Article ; Online: Discovery of genes required for lipoteichoic acid glycosylation predicts two distinct mechanisms for wall teichoic acid glycosylation.
The Journal of biological chemistry
2018 Volume 293, Issue 9, Page(s) 3293–3306
Abstract: The bacterial cell wall is an important and highly complex structure that is essential for bacterial growth because it protects bacteria from cell lysis and environmental insults. A typical Gram-positive bacterial cell wall is composed of peptidoglycan ... ...
Abstract | The bacterial cell wall is an important and highly complex structure that is essential for bacterial growth because it protects bacteria from cell lysis and environmental insults. A typical Gram-positive bacterial cell wall is composed of peptidoglycan and the secondary cell wall polymers, wall teichoic acid (WTA) and lipoteichoic acid (LTA). In many Gram-positive bacteria, LTA is a polyglycerol-phosphate chain that is decorated with d-alanine and sugar residues. However, the function of and proteins responsible for the glycosylation of LTA are either unknown or not well-characterized. Here, using bioinformatics, genetic, and NMR spectroscopy approaches, we found that the |
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MeSH term(s) | Bacillus subtilis/cytology ; Bacillus subtilis/metabolism ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Cell Wall/metabolism ; Conserved Sequence ; Glycosylation ; Lipopolysaccharides/metabolism ; Listeria monocytogenes/cytology ; Listeria monocytogenes/metabolism ; Teichoic Acids/metabolism |
Chemical Substances | Bacterial Proteins ; Lipopolysaccharides ; Teichoic Acids ; lipoteichoic acid (56411-57-5) |
Language | English |
Publishing date | 2018-01-17 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2997-x |
ISSN | 1083-351X ; 0021-9258 |
ISSN (online) | 1083-351X |
ISSN | 0021-9258 |
DOI | 10.1074/jbc.RA117.001614 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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