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  1. Artikel ; Online: Glycerol as a precursor for hepatic de novo glutathione synthesis in human liver.

    Jin, Eunsook S / Malloy, Craig R / Sharma, Gaurav / Finn, Erin / Fuller, Kelly N Z / Reyes, Yesenia Garcia / Lovell, Mark A / Derderian, Sarkis C / Schoen, Jonathan A / Inge, Thomas H / Cree, Melanie G

    Redox biology

    2023  Band 63, Seite(n) 102749

    Abstract: Background: Glycerol is a substrate for gluconeogenesis and fatty acid esterification in the liver, processes which are upregulated in obesity and may contribute to excess fat accumulation. Glycine and glutamate, in addition to cysteine, are components ... ...

    Abstract Background: Glycerol is a substrate for gluconeogenesis and fatty acid esterification in the liver, processes which are upregulated in obesity and may contribute to excess fat accumulation. Glycine and glutamate, in addition to cysteine, are components of glutathione, the major antioxidant in the liver. In principle, glycerol could be incorporated into glutathione via the TCA cycle or 3-phosphoglycerate, but it is unknown whether glycerol contributes to hepatic de novo glutathione biosynthesis.
    Methods: Glycerol metabolism to hepatic metabolic products including glutathione was examined in the liver from adolescents undergoing bariatric surgery. Participants received oral [U-
    Results: Data were collected from 8 participants (2 male, 6 female; age 17.1 years [range 14-19]; BMI 47.4 kg/m
    Conclusions: This is the first report of glycerol incorporation into glutathione through glycine or glutamate metabolism in human liver. This could represent a compensatory mechanism to increase glutathione in the setting of excess glycerol delivery to the liver.
    Mesh-Begriff(e) Humans ; Liver/metabolism ; Glutathione/metabolism ; Glycerol/metabolism ; Male ; Female ; Adolescent ; Young Adult ; Magnetic Resonance Spectroscopy
    Chemische Substanzen Glutathione (GAN16C9B8O) ; Glycerol (PDC6A3C0OX)
    Sprache Englisch
    Erscheinungsdatum 2023-05-16
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2023.102749
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study.

    Wiromrat, Pattara / Bjornstad, Petter / Roncal, Carlos / Cree-Green, Melanie / Baumgartner, Amy / Coe, Gregory / Reyes, Yesenia Garcia / Schäfer, Michal / Truong, Uyen / Pyle, Laura / Johnson, Richard J / Nadeau, Kristen J

    Journal of diabetes and its complications

    2019  Band 33, Heft 6, Seite(n) 434–436

    Abstract: Youth with type 1 diabetes (T1D) carry greater cardiovascular disease (CVD) risk than their nondiabetic peers. Low serum uromodulin (SUMOD) associates with increased CVD mortality in adults. We found that T1D youth have low SUMOD. Lower SUMOD correlated ... ...

    Abstract Youth with type 1 diabetes (T1D) carry greater cardiovascular disease (CVD) risk than their nondiabetic peers. Low serum uromodulin (SUMOD) associates with increased CVD mortality in adults. We found that T1D youth have low SUMOD. Lower SUMOD correlated with aortic stiffness, suggesting its potential as a CVD biomarker in T1D.
    Mesh-Begriff(e) Adolescent ; Adult ; Aorta/diagnostic imaging ; Aorta/physiology ; Biomarkers/blood ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Child ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 1/physiopathology ; Diabetic Angiopathies/blood ; Diabetic Angiopathies/etiology ; Diabetic Angiopathies/prevention & control ; Female ; Glomerular Filtration Rate ; Humans ; Male ; Metformin/therapeutic use ; Pulse Wave Analysis ; Risk Factors ; Treatment Outcome ; Uromodulin/blood ; Vascular Stiffness/drug effects ; Young Adult
    Chemische Substanzen Biomarkers ; Uromodulin ; Metformin (9100L32L2N)
    Sprache Englisch
    Erscheinungsdatum 2019-03-21
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1105840-7
    ISSN 1873-460X ; 1056-8727
    ISSN (online) 1873-460X
    ISSN 1056-8727
    DOI 10.1016/j.jdiacomp.2019.03.001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Achieving ADA/ISPAD clinical guideline goals is associated with higher insulin sensitivity and cardiopulmonary fitness in adolescents with type 1 diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) Studies.

    Bjornstad, Petter / Cree-Green, Melanie / Baumgartner, Amy / Coe, Gregory / Reyes, Yesenia Garcia / Schäfer, Michal / Pyle, Laura / Regensteiner, Judith G / Reusch, Jane Eb / Nadeau, Kristen J

    Pediatric diabetes

    2017  Band 19, Heft 3, Seite(n) 436–442

    Abstract: Objective: Most youth with type 1 diabetes do not meet the American Diabetes Association (ADA) and International Society for Pediatric and Adolescent Diabetes (ISPAD) targets for hemoglobin A1c (HbA1c), blood pressure (BP), lipids, and body mass index ( ... ...

    Abstract Objective: Most youth with type 1 diabetes do not meet the American Diabetes Association (ADA) and International Society for Pediatric and Adolescent Diabetes (ISPAD) targets for hemoglobin A1c (HbA1c), blood pressure (BP), lipids, and body mass index (BMI). We hypothesized that ISPAD/ADA goal achievement would be associated with better insulin sensitivity (IS) and cardiopulmonary fitness.
    Methods: IS was quantified as glucose infusion rate (GIR) from a hyperinsulinemic-euglycemic clamp in youth with type 1 diabetes from the RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) (n = 86) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) (n = 41) cohorts (n = 127; age 15.7 ± 2.2 years, 52% girls). Cardiopulmonary fitness was measured as peak oxygen consumption (VO
    Results: IS was lower in youth who met 0-3 goals (5.2 ± 3.4 mg/kg/min) vs those who met 4 goals (7.4 ± 4.1 mg/kg/min, P = .04) and those who met 5-6 goals (8.5 ± 4.3 mg/kg/min, P = .003), and remained significant after adjustments for sex and diabetes duration. Upright VO
    Conclusions: ADA/ISPAD goal achievement was associated with greater IS and cardiopulmonary fitness.
    Mesh-Begriff(e) Adolescent ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/drug therapy ; Female ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin Resistance ; Male ; Oxygen Consumption ; Practice Guidelines as Topic ; Young Adult
    Chemische Substanzen Hypoglycemic Agents
    Sprache Englisch
    Erscheinungsdatum 2017-10-30
    Erscheinungsland Denmark
    Dokumenttyp Clinical Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1502504-4
    ISSN 1399-5448 ; 1745-1426 ; 1399-543X
    ISSN (online) 1399-5448
    ISSN 1745-1426 ; 1399-543X
    DOI 10.1111/pedi.12598
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 5422: Hefte anzeigen Standort:
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  4. Artikel ; Online: Leptin is associated with cardiopulmonary fitness independent of body-mass index and insulin sensitivity in adolescents with type 1 diabetes: a brief report from the EMERALD study.

    Bjornstad, Petter / Cree-Green, Melanie / Baumgartner, Amy / Coe, Gregory / Reyes, Yesenia Garcia / Schafer, Michal / Pyle, Laura / Regensteiner, Judith G / Reusch, Jane E B / Nadeau, Kristen J

    Journal of diabetes and its complications

    2017  Band 31, Heft 5, Seite(n) 850–853

    Abstract: Cardiopulmonary fitness is decreased in type 1 diabetes for reasons that are incompletely understood. In this study, leptin was associated with exercise capacity independent of insulin sensitivity (IS) and body mass index (BMI), suggesting that leptin ... ...

    Abstract Cardiopulmonary fitness is decreased in type 1 diabetes for reasons that are incompletely understood. In this study, leptin was associated with exercise capacity independent of insulin sensitivity (IS) and body mass index (BMI), suggesting that leptin may relate to cardiopulmonary fitness by mechanisms beyond IS and/or obesity.
    Mesh-Begriff(e) Adiposity ; Adolescent ; Adult ; Biomarkers/blood ; Body Mass Index ; Cardiorespiratory Fitness ; Child ; Colorado ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/metabolism ; Diabetes Mellitus, Type 1/physiopathology ; Exercise Tolerance ; Female ; Humans ; Insulin Resistance ; Leptin/blood ; Male ; Overweight/complications ; Oxygen Consumption ; Pediatric Obesity/complications ; Sex Characteristics ; Young Adult
    Chemische Substanzen Biomarkers ; Leptin
    Sprache Englisch
    Erscheinungsdatum 2017-03-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1105840-7
    ISSN 1873-460X ; 1056-8727
    ISSN (online) 1873-460X
    ISSN 1056-8727
    DOI 10.1016/j.jdiacomp.2017.02.019
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2225: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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