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  1. Article ; Online: Protocol to target a promoter region in human embryonic kidney cells using the CRISPR-dCas9 system for single-locus proteomics.

    Alkhayer, Reem / Ponath, Viviane / Pogge von Strandmann, Elke

    STAR protocols

    2024  Volume 5, Issue 2, Page(s) 103045

    Abstract: The unbiased identification of less-abundant transcription factors, which direct the expression of a target gene, is technically challenging. Here, we present a protocol to analyze the locus-specific chromatin-regulating proteome using in situ capture of ...

    Abstract The unbiased identification of less-abundant transcription factors, which direct the expression of a target gene, is technically challenging. Here, we present a protocol to analyze the locus-specific chromatin-regulating proteome using in situ capture of chromatin interactions by an inactive Cas9 (dCas9). We describe steps for designing guide RNAs and transfection, followed by precipitation of chromatin and associated proteins. In the last step, we describe the elution of DNA and proteins for PCR and mass spectrometric analysis, respectively. For complete details on the use and execution of this protocol, please refer to Alkhayer et al.
    Language English
    Publishing date 2024-04-30
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2024.103045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: Immunmodulatorische Effekte des Histon-Deacetylasen-Inhibitors LBH589 auf die Interaktionen von Lymphozyten und Hodgkin Lymphom-Zelllinien

    Klein, Jan Martin / Pogge von Strandmann, Elke / Schweiger, Michal-Ruth

    2020  

    Institution Universitätsklinikum Köln / Klinik I für Innere Medizin
    Author's details vorgelegt von Jan Martin Klein ; 1. Gutachterin: Professorin Dr. rer. nat. E. Pogge von Standmann, 2. Gutachterin: Universitätsprofessorin Dr. med. Dr. rer. nat. M.-R. Schweiger ; aus dem Zentrum für Innere Medizin der Universität zu Köln, Klinik und Poliklinik für Innere Medizin I, Hämatologie und Onkologie
    Subject code 610
    Language German ; English
    Size 84 Seiten, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2019
    Note Enthält Sonderabdruck aus Zeitschrift in englischer Sprache
    HBZ-ID HT020431597
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 D 307 order for loan Magazin

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  3. Book ; Thesis: The acetyltransferases CBP/p300 regulate the expression of NKG2D ligands on tumor cells

    Çetintaş, Ayşe / Pogge von Strandmann, Elke / Schweiger, Manfred

    2018  

    Institution Universitätsklinikum Köln / Klinik I für Innere Medizin
    Author's details vorgelegt von: Ayşe Çetintaş ; 1. Berichterstatterin: Professorin Dr. rer. nat. E. Pogge von Strandmann, 2. Berichterstatterin: Universitätsprofessorin Dr. med. Dr. rer. nat. M.-R. Schweiger ; aus dem Zentrum für Innere Medizin der Universität zu Köln, Klinik und Poliklinik für Innere Medizin I Hämatologie und Onkologie
    Subject code 610
    Language English
    Size 46 Blätter, Illustrationen
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2018
    Note Zusammenfassung in deutscher und englischer Sprache
    HBZ-ID HT019925848
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 D 8 order for loan Magazin

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  4. Book ; Online ; Thesis: The acetyltransferases CBP/p300 regulate the expression of NKG2D ligands on tumor cells

    Çetintaş, Ayşe / Pogge von Strandmann, Elke / Schweiger, Manfred

    2018  

    Institution Universitätsklinikum Köln / Klinik I für Innere Medizin
    Author's details vorgelegt von: Ayşe Çetintaş ; 1. Berichterstatterin: Professorin Dr. rer. nat. E. Pogge von Strandmann, 2. Berichterstatterin: Universitätsprofessorin Dr. med. Dr. rer. nat. M.-R. Schweiger ; aus dem Zentrum für Innere Medizin der Universität zu Köln, Klinik und Poliklinik für Innere Medizin I Hämatologie und Onkologie
    Subject code 610
    Language English
    Size 1 Online-Ressource (44 Seiten), Illustrationen
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2018
    Note Zusammenfassung in deutscher und englischer Sprache ; Open Access
    HBZ-ID HT019894461
    DOI 10.4126/FRL01-006411508
    Database Repository for Life Sciences

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  5. Book ; Online ; Thesis: The role of the tumor suppressor p53 in the biogenesis and function of extracellular vesicles.

    Linder, Manuel [Verfasser] / Pogge von Strandmann, Elke [Akademischer Betreuer]

    2024  

    Author's details Manuel Linder ; Betreuer: Elke Pogge von Strandmann
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Philipps-Universität Marburg
    Publishing place Marburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Book ; Online ; Thesis: Funktionelle Analyse der Ceramid Synthasen und ihre Rolle in der Immunoseneszenz

    Nordbeck, Johanna / Pogge von Strandmann, Elke / Krönke, Martin

    2013  

    Institution Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
    Author's details vorgelegt von Johanna Nordbeck ; 1. Berichterstatter: Universitätsprofessor Dr. med. M. Krönke, 2. Berichterstatterin: Frau Professor Dr. rer. nat. E. Pogge von Strandmann ; aus dem Institut für Medizinische Mikrobiologie, Immunologie und Hygiene der Universität zu Köln
    Subject code 610
    Language German
    Size 40 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 2013
    HBZ-ID HT018118219
    DOI 10.4126/38m-005447187
    Database Repository for Life Sciences

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  7. Book ; Thesis: Funktionelle Analyse der Ceramid Synthasen und ihre Rolle in der Immunoseneszenz

    Nordbeck, Johanna / Krönke, Martin / Pogge von Strandmann, Elke

    2013  

    Institution Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
    Author's details vorgelegt von Johanna Nordbeck ; 1. Berichterstatter: Universitätsprofessor Dr. med. M. Krönke, 2. Berichterstatterin: Frau Professor Dr. rer. nat. E. Pogge von Strandmann ; aus dem Institut für Medizinische Mikrobiologie, Immunologie und Hygiene der Universität zu Köln
    Subject code 610
    Language German
    Size 40 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 2013
    HBZ-ID HT018208408
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 D 164 order for loan Magazin

    Order via subito

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  8. Article: The Role of Extracellular HSP70 in the Function of Tumor-Associated Immune Cells.

    Linder, Manuel / Pogge von Strandmann, Elke

    Cancers

    2021  Volume 13, Issue 18

    Abstract: Extracellular vesicles released by tumor cells (T-EVs) are known to contain danger-associated molecular patterns (DAMPs), which are released in response to cellular stress to alert the immune system to the dangerous cell. Part of this defense mechanism ... ...

    Abstract Extracellular vesicles released by tumor cells (T-EVs) are known to contain danger-associated molecular patterns (DAMPs), which are released in response to cellular stress to alert the immune system to the dangerous cell. Part of this defense mechanism is the heat shock protein 70 (HSP70), and HSP70-positive T-EVs are known to trigger anti-tumor immune responses. Moreover, extracellular HSP70 acts as an immunogen that contributes to the cross-presentation of major histocompatibility complex (MHC) class I molecules. However, the release of DAMPs, including HSP70, may also induce chronic inflammation or suppress immune cell activity, promoting tumor growth. Here, we summarize the current knowledge on soluble, membrane-bound, and EV-associated HSP70 regarding their functions in regulating tumor-associated immune cells in the tumor microenvironment. The molecular mechanisms involved in the translocation of HSP70 to the plasma membrane of tumor cells and its release via exosomes or soluble proteins are summarized. Furthermore, perspectives for immunotherapies aimed to target HSP70 and its receptors for cancer treatment are discussed and presented.
    Language English
    Publishing date 2021-09-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13184721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online ; Thesis: Deciphering the transcription factors that regulate the NKG2D ligand MICA in cancer cells

    Al khayer, Reem [Verfasser] / Pogge von Strandmann, Elke [Akademischer Betreuer]

    2023  

    Author's details Reem Al khayer ; Betreuer: Elke Pogge von Strandmann
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Philipps-Universität Marburg
    Publishing place Marburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  10. Book ; Online ; Thesis: The role of the oncoprotein SKI in the Natural Killer cell immunosurveillance of pancreatic ductal adenocarcinoma

    Bittermann, Mathis [Verfasser] / Pogge von Strandmann, Elke [Akademischer Betreuer]

    2022  

    Author's details Mathis Bittermann ; Betreuer: Elke Pogge von Strandmann
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Philipps-Universität Marburg
    Publishing place Marburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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