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  1. Article: Hydroxychloroquine Pre-Exposure Prophylaxis for COVID-19 Among Healthcare Workers: Initial Experience from India

    Kadnur, Harshith B. / Aggarwal, Anivita Soneja Manish Singh Komal George Netto Nischal Neeraj Trilangi Praveen Khan Adil Rashid Desai Devashish Mittal Ankit Arunan Bharathi Patidar Diksha Gupta Ankesh Kumar Arvind Soni Kapil Dev Jorwal Pankaj Agarwal Richa Baidya Dalim K. / Mathur, Purva Bhatnagar Sushma Trikha Anjan Rajeshwari S. / Biswas, Ashutosh Pandey Ravindra Wig Naveet Guleria Randeep

    Abstract: Background: Hydroxychloroquine(HCQ) prophylaxis has been proposed for coronavirus disease-2019(COVID-19) This prospective observational study was conducted ... ...

    Abstract Background: Hydroxychloroquine(HCQ) prophylaxis has been proposed for coronavirus disease-2019(COVID-19) This prospective observational study was conducted to
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #1746
    Database COVID19

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  2. Article ; Online: Post COVID-19 sequelae: A prospective observational study from Northern India.

    Naik, Shivdas / Haldar, Soumendra Nath / Soneja, Manish / Mundadan, Netto George / Garg, Prerna / Mittal, Ankit / Desai, Devashish / Trilangi, Praveen Kumar / Chakraborty, Sayan / Begam, Nazneen Nahar / Bhattacharya, Bisakh / Maher, Ganesh / Mahishi, Niranjan / Rajanna, Chaithra / Kumar, Swasthi S / Arunan, Bharathi / Kirtana, J / Gupta, Ankesh / Patidar, Diksha /
    Kodan, Parul / Sethi, Prayas / Ray, Animesh / Jorwal, Pankaj / Kumar, Arvind / Nischal, Neeraj / Sinha, Sanjeev / Biswas, Ashutosh / Wig, Naveet

    Drug discoveries & therapeutics

    2021  Volume 15, Issue 5, Page(s) 254–260

    Abstract: Post COVID-19 sequelae are a constellation of symptoms often reported after recovering from COVID-19. There is a need to better understand the clinical spectrum and long-term course of this clinical entity. The aim of this study is to describe the ... ...

    Abstract Post COVID-19 sequelae are a constellation of symptoms often reported after recovering from COVID-19. There is a need to better understand the clinical spectrum and long-term course of this clinical entity. The aim of this study is to describe the clinical features and risk factors of post COVID-19 sequelae in the North Indian population. This prospective observational study was conducted at a tertiary healthcare centre in Northern India between October 2020 and February 2021. Patients aged >18 years with laboratory-confirmed COVID-19 were recruited after at least two weeks of diagnosis, and details were captured. A total of 1234 patients were recruited and followed up for a median duration of 91 days (IQR: 45-181 days). Among them, 495 (40.1%) had persistent symptoms post-discharge or recovery. In 223 (18.1%) patients, the symptoms resolved within four weeks; 150 (12.1%) patients had symptoms till 12 weeks, and 122 (9.9%) patients had symptoms beyond 12 weeks of diagnosis/symptom-onset of COVID-19. Most common symptoms included myalgia (10.9%), fatigue (5.5%), shortness of breath (6.1%), cough (2.1%), insomnia (1.4%), mood disturbances (0.48%) and anxiety (0.6%). Patients who were hospitalized were more likely to report fatigue as a feature of long COVID. Hypothyroidism (OR: 4.13, 95% CI: 2.2-7.6, p-value < 0.001) and hypoxia (SpO
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/etiology ; COVID-19/pathology ; Cough/epidemiology ; Cough/etiology ; Dyspnea/epidemiology ; Dyspnea/etiology ; Fatigue/epidemiology ; Fatigue/etiology ; Female ; Humans ; India/epidemiology ; Male ; Middle Aged ; Myalgia/epidemiology ; Myalgia/etiology ; Prospective Studies ; Risk Factors ; Sleep Initiation and Maintenance Disorders/epidemiology ; Sleep Initiation and Maintenance Disorders/etiology ; Young Adult
    Language English
    Publishing date 2021-10-30
    Publishing country Japan
    Document type Journal Article ; Observational Study
    ZDB-ID 2568828-5
    ISSN 1881-784X ; 1881-784X
    ISSN (online) 1881-784X
    ISSN 1881-784X
    DOI 10.5582/ddt.2021.01093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Rapid chromatographic immunoassay-based evaluation of COVID-19: A cross-sectional, diagnostic test accuracy study & its implications for COVID-19 management in India.

    Gupta, Ankesh / Khurana, Surbhi / Das, Rojaleen / Srigyan, Deepankar / Singh, Amit / Mittal, Ankit / Singh, Parul / Soneja, Manish / Kumar, Arvind / Singh, Akhil Kant / Soni, Kapil Dev / Meena, Suneeta / Aggarwal, Richa / Sharad, Neha / Aggarwal, Anivita / Kadnur, Harshith / George, Netto / Singh, Komal / Desai, Devashish /
    Trilangi, Praveen / Khan, Adil Rashid / Kiro, Vandana V / Naik, Shivdas / Arunan, Bharthi / Goel, Shivam / Patidar, Diksha / Lathwal, Amit / Dar, Lalit / Trikha, Anjan / Pandey, Ravindra Mohan / Malhotra, Rajesh / Guleria, Randeep / Mathur, Purva / Wig, Naveet

    The Indian journal of medical research

    2021  Volume 153, Issue 1 & 2, Page(s) 126–131

    Abstract: Background & objectives: Coronavirus disease 2019 (COVID-19) has so far affected over 41 million people globally. The limited supply of real-time reverse transcription-polymerase chain reaction (rRT-PCR) kits and reagents has made meeting the rising ... ...

    Abstract Background & objectives: Coronavirus disease 2019 (COVID-19) has so far affected over 41 million people globally. The limited supply of real-time reverse transcription-polymerase chain reaction (rRT-PCR) kits and reagents has made meeting the rising demand for increased testing incompetent, worldwide. A highly sensitive and specific antigen-based rapid diagnostic test (RDT) is the need of the hour. The objective of this study was to evaluate the performance of a rapid chromatographic immunoassay-based test (index test) compared with a clinical reference standard (rRT-PCR).
    Methods: A cross-sectional, single-blinded study was conducted at a tertiary care teaching hospital in north India. Paired samples were taken for RDT and rRT-PCR (reference standard) from consecutive participants screened for COVID-19 to calculate the sensitivity and specificity of the RDT. Further subgroup analysis was done based on the duration of illness and cycle threshold values. Cohen's kappa coefficient was used to measure the level of agreement between the two tests.
    Results: Of the 330 participants, 77 were rRT-PCR positive for SARS-CoV-2. Sixty four of these patients also tested positive for SARS-CoV-2 by RDT. The overall sensitivity and specificity were 81.8 and 99.6 per cent, respectively. The sensitivity of RDT was higher (85.9%) in participants with a duration of illness ≤5 days.
    Interpretation & conclusions: With an excellent specificity and moderate sensitivity, this RDT may be used to rule in COVID-19 in patients with a duration of illness ≤5 days. Large-scale testing based on this RDT across the country would result in quick detection, isolation and treatment of COVID-19 patients.
    MeSH term(s) COVID-19/diagnosis ; COVID-19 Testing ; Chromatography ; Cross-Sectional Studies ; Humans ; Immunoassay ; India ; Sensitivity and Specificity
    Language English
    Publishing date 2021-04-09
    Publishing country India
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_3305_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Hydroxychloroquine Pre-Exposure Prophylaxis for COVID-19 Among Healthcare Workers

    Kadnur, Harshith B. / Aggarwal, Anivita / Soneja, Manish / Singh, Komal / George, Netto / Nischal, Neeraj / Trilangi, Praveen / Khan, Adil Rashid / Desai, Devashish / Mittal, Ankit / Arunan, Bharathi / Patidar, Diksha / Gupta, Ankesh / Kumar, Arvind / Soni, Kapil Dev / Jorwal, Pankaj / Agarwal, Richa / Baidya, Dalim K. / Mathur, Purva /
    Bhatnagar, Sushma / Trikha, Anjan / Rajeshwari, S. / Biswas, Ashutosh / Pandey, Ravindra / Wig, Naveet / Guleria, Randeep

    SSRN Electronic Journal ; ISSN 1556-5068

    Initial Experience from India

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.2139/ssrn.3622350
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Rapid chromatographic immunoassay-based evaluation of COVID-19: A cross-sectional, diagnostic test accuracy study & its implications for COVID-19 management in India

    Gupta, Ankesh / Khurana, Surbhi / Das, Rojaleen / Srigyan, Deepankar / Singh, Amit / Mittal, Ankit / Singh, Parul / Soneja, Manish / Kumar, Arvind / Singh, Akhil Kant / Soni, Kapil Dev / Meena, Suneeta / Aggarwal, Richa / Sharad, Neha / Aggarwal, Anivita / Kadnur, Harshith / George, Netto / Singh, Komal / Desai, Devashish /
    Trilangi, Praveen / Khan, Adil Rashid / Kiro, Vandana V / Naik, Shivdas / Arunan, Bharthi / Goel, Shivam / Patidar, Diksha / Lathwal, Amit / Dar, Lalit / Trikha, Anjan / Pandey, Ravindra Mohan / Malhotra, Rajesh / Guleria, Randeep / Mathur, Purva / Wig, Naveet

    Indian journal of medical research

    Abstract: Background & objectives: : Coronavirus disease 2019 (COVID-19) has so far affected over 41 million people globally. The limited supply of real-time reverse transcription-polymerase chain reaction (rRT-PCR) kits and reagents has made meeting the rising ... ...

    Abstract Background & objectives: : Coronavirus disease 2019 (COVID-19) has so far affected over 41 million people globally. The limited supply of real-time reverse transcription-polymerase chain reaction (rRT-PCR) kits and reagents has made meeting the rising demand for increased testing incompetent, worldwide. A highly sensitive and specific antigen-based rapid diagnostic test (RDT) is the need of the hour. The objective of this study was to evaluate the performance of a rapid chromatographic immunoassay-based test (index test) compared with a clinical reference standard (rRT-PCR). Methods: : A cross-sectional, single-blinded study was conducted at a tertiary care teaching hospital in north India. Paired samples were taken for RDT and rRT-PCR (reference standard) from consecutive participants screened for COVID-19 to calculate the sensitivity and specificity of the RDT. Further subgroup analysis was done based on the duration of illness and cycle threshold values. Cohen's kappa coefficient was used to measure the level of agreement between the two tests. Results: : Of the 330 participants, 77 were rRT-PCR positive for SARS-CoV-2. Sixty four of these patients also tested positive for SARS-CoV-2 by RDT. The overall sensitivity and specificity were 81.8 and 99.6 per cent, respectively. The sensitivity of RDT was higher (85.9%) in participants with a duration of illness ≤5 days. Interpretation & conclusions: : With an excellent specificity and moderate sensitivity, this RDT may be used to rule in COVID-19 in patients with a duration of illness ≤5 days. Large-scale testing based on this RDT across the country would result in quick detection, isolation and treatment of COVID-19 patients.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #910272
    Database COVID19

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    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Rapid chromatographic immunoassay-based evaluation of COVID-19

    Mathur, Purva / Gupta, Ankesh / Khurana, Surbhi / Das, Rojaleen / Srigyan, Deepankar / Singh, Amit / Mittal, Ankit / Singh, Parul / Soneja, Manish / Kumar, Arvind / Singh, AkhilKant / Soni, KapilDev / Meena, Suneeta / Aggarwal, Richa / Sharad, Neha / Aggarwal, Anivita / Kadnur, Harshith / George, Netto / Singh, Komal /
    Desai, Devashish / Trilangi, Praveen / Khan, AdilRashid / Kiro, VandanaV / Naik, Shivdas / Arunan, Bharthi / Goel, Shivam / Patidar, Diksha / Lathwal, Amit / Dar, Lalit / Trikha, Anjan / Pandey, RavindraMohan / Malhotra, Rajesh / Guleria, Randeep / Wig, Naveet

    Indian Journal of Medical Research

    A cross-sectional, diagnostic test accuracy study & its implications for COVID-19 management in India

    2020  

    Keywords General Biochemistry, Genetics and Molecular Biology ; General Medicine ; covid19
    Language English
    Publisher Medknow
    Publishing country in
    Document type Article ; Online
    ZDB-ID 390883-5
    ISSN 0019-5340 ; 0971-5916
    ISSN 0019-5340 ; 0971-5916
    DOI 10.4103/ijmr.ijmr_3305_20
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.143: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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