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  1. Article: SIRT1 Signaling Is Involved in the Vascular Improvement Induced by Moringa Oleifera Seeds during Aging.

    Conti, Valeria / Randriamboavonjy, Joseph Iharinjaka / Rafatro, Herintsoa / Manzo, Valentina / Dal Col, Jessica / Filippelli, Amelia / Corbi, Graziamaria / Tesse, Angela

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 5

    Abstract: Vascular aging is linked to reduce NO bioavailability, endothelial dysfunction, oxidative stress, and inflammation. We previously showed that a 4-week treatment of middle-aged Wistar rats (MAWRs, 46 weeks old) ... ...

    Abstract Vascular aging is linked to reduce NO bioavailability, endothelial dysfunction, oxidative stress, and inflammation. We previously showed that a 4-week treatment of middle-aged Wistar rats (MAWRs, 46 weeks old) with
    Language English
    Publishing date 2023-05-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16050761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Moringa oleifera

    Randriamboavonjy, Joseph Iharinjaka / Heurtebise, Sandrine / Pacaud, Pierre / Loirand, Gervaise / Tesse, Angela

    Oxidative medicine and cellular longevity

    2019  Volume 2019, Page(s) 2567198

    Abstract: Vascular aging is characterized by functional and structural changes of the vessel wall, including endothelial dysfunction, with decreased endothelial ... ...

    Abstract Vascular aging is characterized by functional and structural changes of the vessel wall, including endothelial dysfunction, with decreased endothelial NO
    MeSH term(s) Aging/physiology ; Animals ; Aorta/pathology ; Cardiovascular Diseases/therapy ; Cells, Cultured ; Dietary Supplements ; Endothelium/physiology ; Humans ; Male ; Moringa oleifera ; Myocardial Contraction ; Nitric Oxide Synthase/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Wistar ; Seeds ; Signal Transduction ; Vasodilation
    Chemical Substances Nitric Oxide Synthase (EC 1.14.13.39) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2019-05-13
    Publishing country United States
    Document type Journal Article
    ISSN 1942-0994
    ISSN (online) 1942-0994
    DOI 10.1155/2019/2567198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Moringa oleifera

    Randriamboavonjy, Joseph Iharinjaka / Rio, Marc / Pacaud, Pierre / Loirand, Gervaise / Tesse, Angela

    Oxidative medicine and cellular longevity

    2017  Volume 2017, Page(s) 4129459

    Abstract: ... Moringa ... ...

    Abstract Moringa oleifera
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ISSN 1942-0994
    ISSN (online) 1942-0994
    DOI 10.1155/2017/4129459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Advanced glycation inhibition and protection against endothelial dysfunction induced by coumarins and procyanidins from Mammea neurophylla.

    Dang, Bach Tai / Gény, Charlotte / Blanchard, Patricia / Rouger, Caroline / Tonnerre, Pierre / Charreau, Béatrice / Rakolomalala, Gilbertine / Randriamboavonjy, Joseph Iharinjaka / Loirand, Gervaise / Pacaud, Pierre / Litaudon, Marc / Richomme, Pascal / Séraphin, Denis / Derbré, Séverine

    Fitoterapia

    2014  Volume 96, Page(s) 65–75

    Abstract: Advanced glycation end-products (AGEs) are associated with many pathogenic disorders such as pathogenesis of diabetes or endothelial dysfunction leading to cardiovascular events. Therefore, the identification of new anti-AGE molecules or extracts aims at ...

    Abstract Advanced glycation end-products (AGEs) are associated with many pathogenic disorders such as pathogenesis of diabetes or endothelial dysfunction leading to cardiovascular events. Therefore, the identification of new anti-AGE molecules or extracts aims at preventing such pathologies. Many Clusiaceae and Calophyllaceae species are used in traditional medicines to treat arterial hypertension as well as diabetes. Focusing on these plant families, an anti-AGE plant screening allowed us to select Mammea neurophylla for further phytochemical and biological studies. Indeed, both DCM and MeOH stem bark extracts demonstrated in vitro their ability to prevent inflammation in endothelial cells and to reduce vasoconstriction. A bioguided fractionation of these extracts allowed us to point out 4-phenyl- and 4-(1-acetoxypropyl)coumarins and procyanidins as potent inhibitors of AGE formation, potentially preventing endothelial dysfunction. The fractionation steps also led to the isolation of two new compounds, namely neurophyllols A and B from the DCM bark extract together with thirteen known mammea A and E coumarins (mammea A/AA, mammea A/AB, mammea A/BA, mammea A/BB, mammea A/AA cycloD, mammea A/AB cycloD, disparinol B, mammea A/AB cycloE, ochrocarpin A, mammea A/AA cycloF, mammea A/AB cycloF, mammea E/BA, mammea E/BB) as well as δ-tocotrienol, xanthones (1-hydroxy-7-methoxyxanthone, 2-hydroxyxanthone) and triterpenes (friedelin and betulinic acid). During this study, R,S-asperphenamate, previously described from fungal origin was also purified.
    MeSH term(s) Animals ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Biflavonoids/chemistry ; Biflavonoids/isolation & purification ; Biflavonoids/pharmacology ; Catechin/chemistry ; Catechin/isolation & purification ; Catechin/pharmacology ; Cell Survival/drug effects ; Coumarins/chemistry ; Coumarins/isolation & purification ; Coumarins/pharmacology ; Endothelial Cells ; Fruit/chemistry ; Glycation End Products, Advanced/drug effects ; Male ; Mammea/chemistry ; Molecular Structure ; Plant Bark/chemistry ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Plant Leaves/chemistry ; Proanthocyanidins/chemistry ; Proanthocyanidins/isolation & purification ; Proanthocyanidins/pharmacology ; Rats ; Rats, Wistar ; Triterpenes/chemistry ; Triterpenes/isolation & purification ; Triterpenes/pharmacology ; Xanthones/chemistry ; Xanthones/isolation & purification ; Xanthones/pharmacology
    Chemical Substances Antineoplastic Agents, Phytogenic ; Biflavonoids ; Coumarins ; Glycation End Products, Advanced ; Plant Extracts ; Proanthocyanidins ; Triterpenes ; Xanthones ; 4-phenylcoumarin (13O55K0UYE) ; procyanidin (4852-22-6) ; betulinic acid (4G6A18707N) ; Catechin (8R1V1STN48) ; friedelin (AK21264UAD)
    Language English
    Publishing date 2014-07
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 412385-2
    ISSN 1873-6971 ; 0367-326X
    ISSN (online) 1873-6971
    ISSN 0367-326X
    DOI 10.1016/j.fitote.2014.04.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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