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  1. Artikel: Positron Emission Tomography Imaging of Macrophages in Cancer.

    Parker, Candace C / Lapi, Suzanne E

    Cancers

    2021  Band 13, Heft 8

    Abstract: Macrophages are large phagocytic cells that can be classified as a type of white blood cell and may be either mobile or stationary in tissues. The presence of macrophages in essentially every major disease makes them attractive candidates to serve as ... ...

    Abstract Macrophages are large phagocytic cells that can be classified as a type of white blood cell and may be either mobile or stationary in tissues. The presence of macrophages in essentially every major disease makes them attractive candidates to serve as therapeutic targets and diagnostic biomarkers. Macrophages that are found in the microenvironment of solid tumors are referred to as tumor-associated macrophages (TAMs) and have been shown to influence chemoresistance, immune regulation, tumor initiation and tumor growth. The imaging of TAMs through Positron Emission Tomography (PET) has the potential to provide valuable information on cancer biology, tumor progression, and response to therapy. This review will highlight the versatility of macrophage imaging in cancer through the use of PET.
    Sprache Englisch
    Erscheinungsdatum 2021-04-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13081921
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: In vivo Assessment of the Impact of Molecular Weight on Constructs of

    Bartels, Jennifer L / Fernandez, Solana R / Arnold, Jeffrey S / Parker, Candace C / Tekin, Volkan / O'Malley, Grace / Ralph, David A / Lapi, Suzanne E

    Molecular imaging and biology

    2023  Band 25, Heft 5, Seite(n) 867–874

    Abstract: Purpose: Manocept™ constructs are mannosylated amine dextrans (MADs) that bind with high affinity to the mannose receptor, CD206. Tumor-associated macrophages (TAMs) are the most numerous immune cells in the tumor microenvironment and a recognized ... ...

    Abstract Purpose: Manocept™ constructs are mannosylated amine dextrans (MADs) that bind with high affinity to the mannose receptor, CD206. Tumor-associated macrophages (TAMs) are the most numerous immune cells in the tumor microenvironment and a recognized target for tumor imaging and cancer immunotherapies. Most TAMs express CD206, suggesting utility of MADs to deliver imaging moieties or therapeutics to TAMs. The liver Kupffer cells also express CD206, making them an off-target localization site when targeting CD206 on TAMs. We evaluated TAM targeting strategies using two novel MADs differing in molecular weight in a syngeneic mouse tumor model to determine how varying MAD molecular weights would impact tumor localization. Increased mass dose of the non-labeled construct or a higher molecular weight (HMW) construct were also used to block liver localization and enhance tumor to liver ratios.
    Procedures: Two MADs, 8.7 kDa and 22.6 kDa modified with DOTA chelators, were synthesized and radiolabeled with
    Results: The new constructs were readily synthesized and labeled with
    Conclusion: Novel [
    Mesh-Begriff(e) Mice ; Animals ; Gallium Radioisotopes/chemistry ; Molecular Weight ; Tissue Distribution ; Cell Line, Tumor ; Positron-Emission Tomography/methods
    Chemische Substanzen 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid (1HTE449DGZ) ; Gallium Radioisotopes
    Sprache Englisch
    Erscheinungsdatum 2023-03-07
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2079160-4
    ISSN 1860-2002 ; 1536-1632
    ISSN (online) 1860-2002
    ISSN 1536-1632
    DOI 10.1007/s11307-023-01809-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6468: Hefte anzeigen Standort:
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  3. Artikel ; Online: Evaluation of a CD206-Targeted Peptide for PET Imaging of Macrophages in Syngeneic Mouse Models of Cancer.

    Parker, Candace C / Bin Salam, Ahmad / Song, Patrick N / Gallegos, Carlos / Hunt, Addison / Yates, Clayton / Jaynes, Jesse / Lopez, Henry / Massicano, Adriana V F / Sorace, Anna G / Fernandez, Solana / Houson, Hailey A / Lapi, Suzanne E

    Molecular pharmaceutics

    2023  Band 20, Heft 5, Seite(n) 2415–2425

    Abstract: Tumor-associated macrophages (TAMs) are large phagocytic cells that play numerous roles in cancer biology and are an important component of the relationship between immune system response and tumor progression. The peptide, RP832c, targets the Mannose ... ...

    Abstract Tumor-associated macrophages (TAMs) are large phagocytic cells that play numerous roles in cancer biology and are an important component of the relationship between immune system response and tumor progression. The peptide, RP832c, targets the Mannose Receptor (CD206) expressed on M2-like macrophages and is cross-reactive to both human and murine CD206. Additionally, it exhibits therapeutic properties through its ability to shift the population of TAMs from an M2-like (protumor) toward an M1-like phenotype (antitumor) and has demonstrated promise in inhibiting tumor resistance in PD-L1 unresponsive melanoma murine models. In addition, it has shown inhibition in bleomycin-induced pulmonary fibrosis through interactions with CD206 macrophages.
    Mesh-Begriff(e) Animals ; Humans ; Mice ; Cell Line, Tumor ; Gallium Radioisotopes/chemistry ; Macrophages/metabolism ; Neoplasms/metabolism ; Peptides/metabolism ; Positron-Emission Tomography/methods ; Tissue Distribution ; Mannose Receptor/metabolism
    Chemische Substanzen Gallium Radioisotopes ; Peptides ; Mannose Receptor
    Sprache Englisch
    Erscheinungsdatum 2023-04-04
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.2c00977
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6250: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  4. Artikel ; Online: Sc-HOPO: A Potential Construct for Use in Radioscandium-Based Radiopharmaceuticals.

    Phipps, Michael D / Cingoranelli, Shelbie / Bhupathiraju, N V S Dinesh K / Younes, Ali / Cao, Minhua / Sanders, Vanessa A / Neary, Michelle C / Devany, Matthew H / Cutler, Cathy S / Lopez, Gustavo E / Saini, Shefali / Parker, Candace C / Fernandez, Solana R / Lewis, Jason S / Lapi, Suzanne E / Francesconi, Lynn C / Deri, Melissa A

    Inorganic chemistry

    2023  Band 62, Heft 50, Seite(n) 20567–20581

    Abstract: Three isotopes of scandium─ ...

    Abstract Three isotopes of scandium─
    Mesh-Begriff(e) Animals ; Mice ; Radiopharmaceuticals/chemistry ; Pyridones/chemistry ; Chelating Agents/chemistry ; Positron-Emission Tomography/methods ; Ligands
    Chemische Substanzen Radiopharmaceuticals ; Pyridones ; Chelating Agents ; Ligands
    Sprache Englisch
    Erscheinungsdatum 2023-02-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.2c03931
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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