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  1. Artikel ; Online: Enhanced expression of ncc1 and clc2c in the kidney and urinary bladder accompanies freshwater acclimation in Mozambique tilapia.

    Breves, Jason P / Nelson, Nastasia N / Koltenyuk, Victor / Petro-Sakuma, Cody K / Celino-Brady, Fritzie T / Seale, Andre P

    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

    2021  Band 260, Seite(n) 111021

    Abstract: Euryhaline fishes maintain hydromineral balance in a broad range of environmental salinities via the activities of multiple osmoregulatory organs, namely the gill, gastrointestinal tract, skin, kidney, and urinary bladder. Teleosts residing in freshwater ...

    Abstract Euryhaline fishes maintain hydromineral balance in a broad range of environmental salinities via the activities of multiple osmoregulatory organs, namely the gill, gastrointestinal tract, skin, kidney, and urinary bladder. Teleosts residing in freshwater (FW) environments are faced with the diffusive loss of ions and the osmotic gain of water, and, therefore, the kidney and urinary bladder reabsorb Na
    Mesh-Begriff(e) Acclimatization/physiology ; Animals ; Fresh Water ; Gene Expression Regulation ; Gills/metabolism ; Ions ; Kidney/metabolism ; Male ; Osmoregulation ; Prolactin/metabolism ; Receptors, Prolactin/metabolism ; Salinity ; Seawater ; Solute Carrier Family 12, Member 3/metabolism ; Tilapia/physiology ; Urinary Bladder/metabolism ; Water-Electrolyte Balance/physiology
    Chemische Substanzen Ions ; Receptors, Prolactin ; Solute Carrier Family 12, Member 3 ; Prolactin (9002-62-4)
    Sprache Englisch
    Erscheinungsdatum 2021-06-24
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 121246-1
    ISSN 1531-4332 ; 0300-9629 ; 1095-6433
    ISSN (online) 1531-4332
    ISSN 0300-9629 ; 1095-6433
    DOI 10.1016/j.cbpa.2021.111021
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 44/A: Hefte anzeigen Standort:
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  2. Artikel: Enhanced expression of ncc1 and clc2c in the kidney and urinary bladder accompanies freshwater acclimation in Mozambique tilapia

    Breves, Jason P. / Nelson, Nastasia N. / Koltenyuk, Victor / Petro-Sakuma, Cody K. / Celino-Brady, Fritzie T. / Seale, Andre P.

    Comparative biochemistry and physiology. 2021 Oct., v. 260

    2021  

    Abstract: Euryhaline fishes maintain hydromineral balance in a broad range of environmental salinities via the activities of multiple osmoregulatory organs, namely the gill, gastrointestinal tract, skin, kidney, and urinary bladder. Teleosts residing in freshwater ...

    Abstract Euryhaline fishes maintain hydromineral balance in a broad range of environmental salinities via the activities of multiple osmoregulatory organs, namely the gill, gastrointestinal tract, skin, kidney, and urinary bladder. Teleosts residing in freshwater (FW) environments are faced with the diffusive loss of ions and the osmotic gain of water, and, therefore, the kidney and urinary bladder reabsorb Na⁺ and Cl⁻ to support the production of dilute urine. Nonetheless, the regulated pathways for Na⁺ and Cl⁻ transport by euryhaline fishes, especially in the urinary bladder, have not been fully resolved. Here, we first investigated the ultrastructure of epithelial cells within the urinary bladder of FW-acclimated Mozambique tilapia (Oreochromis mossambicus) by electron microscopy. We then investigated whether tilapia employ Na⁺/Cl⁻ cotransporter 1 (Ncc1) and Clc family Cl⁻ channel 2c (Clc2c) for the reabsorption of Na⁺ and Cl⁻ by the kidney and urinary bladder. We hypothesized that levels of their associated gene transcripts vary inversely with environmental salinity. In whole kidney and urinary bladder homogenates, ncc1 and clc2c mRNA levels were markedly higher in steady-state FW- versus SW (seawater)-acclimated tilapia. Following transfer from SW to FW, ncc1 and clc2c in both the kidney and urinary bladder were elevated within 48 h. A concomitant increase in branchial ncc2, and decreases in Na⁺/K⁺/2Cl⁻cotransporter 1a (nkcc1a) and cystic fibrosis transmembrane regulator 1 (cftr1) levels indicated a transition from Na⁺ and Cl⁻ secretion to absorption by the gills in parallel with the identified renal and urinary bladder responses to FW transfer. Our findings suggest that Ncc1 and Clc2c contribute to the functional plasticity of the kidney and urinary bladder in tilapia.
    Schlagwörter Oreochromis mossambicus ; absorption ; acclimation ; bladder ; cystic fibrosis ; digestive tract ; electron microscopy ; epithelium ; euryhaline species ; freshwater ; genes ; kidneys ; plasticity ; resorption ; salinity ; seawater ; secretion ; symporters ; ultrastructure ; urine
    Sprache Englisch
    Erscheinungsverlauf 2021-10
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    ZDB-ID 121246-1
    ISSN 1531-4332 ; 0300-9629 ; 1095-6433
    ISSN (online) 1531-4332
    ISSN 0300-9629 ; 1095-6433
    DOI 10.1016/j.cbpa.2021.111021
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Bonn

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  3. Artikel: Early-life exposure to 17β-estradiol and 4-nonylphenol impacts the growth hormone/insulin-like growth-factor system and estrogen receptors in Mozambique tilapia, Oreochromis mossambicus

    Celino-Brady, Fritzie T / Petro-Sakuma, Cody K / Breves, Jason P / Lerner, Darren T / Seale, Andre P

    Aquatic toxicology. 2019 Dec., v. 217

    2019  

    Abstract: It is widely recognized that endocrine disrupting chemicals (EDCs) released into the environment through anthropogenic activities can have short-term impacts on physiological and behavioral processes and/or sustained or delayed long-term developmental ... ...

    Abstract It is widely recognized that endocrine disrupting chemicals (EDCs) released into the environment through anthropogenic activities can have short-term impacts on physiological and behavioral processes and/or sustained or delayed long-term developmental effects on aquatic organisms. While numerous studies have characterized the effects of EDCs on temperate fishes, less is known on the effects of EDCs on the growth and reproductive physiology of tropical species. To determine the long-term effects of early-life exposure to common estrogenic chemicals, we exposed Mozambique tilapia (Oreochromis mossambicus) yolk-sac fry to 17β-estradiol (E2) and nonylphenol (NP) and subsequently characterized the expression of genes involved in growth and reproduction in adults. Fry were exposed to waterborne E2 (0.1 and 1 μg/L) and NP (10 and 100 μg/L) for 21 days. After the exposure period, juveniles were reared for an additional 112 days until males were sampled. Gonadosomatic index was elevated in fish exposed to E2 (0.1 μg/L) while hepatosomatic index was decreased by exposure to NP (100 μg/L). Exposure to E2 (0.1 μg/L) induced hepatic growth hormone receptor (ghr) mRNA expression. The high concentration of E2 (1 μg/L), and both concentrations of NP, increased hepatic insulin-like growth-factor 1 (igf1) expression; E2 and NP did not affect hepatic igf2 and pituitary growth hormone (gh) levels. Both E2 (1 μg/L) and NP (10 μg/L) induced hepatic igf binding protein 1b (igfbp1b) levels while only NP (100 μg/L) induced hepatic igfbp2b levels. By contrast, hepatic igfbp6b was reduced in fish exposed to E2 (1 μg/L). There were no effects of E2 or NP on hepatic igfbp4 and igfbp5a expression. Although the expression of three vitellogenin transcripts was not affected, E2 and NP stimulated hepatic estrogen receptor (erα and erβ) mRNA expression. We conclude that tilapia exposed to E2 and NP as yolk-sac fry exhibit subsequent changes in the endocrine systems that control growth and reproduction during later life stages.
    Schlagwörter Oreochromis mossambicus ; adults ; anthropogenic activities ; binding proteins ; endocrine-disrupting chemicals ; estradiol ; estrogen receptors ; exposure duration ; fish ; gene expression ; gonadosomatic index ; hepatosomatic index ; insulin-like growth factor I ; juveniles ; long term effects ; males ; messenger RNA ; nonylphenols ; rearing ; reproduction ; somatotropin ; somatotropin receptors ; vitellogenin ; yolk sac
    Sprache Englisch
    Erscheinungsverlauf 2019-12
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 782699-0
    ISSN 1879-1514 ; 0166-445X
    ISSN (online) 1879-1514
    ISSN 0166-445X
    DOI 10.1016/j.aquatox.2019.105336
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Bonn

    Z 3881: Hefte anzeigen

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  4. Artikel ; Online: Early-life exposure to 17β-estradiol and 4-nonylphenol impacts the growth hormone/insulin-like growth-factor system and estrogen receptors in Mozambique tilapia, Oreochromis mossambicus.

    Celino-Brady, Fritzie T / Petro-Sakuma, Cody K / Breves, Jason P / Lerner, Darren T / Seale, Andre P

    Aquatic toxicology (Amsterdam, Netherlands)

    2019  Band 217, Seite(n) 105336

    Abstract: It is widely recognized that endocrine disrupting chemicals (EDCs) released into the environment through anthropogenic activities can have short-term impacts on physiological and behavioral processes and/or sustained or delayed long-term developmental ... ...

    Abstract It is widely recognized that endocrine disrupting chemicals (EDCs) released into the environment through anthropogenic activities can have short-term impacts on physiological and behavioral processes and/or sustained or delayed long-term developmental effects on aquatic organisms. While numerous studies have characterized the effects of EDCs on temperate fishes, less is known on the effects of EDCs on the growth and reproductive physiology of tropical species. To determine the long-term effects of early-life exposure to common estrogenic chemicals, we exposed Mozambique tilapia (Oreochromis mossambicus) yolk-sac fry to 17β-estradiol (E2) and nonylphenol (NP) and subsequently characterized the expression of genes involved in growth and reproduction in adults. Fry were exposed to waterborne E2 (0.1 and 1 μg/L) and NP (10 and 100 μg/L) for 21 days. After the exposure period, juveniles were reared for an additional 112 days until males were sampled. Gonadosomatic index was elevated in fish exposed to E2 (0.1 μg/L) while hepatosomatic index was decreased by exposure to NP (100 μg/L). Exposure to E2 (0.1 μg/L) induced hepatic growth hormone receptor (ghr) mRNA expression. The high concentration of E2 (1 μg/L), and both concentrations of NP, increased hepatic insulin-like growth-factor 1 (igf1) expression; E2 and NP did not affect hepatic igf2 and pituitary growth hormone (gh) levels. Both E2 (1 μg/L) and NP (10 μg/L) induced hepatic igf binding protein 1b (igfbp1b) levels while only NP (100 μg/L) induced hepatic igfbp2b levels. By contrast, hepatic igfbp6b was reduced in fish exposed to E2 (1 μg/L). There were no effects of E2 or NP on hepatic igfbp4 and igfbp5a expression. Although the expression of three vitellogenin transcripts was not affected, E2 and NP stimulated hepatic estrogen receptor (erα and erβ) mRNA expression. We conclude that tilapia exposed to E2 and NP as yolk-sac fry exhibit subsequent changes in the endocrine systems that control growth and reproduction during later life stages.
    Mesh-Begriff(e) Animals ; Embryo, Nonmammalian/drug effects ; Embryo, Nonmammalian/metabolism ; Estradiol/toxicity ; Growth Hormone/metabolism ; Liver/drug effects ; Male ; Phenols/toxicity ; Receptors, Estrogen/metabolism ; Reproduction/drug effects ; Somatomedins/metabolism ; Tilapia/growth & development ; Tilapia/metabolism ; Vitellogenins/metabolism ; Water Pollutants, Chemical/toxicity
    Chemische Substanzen Phenols ; Receptors, Estrogen ; Somatomedins ; Vitellogenins ; Water Pollutants, Chemical ; Estradiol (4TI98Z838E) ; Growth Hormone (9002-72-6) ; 4-nonylphenol (I03GBV4WEL)
    Sprache Englisch
    Erscheinungsdatum 2019-10-24
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 782699-0
    ISSN 1879-1514 ; 0166-445X
    ISSN (online) 1879-1514
    ISSN 0166-445X
    DOI 10.1016/j.aquatox.2019.105336
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4376: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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