Article ; Online: Closed-loop cervical epidural stimulation partially restores ipsilesional diaphragm EMG after acute C
Respiratory physiology & neurobiology
2023 Volume 320, Page(s) 104182
Abstract: Cervical spinal cord injury creates lasting respiratory deficits which can require mechanical ventilation long-term. We have shown that closed-loop epidural stimulation (CL-ES) elicits respiratory plasticity in the form of increased phrenic network ... ...
| Abstract | Cervical spinal cord injury creates lasting respiratory deficits which can require mechanical ventilation long-term. We have shown that closed-loop epidural stimulation (CL-ES) elicits respiratory plasticity in the form of increased phrenic network excitability (Malone et. al., E Neuro, Vol 9, 0426-21.2021, 2022); however, the ability of this treatment to create functional benefits for breathing function per se after injury has not been demonstrated. Here, we demonstrate in C2 hemisected anesthetized rats, a 20-minute bout of CL-ES administered at current amplitudes below the motor threshold restores paralyzed hemidiaphragm activity in-phase with breathing while potentiating contralesional activity. While this acute bout of stimulation did not elicit the increased network excitability seen in our chronic model, a subset of stimulated animals continued spontaneous ipsilesional diaphragm activity for several seconds after stopping stimulation. These results support the use of CL-ES as a therapeutic to rescue breathing after high cervical spinal cord injury, with the potential to lead to lasting recovery and device independence. |
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| MeSH term(s) | Rats ; Animals ; Diaphragm ; Rats, Sprague-Dawley ; Thorax ; Spinal Cord Injuries ; Respiration ; Phrenic Nerve ; Recovery of Function/physiology ; Cervical Cord |
| Language | English |
| Publishing date | 2023-11-01 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 2077867-3 |
| ISSN | 1878-1519 ; 1569-9048 |
| ISSN (online) | 1878-1519 |
| ISSN | 1569-9048 |
| DOI | 10.1016/j.resp.2023.104182 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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