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  1. Buch ; Online: Green Is the New Red

    Potter, Will

    An Insider's Account of a Social Movement Under Siege

    2011  

    Abstract: An insider tells how environmentalists and animal rights activists have become "the number one domestic terrorism ... ...

    Abstract An insider tells how environmentalists and animal rights activists have become "the number one domestic terrorism threat
    Sprache Englisch
    Umfang Online-Ressource (475 p.)
    Verlag City Lights Publishers
    Erscheinungsort New York
    Dokumenttyp Buch ; Online
    Anmerkung Description based upon print version of record
    ISBN 9780872865389 ; 087286538X
    Datenquelle Katalog der Technische Informationsbibliothek Hannover

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  2. Artikel ; Online: Large-scale sequencing of SARS-CoV-2 genomes from one region allows detailed epidemiology and enables local outbreak management.

    Page, Andrew J / Mather, Alison E / Le-Viet, Thanh / Meader, Emma J / Alikhan, Nabil-Fareed / Kay, Gemma L / de Oliveira Martins, Leonardo / Aydin, Alp / Baker, David J / Trotter, Alexander J / Rudder, Steven / Tedim, Ana P / Kolyva, Anastasia / Stanley, Rachael / Yasir, Muhammad / Diaz, Maria / Potter, Will / Stuart, Claire / Meadows, Lizzie /
    Bell, Andrew / Gutierrez, Ana Victoria / Thomson, Nicholas M / Adriaenssens, Evelien M / Swingler, Tracey / Gilroy, Rachel A J / Griffith, Luke / Sethi, Dheeraj K / Aggarwal, Dinesh / Brown, Colin S / Davidson, Rose K / Kingsley, Robert A / Bedford, Luke / Coupland, Lindsay J / Charles, Ian G / Elumogo, Ngozi / Wain, John / Prakash, Reenesh / Webber, Mark A / Smith, S J Louise / Chand, Meera / Dervisevic, Samir / O'Grady, Justin / The Covid-Genomics Uk Cog-Uk Consortium

    Microbial genomics

    2021  Band 7, Heft 6

    Abstract: The COVID-19 pandemic has spread rapidly throughout the world. In the UK, the initial peak was in April 2020; in the county of Norfolk (UK) and surrounding areas, which has a stable, low-density population, over 3200 cases were reported between March and ...

    Abstract The COVID-19 pandemic has spread rapidly throughout the world. In the UK, the initial peak was in April 2020; in the county of Norfolk (UK) and surrounding areas, which has a stable, low-density population, over 3200 cases were reported between March and August 2020. As part of the activities of the national COVID-19 Genomics Consortium (COG-UK) we undertook whole genome sequencing of the SARS-CoV-2 genomes present in positive clinical samples from the Norfolk region. These samples were collected by four major hospitals, multiple minor hospitals, care facilities and community organizations within Norfolk and surrounding areas. We combined clinical metadata with the sequencing data from regional SARS-CoV-2 genomes to understand the origins, genetic variation, transmission and expansion (spread) of the virus within the region and provide context nationally. Data were fed back into the national effort for pandemic management, whilst simultaneously being used to assist local outbreak analyses. Overall, 1565 positive samples (172 per 100 000 population) from 1376 cases were evaluated; for 140 cases between two and six samples were available providing longitudinal data. This represented 42.6 % of all positive samples identified by hospital testing in the region and encompassed those with clinical need, and health and care workers and their families. In total, 1035 cases had genome sequences of sufficient quality to provide phylogenetic lineages. These genomes belonged to 26 distinct global lineages, indicating that there were multiple separate introductions into the region. Furthermore, 100 genetically distinct UK lineages were detected demonstrating local evolution, at a rate of ~2 SNPs per month, and multiple co-occurring lineages as the pandemic progressed. Our analysis: identified a discrete sublineage associated with six care facilities; found no evidence of reinfection in longitudinal samples; ruled out a nosocomial outbreak; identified 16 lineages in key workers which were not in patients, indicating infection control measures were effective; and found the D614G spike protein mutation which is linked to increased transmissibility dominates the samples and rapidly confirmed relatedness of cases in an outbreak at a food processing facility. The large-scale genome sequencing of SARS-CoV-2-positive samples has provided valuable additional data for public health epidemiology in the Norfolk region, and will continue to help identify and untangle hidden transmission chains as the pandemic evolves.
    Mesh-Begriff(e) COVID-19/epidemiology ; COVID-19/pathology ; COVID-19/virology ; Cluster Analysis ; Disease Outbreaks ; Genetic Linkage ; Genome, Viral ; Humans ; Longitudinal Studies ; Pandemics ; Phylogeny ; Polymorphism, Single Nucleotide ; SARS-CoV-2/classification ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Spike Glycoprotein, Coronavirus/genetics ; United Kingdom/epidemiology ; Whole Genome Sequencing
    Chemische Substanzen Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2021-06-29
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.000589
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Large scale sequencing of SARS-CoV-2 genomes from one region allows detailed epidemiology and enables local outbreak management

    Page, Andrew J / Mather, Alison E / Le Viet, Thanh / Meader, Emma J / Alikhan, Nabil-Fareed J / Kay, Gemma L / de Oliveira Martins, Leonardo / Aydin, Alp / Baker, David J / Trotter, Alexander J. / Rudder, Steven / Tedim, Ana P / Kolyva, Anastasia / Stanley, Rachael / Diaz, Maria / Potter, Will / Stuart, Claire / Meadows, Lizzie / Bell, Andrew /
    Gutierrez, Ana Victoria / Thomson, Nicholas M / Adriaenssens, Evelien M / Swingler, Tracey / Gilroy, Rachel AJ / Griffith, Luke / Sethi, Dheeraj K / Davidson, Rose K / Kingsley, Robert A / Bedford, Luke / Coupland, Lindsay J / Charles, Ian G / Elumogo, Ngozi / Wain, John / Prakash, Reenesh / Webber, Mark A / Smith, SJ Louise / Chand, Meera / Dervisevic, Samir / O'Grady, Justin / The COVID-19 Genomics UK (COG-UK) consortium

    medRxiv

    Abstract: The COVID-19 pandemic has spread rapidly throughout the world. In the UK, the initial peak was in April 2020; in the county of Norfolk (UK) and surrounding areas, which has a stable, low-density population, over 3,200 cases were reported between March ... ...

    Abstract The COVID-19 pandemic has spread rapidly throughout the world. In the UK, the initial peak was in April 2020; in the county of Norfolk (UK) and surrounding areas, which has a stable, low-density population, over 3,200 cases were reported between March and August 2020. As part of the activities of the national COVID-19 Genomics Consortium (COG-UK) we undertook whole genome sequencing of the SARS-CoV-2 genomes present in positive clinical samples from the Norfolk region. These samples were collected by four major hospitals, multiple minor hospitals, care facilities and community organisations within Norfolk and surrounding areas. We combined clinical metadata with the sequencing data from regional SARS-CoV-2 genomes to understand the origins, genetic variation, transmission and expansion (spread) of the virus within the region and provide context nationally. Data were fed back into the national effort for pandemic management, whilst simultaneously being used to assist local outbreak analyses. Overall, 1,565 positive samples (172 per 100,000 population) from 1,376 cases were evaluated; for 140 cases between two and six samples were available providing longitudinal data. This represented 42.6% of all positive samples identified by hospital testing in the region and encompassed those with clinical need, and health and care workers and their families. 1,035 cases had genome sequences of sufficient quality to provide phylogenetic lineages. These genomes belonged to 26 distinct global lineages, indicating that there were multiple separate introductions into the region. Furthermore, 100 genetically-distinct UK lineages were detected demonstrating local evolution, at a rate of ~2 SNPs per month, and multiple co-occurring lineages as the pandemic progressed. Our analysis: identified a sublineage associated with 6 care facilities; found no evidence of reinfection in longitudinal samples; ruled out a nosocomial outbreak; identified 16 lineages in key workers which were not in patients indicating infection control measures were effective; found the D614G spike protein mutation which is linked to increased transmissibility dominates the samples and rapidly confirmed relatedness of cases in an outbreak at a food processing facility. The large-scale genome sequencing of SARS-CoV-2-positive samples has provided valuable additional data for public health epidemiology in the Norfolk region, and will continue to help identify and untangle hidden transmission chains as the pandemic evolves.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-09-30
    Verlag Cold Spring Harbor Laboratory Press
    Dokumenttyp Artikel ; Online
    DOI 10.1101/2020.09.28.20201475
    Datenquelle COVID19

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  4. Buch: Daily Dialogues

    Carr, Herbert Montcalm / Potter, Will

    colloquial English as spoken by the educated classes in England

    1947  

    Verfasserangabe by Herbert Montcalm Carr and Will Dadley-Potter
    Sprache Englisch
    Umfang VIII, 184 S, 8°
    Ausgabenhinweis 10. ed.
    Verlag D.E.F.-Verl
    Erscheinungsort Duisburg
    Dokumenttyp Buch
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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  5. Buch: Daily Dialogues

    Carr, Herbert Montcalm / Potter, Will

    colloquial English as spoken by the educated classes in England

    1947  

    Verfasserangabe by Herbert Montcalm Carr and Will Dadley-Potter
    Sprache Englisch
    Umfang VIII, 184 S, 8°
    Ausgabenhinweis 10. ed.
    Verlag D.E.F.-Verl
    Erscheinungsort Duisburg
    Dokumenttyp Buch
    Datenquelle Katalog der Technische Informationsbibliothek Hannover

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  6. Buch: Daily Dialogues

    Carr, Herbert Montcalm / Dadley-Potter, Will / Potter, Will Dadley-

    Conversational "King's English"

    1949  

    Verfasserangabe Herbert Montcalm Carr; Will Dadley-Potter
    Umfang 186 S, 8
    Ausgabenhinweis 11. Ed
    Verlag D.E.F.-Verl
    Erscheinungsort Duisburg
    Dokumenttyp Buch
    Datenquelle Katalog der Technische Informationsbibliothek Hannover

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  7. Buch: Daily Dialogues

    Carr, H. M / Potter, Will

    1938  

    Verfasserangabe H. M. Carr ; Will Potter
    Sprache Englisch
    Umfang 241 S
    Verlag Elwert
    Erscheinungsort Marburg
    Dokumenttyp Buch
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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  8. Artikel ; Online: Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

    Volz, Erik / Hill, Verity / McCrone, John T. / Price, Anna / Jorgensen, David / O’Toole, Áine / Southgate, Joel / Johnson, Robert / Jackson, Ben / Nascimento, Fabricia F. / Rey, Sara M. / Nicholls, Samuel M. / Colquhoun, Rachel M. / da Silva Filipe, Ana / Shepherd, James / Pascall, David J. / Shah, Rajiv / Jesudason, Natasha / Li, Kathy /
    Jarrett, Ruth / Pacchiarini, Nicole / Bull, Matthew / Geidelberg, Lily / Siveroni, Igor / Goodfellow, Ian / Loman, Nicholas J. / Pybus, Oliver G. / Robertson, Dave / Thomson, Emma C. / Rambaut, Andrew / Connor, Thomas R. / Koshy, Cherian / Wise, Emma / Cortes, Nick / Lynch, Jessica / Kidd, Stephen / Mori, Matilde / Fairley, Derek J. / Curran, Tanya / McKenna, James P. / Adams, Helen / Fraser, Christophe / Golubchik, Tanya / Bonsall, David / Moore, Catrin / Caddy, Sarah L. / Khokhar, Fahad A. / Wantoch, Michelle / Reynolds, Nicola / Warne, Ben / Maksimovic, Joshua / Spellman, Karla / McCluggage, Kathryn / John, Michaela / Beér, Robert / Afifi, Safiah / Morgan, Siân / Marchbank, Angela / Kitchen, C. / Gulliver, Huw / Merrick, Ian / Guest, Martyn / Munn, Robert / Workman, Trudy / Fuller, William / Bresner, Catherine / Snell, Luke B. / Charalampous, Themoula / Nebbia, Gaia / Batra, Rahul / Edgeworth, Jonathan / Robson, Samuel C. / Beckett, Angela / Loveson, Katie F. / Aanensen, David M. / Underwood, Anthony P. / Yeats, Corin A. / Abudahab, Khalil / Taylor, Ben E.W. / Menegazzo, Mirko / Clark, Gemma / Smith, Wendy / Khakh, Manjinder / Fleming, Vicki M. / Lister, Michelle M. / Howson-Wells, Hannah C. / Berry, Louise / Boswell, Tim / Joseph, Amelia / Willingham, Iona / Bird, Paul / Helmer, Thomas / Fallon, Karlie / Holmes, Christopher / Tang, Julian / Raviprakash, Veena / Campbell, Sharon / Sheriff, Nicola / Loose, Matthew W. / Holmes, Nadine / Moore, Christopher / Carlile, Matthew / Wright, Victoria / Sang, Fei / Debebe, Johnny / Coll, Francesc / Signell, Adrian W. / Betancor, Gilberto / Wilson, Harry D. / Feltwell, Theresa / Houldcroft, Charlotte J. / Eldirdiri, Sahar / Kenyon, Anita / Davis, Thomas / Pybus, Oliver / Du Plessis, L. / Zarebski, Alex / Raghwani, Jayna / Kraemer, Moritz / Francois, Sarah / Attwood, Stephen / Vasylyeva, Tetyana / Török, Estée / Hamilton, William L. / Goodfellow, Ian G. / Hall, Grant / Jahun, Aminu S. / Chaudhry, Yasmin / Hosmillo, Myra / Pinckert, Malte L. / Georgana, Iliana / Yakovleva, Anna / Meredith, Luke W. / Moses, S. / Lowe, Hannah / Ryan, Felicity / Fisher, Chloe L. / Awan, Ali R. / Boyes, John / Breuer, Judith / Harris, Kathryn Ann / Brown, Julianne Rose / Shah, Divya / Atkinson, Laura / Lee, Jack C.D. / Alcolea-Medina, Adela / Moore, Nathan / Cortes, Nicholas / Williams, Rebecca / Chapman, Michael R. / Levett, Lisa J. / Heaney, Judith / Smith, Darren L. / Bashton, Matthew / Young, Gregory R. / Allan, John / Loh, Joshua / Randell, Paul A. / Cox, Ali / Madona, Pinglawathee / Holmes, Alison / Bolt, Frances / Price, James / Mookerjee, Siddharth / Rowan, Aileen / Taylor, Graham P. / Ragonnet-Cronin, Manon / Johnson, Rob / Boyd, Olivia / Volz, Erik M. / Brunker, Kirstyn / Smollett, Katherine L. / Quick, Joshua / McMurray, Claire / Stockton, Joanne / Nicholls, Sam / Rowe, William / Poplawski, Radoslaw / Martinez-Nunez, Rocio T. / Mason, Jenifer / Robinson, Trevor I. / O'Toole, Elaine / Watts, Joanne / Breen, Cassie / Cowell, Angela / Ludden, Catherine / Sluga, Graciela / Machin, Nicholas W. / Ahmad, Shazaad S.Y. / George, Ryan P. / Halstead, Fenella / Sivaprakasam, Venkat / Shepherd, James G. / Asamaphan, Patawee / Niebel, Marc O. / Li, Kathy K. / Shah, Rajiv N. / Jesudason, Natasha G. / Parr, Yasmin A. / Tong, Lily / Broos, Alice / Mair, Daniel / Nichols, Jenna / Carmichael, Stephen N. / Nomikou, Kyriaki / Aranday-Cortes, Elihu / Johnson, NaTasha / Starinskij, Igor / Orton, Richard J. / Hughes, Joseph / Vattipally, Sreenu / Singer, Joshua B. / Hale, Antony D. / Macfarlane-Smith, Louissa R. / Harper, Katherine L. / Taha, Yusri / Payne, Brendan A.I. / Burton-Fanning, Shirelle / Waugh, Sheila / Collins, Jennifer / Eltringham, Gary / Templeton, Kate E. / McHugh, Martin P. / Dewar, Rebecca / Wastenge, Elizabeth / Dervisevic, Samir / Stanley, Rachael / Prakash, Reenesh / Stuart, Claire / Elumogo, Ngozi / Sethi, Dheeraj K. / Meader, Emma J. / Coupland, Lindsay J. / Potter, Will / Graham, Clive / Barton, Edward / Padgett, Debra / Scott, Garren / Swindells, Emma / Greenaway, Jane / Nelson, Andrew / Yew, Wen C. / Resende Silva, Paola C. / Andersson, Monique / Shaw, Robert / Peto, Timothy / Justice, Anita / Eyre, David / Crooke, Derrick / Hoosdally, Sarah / Sloan, Tim J. / Duckworth, Nichola / Walsh, Sarah / Chauhan, Anoop J. / Glaysher, Sharon / Bicknell, Kelly / Wyllie, Sarah / Butcher, Ethan / Elliott, Scott / Lloyd, Allyson / Impey, Robert / Levene, Nick / Monaghan, Lynn / Bradley, Declan T. / Allara, Elias / Pearson, Clare / Muir, Peter / Vipond, Ian B. / Hopes, Richard / Pymont, Hannah M. / Hutchings, Stephanie / Curran, Martin D. / Parmar, Surendra / Lackenby, Angie / Mbisa, Tamyo / Platt, Steven / Miah, Shâhjahân / Bibby, David / Manso, Carmen / Hubb, Jonathan / Chand, Meera / Dabrera, Gavin / Ramsay, Mary / Bradshaw, Daniel / Thornton, Alicia / Myers, Richard / Schaefer, Ulf / Groves, Natalie / Gallagher, Eileen / Lee, David / Williams, David / Ellaby, Nicholas / Harrison, Ian / Hartman, Hassan / Manesis, Nikos / Patel, Vineet / Bishop, Chloe / Chalker, Vicki / Osman, Husam / Bosworth, Andrew / Robinson, Esther / Holden, Matthew T.G. / Shaaban, Sharif / Birchley, Alec / Adams, Alexander / Davies, Alisha / Gaskin, Amy / Plimmer, Amy / Gatica-Wilcox, Bree / McKerr, Caoimhe / Moore, Catherine / Williams, Chris / Heyburn, David / De Lacy, Elen / Hilvers, Ember / Downing, Fatima / Shankar, Giri / Jones, Hannah / Asad, Hibo / Coombes, Jason / Watkins, Joanne / Evans, Johnathan M. / Fina, Laia / Gifford, Laura / Gilbert, Lauren / Graham, Lee / Perry, Malorie / Morgan, Mari / Cronin, Michelle / Craine, Noel / Jones, Rachel / Howe, Robin / Corden, Sally / Rey, Sara / Kumziene-Summerhayes, Sara / Taylor, Sarah / Cottrell, Simon / Jones, Sophie / Edwards, Sue / O’Grady, Justin / Page, Andrew J. / Wain, John / Webber, Mark A. / Mather, Alison E. / Baker, David J. / Rudder, Steven / Yāsir, Muḥammad / Thomson, Nicholas M. / Aydin, Alp / Tedim, Ana P. / Kay, Gemma L. / Trotter, Alexander J. / Gilroy, Rachel A.J. / Alikhan, Nabil-Fareed / de Oliveira Martins, Leonardo / Le-Viet, Thanh / Meadows, Lizzie / Kolyva, Anastasia / Diaz, Maria / Bell, Andrew / Gutierrez, Ana Victoria / Charles, Ian G. / Adriaenssens, Evelien M. / Kingsley, Robert A. / Casey, Anna / Simpson, D. A. / Molnár, Zoltán / Thompson, Thomas / Acheson, Erwan / Masoli, Jane A.H. / Knight, Bridget A. / Hattersley, Andrew / Ellard, Sian / Auckland, Cressida / Mahungu, Tabitha W. / Irish-Tavares, Dianne / Haque, Tanzina / Bourgeois, Yann / Scarlett, Garry P. / Partridge, David G. / Raza, Mohammad / Evans, Cariad / Johnson, Kate / Liggett, Steven / Baker, Paul / Essex, Sarah / Lyons, Ronan A. / Caller, Laura G. / Castellano, Sergi / Williams, Rachel J. / Kristiansen, Mark / Roy, Sunando / Williams, Charlotte A. / Dyal, Patricia L. / Tutill, Helena J. / Panchbhaya, Yasmin N. / Forrest, Leysa M. / Niola, Paola / Findlay, Jacqueline / Brooks, Tony T. / Gavriil, Artemis / Mestek-Boukhibar, Lamia / Weeks, Sam / Pandey, Sarojini / Berry, Lisa / Jones, K. E. / Richter, Alex / Beggs, Andrew / Smith, Colin P. / Bucca, Giselda / Hesketh, Andrew R. / Harrison, Ewan M. / Peacock, Sharon J. / Eser, Sophie / Churcher, Carol M. / Bellis, Katherine L. / Girgis, Sophia T. / Naydenova, Plamena / Blane, Beth / Sridhar, Sushmita / Ruis, Chris / Forrest, Sally / Cormie, Claire / Gill, Harmeet K. / Dias, Joana / Higginson, Ellen E. / Maes, Mailis / Young, Jamie / Kermack, Leanne M. / Hadjirin, Nazreen F. / Aggarwal, Dinesh / Griffith, Luke / Swingler, Tracey / Davidson, Rose K. / Williams, Thomas / Balcazar, Carlos E. / Gallagher, Michael D. / O'Toole, Áine / Rooke, Stefan / Colquhoun, Rachel / Ashworth, Jordan / McCrone, J.T. / Scher, Emily / Yu, Xiaoyu / Williamson, Kathleen A. / Stanton, Thomas D. / Michell, Stephen L. / Bewshea, Claire M. / Temperton, Ben / Michelsen, Michelle L. / Warwick-Dugdale, Joanna / Manley, Robin / Farbos, Audrey / Harrison, James W. / Sambles, Christine M. / Studholme, David J. / Jeffries, Aaron R. / Darby, Alistair C. / Hiscox, Julian A. / Paterson, Steve / Iturriza-Gomara, Miren / Jackson, Kathryn A. / Lucaci, Anita O. / Vamos, Edith E. / Hughes, Margaret / Rainbow, Lucille / Eccles, Richard / Nelson, Charlotte / Whitehead, Mark / Turtle, Lance / Haldenby, Sam T. / Gregory, Richard / Gemmell, Matthew / Kwiatkowski, Dominic / de Silva, Thushan I. / Smith, Nikki / Angyal, Adrienn / Lindsey, Benjamin B. / Groves, Danielle C. / Green, Luke R. / Wang, Dennis / Freeman, Timothy M. / Parker, Matthew D. / Keeley, Alexander J. / Parsons, Paul J. / Tucker, Rachel M. / Brown, Rebecca / Wyles, Matthew / Constantinidou, Chrystala / Unnikrishnan, Meera / Ott, Sascha / Cheng, Jeffrey K.J. / Bridgewater, Hannah E. / Frost, Lucy R. / Taylor-Joyce, Grace / Stark, Richard / Baxter, Laura / Alam, Mohammad T. / Brown, Paul E. / McClure, Patrick C. / Chappell, Joseph G. / Tsoleridis, Theocharis / Ball, Jonathan / Gramatopoulos, Dimitris / Buck, David / Todd, John A. / Green, Angie / Trebes, Amy / MacIntyre-Cockett, George / de Cesare, Mariateresa / Langford, Cordelia / Alderton, Alex / Amato, Roberto / Goncalves, Sonia / Jackson, David K. / Johnston, Ian / Sillitoe, John / Palmer, Steve / Lawniczak, Mara / Berriman, Matt / Danesh, John / Livett, Rich / Shirley, Lesley / Farr, Ben / Quail, Mike / Thurston, Scott / Park, Naomi / Betteridge, Emma / Weldon, Danni / Goodwin, Scott / Nelson, Rachel / Beaver, Charlotte / Letchford, Laura / Jackson, David A. / Foulser, Luke / McMinn, Liz / Prestwood, Liam / Kay, Sally / Kane, Leanne / Dorman, Matthew J. / Martincorena, Inigo / Puethe, Christoph / Keatley, Jon-Paul / Tonkin-Hill, Gerry / Smith, Christen / Jamrozy, Dorota / Beale, Mathew A. / Patel, Minal / Ariani, Cristina / Spencer-Chapman, Michael / Drury, Eleanor / Lo, Stephanie / Rajatileka, Shavanthi / Scott, Carol / James, Keith / Buddenborg, Sarah K. / Berger, Duncan J. / Patel, Gaurang / Garcia-Casado, Maria V. / Dibling, Thomas / McGuigan, Samantha / Rogers, Hazel A. / Hunter, Adam D. / Souster, Emily / Neaverson, Alexandra S.

    Cell. 2021 Jan. 07, v. 184, no. 1 p.64-75.e11

    2021  

    Abstract: Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the ... ...

    Körperschaft COG-UK Consortium
    Abstract Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant.
    Schlagwörter COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; data collection ; founder effect ; genetic analysis ; genome ; mortality ; mutation ; pathogenicity ; phylogeny ; viral load ; United Kingdom ; COVID-19 ; SARS-CoV-2 ; evolution ; epidemiology ; spike
    Sprache Englisch
    Erscheinungsverlauf 2021-0107
    Umfang p. 64-75.e11.
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel ; Online
    Anmerkung NAL-AP-2-clean
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2020.11.020
    Datenquelle NAL Katalog (AGRICOLA)

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  9. Artikel ; Online: Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

    E., Alm / E. K., Broberg / T., Connor / E. B., Hodcroft / A. B., Komissarov / S., Maurer-Stroh / A., Melidou / R. A., Neher / A., O'Toole / Niko Beerenwinkel, Pereyaslov D. / Posada-Céspedes, Susana / Philipp Jablonski, Kim / Falé Ferreira, Pedro / Topolsky, Ivan / Avšič-Županc, Tatjana / Korva, Miša / Poljak, Mario / Zakotnik, Samo / Mark Zorec, Tomaž /
    Bragstad, Karoline / Hungnes, Olav / Stene-Johansen, Kathrine / Reusken, Chantal / Meijer, Adam / Vennema, Harry / Ruiz-Roldán, Lidia / Alma Bracho, María / García-González, Neris / Chiner-Oms, Álvaro / Cancino-Muñoz, Irving / Comas, Iñaki / A Goig, Galo / Torres-Puente, Manuela / G López, Mariana / Martínez-Priego, Llúcia / D'Auria, Giuseppe / Ferrús-Abad, Loreto / de Marco, Griselda / Galan-Vendrell, Inmaculada / Carbó-Ramirez, Sandra / Ruíz-Hueso, Paula / Coscollá, Mireia / Polackova, Katerina / Kramna, Lenka / Cinek, Ondrej / Richter, Jan / Krashias, George / Tryfonos, Christina / Bashiardes, Stavros / Koptides, Dana / Christodoulou, Christina / Bartolini, Barbara / Em Gruber, Cesare / Di Caro, Antonino / Castilletti, Concetta / Stefani, Fabrizio / Giordana Rimoldi, Sara / Romeri, Francesca / Salerno, Franco / Polesello, Stefano / Nagy, Alexander / Jirincova, Helena / Vecerova, Jaromira / Novakova, Ludmila / Cordey, Samuel / Murtskhvaladze, Marine / Kotaria, Nato / Schär, Tobias / Beisel, Christian / Vugrek, Oliver / Rokić, Filip / Trgovec-Greif, Lovro / Jurak, Igor / Rukavina, Tomislav / Sučić, Neven / Schønning, Kristian / M Karst, Søren / H Kirkegaard, Rasmus / Y Michaelsen, Thomas / Aa Sørensen, Emil / Knutson, Simon / Brandt, Jakob / Le-Quy, Vang / Sørensen, Trine / Petersen, Celine / Schou Pedersen, Martin / Løkkegaard Larsen, Sanne / Nielsine Skov, Marianne / Rasmussen, Morten / Fonager, Jannik / Fomsgaard, Anders / Amirovich Maksyutov, Rinat / Vasil'Evna Gavrilova, Elena / Victorovich Pyankov, Oleg / Alexandrovich Bodnev, Sergey / Vladimirovna Tregubchak, Tatyana / Nikolayevich Shvalov, Alexander / Victorovich Antonets, Denis / Cristina Resende, Paola / Goya, Stephanie / Perrin, Amandine / Tc Lee, Raphael / Yadahalli, Shilpa / X Han, Alvin / A Russell, Colin / Schmutz, Stefan / Zaheri, Maryam / Kufner, Verena / Huber, Michael / Trkola, Alexandra / Antwerpen, Markus / C Walter, Mathias / van der Werf, Sylvie / Gambaro, Fabiana / Behillil, Sylvie / Enouf, Vincent / Donati, Flora / Ustinova, Monta / Rovite, Vita / Klovins, Janis / Savicka, Oksana / K Wienecke-Baldacchino, Anke / Ragimbeau, Catherine / Fournier, Guillaume / Mossong, Joël / W Aberle, Stephan / Haukland, Mattias / Enkirch, Theresa / Advani, Abdolreza / Lind Karlberg, Maria / Karlsson Lindsjö, Oskar / Broddesson, Sandra / Sláviková, Monika / Ličková, Martina / Klempa, Boris / Staroňová, Edita / Tichá, Elena / Szemes, Tomáš / Rusňáková, Diana / Stadler, Tanja / Quer, Josep / Anton, Andres / Andres, Cristina / Piñana, Maria / Garcia-Cehic, Damir / Pumarola, Tomas / Izopet, Jacques / Gioula, Georgia / Exindari, Maria / Papa, Anna / Chatzidimitriou, Dimitrios / Metallidis, Symeon / Pappa, Stella / Macek Jr, Milan / Geryk, Jan / Brož, Petr / Briksí, Aleš / Hubáček, Petr / Dřevínek, Pavel / Zajac, Miroslav / Kvapil, Petr / Holub, Michal / Kvapilová, Kateřina / Novotný, Adam / Kašný, Martin / Klempt, Petr / Vapalahti, Olli / Smura, Teemu / Sironen, Tarja / Selhorst, Philippe / Anthony, Colin / Ariën, Kevin / Simon-Loriere, Etienne / Rabalski, Lukasz / Bienkowska-Szewczyk, Krystyna / Borges, Vítor / Isidro, Joana / Paulo Gomes, João / Guiomar, Raquel / Pechirra, Pedro / Costa, Inês / Duarte, Sílvia / Vieira, Luís / Pyrc, Krzysztof / S Zuckerman, Neta / Turdikulova, Shahlo / Abdullaev, Alisher / Dalimova, Dilbar / Abdurakhimov, Abror / Tagliabracci, Adriano / Alessandrini, Federica / Melchionda, Filomena / Onofri, Valerio / Turchi, Chiara / Bagnarelli, Patrizia / Menzo, Stefano / Caucci, Sara / Di Sante, Laura / Popa, Alexandra / Genger, Jakob-Wendelin / Agerer, Benedikt / Lercher, Alexander / Endler, Lukas / Smyth, Mark / Penz, Thomas / Schuster, Michael / Senekowitsch, Martin / Laine, Jan / Bock, Christoph / Bergthaler, Andreas / Shevtsov, Alexandr / Kalendar, Ruslan / Ramanculov, Yerlan / Graf, Alexander / Muenchhoff, Maximilian / T Keppler, Oliver / Krebs, Stefan / Blum, Helmut / Marcello, Alessandro / Licastro, Danilo / D'Agaro, Pierlanfranco / Laubscher, Florian / Vidanovic, Dejan / Tesovic, Bojana / Volkening, Jeremy / Clementi, Nicola / Mancini, Nicasio / Rupnik, Maja / Mahnic, Aleksander / Walker, Andreas / Houwaart, Torsten / Wienemann, Tobias / Kohns Vasconcelos, Malte / Strelow, Daniel / Ole Jensen, Björn-Erik / Senff, Tina / Hülse, Lisanna / Adams, Ortwin / Andree, Marcel / Hauka, Sandra / Feldt, Torsten / Keitel, Verena / Kindgen-Milles, Detlef / Timm, Jörg / Pfeffer, Klaus / T Dilthey, Alexander / Moore, Catherine / Ozdarendeli, Aykut / Terkis Islam Pavel, Shaikh / Yetiskin, Hazel / Aydin, Gunsu / Holyavkin, Can / Ali Uygut, Muhammet / Cevik, Ceren / Shchetinin, Alexey / Gushchin, Vladimir / Dinler-Doganay, Gizem / Doganay, Levent / Kizilboga-Akgun, Tugba / Karacan, Ilker / Pancer, Katarzyna / Maes, Piet / Martí-Carreras, Joan / Wawina-Bokalanga, Tony / Vanmechelen, Bert / Thürmer, Andrea / Wedde, Marianne / Dürrwald, Ralf / Von Kleist, Max / Drechsel, Oliver / Wolff, Thorsten / Fuchs, Stephan / Kmiecinski, Rene / Michel, Janine / Nitsche, Andreas / Casas, Inmaculada / Iglesias Caballero, María / Zaballos, Ángel / Jiménez, Pilar / Jiménez, Mercedes / Monzón Fernández, Sara / Varona Fernández, Sarai / Cuesta De La Plaza, Isabel / Fadeev, Artem / Ivanova, Anna / Sergeeva, Mariia / Stefanelli, Paola / Estee Torok, M / Hall, Grant / da Silva Filipe, Ana / Turtle, Lance / Afifi, Safiah / Mccluggage, Kathryn / Beer, Robert / Ledesma, Juan / Maksimovic, Joshua / Spellman, Karla / L Hamilton, William / Marchbank, Angela / Alexander Southgate, Joel / Underwood, Anthony / Taylor, Ben / Yeats, Corin / Abudahab, Khalil / R Gemmell, Matthew / Eccles, Richard / Lucaci, Anita / Abigail Nelson, Charlotte / Rainbow, Lucille / Whitehead, Mark / Gregory, Richard / Haldenby, Sam / Paterson, Steve / A Hughes, Margaret / D Curran, Martin / Baker, David / Tucker, Rachel / R Green, Luke / Feltwell, Theresa / D Halstead, Fenella / Wyles, Matthew / S Jahun, Aminu / Y Ahmad, Shazaad S / Georgana, Iliana / Goodfellow, Ian / Yakovleva, Anna / W Meredith, Luke / Gavriil, Artemis / Raza Awan, Ali / Fisher, Chloe / Edgeworth, Jonathan / Lynch, Jessica / Moore, Nathan / Williams, Rebecca / P Kidd, Stephen / Cortes, Nicholas / Brunker, Kirstyn / T Mccrone, John / Quick, Joshua / Duckworth, Nichola / Walsh, Sarah / Sloan, Tim / Ludden, Catherine / P George, Ryan / Eltringham, Gary / R Brown, Julianne / Aranday-Cortes, Elihu / G Shepherd, James / Hughes, Joseph / K Li, Kathy / C Williams, Thomas / Johnson, Natasha / Jesudason, Natasha / Mair, Daniel / Thomson, Emma / Shah, Rajiv / A Parr, Yasmin / Carmichael, Stephen / L Robertson, David / Nomikou, Kyriaki / Broos, Alice / Niebel, Marc / Smollett, Katherine / Tong, Lily / Miah, Shahjahan / Wittner, Anita / Phillips, Nicole / Payne, Brendan / Dewar, Rebecca / Holmes, Alison / Bolt, Frances / R Price, James / Mookerjee, Siddharth / K Sethi, Dheeraj / Potter, Will / Stanley, Rachael / Prakash, Reenesh / Dervisevic, Samir / Clive Graham, Jonathan / Nelson, Andrew / Smith, Darren / R Young, Gregory / Chyin Yew, Wen / A Todd, John / Trebes, Amy / Andersson, Monique / Bull, Matthew / Watkins, Joanne / Birchley, Alec / Gatica-Wilcox, Bree / Gilbert, Lauren / Kumžiene-Summerhayes, Sara / Rey, Sara / Chauhan, Anoop / Butcher, Ethan / Bicknell, Kelly / Elliott, Scott / Glaysher, Sharon / Lackenby, Angie / Bibby, David / Platt, Steven / Mohamed, Hodan / William Machin, Nicholas / Lutamyo Mbisa, Jean / Evans, Jonathan / Perry, Malorie / Pacchiarini, Nicole / Corden, Sally / Geraint Adams, Alexander / Gaskin, Amy / Coombs, Jason / John Graham, Lee / Cottrell, Simon / Morgan, Mari / Gifford, Laura / Kolyva, Anastasia / John Rudder, Steven / J Trotter, Alexander / E Mather, Alison / Aydin, Alp / J Page, Andrew / L Kay, Gemma / de Oliveira Martins, Leonardo / Yasir, Muhammad / Alikhan, Nabil-Fareed / M Thomson, Nicholas / Gilroy, Rachel / A Kingsley, Robert / O'Grady, Justin / Victoria Gutierrez, Ana / Diaz, Maria / Le Viet, Thanh / P Tedim, Ana / M Adriaenssens, Evelien / Patrick Mcclure, C / Moore, Christopher / Sang, Fei / Clark, Gemma / C Howson-Wells, Hannah / Debebe, Johnny / Ball, Jonathan / Chappell, Joseph / Khakh, Manjinder / Carlile, Matthew / Loose, Matthew / M Lister, Michelle / Holmes, Nadine / Tsoleridis, Theocharis / M Fleming, Vicki / Wright, Victoria / Smith, Wendy / D Gallagher, Michael / Parker, Matthew / G Partridge, David / Evans, Cariad / Baker, Paul / Essex, Sarah / Liggett, Steven / J Keeley, Alexander / Bashton, Matthew / Rooke, Stefan / Jane Meader, Emma / Enrique Balcazar Lopez, Carlos / Angyal, Adrienn / Kristiansen, Mark / J Tutill, Helena / Findlay, Jacqueline / Mestek-Boukhibar, Lamia / Forrest, Leysa / Dyal, Patricia / J Williams, Rachel / Panchbhaya, Yasmin / A Williams, Charlotte / Roy, Sunando / Pandey, Sarojini / Stockton, Jo / J Loman, Nicholas / Poplawski, Radoslaw / Nicholls, Samuel / M Rowe, W P / Khokhar, Fahad / Lars Pinckert, Malte / Hosmillo, Myra / Chaudhry, Yasmin / G Caller, Laura / K Davidson, Rose / Griffith, Luke / Rambaut, Andrew / Jackson, Ben / Colquhoun, Rachel / Hill, Verity / Nichols, Jenna / Asamaphan, Patawee / Darby, Alistair / A Jackson, Kathryn / Iturriza-Gomara, Miren / Edith Vamos, Ecaterina / Green, Angie / Aanensen, David / Bonsall, David / Buck, David / Macintyre-Cockett, George / de Cesare, Mariateresa / Pybus, Oliver / Golubchik, Tanya / Scarlett, Garry / F Loveson, Katie / C Robson, Samuel / Beckett, Angela / Lindsey, Benjamin / C Groves, Danielle / J Parsons, Paul / P Mchugh, Martin / Daniel Barnes, James / F Manso, Carmen / Grammatopoulos, Dimitris / Elisabeth Menger, Katja / Harrison, Ewan / Gunson, Rory / J Peacock, Sharon / Gonzalez, Gabriel / Carr, Michael / Mihaela, Lazar / Popovici, Odette / Brytting, Mia / Bresner, Catherine / Fuller, William / Workman, Trudy / F Mentis, Andreas / Kossyvakis, Athanasios / Karamitros, Timokratis / Pogka, Vasiliki / Kalliaropoulos, Antonios / Horefti, Elina / Kontou, Aspasia / Martinez-Gonzalez, Beatriz / Labropoulou, Voula / Voulgari-Kokota, Androniki / Evangelidou, Maria / Bizta, Panagiota / Belimezi, Maria / Lambrechts, Laurens / Z Doymaz, Mehmet / Kalkan Yazici, Merve / S Cetin, Nesibe / Karaaslan, Elif / Kallio-Kokko, Hannimari / Virtanen, Jenni / Suvanto, Maija / Truong Nguyen, Phuoc / Ellonen, Pekka / Hannula, Sari / Kangas, Harri / B Sreenu, Vattipally / Burián, Katalin / Terhes, Gabriella / Gombos, Katalin / Gyenesei, Attila / Urbán, Péter / Herczeg, Róbert / Jakab, Ferenc / Kemenesi, Gábor / Endre Tóth, Gábor / Somogyi, Balázs / Zana, Brigitta / Zeghbib, Safia / Kuczmog, Anett / Földes, Fanni / Lanszki, Zsófia / Madai, Mónika / Papp, Henrietta / Nagy, Ágnes / István Pereszlényi, Csaba / Csaba Babinszky, Gergely / Dudás, Gábor / Csoma, Eszter / N Abou Tayoun, Ahmad / A Alsheikh-Ali, Alawi / Loney, Tom / Nowotny, Norbert / Abdul-Wahab, Osama / Gonzalez-Candelas, Fernando / H Andersen, Martin / Sarah Taylor, And

    2020  

    Abstract: We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence ... ...

    Abstract We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence data from the World Health Organization European Region available until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation, compare the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2.
    Schlagwörter COVID-19 ; Europe ; NGS ; nomenclature ; SARS-CoV-2 ; sequencing ; WGS ; Base Sequence ; Betacoronavirus ; Coronavirus ; Coronavirus Infections ; Genome ; Viral ; Humans ; Phylogeography ; Pneumonia ; RNA Replicase ; RNA ; Severe Acute Respiratory Syndrome ; Spatio-Temporal Analysis ; World Health Organization ; Pandemics ; covid19
    Sprache Englisch
    Erscheinungsland it
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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