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  1. Buch ; Dissertation / Habilitation: Rolle des TGF-beta Signalweges für die Aufrechterhaltung der Stammzellcharakteristik bei Karzinomstammzellen des Pankreas

    Gafarli, Samra / Rückert, Felix

    2021  

    Körperschaft Universität Heidelberg
    Verfasserangabe vorgelegt von Samra Gafarli ; Referent: Herr Prof. Dr. med. Felix Rückert
    Sprache Deutsch
    Umfang 83 Seiten, Illustrationen, Diagramme, 30 cm
    Erscheinungsort Heidelberg
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dissertation, Ruprecht-Karls-Universität zu Heidelberg, 2021
    HBZ-ID HT021406044
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  2. Buch ; Dissertation / Habilitation: TGF-? pathway activity and the expression of SPARC and TSP-1 in pancratic versus biliary tract cancers

    Aghamaliyev, Ughur / Rückert, Felix

    2020  

    Körperschaft Universität Heidelberg
    Verfasserangabe vorgelegt von Ughur Aghamaliyev ; Referent: Prof. Dr. med. Felix Rueckert
    Sprache Englisch
    Umfang 68 Blätter, Diagramme, Illustrationen
    Erscheinungsort Heidelberg
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dissertation, Ruprecht-Karls-Universität Heidelberg, 2021
    HBZ-ID HT021387921
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  3. Buch ; Dissertation / Habilitation: Analyse des Kurz- und Langzeitergebnisses nach Resektion von intrahepatischen und extrahepatischen cholangiozellulären Karzinomen

    Rahimli, Mirhasan / Rückert, Felix

    2019  

    Titelvarianten Kurzzeitergebnisses
    Körperschaft Universität Heidelberg
    Verfasserangabe vorgelegt von Mirhasan Rahimli ; Referent: Prof. Dr. med. Felix Rückert
    Sprache Deutsch
    Umfang 99 Blätter, Diagramme, Illustrationen
    Erscheinungsort Heidelberg
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dissertation, Ruprecht-Karls-Universität zu Heidelberg, 2020
    HBZ-ID HT020907988
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  4. Buch ; Dissertation / Habilitation: Analyse des histologischen Spektrums resezierter Lebermetastasen an der Chirurgischen Klinik der Universitätsmedizin Mannheim

    Zaltenbach, Benjamin / Rückert, Felix

    2021  

    Körperschaft Universität Heidelberg
    Verfasserangabe vorgelegt von Benjamin Rouven Zaltenbach ; Referent: Prof. Dr. med. F. Rückert
    Sprache Deutsch
    Umfang 90 Blätter, Diagramme, 30 cm
    Erscheinungsort Heidelberg
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dissertation, Ruprecht-Karls-Universität zu Heidelberg, 2021
    HBZ-ID HT021406043
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  5. Buch ; Dissertation / Habilitation: Bilirubin and PTEN/PI3K/AKT interactions on the proliferative and inflammatory signaling pathways in cholangiocytes

    Wang, Qikun / Rückert, Felix

    2021  

    Körperschaft Universität Heidelberg
    Verfasserangabe vorgelegt von Qikun Wang ; Referent: Prof. Dr. med. Felix Rueckert
    Sprache Englisch
    Umfang 58 Blätter, Diagramme, Illustrationen
    Erscheinungsort Heidelberg
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dissertation, Ruprecht-Karls-Universität Heidelberg, 2023
    HBZ-ID HT030626435
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  6. Buch ; Online ; Dissertation / Habilitation: Potential Therapeutic Effect of Human Adipose-Derived Stem Cells on hypoxia in vitro and in vivo

    Zheng, Jiaxing [Verfasser] / Rückert, Felix [Akademischer Betreuer]

    2022  

    Verfasserangabe Jiaxing Zheng ; Betreuer: Felix Rückert
    Schlagwörter Biowissenschaften, Biologie ; Life Science, Biology
    Thema/Rubrik (Code) sg570
    Sprache Englisch
    Verlag Universitätsbibliothek Heidelberg
    Erscheinungsort Heidelberg
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  7. Buch ; Online ; Dissertation / Habilitation: Analyse der neuen ISGLS-Definition der postoperativen Leberblutung (PHH) – Relevanz und Anwendung in der Klinik

    Tesfazgi, Winta [Verfasser] / Rückert, Felix [Akademischer Betreuer]

    2022  

    Verfasserangabe Winta Tesfazgi ; Betreuer: Felix Rückert
    Schlagwörter Medizin, Gesundheit ; Medicine, Health
    Thema/Rubrik (Code) sg610
    Sprache Deutsch
    Verlag Universitätsbibliothek Heidelberg
    Erscheinungsort Heidelberg
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  8. Buch ; Online ; Dissertation / Habilitation: Einfluss des metabolischen Status und postoperativer Pankreatitiden auf die Entwicklung postoperativer Pankreasfisteln

    Reeg, Alina [Verfasser] / Rückert, Felix [Akademischer Betreuer]

    2021  

    Verfasserangabe Alina Christina Reeg ; Betreuer: Felix Rückert
    Schlagwörter Medizin, Gesundheit ; Medicine, Health
    Thema/Rubrik (Code) sg610
    Sprache Deutsch
    Verlag Universitätsbibliothek Heidelberg
    Erscheinungsort Heidelberg
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  9. Artikel ; Online: Impact of spleen preservation on the incidence of postoperative pancreatic fistula after distal pancreatectomy: Is less more?

    Șandra-Petrescu, Flavius / Tzatzarakis, Emmanouil / Mansour Basha, Mamdouh / Rückert, Felix / Reissfelder, Christoph / Birgin, Emrullah / Rahbari, Nuh N

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

    2022  Band 22, Heft 7, Seite(n) 1013–1019

    Abstract: Background: Postoperative pancreatic fistula (POPF) remains a major complication after distal pancreatectomy (DP) with a significant impact on patients' quality of life. There is limited evidence that preservation of the spleen reduces the risk of POPF. ...

    Abstract Background: Postoperative pancreatic fistula (POPF) remains a major complication after distal pancreatectomy (DP) with a significant impact on patients' quality of life. There is limited evidence that preservation of the spleen reduces the risk of POPF. Therefore, we aimed to investigate the impact of splenectomy on perioperative outcome.
    Methods: Data from patients who underwent DP for malignant and benign disease at our institution between 2004 and 2021 were reviewed. Patients were grouped according to spleen preservation (SP-DP) and splenectomy (DPS). Intraoperative parameters and postoperative outcomes were compared between groups. Univariable and multivariable analyses were used to investigate factors that influence the occurrence of clinically relevant (cr)POPF.
    Results: A total of 199 patients were included, of whom 61 (30.7%) patients underwent SP-DP. Patients who underwent SP-DP had a significantly lower rate of crPOPF (p = 0.022), shorter hospital stay (p = 0.003), and less readmissions (p = 0.012). On multivariate analysis, obesity (OR 2.88, p = 0.021), benign lesions (OR 2.35, p = 0.018), postoperative acute pancreatitis (OR 2.53, p = 0.028), and splenectomy (OR 2.83, p = 0.011) were independent risk factors associated with the onset of crPOPF.
    Discussion: Preservation of the spleen reduces the risk of crPOPF in patients undergoing distal pancreatectomy for benign and malignant disease.
    Mesh-Begriff(e) Humans ; Pancreatectomy/adverse effects ; Pancreatic Fistula/epidemiology ; Pancreatic Fistula/etiology ; Pancreatic Fistula/prevention & control ; Spleen ; Incidence ; Quality of Life ; Acute Disease ; Pancreatic Neoplasms/pathology ; Retrospective Studies ; Pancreatitis/complications ; Postoperative Complications/epidemiology ; Postoperative Complications/prevention & control ; Postoperative Complications/etiology
    Sprache Englisch
    Erscheinungsdatum 2022-08-03
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2056680-3
    ISSN 1424-3911 ; 1424-3903
    ISSN (online) 1424-3911
    ISSN 1424-3903
    DOI 10.1016/j.pan.2022.07.012
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Comparison of Tumour-Specific Phenotypes in Human Primary and Expandable Pancreatic Cancer Cell Lines.

    Guo, Feng / Kan, Kejia / Rückert, Felix / Rückert, Wolfgang / Li, Lin / Eberhard, Johannes / May, Tobias / Sticht, Carsten / Dirks, Wilhelm G / Reißfelder, Christoph / Pallavi, Prama / Keese, Michael

    International journal of molecular sciences

    2023  Band 24, Heft 17

    Abstract: There is an ongoing need for patient-specific chemotherapy for pancreatic cancer. Tumour cells isolated from human tissues can be used to predict patients' response to chemotherapy. However, the isolation and maintenance of pancreatic cancer cells is ... ...

    Abstract There is an ongoing need for patient-specific chemotherapy for pancreatic cancer. Tumour cells isolated from human tissues can be used to predict patients' response to chemotherapy. However, the isolation and maintenance of pancreatic cancer cells is challenging because these cells become highly vulnerable after losing the tumour microenvironment. Therefore, we investigated whether the cells retained their original characteristics after lentiviral transfection and expansion. Three human primary pancreatic cancer cell lines were lentivirally transduced to create expandable (Ex) cells which were then compared with primary (Pri) cells. No obvious differences in the morphology or epithelial-mesenchymal transition (EMT) were observed between the primary and expandable cell lines. The two expandable cell lines showed higher proliferation rates in the 2D and 3D models. All three expandable cell lines showed attenuated migratory ability. Differences in gene expression between primary and expandable cell lines were then compared using RNA-Seq data. Potential target drugs were predicted by differentially expressed genes (DEGs), and differentially expressed pathways (DEPs) related to tumour-specific characteristics such as proliferation, migration, EMT, drug resistance, and reactive oxygen species (ROS) were investigated using the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. We found that the two expandable cell lines expressed similar chemosensitivity and redox-regulatory capability to gemcitabine and oxaliplatin in the 2D model as compared to their counterparts. In conclusion, we successfully generated expandable primary pancreatic cancer cell lines using lentiviral transduction. These expandable cells not only retain some tumour-specific biological traits of primary cells but also show an ongoing proliferative capacity, thereby yielding sufficient material for drug response assays, which may provide a patient-specific platform for chemotherapy drug screening.
    Mesh-Begriff(e) Humans ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Pancreas ; Cell Line ; Phenotype ; Tumor Microenvironment/genetics ; Pancreatic Neoplasms
    Sprache Englisch
    Erscheinungsdatum 2023-08-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241713530
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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