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  1. Artikel: Are Kidneys Affected by SARS-CoV-2 Infection? An Updated Review on COVID-19-Associated AKI.

    Fabrizi, Fabrizio / Nardelli, Luca / Regalia, Anna / Zanoni, Francesca / Castellano, Giuseppe

    Pathogens (Basel, Switzerland)

    2024  Band 13, Heft 4

    Abstract: Background: Human kidneys are an important target of SARS-CoV-2 infection, and many renal abnormalities have been found in patients with SARS-CoV-2 infection, including proteinuria, hematuria, and acute kidney injury. Acute kidney injury is now ... ...

    Abstract Background: Human kidneys are an important target of SARS-CoV-2 infection, and many renal abnormalities have been found in patients with SARS-CoV-2 infection, including proteinuria, hematuria, and acute kidney injury. Acute kidney injury is now considered a common complication of COVID-19, and the epidemiology of AKI in SARS-CoV-2-infected patients continues to be controversial.
    Aim and methods: We have carried out a narrative review to evaluate the frequency and risk factors for AKI among patients hospitalized due to COVID-19, and the latest surveys on this topic have been included. The mechanisms by which AKI occurs in COVID-19 patients have also been reviewed.
    Results: Multiple risk factors for the development of AKI in patients with SARS-CoV-2 infection have been identified; these have been classified in various groups (management and background factors, among others). SARS-CoV-2 targets the kidneys by indirect activity, but SARS-CoV-2 infects tubular epithelial cells and podocytes. We retrieved 24 reports (
    Conclusions: AKI is a common complication of hospitalized SARS-CoV-2-infected patients, and some comorbidities are important risk factors for it. The direct activity of the virus on the kidneys has been mentioned in the pathogenesis of AKI in SARS-CoV-2 patients. Further studies are ongoing in order to identify the mechanisms underlying the kidney injury in this population. The role of AKI on survival in SARS-CoV-2-infected patients is another area of active investigation.
    Sprache Englisch
    Erscheinungsdatum 2024-04-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens13040325
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: The Impact of Antiviral Treatment of Hepatitis B Virus after Kidney Transplant and the Latest Insights.

    Fabrizi, Fabrizio / Donato, Maria Francesca / Tripodi, Federica / Regalia, Anna / Lampertico, Pietro / Castellano, Giuseppe

    Pathogens (Basel, Switzerland)

    2023  Band 12, Heft 2

    Abstract: Background: The current frequency of hepatitis B virus infection in patients with advanced chronic kidney disease (CKD) (including patients on maintenance dialysis and kidney transplant recipients) is low but not negligible worldwide. HBV has a ... ...

    Abstract Background: The current frequency of hepatitis B virus infection in patients with advanced chronic kidney disease (CKD) (including patients on maintenance dialysis and kidney transplant recipients) is low but not negligible worldwide. HBV has a deleterious effect on survival after a kidney transplant; antiviral treatments improved the short-term outcomes of kidney transplant recipients, but their long-term impact remains uncertain.
    Aim: The aim of this review is to assess the role of antiviral therapy for HBV in improving survival after a kidney transplant. The recent publication of large surveys has prompted us to update the available evidence on the impact of HBV on patient and graft survival after a kidney transplant.
    Methods: We have conducted an extensive review of the medical literature, and various research engines have been used.
    Results: We retrieved several studies (
    Conclusions: The recent availability of safe and effective antiviral drugs for the treatment of HBV has meant that the survival curves of HBsAg-positive patients on antiviral therapy and HBsAg-negative patients after a kidney transplant can be comparable. Antiviral therapy should be systematically proposed to HBV-positive kidney transplant recipients and candidates to avoid the deleterious hepatic and extra-hepatic effects of chronic HBV replication.
    Sprache Englisch
    Erscheinungsdatum 2023-02-17
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12020340
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Kidney transplantation in patients with ANCA-associated vasculitis is associated with a high incidence of post-transplant cancer.

    Perna, Alessandro / Campise, Mariarosaria / Alfieri, Carlo Maria / Regalia, Anna / Cresseri, Donata / Gandolfo, Maria Teresa / Castellano, Giuseppe

    Journal of nephrology

    2024  

    Abstract: Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare disease with limited data on outcomes after transplantation.: Methods: In this single-center retrospective cohort study, we describe the outcomes of kidney ... ...

    Abstract Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare disease with limited data on outcomes after transplantation.
    Methods: In this single-center retrospective cohort study, we describe the outcomes of kidney transplant patients with AAV transplanted at our institute from February 2006 to January 2022.
    Results: We identified 9 patients among 1026 with a pre-transplant diagnosis of AAV; all patients had received previous treatment with cyclophosphamide. Maintenance immunosuppression after transplantation was tacrolimus-based in 89% of the patients. At the end of a mean follow-up of 132 ± 61.1 months after transplantation, only one case of extrarenal vasculitis relapse was observed. The relapse rate was 0.01 per patient per year, which is comparable to that reported in the literature. However, seven patients were diagnosed with cancer after a mean follow-up of 81.4 months after transplantation; six had skin cancer and three had renal cell carcinoma (RCC) of the native kidneys (cumulative incidence of 78%). One patient died from metastatic squamous cell carcinoma.
    Conclusion: In this study, we found a noticeable decrease in disease relapse (1 relapse in the present cohort vs 7 relapses in 19 patients in the previous cohort) in kidney transplant patients with AAV compared with previous data from our group (December 1987-January 2006). Conversely, we found a high incidence of post-transplant cancer. This result could be attributed to reduced immunosurveillance due to immunosuppression therapy before and after transplantation. Therefore, constant cancer early diagnosis and prevention is mandatory during the post-transplant follow-up of AAV patients.
    Sprache Englisch
    Erscheinungsdatum 2024-06-04
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-024-01951-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Post-Transplant Diabetes Mellitus in Kidney-Transplanted Patients: Related Factors and Impact on Long-Term Outcome.

    Alfieri, Carlo / Campioli, Edoardo / Fiorina, Paolo / Orsi, Emanuela / Grancini, Valeria / Regalia, Anna / Campise, Mariarosaria / Verdesca, Simona / Delfrate, Nicholas Walter / Molinari, Paolo / Pisacreta, Anna Maria / Favi, Evaldo / Messa, Piergiorgio / Castellano, Giuseppe

    Nutrients

    2024  Band 16, Heft 10

    Abstract: This study aimed to investigate the prevalence and determinants of glucose metabolism abnormalities and their impact on long-term clinical outcomes in kidney transplant recipients (KTxps). A retrospective analysis of 832 KTxps (2004-2020) was performed. ... ...

    Abstract This study aimed to investigate the prevalence and determinants of glucose metabolism abnormalities and their impact on long-term clinical outcomes in kidney transplant recipients (KTxps). A retrospective analysis of 832 KTxps (2004-2020) was performed. Patients were assessed at 1 (T1), 6 (T6), and 12 (T12) months post-transplantation and clinically followed for an average of 103 ± 60 months. At T6, 484 patients underwent an oral glucose tolerance test for the diagnosis of alterations in glucose metabolism (AMG+) or post-transplant diabetes mellitus (PTDM+). The prevalence of pre-transplant diabetes was 6.2%, with 22.4% of PTDM+ within the 1st year. Patients with AMG were older and exhibited altered lipid profiles, higher body mass index, and increased inflammatory indices. Age at transplantation, lipid profile, and inflammatory status were significant determinants of PTDM. Graft loss was unaffected by glucose metabolism alterations. Survival analysis demonstrated significantly worse long-term survival for KTxps with diabetes (pre- and PTDM+,
    Mesh-Begriff(e) Humans ; Kidney Transplantation/adverse effects ; Male ; Female ; Middle Aged ; Retrospective Studies ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/etiology ; Adult ; Glucose Tolerance Test ; Blood Glucose/metabolism ; Risk Factors ; Treatment Outcome ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Graft Survival ; Prevalence ; Aged ; Time Factors
    Chemische Substanzen Blood Glucose
    Sprache Englisch
    Erscheinungsdatum 2024-05-17
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16101520
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Corrigendum: Impact of hyperparathyroidism and its different subtypes on long term graft outcome: a single Transplant Center cohort study.

    Molinari, Paolo / Regalia, Anna / Leoni, Alessandro / Campise, Mariarosaria / Cresseri, Donata / Cicero, Elisa / Vettoretti, Simone / Nardelli, Luca / Brigati, Emilietta / Favi, Evaldo / Messa, Piergiorgio / Castellano, Giuseppe / Alfieri, Carlo M

    Frontiers in medicine

    2024  Band 11, Seite(n) 1362741

    Abstract: This corrects the article DOI: 10.3389/fmed.2023.1221086.]. ...

    Abstract [This corrects the article DOI: 10.3389/fmed.2023.1221086.].
    Sprache Englisch
    Erscheinungsdatum 2024-01-30
    Erscheinungsland Switzerland
    Dokumenttyp Published Erratum
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2024.1362741
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Rate and predictors of chronic organ damage accrual in active lupus nephritis: a single centre experience over 18 years of observation.

    Frontini, Giulia / Tamborini, Francesco / Porata, Giulia / Regalia, Anna / Binda, Valentina / Moroni, Gabriella

    Clinical and experimental rheumatology

    2021  Band 40, Heft 5, Seite(n) 872–881

    Abstract: Objectives: We aimed to identify the rates and predictors of chronic damage accrual and mortality in lupus nephritis (LN).: Methods: We retrospectively measured SLICC/ACR Damage Index (SDI) in biopsy proven active LN with at least 5 years follow-up. ... ...

    Abstract Objectives: We aimed to identify the rates and predictors of chronic damage accrual and mortality in lupus nephritis (LN).
    Methods: We retrospectively measured SLICC/ACR Damage Index (SDI) in biopsy proven active LN with at least 5 years follow-up. We searched for the predictors of first SDI increase and death at univariate and multivariate regression analysis. Then, we considered clinical/biochemical/histological features at diagnosis, corticosteroids dose and proportion of follow-up in complete renal remission.
    Results: 187 patients (91.4% females, age 28.1 years, 95.7% Caucasians) were included. After a median follow-up of 18.6 years, 26 patients (13.9%) died, 116 (62%) accrued damage. SDI annual rate has significantly reduced over the last decades (from a mean of 0.14±0.17 in 1970-1985, to 0.09±0.21 in 1986-2001, to 0.07±0.1 in 2002-2019; p=0.0032). SDI increases occurred more frequently in renal (22.5%), ocular (18.2%), cardiovascular, neuropsychiatric (13.4% both) and malignancy (12.8%) domains. First SDI increase free survival was 73.3%, 59.8%, 49.9% and 38% at 5,10,15 and 20 years. At multivariate analysis, hypertension (HR:1.699, CI:1.126-2.457, p=0.011), presentation with acute renal dysfunction (HR:1.587,CI:1.082-2.327, p=0.018) and average prednisone dose >5mg/day (HR:3.378, CI:1.984-5.751, p<0.0001) independently predicted damage. Achievement of complete renal remission (HR:0.993, CI:0.987-0.999, p<0.039) reduced the risk of damage. Age (HR:1.063, CI:1.027-1.099, p=0.0004), hypertension (HR:3.096, CI:1.211-7.912, p=0.019), and no immunosuppressors as maintenance therapy (HR:4.168, CI:1.212-14.336, p=0.024) predicted mortality at multivariate analysis.
    Conclusions: Besides arterial hypertension, presentation with acute renal dysfunction and corticosteroids dose predict SDI increase in LN, while achieving renal remission prevents damage. Aggressive therapy to induce remission in the acute phases of LN and low corticosteroids dose in maintenance therapy may prevent the increase of chronic damage.
    Mesh-Begriff(e) Adrenal Cortex Hormones/therapeutic use ; Adult ; Female ; Humans ; Hypertension ; Kidney/pathology ; Lupus Erythematosus, Systemic ; Lupus Nephritis/diagnosis ; Lupus Nephritis/drug therapy ; Lupus Nephritis/pathology ; Male ; Retrospective Studies ; Severity of Illness Index
    Chemische Substanzen Adrenal Cortex Hormones
    Sprache Englisch
    Erscheinungsdatum 2021-09-07
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/ig0lu0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2002: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Artikel: Vitamin D Status and SARS-CoV-2 Infection in a Cohort of Kidney Transplanted Patients

    Regalia, Anna / Benedetti, Matteo / Malvica, Silvia / Alfieri, Carlo / Campise, Mariarosaria / Cresseri, Donata / Gandolfo, Maria Teresa / Tripodi, Federica / Castellano, Giuseppe / Messa, Piergiorgio

    Nutrients. 2022 Jan. 13, v. 14, no. 2

    2022  

    Abstract: Background: Recently the protective role of 25-hydroxyvitamin D (25(OH)D) against viral infections has been hypothesized. We evaluated the association between vitamin D status and SARS-CoV-2 infection susceptibility and severity in a cohort of kidney ... ...

    Abstract Background: Recently the protective role of 25-hydroxyvitamin D (25(OH)D) against viral infections has been hypothesized. We evaluated the association between vitamin D status and SARS-CoV-2 infection susceptibility and severity in a cohort of kidney transplanted patients (KTxp). Methods: A total of 61 KTxp with SARS-CoV-2 infection (COV+) were matched with 122 healthy KTxp controls (COV−). Main biochemical parameters at 1, 6, and 12 months before SARS-CoV-2 infection were recorded. Vitamin D status was considered as the mean of two 25(OH)D measures obtained 6 ± 2 months apart during the last year. The severity of SARS-CoV-2 infection was based on the need for hospitalization (HOSP+) and death (D+). Results: 25(OH)D levels were lower in COV+ than in controls [19(12–26) vs. 23(17–31) ng/mL, p = 0.01]. No differences among the other biochemical parameters were found. The SARS-CoV-2 infection discriminative power of 25(OH)D was evaluated by ROC-curve (AUC 0.61, 95% CI 0.5–0.7, p = 0.01). 25(OH)D was not significantly different between HOSP+ and HOSP− [17(8–25) vs. 20(15–26) ng/mL, p = 0.19] and between D+ and D− [14(6–23) vs. 20(14–26) ng/mL, p = 0.22] and had no significant correlation with disease length. Conclusions: During the year preceding the infection, 25(OH)D levels were lower in COV+ KTxp in comparison with controls matched for demographic features and comorbidities. No significant association between vitamin D status and SARS-CoV-2 infection related outcomes was found.
    Schlagwörter Severe acute respiratory syndrome coronavirus 2 ; death ; kidneys ; protective effect
    Sprache Englisch
    Erscheinungsverlauf 2022-0113
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14020317
    Datenquelle NAL Katalog (AGRICOLA)

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  8. Artikel: Nutritional Vitamin D in Renal Transplant Patients: Speculations and Reality

    Messa, Piergiorgio / Regalia, Anna / Alfieri, Carlo Maria

    Nutrients. 2017 May 27, v. 9, no. 6

    2017  

    Abstract: Reduced levels of nutritional vitamin D are commonly observed in most chronic kidney disease (CKD) patients and particularly in patients who have received a kidney transplant (KTx). In the complex clinical scenario characterizing the recipients of a ... ...

    Abstract Reduced levels of nutritional vitamin D are commonly observed in most chronic kidney disease (CKD) patients and particularly in patients who have received a kidney transplant (KTx). In the complex clinical scenario characterizing the recipients of a renal graft, nutritional vitamin D deficiency has been put in relation not only to the changes of mineral and bone metabolism (MBM) after KTx, but also to most of the medical complications which burden KTx patients. In fact, referring to its alleged pleiotropic (non-MBM related) activities, vitamin D has been claimed to play some role in the occurrence of cardiovascular, metabolic, immunologic, neoplastic and infectious complications commonly observed in KTx recipients. Furthermore, low nutritional vitamin D levels have also been connected with graft dysfunction occurrence and progression. In this review, we will discuss the purported and the demonstrated effects of native vitamin D deficiency/insufficiency in most of the above mentioned fields, dealing separately with the MBM-related and the pleiotropic effects.
    Schlagwörter bone metabolism ; kidney diseases ; kidney transplant ; patients ; pleiotropy ; vitamin D ; vitamin D deficiency
    Sprache Englisch
    Erscheinungsverlauf 2017-0527
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu9060550
    Datenquelle NAL Katalog (AGRICOLA)

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  9. Artikel ; Online: Nutritional Vitamin D in Renal Transplant Patients: Speculations and Reality.

    Messa, Piergiorgio / Regalia, Anna / Alfieri, Carlo Maria

    Nutrients

    2017  Band 9, Heft 6

    Abstract: Reduced levels of nutritional vitamin D are commonly observed in most chronic kidney disease (CKD) patients and particularly in patients who have received a kidney transplant (KTx). In the complex clinical scenario characterizing the recipients of a ... ...

    Abstract Reduced levels of nutritional vitamin D are commonly observed in most chronic kidney disease (CKD) patients and particularly in patients who have received a kidney transplant (KTx). In the complex clinical scenario characterizing the recipients of a renal graft, nutritional vitamin D deficiency has been put in relation not only to the changes of mineral and bone metabolism (MBM) after KTx, but also to most of the medical complications which burden KTx patients. In fact, referring to its alleged pleiotropic (non-MBM related) activities, vitamin D has been claimed to play some role in the occurrence of cardiovascular, metabolic, immunologic, neoplastic and infectious complications commonly observed in KTx recipients. Furthermore, low nutritional vitamin D levels have also been connected with graft dysfunction occurrence and progression. In this review, we will discuss the purported and the demonstrated effects of native vitamin D deficiency/insufficiency in most of the above mentioned fields, dealing separately with the MBM-related and the pleiotropic effects.
    Sprache Englisch
    Erscheinungsdatum 2017-05-27
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu9060550
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Impact of hyperparathyroidism and its different subtypes on long term graft outcome: a single Transplant Center cohort study.

    Molinari, Paolo / Regalia, Anna / Leoni, Alessandro / Campise, Mariarosaria / Cresseri, Donata / Cicero, Elisa / Vettoretti, Simone / Nardelli, Luca / Brigati, Emilietta / Favi, Evaldo / Messa, Piergiorgio / Castellano, Giuseppe / Alfieri, Carlo M

    Frontiers in medicine

    2023  Band 10, Seite(n) 1221086

    Abstract: Purpose: We studied the association between parathormone (PTH) levels and long-term graft loss in RTx patients (RTx-p).: Methods: We retrospectively evaluated 871 RTx-p, transplanted in our unit from Jan-2004 to Dec-2020 assessing renal function and ... ...

    Abstract Purpose: We studied the association between parathormone (PTH) levels and long-term graft loss in RTx patients (RTx-p).
    Methods: We retrospectively evaluated 871 RTx-p, transplanted in our unit from Jan-2004 to Dec-2020 assessing renal function and mineral metabolism parameters at 1, 6, and 12 months after RTx. Graft loss and death with functioning graft during follow-up (FU, 8.3[5.4-11.4] years) were checked.
    Results: At month-1, 79% had HPT, of which 63% with secondary HPT (SHPT) and 16% tertiary HPT (THPT); at month-6, HPT prevalence was 80% of which SHPT 64% and THPT 16%; at month-12 HPT prevalence was 77% of which SHPT 62% and THPT 15%. A strong significant correlation was found between HPT type, PTH levels and graft loss at every time point. Mean PTH exposure remained strongly and independently associated to long term graft loss (OR 3.1 [1.4-7.1],
    Conclusion: High PTH levels during 1st year of RTx seem to be associated with long term graft loss.
    Sprache Englisch
    Erscheinungsdatum 2023-08-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1221086
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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