Article ; Online: Use of PET/CT to detect myocardial inflammation and the risk of malignant arrhythmia in chronic Chagas disease.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
2023 Volume 30, Issue 6, Page(s) 2702–2711
Abstract: Background: Chagas heart disease (CHD) is characterized by progressive myocardial inflammation associated with myocardial fibrosis and segmental abnormalities that may lead to malignant ventricular arrhythmia and sudden cardiac death. This arrhythmia ... ...
Abstract | Background: Chagas heart disease (CHD) is characterized by progressive myocardial inflammation associated with myocardial fibrosis and segmental abnormalities that may lead to malignant ventricular arrhythmia and sudden cardiac death. This arrhythmia might be related to the persistence of parasitemia or inflammation in the myocardium in late-stage CHD. Positron emission tomography/computed tomography (PET/CT) has been used to detect myocardial inflammation in non-ischemic cardiomyopathies, such as sarcoidosis, and might be useful for risk prediction in patients with CHD. Methods and results: Twenty-four outpatients with chronic CHD were enrolled in this prospective cross-sectional study between May 2019 and March 2022. The patients were divided into two groups: those with sustained ventricular tachycardia and/or aborted sudden cardiac death who required implantable cardioverter-defibrillators, and those with the same stages of CHD and no complex ventricular arrhythmia. Patients underwent Conclusion: 18 |
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MeSH term(s) | Humans ; Positron Emission Tomography Computed Tomography ; Fluorodeoxyglucose F18 ; Positron-Emission Tomography/methods ; Gallium Radioisotopes ; Cross-Sectional Studies ; Parasitemia ; Prospective Studies ; Myocarditis/diagnostic imaging ; Arrhythmias, Cardiac/diagnostic imaging ; Inflammation/diagnostic imaging ; Heart Diseases ; Death, Sudden, Cardiac ; Chagas Disease/complications ; Chagas Disease/diagnostic imaging |
Chemical Substances | Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Gallium Radioisotopes |
Language | English |
Publishing date | 2023-08-21 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 1212505-2 |
ISSN | 1532-6551 ; 1071-3581 |
ISSN (online) | 1532-6551 |
ISSN | 1071-3581 |
DOI | 10.1007/s12350-023-03350-z |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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