LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 3 von insgesamt 3

Suchoptionen

  1. Artikel ; Online: Targeting Morphine-Responsive Neurons: Generation of a Knock-In Mouse Line Expressing Cre Recombinase from the Mu-Opioid Receptor Gene Locus.

    Bailly, Julie / Del Rossi, Natalie / Runtz, Léonie / Li, Jing-Jing / Park, DaWoon / Scherrer, Grégory / Tanti, Arnaud / Birling, Marie-Christine / Darcq, Emmanuel / Kieffer, Brigitte L

    eNeuro

    2020  Band 7, Heft 3

    Abstract: The mu-opioid receptor (MOR) modulates nociceptive pathways and reward processing, and mediates the strong analgesic and addictive properties of both medicinal as well as abused opioid drugs. MOR function has been extensively studied, and tools to ... ...

    Abstract The mu-opioid receptor (MOR) modulates nociceptive pathways and reward processing, and mediates the strong analgesic and addictive properties of both medicinal as well as abused opioid drugs. MOR function has been extensively studied, and tools to manipulate or visualize the receptor protein are available. However, circuit mechanisms underlying MOR-mediated effects are less known, because genetic access to MOR-expressing neurons is lacking. Here we report the generation of a knock-in
    Mesh-Begriff(e) Animals ; Habenula/metabolism ; Integrases/genetics ; Mice ; Morphine/pharmacology ; Neurons/metabolism ; Receptors, Opioid, mu/genetics ; Receptors, Opioid, mu/metabolism
    Chemische Substanzen Receptors, Opioid, mu ; Morphine (76I7G6D29C) ; Cre recombinase (EC 2.7.7.-) ; Integrases (EC 2.7.7.-)
    Sprache Englisch
    Erscheinungsdatum 2020-05-29
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2800598-3
    ISSN 2373-2822 ; 2373-2822
    ISSN (online) 2373-2822
    ISSN 2373-2822
    DOI 10.1523/ENEURO.0433-19.2020
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel: Quantification of wind damage to New Zealand's planted forests

    Moore, John R / Manley, Bruce R / Park, Dawoon / Scarrott, Carl J

    Forestry. 2013 Apr., v. 86, no. 2

    2013  

    Abstract: Wind has a significant impact on planted forests in New Zealand, but the extent of loss and its spatial and temporal variability have not been quantified. Therefore, a formal analysis was undertaken using a database containing 78 records of wind damage ... ...

    Abstract Wind has a significant impact on planted forests in New Zealand, but the extent of loss and its spatial and temporal variability have not been quantified. Therefore, a formal analysis was undertaken using a database containing 78 records of wind damage in planted forests that spanned the period between 1945 and 2010. Approximately 63 000 ha of damage was recorded during this period. The damage that occurred in a single event ranged from 2.8 to 26 000 ha, with a median of 90 ha, and in most cases was confined to a single wood supply region. The relative risk of wind damage for each wood supply region was estimated by calculating the percentage of total net stocked area (NSA) that has been damaged by wind. Across all wood supply regions, an average of 0.21 per cent of NSA per annum has been damaged by wind; however, in the most affected region, the average level of damage was 0.94 per cent of NSA per annum, whereas in the least affected region it was 0.03 per cent. The probability of different levels of annual damage was modelled along with the level of damage associated with different return periods using a generalized Pareto distribution. Using this model, the mean return period for 500 ha of damage was estimated to be 5.0 years with 95% confidence interval (4.5, 6.2) years, whereas for 1000 ha of damage it was estimated to be 6.4 (4.8, 9.9) years.
    Schlagwörter confidence interval ; databases ; forests ; models ; relative risk ; temporal variation ; wind ; wind damage ; wood ; New Zealand
    Sprache Englisch
    Erscheinungsverlauf 2013-04
    Umfang p. 173-183.
    Erscheinungsort Oxford University Press
    Dokumenttyp Artikel
    ZDB-ID 212942-5
    ISSN 0015-752X
    ISSN 0015-752X
    DOI 10.1093/forestry/cps076
    Datenquelle NAL Katalog (AGRICOLA)

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Bonn

    Z 769: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  3. Artikel: Quantification of wind damage to New Zealand's planted forests

    Moore, John R. / Manley, Bruce R. / Park, Dawoon / Scarrott, Carl J.

    Forestry

    Band v. 86,, Heft no. 2

    Abstract: Wind has a significant impact on planted forests in New Zealand, but the extent of loss and its spatial and temporal variability have not been quantified. Therefore, a formal analysis was undertaken using a database containing 78 records of wind damage ... ...

    Abstract Wind has a significant impact on planted forests in New Zealand, but the extent of loss and its spatial and temporal variability have not been quantified. Therefore, a formal analysis was undertaken using a database containing 78 records of wind damage in planted forests that spanned the period between 1945 and 2010. Approximately 63 000 ha of damage was recorded during this period. The damage that occurred in a single event ranged from 2.8 to 26 000 ha, with a median of 90 ha, and in most cases was confined to a single wood supply region. The relative risk of wind damage for each wood supply region was estimated by calculating the percentage of total net stocked area (NSA) that has been damaged by wind. Across all wood supply regions, an average of 0.21 per cent of NSA per annum has been damaged by wind; however, in the most affected region, the average level of damage was 0.94 per cent of NSA per annum, whereas in the least affected region it was 0.03 per cent. The probability of different levels of annual damage was modelled along with the level of damage associated with different return periods using a generalized Pareto distribution. Using this model, the mean return period for 500 ha of damage was estimated to be 5.0 years with 95% confidence interval (4.5, 6.2) years, whereas for 1000 ha of damage it was estimated to be 6.4 (4.8, 9.9) years.
    Schlagwörter models ; forests ; wind ; wood ; wind damage ; relative risk ; databases ; confidence interval ; temporal variation
    Sprache Englisch
    Dokumenttyp Artikel
    ISSN 0015-752X
    Datenquelle AGRIS - International Information System for the Agricultural Sciences and Technology

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Zum Seitenanfang