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  1. Article ; Online: Complications of moderate sedation versus monitored anesthesia care in endoscopic retrograde cholangiopancreatography: A retrospective analysis.

    Ren, Aolin / Ni, Jingbin / Wang, Dutian / Zhu, Minmin

    Asian journal of surgery

    2023  Volume 46, Issue 7, Page(s) 2842–2843

    MeSH term(s) Humans ; Cholangiopancreatography, Endoscopic Retrograde/adverse effects ; Conscious Sedation/adverse effects ; Retrospective Studies ; Anesthesia/adverse effects ; Pancreatitis/etiology
    Language English
    Publishing date 2023-02-02
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.01.067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2831: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Association between reversal agents (sugammadex vs. neostigmine) for neuromuscular block and postoperative pulmonary complications: A retrospective analysis.

    Ren, Aolin / Fan, Meihan / Gu, Zhen / Liang, Xiao / Xu, Liuhang / Liu, Chengjun / Wang, Dutian / Chang, Hanxuan / Zhu, Minmin

    British journal of clinical pharmacology

    2024  

    Abstract: Aims: Residual neuromuscular blockade has been linked to pulmonary complications in the postoperative period. This study aimed to determine whether sugammadex was associated with a lower risk of postoperative pulmonary complications (PPCs) compared with ...

    Abstract Aims: Residual neuromuscular blockade has been linked to pulmonary complications in the postoperative period. This study aimed to determine whether sugammadex was associated with a lower risk of postoperative pulmonary complications (PPCs) compared with neostigmine.
    Methods: This retrospective cohort study was conducted in a tertiary academic medical center. Patients ≥18 year of age undergoing noncardiac surgical procedures with general anesthesia and mechanical ventilation were enrolled between January 2019 and September 2021. We identified all patients receiving rocuronium and reversal with neostigmine or sugammadex via electronic medical record review. The primary endpoint was a composite of PPCs (including pneumonia, atelectasis, respiratory failure, pulmonary embolism, pleural effusion, or pneumothorax). The incidence of PPCs was compared using propensity score analysis.
    Results: A total of 1786 patients were included in this study. Among these patients, 976 (54.6%) received neostigmine, and 810 (45.4%) received sugammadex. In the whole sample, PPCs occurred in 81 (4.54%) subjects (7.04% sugammadex vs. 2.46% neostigmine). Baseline covariates were well balanced between groups after overlap weighting. Patients in the sugammadex group had similar risk (overlap weighting OR: 0.75; 95% CI: 0.40 to 1.41) compared to neostigmine. The sensitivity analysis showed consistent results. In subgroup analysis, the interaction P-value for the reversal agents stratified by surgery duration was 0.011.
    Conclusion: There was no significant difference in the rate of PPCs when the neuromuscular blockade was reversed with sugammadex compared to neostigmine. Patients undergoing prolonged surgery may benefit from sugammadex, which needs to be further investigated.
    Language English
    Publishing date 2024-04-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.16056
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    Zs.A 1118: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Sevoflurane enhances autophagy via Rac1 to attenuate lung ischaemia‒reperfusion injury.

    Ding, Xian / Gao, Xiang / Ren, Aolin / Xu, Jingjing / Jiang, Xuliang / Liang, Xiao / Xie, Kangjie / Zhou, Yan / Hu, Chunxiao / Huang, Dongxiao

    Chemico-biological interactions

    2024  Volume 397, Page(s) 111078

    Abstract: Sevoflurane can attenuate lung ischaemia‒reperfusion injury (LIRI). However, the protective mechanism is unclear. In this study, we developed a LIRI model in vivo that animals (SD, n = 15) were subjected to the administration of 2.2 % sevoflurane 30 min ... ...

    Abstract Sevoflurane can attenuate lung ischaemia‒reperfusion injury (LIRI). However, the protective mechanism is unclear. In this study, we developed a LIRI model in vivo that animals (SD, n = 15) were subjected to the administration of 2.2 % sevoflurane 30 min before the onset of left pulmonary artery clamping for 45 min, which was then followed by 60 min of reperfusion treatment. Then, transcriptome sequencing was used to analyse lung tissues. Autophagy inhibition (3-MA) and Rac1-overexpression transfection plasmids were used in BEAS-2B cells, and BEAS-2B cells were subjected to hypoxia reoxygenation (H/R) and sevoflurane treatment. In both animal tissue and cells, inflammatory cytokines and apoptotic and autophagy molecules were measured by quantitative real-time PCR, western blotting and immunostaining. As a result, decreased arterial partial oxygen and damage to the histological structure of lung tissues were observed in LIRI model rats, and these effects were reversed by sevoflurane treatment. Activation of inflammation (elevated IL-1β, IL-6, and TNF-α) and apoptosis (elevated cleaved caspase3/caspase3 and Bax, degraded expression of Bcl2) and inhibition of autophagy (elevated P62, degraded expression of Beclin1 and LC3-II/LC3I) in the model group were ameliorated by sevoflurane. Transcriptome sequencing indicated that the PI3K/Akt pathway regulated by Rac1 plays an important role in LIRI. Furthermore, overexpression of Rac1 in a cell line inhibited the protective effect of sevoflurane in LIRI. Autophagy inhibition (3-MA) also prevented the protective effect of sevoflurane on inflammation and apoptosis. As shown in the present study, sevoflurane enhances autophagy via Rac1/PI3K/AKT signalling to attenuate lung ischaemia‒reperfusion injury.
    Language English
    Publishing date 2024-05-28
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 218799-1
    ISSN 1872-7786 ; 0009-2797
    ISSN (online) 1872-7786
    ISSN 0009-2797
    DOI 10.1016/j.cbi.2024.111078
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    Zs.A 686: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: In Reference to Effects of Preoperative Anxiety on Postoperative Delirium in Elderly Patients [Response to Letter].

    Ren, Aolin / Zhang, Na / Zhu, He / Zhou, Kang / Cao, Yuan / Liu, Jindong

    Clinical interventions in aging

    2021  Volume 16, Page(s) 939–940

    MeSH term(s) Aged ; Anxiety ; Anxiety Disorders ; Delirium ; Humans
    Language English
    Publishing date 2021-05-25
    Publishing country New Zealand
    Document type Letter ; Comment
    ZDB-ID 2364924-0
    ISSN 1178-1998 ; 1176-9092
    ISSN (online) 1178-1998
    ISSN 1176-9092
    DOI 10.2147/CIA.S319574
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    Zs.A 6742: Show issues Location:
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  5. Article ; Online: Effects of Preoperative Anxiety on Postoperative Delirium in Elderly Patients Undergoing Elective Orthopedic Surgery: A Prospective Observational Cohort Study.

    Ren, Aolin / Zhang, Na / Zhu, He / Zhou, Kang / Cao, Yuan / Liu, Jindong

    Clinical interventions in aging

    2021  Volume 16, Page(s) 549–557

    Abstract: Background: Postoperative delirium (POD) is common and has negative effects on elderly patients. There is a critical need to identify patients at high risk of POD so that providers can better offer targeted interventions in the preoperative and ... ...

    Abstract Background: Postoperative delirium (POD) is common and has negative effects on elderly patients. There is a critical need to identify patients at high risk of POD so that providers can better offer targeted interventions in the preoperative and intraoperative periods. We aimed to characterize the prevalence of preoperative anxiety and investigate whether preoperative anxiety predicted the onset of POD in elderly patients undergoing elective orthopedic surgery.
    Methods: We conducted a prospective observational cohort study of elderly patients (aged 65 years or older) undergoing elective orthopedic surgery. Preoperative anxiety was assessed using the Hospital Anxiety and Depression Scale-Anxiety (HADS-A), with clinically significant values defined as HADS-A>7. POD was diagnosed according to the Confusion Assessment Method (CAM) criteria on the 5 postoperative days. To determine the independent risk factors for POD, multivariable logistic regression was conducted, including those variables with a p-value <0.05 at univariate analysis.
    Results: There were 263 patients included in the study. Seventy-three (27.8%) patients were diagnosed to be POD. Median duration of delirium was 2 days. Forty (15.2%) patients were assessed to experience preoperative anxiety. The occurrence of preoperative anxiety in total hip arthroplasty (THA), proximal femoral nail antirotation (PFNA), and total knee arthroplasty (TKA) was 12.5%, 16.1%, and 19.5%, respectively. Based on multivariable analysis, only age (odds ratio [OR]= 1.099, 95% Confidence Interval [CI]: 1.013-1.192;
    Conclusion: In conclusion, the current study reveals that preoperative anxiety helps to predict the risk of POD in elderly patients undergoing elective orthopedic surgery. Relieving preoperative anxiety could be a new target for preventive interventions to reduce POD.
    MeSH term(s) Aged ; Aged, 80 and over ; Anxiety/epidemiology ; Cohort Studies ; Delirium/epidemiology ; Elective Surgical Procedures/adverse effects ; Female ; Humans ; Logistic Models ; Male ; Mental Status and Dementia Tests ; Odds Ratio ; Orthopedic Procedures/adverse effects ; Postoperative Complications/epidemiology ; Prospective Studies ; Risk Factors
    Language English
    Publishing date 2021-03-26
    Publishing country New Zealand
    Document type Journal Article ; Observational Study
    ZDB-ID 2364924-0
    ISSN 1178-1998 ; 1176-9092
    ISSN (online) 1178-1998
    ISSN 1176-9092
    DOI 10.2147/CIA.S300639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6742: Show issues Location:
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  6. Article ; Online: Impact of Dexmedetomidine Infusion on Postoperative Acute Kidney Injury in Elderly Patients Undergoing Major Joint Replacement: A Retrospective Cohort Study.

    Zhu, He / Ren, Aolin / Zhou, Kang / Chen, Qiuchong / Zhang, Mengjun / Liu, Jindong

    Drug design, development and therapy

    2020  Volume 14, Page(s) 4695–4701

    Abstract: Purpose: Postoperative acute kidney injury (AKI) is a frequent complication in elderly patients that increases morbidity and mortality. Approximately 1.7 million people die from AKI worldwide every year. Dexmedetomidine (Dex) is often used as an adjunct ...

    Abstract Purpose: Postoperative acute kidney injury (AKI) is a frequent complication in elderly patients that increases morbidity and mortality. Approximately 1.7 million people die from AKI worldwide every year. Dexmedetomidine (Dex) is often used as an adjunct to multimodal analgesia. Our study investigated whether Dex could safely decrease the incidence of AKI in elderly patients undergoing major joint replacement.
    Methods: A single-center retrospective study was conducted in patients aged >65 years undergoing major joint replacement. Propensity score-matching analysis was used, and a total of 1,006 patients were matched successfully. The primary outcome was the incidence of postoperative AKI. Secondary outcomes included perioperative adverse complications, opioid consumption, time to extubation, and length of hospital stay.
    Results: Among the 1,006 patients included, postoperative AKI occurred in 9.3% (n=94). The Dex group (perioperative Dex infusion) had lower incidence of postoperative AKI than the control group (7.2% vs 11.5%,
    Conclusion: This retrospective study showed Dex infusion in elderly patients undergoing major joint replacement was associated with lower incidence of postoperative AKI, less opioid consumption, and shorter extubation time and hospital stay. However, the Dex group had higher incidence of bradycardia. We found no statistical differences in other perioperative adverse complications between the groups.
    MeSH term(s) Acute Kidney Injury/complications ; Acute Kidney Injury/drug therapy ; Acute Kidney Injury/surgery ; Aged ; Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/therapeutic use ; Arthroplasty, Replacement/adverse effects ; Cohort Studies ; Dexmedetomidine/administration & dosage ; Dexmedetomidine/therapeutic use ; Female ; Humans ; Infusions, Intravenous ; Male ; Postoperative Period ; Retrospective Studies
    Chemical Substances Analgesics, Opioid ; Dexmedetomidine (67VB76HONO)
    Language English
    Publishing date 2020-11-02
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2451346-5
    ISSN 1177-8881 ; 1177-8881
    ISSN (online) 1177-8881
    ISSN 1177-8881
    DOI 10.2147/DDDT.S278342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The correlation between intraoperative renal resistive index and cardiac surgery-associated acute kidney injury - A pilot, prospective, observational, single center study.

    Zhou, Kang / Ren, Aolin / Zhu, He / Zhang, Hui / Li, Qing / Liu, Jindong

    Journal of clinical anesthesia

    2020  Volume 67, Page(s) 110066

    MeSH term(s) Acute Kidney Injury/etiology ; Cardiac Surgical Procedures/adverse effects ; Humans ; Kidney/diagnostic imaging ; Prospective Studies
    Language English
    Publishing date 2020-09-23
    Publishing country United States
    Document type Letter ; Observational Study
    ZDB-ID 1011618-7
    ISSN 1873-4529 ; 0952-8180
    ISSN (online) 1873-4529
    ISSN 0952-8180
    DOI 10.1016/j.jclinane.2020.110066
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    Zs.A 2622: Show issues Location:
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