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  1. Artikel ; Online: Chemical composition, seasonal variation and antiaging activities of essential oil from

    Rabie, Omyma / El-Nashar, Heba A S / Majrashi, Taghreed A / Al-Warhi, Tarfah / El Hassab, Mahmoud A / Eldehna, Wagdy M / Mostafa, Nada M

    Journal of enzyme inhibition and medicinal chemistry

    2023  Band 38, Heft 1, Seite(n) 2224944

    Abstract: ... ...

    Abstract Callistemon
    Mesh-Begriff(e) Oils, Volatile/pharmacology ; Oils, Volatile/analysis ; Oils, Volatile/chemistry ; Seasons ; Acetylcholinesterase ; Eucalyptol/pharmacology ; Eucalyptol/analysis ; Egypt ; Molecular Docking Simulation ; Plant Leaves/chemistry ; Myrtaceae/chemistry ; Pancreatic Elastase
    Chemische Substanzen Oils, Volatile ; Acetylcholinesterase (EC 3.1.1.7) ; Eucalyptol (RV6J6604TK) ; Pancreatic Elastase (EC 3.4.21.36)
    Sprache Englisch
    Erscheinungsdatum 2023-06-27
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2082578-X
    ISSN 1475-6374 ; 1475-6366
    ISSN (online) 1475-6374
    ISSN 1475-6366
    DOI 10.1080/14756366.2023.2224944
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Phytochemical profiling and neuroprotective activity of Callistemon subulatus leaves against cyclophosphamide-induced chemobrain.

    Rabie, Omyma / El-Nashar, Heba A S / George, Mina Y / Majrashi, Taghreed A / Al-Warhi, Tarfah / Hassan, Fatma E / Eldehna, Wagdy M / Mostafa, Nada M

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Band 167, Seite(n) 115596

    Abstract: Cyclophosphamide (CPA) is a chemotherapeutic drug used for various types of cancers. However, patients receiving CPA for long periods suffer cognitive impairment associated with difficulties in learning, decreased concentration, and impaired memory. ... ...

    Abstract Cyclophosphamide (CPA) is a chemotherapeutic drug used for various types of cancers. However, patients receiving CPA for long periods suffer cognitive impairment associated with difficulties in learning, decreased concentration, and impaired memory. Chemotherapy-induced cognitive impairment, known as chemobrain, has been attributed to enhanced oxidative stress and inflammatory response. The current study aimed to identify the phytoconstituents of Callistemon subulatus extract (CSE) using HPLC-ESI/MS-MS analysis and evaluate its neuroprotective activity against CPA-induced chemobrain in rats. Fourteen compounds were identified following HPLC analysis including, five phlorglucinols, four flavonol glycosides, a triterpene, and a phenolic acid. Forty rats were divided into five groups treated for ten days as follows; group I (control group), group II received CPA (200 mg/kg, i.p.) on the 7th day, groups III and IV received CSE (200 and 400 mg/kg respectively, orally) for ten days and CPA (200 mg/kg, i.p.) on the 7th day, and group V received only CSE (400 mg/kg, orally) for ten days. The administration of CSE effectively ameliorated the deleterious effects of CPA on spatial and short-term memories, as evidenced by behavioral tests, Y-maze and passive avoidance. Such findings were further confirmed by histological examination. In addition, CSE counteracted the effect of CPA on hippocampal acetylcholinesterase (AChE) activity enhancing the level of acetylcholine. Owing to the CSE antioxidant properties, it hindered the CPA-induced redox imbalance, which is represented by decreased catalase and reduced glutathione levels, as well as enhanced lipid peroxidation. Therefore, CSE may be a promising natural candidate for protection against CPA-induced chemobrain in cancer patients.
    Mesh-Begriff(e) Humans ; Rats ; Animals ; Chemotherapy-Related Cognitive Impairment ; Acetylcholinesterase/metabolism ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Oxidative Stress ; Cyclophosphamide/toxicity ; Neuroprotective Agents/pharmacology
    Chemische Substanzen Acetylcholinesterase (EC 3.1.1.7) ; Antioxidants ; Cyclophosphamide (8N3DW7272P) ; Neuroprotective Agents
    Sprache Englisch
    Erscheinungsdatum 2023-10-03
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.115596
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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