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  1. Artikel: In vitro antioxidant, antimutagenic and genoprotective activity of Rosa roxburghii fruit extract

    van der Westhuizen, Francois H / van Rensburg, Catharina S. Janse / Rautenbach, George S / Marnewick, Jeanine L / Loots, Du Toit / Huysamen, Cristal / Louw, Roan / Pretorius, Pieter J / Erasmus, Elardus

    Phytotherapy research. 2008 Mar., v. 22, no. 3

    2008  

    Abstract: The antioxidant properties of the fruit of the Rosa roxburghii (RR) plant have been associated with several putative health promoting effects. The possible cytotoxic, mutagenic/antimutagenic and genotoxic effects of RR fruit extract were investigated. ... ...

    Abstract The antioxidant properties of the fruit of the Rosa roxburghii (RR) plant have been associated with several putative health promoting effects. The possible cytotoxic, mutagenic/antimutagenic and genotoxic effects of RR fruit extract were investigated. The effect on antioxidant status and protection against induced oxidative stress were also investigated using primary rat hepatocytes. A RR fruit extract containing 45 g/L total ascorbic acid and 65 g/L total polyphenols was used in this study. Dilutions up to 0.08% (v/v) increased significantly the antioxidant status in primary rat hepatocytes. The glutathione redox state was decreased with RR treatment but was increased in Chang liver cells and MT-2 lymphoblast. No cyto- or genotoxicity were observed at levels of up to 5% (v/v) of the fruit extract. In addition, a significant protection against t-BHP induced oxidative stress was observed in primary rat hepatocytes. The Ames test revealed no mutagenic activity using the Salmonella typhimurium strains TA98, TA100 and TA102. A significant antimutagenic effect of the extract was observed against the metabolic activated mutagens 2-acetylaminofluorene and aflatoxin B1 and to a lesser extent against methyl methanesulfonate. It is concluded that these results support the associated health promoting potential of Rosa Roxburghii fruit and in particular against oxidative stress. Copyright © 2007 John Wiley & Sons, Ltd.
    Schlagwörter Ames test ; Rosa ; Salmonella typhimurium ; aflatoxin B1 ; antimutagenic activity ; antioxidant activity ; antioxidants ; ascorbic acid ; cytotoxicity ; fruit extracts ; fruits ; genotoxicity ; hepatocytes ; methyl methanesulfonate ; mutagenicity ; oxidative stress ; polyphenols ; rats
    Sprache Englisch
    Erscheinungsverlauf 2008-03
    Umfang p. 376-383.
    Erscheinungsort John Wiley & Sons, Ltd.
    Dokumenttyp Artikel
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.2330
    Datenquelle NAL Katalog (AGRICOLA)

    Volltext online

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  2. Artikel ; Online: In vitro antioxidant, antimutagenic and genoprotective activity of Rosa roxburghii fruit extract.

    van der Westhuizen, Francois H / van Rensburg, Catharina S Janse / Rautenbach, George S / Marnewick, Jeanine L / Loots, Du Toit / Huysamen, Cristal / Louw, Roan / Pretorius, Pieter J / Erasmus, Elardus

    Phytotherapy research : PTR

    2008  Band 22, Heft 3, Seite(n) 376–383

    Abstract: The antioxidant properties of the fruit of the Rosa roxburghii (RR) plant have been associated with several putative health promoting effects. The possible cytotoxic, mutagenic/antimutagenic and genotoxic effects of RR fruit extract were investigated. ... ...

    Abstract The antioxidant properties of the fruit of the Rosa roxburghii (RR) plant have been associated with several putative health promoting effects. The possible cytotoxic, mutagenic/antimutagenic and genotoxic effects of RR fruit extract were investigated. The effect on antioxidant status and protection against induced oxidative stress were also investigated using primary rat hepatocytes. A RR fruit extract containing 45 g/L total ascorbic acid and 65 g/L total polyphenols was used in this study. Dilutions up to 0.08% (v/v) increased significantly the antioxidant status in primary rat hepatocytes. The glutathione redox state was decreased with RR treatment but was increased in Chang liver cells and MT-2 lymphoblast. No cyto- or genotoxicity were observed at levels of up to 5% (v/v) of the fruit extract. In addition, a significant protection against t-BHP induced oxidative stress was observed in primary rat hepatocytes. The Ames test revealed no mutagenic activity using the Salmonella typhimurium strains TA98, TA100 and TA102. A significant antimutagenic effect of the extract was observed against the metabolic activated mutagens 2-acetylaminofluorene and aflatoxin B1 and to a lesser extent against methyl methanesulfonate. It is concluded that these results support the associated health promoting potential of Rosa Roxburghii fruit and in particular against oxidative stress.
    Mesh-Begriff(e) Animals ; Antimutagenic Agents/pharmacology ; Antioxidants/pharmacology ; Carcinogens/pharmacology ; Cells, Cultured ; Comet Assay ; DNA Damage/drug effects ; Fruit/chemistry ; Glutathione/analysis ; Glutathione/drug effects ; Hepatocytes/cytology ; Hepatocytes/drug effects ; Male ; Oxidation-Reduction/drug effects ; Oxidative Stress/drug effects ; Plant Extracts/pharmacology ; Plant Extracts/toxicity ; Rats ; Rats, Sprague-Dawley ; Rosa/chemistry ; Salmonella typhimurium/drug effects ; tert-Butylhydroperoxide/pharmacology
    Chemische Substanzen Antimutagenic Agents ; Antioxidants ; Carcinogens ; Plant Extracts ; tert-Butylhydroperoxide (955VYL842B) ; Glutathione (GAN16C9B8O)
    Sprache Englisch
    Erscheinungsdatum 2008-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.2330
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 3092: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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