Treffer 1 - 10 von insgesamt 2633
The Western journal of the medical and physical sciences
2023 Band 1, Heft 4, Seite(n) 656
| Sprache | Englisch |
|---|---|
| Erscheinungsdatum | 2023-12-12 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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The Southern medical record
2022 Band 14, Heft 1, Seite(n) 17–20
| Sprache | Englisch |
|---|---|
| Erscheinungsdatum | 2022-08-26 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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International journal of molecular sciences
2021 Band 22, Heft 11
Abstract: Plant mitochondria have large genomes to house a small number of key genes. Most mitochondria do not contain a whole genome. Despite these latter characteristics, the mitochondrial genome is faithfully maternally inherited. To maintain the mitochondrial ... ...
| Abstract | Plant mitochondria have large genomes to house a small number of key genes. Most mitochondria do not contain a whole genome. Despite these latter characteristics, the mitochondrial genome is faithfully maternally inherited. To maintain the mitochondrial genes-so important for energy production-the fusion and fission of mitochondria are critical. Fission in plants is better understood than fusion, with the dynamin-related proteins (DRP 3A and 3B) driving the constriction of the mitochondrion. How the endoplasmic reticulum and the cytoskeleton are linked to the fission process is not yet fully understood. The fusion mechanism is less well understood, as obvious orthologues are not present. However, there is a recently described gene, |
|---|---|
| Mesh-Begriff(e) | Animals ; Cytoskeleton/genetics ; Genome, Mitochondrial/genetics ; Humans ; Life Cycle Stages/genetics ; Life Cycle Stages/physiology ; Mitochondria/genetics ; Mitochondria/physiology ; Mitochondrial Dynamics/genetics ; Mitochondrial Dynamics/physiology ; Mitochondrial Proteins/genetics ; Plants/genetics |
| Chemische Substanzen | Mitochondrial Proteins |
| Sprache | Englisch |
| Erscheinungsdatum | 2021-05-21 |
| Erscheinungsland | Switzerland |
| Dokumenttyp | Journal Article ; Review |
| ZDB-ID | 2019364-6 |
| ISSN | 1422-0067 ; 1422-0067 ; 1661-6596 |
| ISSN (online) | 1422-0067 |
| ISSN | 1422-0067 ; 1661-6596 |
| DOI | 10.3390/ijms22115429 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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surgical, audiological and elctrophysiological issues
2004
| Verfasserangabe | door Jaydip Ray |
|---|---|
| Sprache | Englisch ; Niederländisch |
| Umfang | 187 S. : Ill., graph. Darst. |
| Erscheinungsland | Niederlande |
| Dokumenttyp | Buch ; Dissertation / Habilitation |
| Dissertation / Habilitation | Nijmegen, Univ., Diss., 2004 |
| HBZ-ID | HT015521563 |
| ISBN | 90-9018669-7 ; 978-90-9018669-6 |
| Datenquelle | Katalog ZB MED Medizin, Gesundheit |
| Signatur | Leihstatus | Standort |
|---|---|---|
| 2008 E 390 | bestellbar zur Ausleihe | Magazin |
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International Journal of Molecular Sciences, Vol 22, Iss 5429, p
2021 Band 5429
Abstract: Plant mitochondria have large genomes to house a small number of key genes. Most mitochondria do not contain a whole genome. Despite these latter characteristics, the mitochondrial genome is faithfully maternally inherited. To maintain the mitochondrial ... ...
| Abstract | Plant mitochondria have large genomes to house a small number of key genes. Most mitochondria do not contain a whole genome. Despite these latter characteristics, the mitochondrial genome is faithfully maternally inherited. To maintain the mitochondrial genes—so important for energy production—the fusion and fission of mitochondria are critical. Fission in plants is better understood than fusion, with the dynamin-related proteins (DRP 3A and 3B) driving the constriction of the mitochondrion. How the endoplasmic reticulum and the cytoskeleton are linked to the fission process is not yet fully understood. The fusion mechanism is less well understood, as obvious orthologues are not present. However, there is a recently described gene, MIRO2 , that appears to have a significant role, as does the ER and cytoskeleton. Massive mitochondrial fusion (MMF or hyperfusion) plays a significant role in plants. MMF occurs at critical times of the life cycle, prior to flowering, in the enlarging zygote and at germination, mixing the cells’ mitochondrial population—the so-called “discontinuous whole”. MMF in particular aids genome repair, the conservation of critical genes and possibly gives an energy boost to important stages of the life cycle. MMF is also important in plant regeneration, an important component of plant biotechnology. |
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| Schlagwörter | plant mitochondria ; plant mitochondrial fusion ; plant mitochondrial fission ; plant mitochondrial DNA ; massive mitochondrial fusion in plants ; plant life cycle ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999 |
| Thema/Rubrik (Code) | 580 |
| Sprache | Englisch |
| Erscheinungsdatum | 2021-05-01T00:00:00Z |
| Verlag | MDPI AG |
| Dokumenttyp | Artikel ; Online |
| Datenquelle | BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl) |
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BMJ neurology open
2023 Band 5, Heft 2, Seite(n) e000492
Abstract: Introduction: OnabotulinumtoxinA for migraine involves 31 injected repeated every 12 weeks. Tolerability is a significant factor impacting discontinuation. Music medicine has not been studied previously as an intervention to improve the tolerability of ... ...
| Abstract | Introduction: OnabotulinumtoxinA for migraine involves 31 injected repeated every 12 weeks. Tolerability is a significant factor impacting discontinuation. Music medicine has not been studied previously as an intervention to improve the tolerability of injections. Methodology: A single-centre prospective cohort study was undertaken. Following baseline, patients had music played during the procedure. Change in Visual Analogue Score (VAS) was assessed as the primary outcome. Results: Over 6 months, 50 patients were recruited with a median age of 42, and median duration of therapy of 13.5 months. 'Quiet calm classical music' was associated with a significant reduction in VAS (z=-4.7, p<0.001). Duration of therapy, disease state or headache frequency had no correlation with change in VAS. Conclusion: Music medicine is associated with a significant reduction in the procedural pain of onabotulinumtoxinA injections in prospective study. Further study is required to explore other modifiable factors to improve patient experience. |
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| Sprache | Englisch |
| Erscheinungsdatum | 2023-09-26 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article |
| ISSN | 2632-6140 |
| ISSN (online) | 2632-6140 |
| DOI | 10.1136/bmjno-2023-000492 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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2023 Band 10, Heft 3, Seite(n) 195–204
Abstract: Delays and waiting in urgent and emergency care (UEC) services are causing avoidable harm to patients and affecting staff morale. Patients are often having a poor experience of using UEC services, increasing stress and anxiety for both their families and ...
| Abstract | Delays and waiting in urgent and emergency care (UEC) services are causing avoidable harm to patients and affecting staff morale. Patients are often having a poor experience of using UEC services, increasing stress and anxiety for both their families and themselves, delaying their recovery. Despite the constraints of available permanent staffing, funding and competing NHS priorities, changes along the whole UEC pathway in and out of hospital, admitted and non-admitted pathways need to be made safe, timely and accessible, to provide clinically appropriate care for patients. Changes in clinician behaviour, culture, and training toward the management and sharing of clinical risk differently along the whole UEC pathway are also required. Modifying operational processes with a focus on patients in different UEC settings will improve productivity, flow and the patient experience. There is a need to do things differently rather than continuing as we are and expecting a different result to unlock the perennial UEC crisis. |
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| Sprache | Englisch |
| Erscheinungsdatum | 2023-12-14 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article |
| ZDB-ID | 3016427-8 |
| ISSN | 2514-6653 ; 2514-6645 |
| ISSN (online) | 2514-6653 |
| ISSN | 2514-6645 |
| DOI | 10.7861/fhj.2023-0085 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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Current opinion in cell biology
2024 Band 88, Seite(n) 102372
Abstract: Phosphoinositide 3-kinases regulate many cellular functions, including migration, growth, proliferation, and cell survival. Early studies equated the inhibition of Class I PI3Ks with loss of; phosphatidylinositol 3,4,5-trisphosphate (PIP3), but over time, ...
| Abstract | Phosphoinositide 3-kinases regulate many cellular functions, including migration, growth, proliferation, and cell survival. Early studies equated the inhibition of Class I PI3Ks with loss of; phosphatidylinositol 3,4,5-trisphosphate (PIP3), but over time, it was realised that these; treatments also depleted phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2). In recent years, the; use of better tools and an improved understanding of its metabolism have allowed for the; identification of specific roles of PI(3,4)P2. This includes the production of PI(3,4)P2 and the; activation of its effector Akt2 in response to growth factor signalling. In contrast, a lysosomal pool of PI(3,4)P2 is a negative regulator of mTORC1 during growth factor deprivation. A growing body of literature also demonstrates that PI(3,4)P2 controls many dynamic plasmalemmal processes. The significance of PI(3,4)P |
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| Sprache | Englisch |
| Erscheinungsdatum | 2024-05-21 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article ; Review |
| ZDB-ID | 1026381-0 |
| ISSN | 1879-0410 ; 0955-0674 |
| ISSN (online) | 1879-0410 |
| ISSN | 0955-0674 |
| DOI | 10.1016/j.ceb.2024.102372 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 2963: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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Functional plant biology : FPB
2020 Band 35, Heft 4, Seite(n) 253–264
Abstract: Medicago truncatula Gaertn. cv. Jemalong, a pasture species used in Australian agriculture, was first proposed as a model legume in 1990. Since that time M. truncatula, along with Lotus japonicus (Regal) Larsen, has contributed to major advances in ... ...
| Abstract | Medicago truncatula Gaertn. cv. Jemalong, a pasture species used in Australian agriculture, was first proposed as a model legume in 1990. Since that time M. truncatula, along with Lotus japonicus (Regal) Larsen, has contributed to major advances in understanding rhizobia Nod factor perception and the signalling pathway involved in nodule formation. Research using M. truncatula as a model has expanded beyond nodulation and the allied mycorrhizal research to investigate interactions with insect pests, plant pathogens and nematodes. In addition to biotic stresses the genetic mechanisms to ameliorate abiotic stresses such as salinity and drought are being investigated. Furthermore, M. truncatula is being used to increase understanding of plant development and cellular differentiation, with nodule differentiation providing a different perspective to organogenesis and meristem biology. This legume plant represents one of the major evolutionary success stories of plant adaptation to its environment, and it is particularly in understanding the capacity to integrate biotic and abiotic plant responses with plant growth and development that M. truncatula has an important role to play. The expanding genomic and genetic toolkit available with M. truncatula provides many opportunities for integrative biological research with a plant which is both a model for functional genomics and important in agricultural sustainability. |
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| Sprache | Englisch |
| Erscheinungsdatum | 2020-07-21 |
| Erscheinungsland | Australia |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2071582-1 |
| ISSN | 1445-4416 ; 1445-4408 |
| ISSN (online) | 1445-4416 |
| ISSN | 1445-4408 |
| DOI | 10.1071/FP07297 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
| Z 4753: Hefte anzeigen |
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Physical chemistry chemical physics : PCCP
2022 Band 24, Heft 12, Seite(n) 7274–7292
Abstract: We present a theoretical investigation of the excited-state intermolecular proton transfer process in a 2-aminopyridine dimer. Previous experimental and theoretical studies on this doubly hydrogen bonded system have attributed an ultrafast 50 fs ... ...
| Abstract | We present a theoretical investigation of the excited-state intermolecular proton transfer process in a 2-aminopyridine dimer. Previous experimental and theoretical studies on this doubly hydrogen bonded system have attributed an ultrafast 50 fs timescale to the process at low excitation wavelengths and have shown that it involves access to the charge transfer (CT) states of the dimer. We have carried out a trajectory-based surface hopping study of the proton transfer process. To this end, we have further studied the key intersections between locally excited (LE) and CT states that facilitate the proton transfer as well as the eventual ground state return at the XMS-CASPT2 level of theory. The dynamical simulations to investigate the charge transfer-driven event are performed at both the XMS-CASPT2 and TDDFT levels of theory. Trajectories are initiated from the excited states that are either already of CT character or become so upon a short extension of the NH bond. This kind of dynamics is found to be ultrafast with a timescale of about 100 fs, where the dimer rapidly accesses the LE/CT intersection regions en route to single proton transfer. After the transfer, some trajectories are also able to reach the ground state as well through a non-adiabatic transition. In contrast, trajectories that are initiated on an LE state remain on states of that character and do not show proton transfer. However, additionally providing 3 or 4 quanta of initial excitation to the NH stretch was found to promote CT state-driven proton transfer in the dimer. |
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| Sprache | Englisch |
| Erscheinungsdatum | 2022-03-23 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article |
| ZDB-ID | 1476244-4 |
| ISSN | 1463-9084 ; 1463-9076 |
| ISSN (online) | 1463-9084 |
| ISSN | 1463-9076 |
| DOI | 10.1039/d1cp05517h |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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