Artikel ; Online: Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage.
2024 Band 43, Heft 3, Seite(n) 113911
Abstract: Claudin-5 (CLDN5) is an endothelial tight junction protein essential for blood-brain barrier (BBB) formation. Abnormal CLDN5 expression is common in brain disease, and knockdown of Cldn5 at the BBB has been proposed to facilitate drug delivery to the ... ...
Abstract | Claudin-5 (CLDN5) is an endothelial tight junction protein essential for blood-brain barrier (BBB) formation. Abnormal CLDN5 expression is common in brain disease, and knockdown of Cldn5 at the BBB has been proposed to facilitate drug delivery to the brain. To study the consequences of CLDN5 loss in the mature brain, we induced mosaic endothelial-specific Cldn5 gene ablation in adult mice (Cldn5 |
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Mesh-Begriff(e) | Animals ; Mice ; Biological Transport ; Blood-Brain Barrier/metabolism ; Brain/metabolism ; Claudin-5/genetics ; Claudin-5/metabolism ; Endothelial Cells/metabolism |
Chemische Substanzen | Claudin-5 ; Cldn5 protein, mouse |
Sprache | Englisch |
Erscheinungsdatum | 2024-03-05 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article |
ZDB-ID | 2649101-1 |
ISSN | 2211-1247 ; 2211-1247 |
ISSN (online) | 2211-1247 |
ISSN | 2211-1247 |
DOI | 10.1016/j.celrep.2024.113911 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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