Artikel ; Online: Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease.
2022 Band 11
Abstract: Host immune responses contribute to dengue's pathogenesis and severity, yet the possibility that failure in endogenous inflammation resolution pathways could characterise the disease has not been contemplated. The pro-resolving protein Annexin A1 (AnxA1) ...
| Abstract | Host immune responses contribute to dengue's pathogenesis and severity, yet the possibility that failure in endogenous inflammation resolution pathways could characterise the disease has not been contemplated. The pro-resolving protein Annexin A1 (AnxA1) is known to counterbalance overexuberant inflammation and mast cell (MC) activation. We hypothesised that inadequate AnxA1 engagement underlies the cytokine storm and vascular pathologies associated with dengue disease. Levels of AnxA1 were examined in the plasma of dengue patients and infected mice. Immunocompetent, interferon (alpha and beta) receptor one knockout (KO), AnxA1 KO, and formyl peptide receptor 2 (FPR2) KO mice were infected with |
|---|---|
| Mesh-Begriff(e) | Animals ; Annexin A1/metabolism ; Dengue/drug therapy ; Humans ; Inflammation/pathology ; Mice ; Peptides/metabolism ; Receptors, Formyl Peptide/metabolism ; Receptors, Lipoxin/metabolism |
| Chemische Substanzen | Annexin A1 ; FPR2 protein, human ; Peptides ; Receptors, Formyl Peptide ; Receptors, Lipoxin |
| Sprache | Englisch |
| Erscheinungsdatum | 2022-03-16 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2687154-3 |
| ISSN | 2050-084X ; 2050-084X |
| ISSN (online) | 2050-084X |
| ISSN | 2050-084X |
| DOI | 10.7554/eLife.73853 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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