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  1. Artikel: Bromocriptine inhibits proliferation in the endometrium from women with adenomyosis.

    Tang, Yiqun / Ponandai-Srinivasan, Sakthivignesh / Frisendahl, Caroline / Andersson, Johanna K / Pavone, Dora / Stewart, Elizabeth A / Lalitkumar, Parameswaran Grace Luther / Korsching, Eberhard / Bogavarappu, Nageswara Rao / Gemzell-Danielsson, Kristina

    Frontiers in endocrinology

    2023  Band 14, Seite(n) 1026168

    Abstract: Objective: Bromocriptine treatment has been shown to reduce menstrual bleeding and pain in women with adenomyosis in a pilot clinical trial. The underlying mechanism contributing to the treatment effect is however unknown. The purpose of this study was ... ...

    Abstract Objective: Bromocriptine treatment has been shown to reduce menstrual bleeding and pain in women with adenomyosis in a pilot clinical trial. The underlying mechanism contributing to the treatment effect is however unknown. The purpose of this study was to explore the effect of bromocriptine on the proliferation and migration properties of the endometrium in women with adenomyosis, by assessing cellular and molecular changes after six months of vaginal bromocriptine treatment.
    Methods: Endometrial specimens were collected during the proliferative phase from women with adenomyosis (n=6) before (baseline) and after six months of treatment with vaginal bromocriptine. Immunohistochemistry was used to determine changes in the protein expression of Ki67 in the endometrium of women with adenomyosis. Primary endometrial stromal cells isolated at baseline were expanded
    Results: Vaginal bromocriptine treatment reduced the Ki67 protein expression in the endometrium of women with adenomyosis and did not change the prolactin mRNA expression and protein concentration of prolactin in endometrial tissues. Bromocriptine significantly inhibited the proliferative and migrative abilities of endometrial stromal cells derived from women with adenomyosis
    Conclusion: Bromocriptine treatment exhibits an anti-proliferative effect in the endometrium of women with adenomyosis
    Mesh-Begriff(e) Humans ; Female ; Adenomyosis/drug therapy ; Bromocriptine/pharmacology ; Bromocriptine/therapeutic use ; Ki-67 Antigen/metabolism ; Prolactin/metabolism ; Endometrium/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Cell Proliferation
    Chemische Substanzen Bromocriptine (3A64E3G5ZO) ; Ki-67 Antigen ; Prolactin (9002-62-4) ; MicroRNAs
    Sprache Englisch
    Erscheinungsdatum 2023-03-09
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1026168
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Epidemiology and Risk Factors of Uterine Fibroids.

    Pavone, Dora / Clemenza, Sara / Sorbi, Flavia / Fambrini, Massimiliano / Petraglia, Felice

    Best practice & research. Clinical obstetrics & gynaecology

    2018  Band 46, Seite(n) 3–11

    Abstract: Risk factors, both modifiable and non-modifiable, are associated with the development of fibroids. These include age, race, endogenous and exogenous hormonal factors, obesity, uterine infection, and lifestyle (diet, caffeine and alcohol consumption, ... ...

    Abstract Risk factors, both modifiable and non-modifiable, are associated with the development of fibroids. These include age, race, endogenous and exogenous hormonal factors, obesity, uterine infection, and lifestyle (diet, caffeine and alcohol consumption, physical activity, stress, and smoking). Some of the epidemiological data were conflicting; consequently, further studies are needed to better understand the factors that influence fibroid prevalence.
    Mesh-Begriff(e) African Continental Ancestry Group/statistics & numerical data ; Age Factors ; European Continental Ancestry Group/statistics & numerical data ; Female ; Humans ; Leiomyoma/epidemiology ; Leiomyoma/etiology ; Leiomyoma/genetics ; Prevalence ; Risk Factors ; Uterine Neoplasms/epidemiology ; Uterine Neoplasms/etiology ; Uterine Neoplasms/genetics
    Sprache Englisch
    Erscheinungsdatum 2018-01
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2050090-7
    ISSN 1532-1932 ; 1521-6934
    ISSN (online) 1532-1932
    ISSN 1521-6934
    DOI 10.1016/j.bpobgyn.2017.09.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Prevalence of Infertility Among Patients With Isthmocele and Fertility Outcome After Isthmocele Surgical Treatment: A Retrospective Study.

    Calzolari, Stefano / Sisti, Giovanni / Pavone, Dora / Ciocia, Eleonora / Bianchini, Natalia / Cozzolino, Mauro

    The Ochsner journal

    2019  Band 19, Heft 3, Seite(n) 204–209

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2019-09-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1524-5012
    ISSN 1524-5012
    DOI 10.31486/toj.18.0048
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  4. Artikel ; Online: High grade cervical intraepithelial neoplasia positive biopsy: the importance of accurate pre-operative workup.

    Bussani, Cecilia / Malentacchi, Francesca / Andersson, Karin L / Fambrini, Massimiliano / Coco, Chiara / Pavone, Dora / Fantappiè, Giulia / Turrini, Irene / Dubini, Valeria / Petraglia, Felice / Sorbi, Flavia

    Minerva ginecologica

    2021  Band 72, Heft 6, Seite(n) 413–419

    Abstract: Background: In cervical cancer screening programs, women with abnormal cytology and confirmation by biopsy are referred for colposcopy for histological evaluation.: Methods: We characterized the presence and the genotype of HPV by Linear Array HPV ... ...

    Abstract Background: In cervical cancer screening programs, women with abnormal cytology and confirmation by biopsy are referred for colposcopy for histological evaluation.
    Methods: We characterized the presence and the genotype of HPV by Linear Array HPV genotyping assay in cytological samples collected from about 400 women undergoing conization, with reported high CIN grade after biopsy.
    Results: The most prevalent genotype was HPV 16, with an increasing presence depending on the severity of the CIN and with the highest incidence in the 26-35 age range. In the group of younger women (<25) we found the highest percentage of CIN3 (39.3%) and the lowest of CIN1 (17.9%). An increase of CIN1 with increasing age was observed. A different distribution of HPV presence was observed depending on CIN grade (P<0.001): CIN1 HPV negative samples were 46.3%, CIN2: 5.8% and CIN3: 1.4%. Interesting, in the analyzed cohort, we observed the presence of 30% of CIN1. Moreover, within CIN1, 85% of them were associated to negative HPV detection, this observation suggested that the detection of HPV presence may be useful to identify low CIN grade that should be reconsidered for surgical treatment.
    Conclusions: These findings suggest implementing the protocol for the management of women with high risk precancer lesions, with a further HPV test before surgical treatment. The evaluation of HPV presence and genotype before conization might represent a useful tool in reducing or postpone the conization treatment.
    Mesh-Begriff(e) Adult ; Age Factors ; Aged ; Alphapapillomavirus/genetics ; Alphapapillomavirus/isolation & purification ; Biopsy ; Cervical Intraepithelial Neoplasia/pathology ; Cervical Intraepithelial Neoplasia/surgery ; Cervical Intraepithelial Neoplasia/virology ; Cervix Uteri/pathology ; Cervix Uteri/virology ; Conization ; Female ; Genotype ; Human papillomavirus 16/genetics ; Human papillomavirus 16/isolation & purification ; Humans ; Middle Aged ; Preoperative Care ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/surgery ; Uterine Cervical Neoplasms/virology ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2021-01-06
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 80159-8
    ISSN 1827-1650 ; 0026-4784 ; 0325-8793
    ISSN (online) 1827-1650
    ISSN 0026-4784 ; 0325-8793
    DOI 10.23736/S0026-4784.20.04587-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Spontaneous Resolution of an Acquired Uterine Arteriovenous Malformation in an Elderly Primigravida.

    Ghizzoni, Viola / Gabbrielli, Silvia / Mannini, Luca / Sorbi, Flavia / Turrini, Irene / Fantappiè, Giulia / Pavone, Dora / Fambrini, Massimiliano / Noci, Ivo

    The American journal of case reports

    2018  Band 19, Seite(n) 1140–1145

    Abstract: BACKGROUND Uterine arteriovenous malformation (AVM) is an uncommon lesion characterized by an abnormal connection between arterial and venous circulation that can be congenital or acquired. Acquired uterine AVMs are generally traumatic and follow ... ...

    Abstract BACKGROUND Uterine arteriovenous malformation (AVM) is an uncommon lesion characterized by an abnormal connection between arterial and venous circulation that can be congenital or acquired. Acquired uterine AVMs are generally traumatic and follow delivery, abortion, curettage, or uterine surgery. CASE REPORT A 45-year-old female who was gravida 1 para 0 presented to our hospital with severe vaginal bleeding. Two weeks before, the patient underwent therapeutic abortion. At admission, a transvaginal ultrasound showed an unclear intrauterine lesion that spread out to the myometrium. Color Doppler evaluation demonstrated an elevated color score. Beta human chorionic gonadotropin (beta-hCG) levels were measured at admission and daily repeated, with a progressive decrease of values up to a negative level. A pelvic magnetic resonance imaging described an area of tubular and tortuous structures involving the myometrium. A computed tomography angiography confirmed the presence of a lesion infiltrating the endometrium and myometrium containing arteriovenous structures with a highly enhanced effect. Despite these findings, the patient was clinically stable. A diagnosis of uterine AVM was made and, after accurate counselling with the patient, she was discharged and underwent "watch and wait" management. After 35 days, the patient had a follow-up ultrasound that showed a complete resolution of the uterine lesion. CONCLUSIONS AVM should be considered in the presence of heavy and sudden vaginal bleeding in a patient with risk factors for acquired AVM. A color Doppler ultrasound scan should be performed as the first approach and an expectant management should be taken into account especially with a patient of childbearing age and hemodynamic instability.
    Mesh-Begriff(e) Abortion, Therapeutic/adverse effects ; Arteriovenous Malformations/diagnostic imaging ; Arteriovenous Malformations/etiology ; Arteriovenous Malformations/therapy ; Conservative Treatment ; Female ; Humans ; Middle Aged ; Pregnancy ; Remission, Spontaneous ; Ultrasonography, Doppler, Color ; Uterine Hemorrhage/diagnostic imaging ; Uterine Hemorrhage/etiology ; Uterine Hemorrhage/therapy ; Uterus/blood supply ; Uterus/diagnostic imaging ; Watchful Waiting
    Sprache Englisch
    Erscheinungsdatum 2018-09-27
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.909635
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: HPV genotype distribution and age correlation in a selected Italian population undergoing conization.

    Malentacchi, Francesca / Bussani, Cecilia / Pavone, Dora / Anderson, Karin L / Fambrini, Massimiliano / Cocco, Chiara / Fantappiè, Giulia / Pieralli, Annalisa / Dubini, Valeria / Petraglia, Felice / Sorbi, Flavia

    Minerva ginecologica

    2020  Band 72, Heft 1, Seite(n) 1–11

    Abstract: Background: Detection and genotyping of human papillomavirus (HPV) has gained increasing importance in cervical cancer prevention and treatment of cervical intraepithelial neoplasia (CIN). This study aims to determine the HPV type distribution in ... ...

    Abstract Background: Detection and genotyping of human papillomavirus (HPV) has gained increasing importance in cervical cancer prevention and treatment of cervical intraepithelial neoplasia (CIN). This study aims to determine the HPV type distribution in cervical specimens obtained from women diagnosed with CIN. We evaluated in a selected Italian population the distribution of HPV genotypes.
    Methods: Cervical samples were collected from women undergoing laser CO2 conization for high grade at Colposcopic Laser Surgery Unit of the Careggi University Hospital and at the Colposcopy Service of Local Health Unit Toscana Centro in Florence, Italy, between September 2014 and February 2017. HPV genotyping was performed using the LINEAR ARRAY® HPV Genotyping Test.
    Results: Three hundred and six patients were enrolled. HPV infection was detected on 244 samples (79.7%). A different rate of mono- and poly-infections was observed, with higher poly-infection rates in younger women. Moreover, depending on different age groups (clustered in 5-years interval from 22 to 69 years old) significant different distribution of HPV was fund as genotype, phylogenetic type and cancer-related risk.
    Conclusions: Our results suggest that some physiological conditions (i.e. menopause), could influence selection and clearance of specific HPV genotypes. The results of this study represent the basis for supporting the HPV genotyping as clinical tool providing benefits in the management of women with high CIN grade.
    Mesh-Begriff(e) Adult ; Age Factors ; Aged ; Cervical Intraepithelial Neoplasia/surgery ; Cervical Intraepithelial Neoplasia/virology ; Cervix Uteri/virology ; Conization/methods ; Cross-Sectional Studies ; Female ; Genotype ; Genotyping Techniques/methods ; Humans ; Italy ; Laser Therapy/methods ; Middle Aged ; Papillomaviridae/genetics ; Papillomaviridae/isolation & purification ; Papillomavirus Infections/epidemiology ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2020-03-10
    Erscheinungsland Italy
    Dokumenttyp Journal Article ; Multicenter Study
    ZDB-ID 80159-8
    ISSN 1827-1650 ; 0026-4784 ; 0325-8793
    ISSN (online) 1827-1650
    ISSN 0026-4784 ; 0325-8793
    DOI 10.23736/S0026-4784.20.04506-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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