications ; Humans ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/therapy ; Ventricular Dysfunction, Right/etiology ; Ventricular Function, Right
    Sprache Englisch
    Erscheinungsdatum 2022-05-20
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-022-06742-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Mechanisms of Post-critical Illness Cardiovascular Disease.

    Owen, Andrew / Patel, Jaimin M / Parekh, Dhruv / Bangash, Mansoor N

    Frontiers in cardiovascular medicine

    2022  Band 9, Seite(n) 854421

    Abstract: Prolonged critical care stays commonly follow trauma, severe burn injury, sepsis, ARDS, and complications of major surgery. Although patients leave critical care following homeostatic recovery, significant additional diseases affect these patients during ...

    Abstract Prolonged critical care stays commonly follow trauma, severe burn injury, sepsis, ARDS, and complications of major surgery. Although patients leave critical care following homeostatic recovery, significant additional diseases affect these patients during and beyond the convalescent phase. New cardiovascular and renal disease is commonly seen and roughly one third of all deaths in the year following discharge from critical care may come from this cluster of diseases. During prolonged critical care stays, the immunometabolic, inflammatory and neurohumoral response to severe illness in conjunction with resuscitative treatments primes the immune system and parenchymal tissues to develop a long-lived pro-inflammatory and immunosenescent state. This state is perpetuated by persistent Toll-like receptor signaling, free radical mediated isolevuglandin protein adduct formation and presentation by antigen presenting cells, abnormal circulating HDL and LDL isoforms, redox and metabolite mediated epigenetic reprogramming of the innate immune arm (trained immunity), and the development of immunosenescence through T-cell exhaustion/anergy through epigenetic modification of the T-cell genome. Under this state, tissue remodeling in the vascular, cardiac, and renal parenchymal beds occurs through the activation of pro-fibrotic cellular signaling pathways, causing vascular dysfunction and atherosclerosis, adverse cardiac remodeling and dysfunction, and proteinuria and accelerated chronic kidney disease.
    Sprache Englisch
    Erscheinungsdatum 2022-07-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.854421
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Definition and evolution of right ventricular dysfunction in critically ill COVID-19 patients.

    Chotalia, Minesh / Bangash, Mansoor N / Patel, Jaimin M / Parekh, Dhruv

    Annals of intensive care

    2022  Band 12, Heft 1, Seite(n) 82

    Sprache Englisch
    Erscheinungsdatum 2022-08-30
    Erscheinungsland Germany
    Dokumenttyp Letter ; Comment
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-022-01055-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: The authors reply.

    Chotalia, Minesh / Ali, Muzzammil / Alderman, Joseph / Kalla, Manish / Parekh, Dhruv / Bangash, Mansoor / Patel, Jaimin

    Critical care medicine

    2023  Band 50, Heft 4, Seite(n) e395–e396

    Sprache Englisch
    Erscheinungsdatum 2023-02-03
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005452
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: COVID-19 and the liver: little cause for concern.

    Bangash, Mansoor N / Patel, Jaimin / Parekh, Dhruv

    The lancet. Gastroenterology & hepatology

    2020  Band 5, Heft 6, Seite(n) 529–530

    Mesh-Begriff(e) Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Humans ; Liver Diseases/virology ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-03-20
    Erscheinungsland Netherlands
    Dokumenttyp Letter
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(20)30084-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: The authors reply.

    Chotalia, Minesh / Ali, Muzzammil / Alderman, Joseph / Kalla, Manish / Parekh, Dhruv / Bangash, Mansoor / Patel, Jaimin

    Critical care medicine

    2022  Band 50, Heft 4, Seite(n) e398–e399

    Sprache Englisch
    Erscheinungsdatum 2022-02-09
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005453
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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