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  1. Artikel ; Online: Natural killer cells and BNT162b2 mRNA vaccine reactogenicity and durability.

    Graydon, Elizabeth K / Conner, Tonia L / Dunham, Kim / Olsen, Cara / Goguet, Emilie / Coggins, Si'Ana A / Rekedal, Marana / Samuels, Emily / Jackson-Thompson, Belinda / Moser, Matthew / Lindrose, Alyssa / Hollis-Perry, Monique / Wang, Gregory / Maiolatesi, Santina / Alcorta, Yolanda / Reyes, Anatalio / Wong, Mimi / Ramsey, Kathy / Davies, Julian /
    Parmelee, Edward / Ortega, Orlando / Sanchez, Mimi / Moller, Sydney / Inglefield, Jon / Tribble, David / Burgess, Timothy / O'Connell, Robert / Malloy, Allison M W / Pollett, Simon / Broder, Christopher C / Laing, Eric D / Anderson, Stephen K / Mitre, Edward

    Frontiers in immunology

    2023  Band 14, Seite(n) 1225025

    Abstract: Introduction: Natural killer (NK) cells can both amplify and regulate immune responses to vaccination. Studies in humans and animals have observed NK cell activation within days after mRNA vaccination. In this study, we sought to determine if baseline ... ...

    Abstract Introduction: Natural killer (NK) cells can both amplify and regulate immune responses to vaccination. Studies in humans and animals have observed NK cell activation within days after mRNA vaccination. In this study, we sought to determine if baseline NK cell frequencies, phenotype, or function correlate with antibody responses or inflammatory side effects induced by the Pfizer-BioNTech COVID-19 vaccine (BNT162b2).
    Methods: We analyzed serum and peripheral blood mononuclear cells (PBMCs) from 188 participants in the Prospective Assessment of SARS-CoV-2 Seroconversion study, an observational study evaluating immune responses in healthcare workers. Baseline serum samples and PBMCs were collected from all participants prior to any SARS-CoV-2 infection or vaccination. Spike-specific IgG antibodies were quantified at one and six months post-vaccination by microsphere-based multiplex immunoassay. NK cell frequencies and phenotypes were assessed on pre-vaccination PBMCs from all participants by multi-color flow cytometry, and on a subset of participants at time points after the 1
    Results: Key observations include: 1) circulating NK cells exhibit evidence of activation in the week following vaccination, 2) individuals with high symptom scores after 1
    Discussion: These results suggest that NK cell activation by BNT162b2 vaccination may contribute to vaccine-induced inflammatory symptoms and reduce durability of vaccine-induced antibody responses.
    Mesh-Begriff(e) Animals ; Humans ; BNT162 Vaccine ; Leukocytes, Mononuclear ; Prospective Studies ; COVID-19/prevention & control ; SARS-CoV-2 ; Drug-Related Side Effects and Adverse Reactions ; Immunoglobulin G ; mRNA Vaccines
    Chemische Substanzen BNT162 Vaccine ; Immunoglobulin G
    Sprache Englisch
    Erscheinungsdatum 2023-08-25
    Erscheinungsland Switzerland
    Dokumenttyp Observational Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1225025
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Immune and behavioral correlates of protection against symptomatic post-vaccination SARS-CoV-2 infection.

    Goguet, Emilie / Olsen, Cara H / Meyer, William A / Ansari, Sara / Powers, John H / Conner, Tonia L / Coggins, Si'Ana A / Wang, Wei / Wang, Richard / Illinik, Luca / Sanchez Edwards, Margaret / Jackson-Thompson, Belinda M / Hollis-Perry, Monique / Wang, Gregory / Alcorta, Yolanda / Wong, Mimi A / Saunders, David / Mohammed, Roshila / Balogun, Bolatito /
    Kobi, Priscilla / Kosh, Lakeesha / Bishop-Lilly, Kimberly / Cer, Regina Z / Arnold, Catherine E / Voegtly, Logan J / Fitzpatrick, Maren / Luquette, Andrea E / Malagon, Francisco / Ortega, Orlando / Parmelee, Edward / Davies, Julian / Lindrose, Alyssa R / Haines-Hull, Hannah / Moser, Matthew S / Samuels, Emily C / Rekedal, Marana S / Graydon, Elizabeth K / Malloy, Allison M W / Tribble, David R / Burgess, Timothy H / Campbell, Wesley / Robinson, Sara / Broder, Christopher C / O'Connell, Robert J / Weiss, Carol D / Pollett, Simon / Laing, Eric D / Mitre, Edward

    Frontiers in immunology

    2024  Band 15, Seite(n) 1287504

    Abstract: Introduction: We sought to determine pre-infection correlates of protection against SARS-CoV-2 post-vaccine inzfections (PVI) acquired during the first Omicron wave in the United States.: Methods: Serum and saliva samples from 176 vaccinated adults ... ...

    Abstract Introduction: We sought to determine pre-infection correlates of protection against SARS-CoV-2 post-vaccine inzfections (PVI) acquired during the first Omicron wave in the United States.
    Methods: Serum and saliva samples from 176 vaccinated adults were collected from October to December of 2021, immediately before the Omicron wave, and assessed for SARS-CoV-2 Spike-specific IgG and IgA binding antibodies (bAb). Sera were also assessed for bAb using commercial assays, and for neutralization activity against several SARS-CoV-2 variants. PVI duration and severity, as well as risk and precautionary behaviors, were assessed by questionnaires.
    Results: Serum anti-Spike IgG levels assessed by research assay, neutralization titers against Omicron subvariants, and low home risk scores correlated with protection against PVIs after multivariable regression analysis. Commercial assays did not perform as well as research assay, likely due to their lower dynamic range.
    Discussion: In the 32 participants that developed PVI, anti-Spike IgG bAbs correlated with lower disease severity and shorter duration of illness.
    Mesh-Begriff(e) Adult ; Humans ; COVID-19/prevention & control ; SARS-CoV-2 ; COVID-19 Vaccines ; Antibodies, Viral ; Immunoglobulin G
    Chemische Substanzen COVID-19 Vaccines ; Antibodies, Viral ; Immunoglobulin G
    Sprache Englisch
    Erscheinungsdatum 2024-03-19
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1287504
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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