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  1. Artikel ; Online: Socio-economic disparities in the dispensation of antibiotics in Sweden 2016-2017: An intersectional analysis of individual heterogeneity and discriminatory accuracy.

    Wemrell, Maria / Lenander, Cecilia / Hansson, Kristofer / Perez, Raquel Vicente / Hedin, Katarina / Merlo, Juan

    Scandinavian journal of public health

    2021  Band 50, Heft 3, Seite(n) 347–354

    Abstract: Aims: ...

    Abstract Aims:
    Mesh-Begriff(e) Anti-Bacterial Agents/therapeutic use ; Female ; Humans ; Income ; Public Health ; Socioeconomic Factors ; Sweden/epidemiology
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2021-01-18
    Erscheinungsland Sweden
    Dokumenttyp Journal Article
    ZDB-ID 1475054-5
    ISSN 1651-1905 ; 1403-4948
    ISSN (online) 1651-1905
    ISSN 1403-4948
    DOI 10.1177/1403494820981496
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Splanchnic Vein Thrombosis in Inflammatory Bowel Disease

    Maria Puig / Helena Masnou / Francisco Mesonero / Luís Menchén / Luís Bujanda / Jesús Castro / Irene González-Partida / Raquel Vicente / Carlos González-Muñoza / Marisa Iborra / Mónica Sierra / José María Huguet / María José García / Ruth De Francisco / Francisco Javier García-Alonso / Míriam Mañosa / Eugeni Domènech / on behalf of ENEIDA-GETECCU Registry

    Journal of Clinical Medicine, Vol 12, Iss 23, p

    An Observational Study from the ENEIDA Registry and Systematic Review

    2023  Band 7366

    Abstract: Background: Thromboembolic events are frequent among patients with inflammatory bowel disease (IBD). However, there is little information on the prevalence, features and outcomes of splanchnic vein thrombosis (SVT) in patients with IBD. Aims: To describe ...

    Abstract Background: Thromboembolic events are frequent among patients with inflammatory bowel disease (IBD). However, there is little information on the prevalence, features and outcomes of splanchnic vein thrombosis (SVT) in patients with IBD. Aims: To describe the clinical features and outcomes of SVT in patients with IBD and to perform a systematic review of these data with published cases and series. Methods: A retrospective observational study from the Spanish nationwide ENEIDA registry was performed. A systematic search of the literature was performed to identify studies with at least one case of SVT in IBD patients. Results: A new cohort of 49 episodes of SVT from the Eneida registry and 318 IBD patients with IBD identified from the literature review (sixty studies: two multicentre, six single-centre and fifty-two case reports or case series) were analysed. There was a mild predominance of Crohn’s disease and the most frequent clinical presentation was abdominal pain with or without fever followed by the incidental finding in cross-sectional imaging techniques. The most frequent SVT location was the main portal trunk in two-thirds of the cases, followed by the superior mesenteric vein. Anticoagulation therapy was prescribed in almost 90% of the cases, with a high rate of radiologic resolution of SVT. Thrombophilic conditions other than IBD itself were found in at least one-fifth of patients. Conclusions: SVT seems to be a rare (or underdiagnosed) complication in IBD patients. SVT is mostly associated with disease activity and evolves suitably when anticoagulation therapy is started.
    Schlagwörter prevalence ; splanchnic vein thrombosis ; inflammatory bowel disease ; outcome ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-11-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel: Effectiveness and safety of ustekinumab in bio-naïve Crohn's disease patients: a multicentre observational retrospective study.

    Teresa, Valdés Delgado / Rául, Olmedo Martín / Marisa, Iborra / Claudia, Herrera de Guisé / Esteban, Fuentes-Valenzuela / Luigi, Melcarne / Mª Mar, Martín-Rodríguez / Lilyan, Kolle Casso / Luisa, De Castro Parga / Ángel, Ponferrada Díaz / Raquel, Vicente Lidón / Noemí, Manceñido Marcos / Benito, Velayos Jiménez / Marta, Lázaro Sáez / Beatriz, López Cauce / Francisco, Mesonero Gismero / Pau, Gilabert Álvarez / Federico, Argüelles-Arias

    Therapeutic advances in gastroenterology

    2023  Band 16, Seite(n) 17562848231153560

    Abstract: Background: Clinical trials have demonstrated the efficacy and safety of ustekinumab in Crohn's disease (CD). However, more data are necessary on the effectiveness of ustekinumab in bio-naïve patients in real-life studies.: Objectives: The aim of our ...

    Abstract Background: Clinical trials have demonstrated the efficacy and safety of ustekinumab in Crohn's disease (CD). However, more data are necessary on the effectiveness of ustekinumab in bio-naïve patients in real-life studies.
    Objectives: The aim of our study was to evaluate the effectiveness and safety of ustekinumab in patients with CD refractory or intolerant to conventional therapy and without previous exposure to biological drugs.
    Design: We performed a nationwide, observational, retrospective, multicentre study including patients with CD, in which ustekinumab was used as the first biological drug.
    Methods: The corticosteroid-free clinical and biological response and remission were analysed at weeks 16, 24, 52 and 72. Clinical remission was defined as Harvey-Bradshaw index ⩽ 4 and biological remission as a faecal calprotectin (FC) <250 mg/g and C-reactive protein (CRP) <5 mg/L. Moreover, the persistence of the treatment and any adverse events were assessed.
    Results: In all, 84 patients were included in the study, males and females were equally distributed, with a median age of 63 years [interquartile range (IQR): 51-75] and a median disease duration of 6.8 years [IQR: 3.6-17.0]. The majority (86.9%) of patients were treated with ustekinumab as monotherapy, without concomitant immunosuppressive medication. The proportion of patients in corticosteroid-free clinical remission or response at weeks 16, 24, 52 and 72 was 93.3% (56/60), 86.8% (46/53), 82.2% (37/45) and 71.4% (30/42), respectively. CRP returned to normal values in 47.6%, 43.2%, 50% and 52.4% of patients at weeks 16, 24, 52 and 72, respectively. Similarly, FC was normalized in 45.5%, 45.5%, 48.6% and 50% of patients at weeks 16, 24, 52 and 72, respectively. The cumulative probability of remaining on ustekinumab treatment was 84.8% (95% confidence interval: 73.3-91.6) after 72 weeks. Ustekinumab was discontinued in 10 patients (11.9%) within 72 weeks of follow-up. Reasons for discontinuing treatment were lack of response (
    Conclusions: Ustekinumab was effective and safe in Spanish bio-naïve CD patients, showing a quicker and more durable response than obtained in patients with previous biological treatment. In this cohort of bio-naïve patients starting on ustekinumab, the average age was high.
    Plain language summary: Effectiveness and safety of ustekinumab in Crohn's disease patients not previously exposed to other biological therapies
    Sprache Englisch
    Erscheinungsdatum 2023-02-09
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2440710-0
    ISSN 1756-2848 ; 1756-283X
    ISSN (online) 1756-2848
    ISSN 1756-283X
    DOI 10.1177/17562848231153560
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Enfermedad de Crohn y colitis ulcerosa

    Beatriz Sicilia / Raquel Vicente / Fernando Gomollón

    Acta Gastroenterológica Latinoamericana, Vol 39, Iss 2, Pp 135-

    discusión de la epidemiología clásica

    2009  Band 145

    Abstract: La incidencia y consecuentemente la prevalencia de las enfermedades Inflamatorias intestinales (EII) ha aumentado en las últimas décadas. Pueden debutar a cualquier edad sin predominio claro de sexo y con porcentajes similares a los de la población ... ...

    Abstract La incidencia y consecuentemente la prevalencia de las enfermedades Inflamatorias intestinales (EII) ha aumentado en las últimas décadas. Pueden debutar a cualquier edad sin predominio claro de sexo y con porcentajes similares a los de la población general en términos de mortalidad en su evolución natural, pero con una mayor incidencia de cáncer colorrectal relacionado claramente con la inflamación crónica y la duración de la enfermedad. Muy probablemente las EII sean enfermedades poligénicas que comparten genes que aumentarían la susceptibilidad de padecerlas y por el contrario se asocian a genes específicos para cada una de ellas (EC y CU). Entre los factores de riesgo ambientales que alterarían la respuesta inmune originando los diferentes fenotipos que conocemos de ambas enfermedades es el tabaco el que mayor significación tiene, con un comportamiento diferente en ambas enfermedades, aunque también se han descrito asociaciones con la apendicectomía, los anticonceptivos, las infecciones, la dieta, la higiene en la infancia y la toma de antiinflamatorios no esteroideos.
    Schlagwörter Diseases of the digestive system. Gastroenterology ; RC799-869 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Sprache Spanisch
    Erscheinungsdatum 2009-01-01T00:00:00Z
    Verlag Sociedad Argentina de Gastroenterología
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain

    María Chaparro / Ana Garre / Andrea Núñez Ortiz / María Teresa Diz-Lois Palomares / Cristina Rodríguez / Sabino Riestra / Milagros Vela / José Manuel Benítez / Estela Fernández Salgado / Eugenia Sánchez Rodríguez / Vicent Hernández / Rocío Ferreiro-Iglesias / Ángel Ponferrada Díaz / Jesús Barrio / José María Huguet / Beatriz Sicilia / María Dolores Martín-Arranz / Xavier Calvet / Daniel Ginard /
    Inmaculada Alonso-Abreu / Luis Fernández-Salazar / Pilar Varela Trastoy / Montserrat Rivero / Isabel Vera-Mendoza / Pablo Vega / Pablo Navarro / Mónica Sierra / José Luis Cabriada / Mariam Aguas / Raquel Vicente / Mercè Navarro-Llavat / Ana Echarri / Fernando Gomollón / Elena Guerra del Río / Concepción Piñero / María José Casanova / Katerina Spicakova / Jone Ortiz de Zarate / Emilio Torrella Cortés / Ana Gutiérrez / Horacio Alonso-Galán / Álvaro Hernández-Martínez / José Miguel Marrero / Rufo Lorente Poyatos / Margalida Calafat / Lidia Martí Romero / Pilar Robledo / Orencio Bosch / Nuria Jiménez / María Esteve Comas / José María Duque / Ana María Fuentes Coronel / Manuela Josefa Sampedro / Eva Sesé Abizanda / Belén Herreros Martínez / Liliana Pozzati / Hipólito Fernández Rosáenz / Belén Crespo Suarez / Pilar López Serrano / Alfredo J. Lucendo / Margarita Muñoz Vicente / Fernando Bermejo / José Joaquín Ramírez Palanca / Margarita Menacho / Amalia Carmona / Raquel Camargo / Sandra Torra Alsina / Nuria Maroto / Juan Nerín de la Puerta / Elena Castro / Ignacio Marín-Jiménez / Belén Botella / Amparo Sapiña / Noelia Cruz / José Luis F. Forcelledo / Abdel Bouhmidi / Carlos Castaño-Milla / Verónica Opio / Isabel Nicolás / Marcos Kutz / Alfredo Abraldes Bechiarelli / Jordi Gordillo / Yolanda Ber / Yolanda Torres Domínguez / María Teresa Novella Durán / Silvia Rodríguez Mondéjar / Francisco J. Martínez-Cerezo / Lilyan Kolle / Miriam Sabat / Cesar Ledezma / Eduardo Iyo / Óscar Roncero / Rebeca Irisarri / Laia Lluis / Isabel Blázquez Gómez / Eva María Zapata / María José Alcalá / Cristina Martínez Pascual / María Montealegre / Laura Mata / Ana Monrobel / Alejandro Hernández Camba / Luis Hernández / María Tejada / Alberto Mir / María Luisa Galve / Marta Soler / Daniel Hervías / José Antonio Gómez-Valero / Manuel Barreiro-de Acosta / Fernando Rodríguez-Artalejo / Esther García-Esquinas / Javier P. Gisbert / on behalf of the EpidemIBD study group of GETECCU

    Journal of Clinical Medicine, Vol 10, Iss 2885, p

    Large-Scale Epidemiological Study

    2021  Band 2885

    Abstract: 1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: ... ...

    Abstract (1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD—Crohn’s disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)—during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31–56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery.
    Schlagwörter epidemiology ; incidence ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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