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  1. Artikel ; Online: Improving the efficacy of peptide vaccines in cancer immunotherapy.

    Zahedipour, Fatemeh / Jamialahmadi, Khadijeh / Zamani, Parvin / Reza Jaafari, Mahmoud

    International immunopharmacology

    2023  Band 123, Seite(n) 110721

    Abstract: Peptide vaccines have shown great potential in cancer immunotherapy by targeting tumor antigens and activating the patient's immune system to mount a specific response against cancer cells. However, the efficacy of peptide vaccines in inducing a ... ...

    Abstract Peptide vaccines have shown great potential in cancer immunotherapy by targeting tumor antigens and activating the patient's immune system to mount a specific response against cancer cells. However, the efficacy of peptide vaccines in inducing a sustained immune response and achieving clinical benefit remains a major challenge. In this review, we discuss the current status of peptide vaccines in cancer immunotherapy and strategies to improve their efficacy. We summarize the recent advancements in the development of peptide vaccines in pre-clinical and clinical settings, including the use of novel adjuvants, neoantigens, nano-delivery systems, and combination therapies. We also highlight the importance of personalized cancer vaccines, which consider the unique genetic and immunological profiles of individual patients. We also discuss the strategies to enhance the immunogenicity of peptide vaccines such as multivalent peptides, conjugated peptides, fusion proteins, and self-assembled peptides. Although, peptide vaccines alone are weak immunogens, combining peptide vaccines with other immunotherapeutic approaches and developing novel approaches such as personalized vaccines can be promising methods to significantly enhance their efficacy and improve the clinical outcomes for cancer patients.
    Mesh-Begriff(e) Humans ; Neoplasms ; Antigens, Neoplasm ; Cancer Vaccines ; Vaccines, Subunit/therapeutic use ; Immunotherapy ; Peptides/therapeutic use
    Chemische Substanzen Antigens, Neoplasm ; Cancer Vaccines ; Vaccines, Subunit ; Peptides
    Sprache Englisch
    Erscheinungsdatum 2023-08-03
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2023.110721
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Nanocarriers Call the Last Shot in the Treatment of Brain Cancers.

    Mehrabian, Amin / Mashreghi, Mohammad / Dadpour, Saba / Badiee, Ali / Arabi, Leila / Hoda Alavizadeh, Seyedeh / Alia Moosavian, Seyedeh / Reza Jaafari, Mahmoud

    Technology in cancer research & treatment

    2022  Band 21, Seite(n) 15330338221080974

    Abstract: Our brain is protected by physio-biological barriers. The blood-brain barrier (BBB) main mechanism of protection relates to the abundance of tight junctions (TJs) and efflux pumps. Although BBB is crucial for healthy brain protection against toxins, it ... ...

    Abstract Our brain is protected by physio-biological barriers. The blood-brain barrier (BBB) main mechanism of protection relates to the abundance of tight junctions (TJs) and efflux pumps. Although BBB is crucial for healthy brain protection against toxins, it also leads to failure in a devastating disease like brain cancer. Recently, nanocarriers have been shown to pass through the BBB and improve patients' survival rates, thus becoming promising treatment strategies. Among nanocarriers, inorganic nanocarriers, solid lipid nanoparticles, liposomes, polymers, micelles, and dendrimers have reached clinical trials after delivering promising results in preclinical investigations. The size of these nanocarriers is between 10 and 1000
    Mesh-Begriff(e) Brain/metabolism ; Brain Neoplasms/drug therapy ; Brain Neoplasms/metabolism ; Drug Delivery Systems/methods ; Humans ; Liposomes/metabolism ; Nanoparticles/chemistry
    Chemische Substanzen Lipid Nanoparticles ; Liposomes
    Sprache Englisch
    Erscheinungsdatum 2022-03-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2146365-7
    ISSN 1533-0338 ; 1533-0346
    ISSN (online) 1533-0338
    ISSN 1533-0346
    DOI 10.1177/15330338221080974
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Improved photostability, reduced skin permeation and irritation of isotretinoin by solid lipid nanoparticles.

    Shiva, Golmohammadzadeh / Somaye, Mortezania / Reza, Jaafari Mahmoud

    Acta pharmaceutica (Zagreb, Croatia)

    2012  Band 62, Heft 4, Seite(n) 547–562

    Abstract: The aim of this study was to develop new solid lipid nanoparticles of isotretinoin (IT-SLNs) and evaluate the ability of IT-SLNs to improve photostability, reduce skin permeation and irritating effects. IT-SLNs were prepared by the hot high pressure ... ...

    Abstract The aim of this study was to develop new solid lipid nanoparticles of isotretinoin (IT-SLNs) and evaluate the ability of IT-SLNs to improve photostability, reduce skin permeation and irritating effects. IT-SLNs were prepared by the hot high pressure homogenization method. Size, zeta potential and morphological characteristics of the preparations were assessed by transmission electron microscopy (TEM) and thermotropic properties with differential scanning calorimetry (DSC). IT-SLNs had a small average diameter of 74.05 ± 8.91 nm and high encapsulation efficiency (EE) of 80.6 ± 1.2 %. The results showed that the entrapment of IT into SLNs reduced significantly its photodegradation. The in vitro permeation data showed that IT-SLNs can accumulate in the different layers of the skin and prevent systemic uptake of IT in mouse skin. IT-SLNs also significantly increased IT accumulation in the different layers of the stratum corneum of human skin. IT-SLN formulation was significantly less irritating compared to commercial IT-GEL, which shows its potential for improving skin tolerability and being a carrier for topical delivery of IT.
    Mesh-Begriff(e) Animals ; Calorimetry, Differential Scanning ; Drug Carriers/administration & dosage ; Drug Carriers/analysis ; Drug Carriers/metabolism ; Drug Delivery Systems/methods ; Drug Stability ; Glycerides ; Humans ; Isotretinoin/administration & dosage ; Isotretinoin/chemistry ; Isotretinoin/pharmacokinetics ; Lipids/chemistry ; Mice ; Microscopy, Electron, Transmission ; Nanoparticles/administration & dosage ; Nanoparticles/analysis ; Photolysis ; Polysorbates ; Rabbits ; Skin/metabolism ; Skin Absorption ; Skin Irritancy Tests
    Chemische Substanzen Drug Carriers ; Glycerides ; Lipids ; Polysorbates ; glyceryl monostearate (230OU9XXE4) ; Isotretinoin (EH28UP18IF)
    Sprache Englisch
    Erscheinungsdatum 2012-12
    Erscheinungsland Croatia
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1111806-4
    ISSN 1846-9558 ; 1330-0075
    ISSN (online) 1846-9558
    ISSN 1330-0075
    DOI 10.2478/v10007-012-0032-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Preparation and characterization of different liposomal formulations containing P5 HER2/neu-derived peptide and evaluation of their immunological responses and antitumor effects.

    Shariat, Sheida / Badiee, Ali / Amir Jalali, Seyed / Mansourian, Mercedeh / Alireza Mortazavi, Seyed / Reza Jaafari, Mahmoud

    Iranian journal of basic medical sciences

    2015  Band 18, Heft 5, Seite(n) 506–513

    Abstract: Objectives: Tumor-associated antigen (TAA) subunit-based vaccines constitute promising tools for anticancer immunotherapy. However, a major limitation in the development of such vaccines is the poor immunogenicity of peptides when used alone. The aim of ...

    Abstract Objectives: Tumor-associated antigen (TAA) subunit-based vaccines constitute promising tools for anticancer immunotherapy. However, a major limitation in the development of such vaccines is the poor immunogenicity of peptides when used alone. The aim of this study was to develop an efficient vaccine delivery system and adjuvant to enhance anti-tumor activity of a synthetic HER2/neu derived peptide (P5).
    Materials and methods: P5 peptide was encapsulated with different liposomal formulations composed of DMPC:DMPG:Chol:DOPE and loaded with monophosphoryl lipid A (MPL). All formulations were characterized for their physicochemical properties. To evaluate vaccine efficacy, BALB/c mice were first immunized with free peptide or liposomal formulations, then, inoculated with a subcutaneous injection of TUBO tumor cells. Enzyme-linked immunospot, cytotoxicity and intracellular cytokine assays, as well as tumor size and animal survival analysis, were performed to evaluate the immune responses.
    Results: The results demonstrated that P5 encapsulated into liposomal formulations was not able to induce CD8 and CD4 T cells to produce IFN-γ. That is why, a potent CTL response and antitumor immunity was not induced.
    Conclusion: The Lip-DOPE-P5-MPL formulation in spite of using pH-sensitive lipid to direct intracellular trafficking of peptide to MHC I presentation pathway and MPL to enhance peptide adjuvanticity was interesting. The failure in inducing anti-tumor immunity may be attributed to low uptake of anionic conventional liposomes by dendritic cells (DCs) that have negative surface charge.
    Sprache Englisch
    Erscheinungsdatum 2015-06-09
    Erscheinungsland Iran
    Dokumenttyp Journal Article
    ZDB-ID 2500485-2
    ISSN 2008-3874 ; 2008-3866
    ISSN (online) 2008-3874
    ISSN 2008-3866
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Phylogenetic Analysis of Selected Menthol-Producing Species Belonging to the Lamiaceae Family.

    Mirzaei, Motahareh / Mirzaei, Hamed / Sahebkar, Amirhossein / Bagherian, Ali / Masoud Khoi, Mohammad Jaber / Reza Mirzaei, Hamid / Salehi, Rasoul / Reza Jaafari, Mahmoud / Kazemi Oskuee, Reza

    Nucleosides, nucleotides & nucleic acids

    2015  Band 34, Heft 9, Seite(n) 650–657

    Abstract: Menthol is an organic compound with diverse medicinal and commercial applications, and is made either synthetically or through extraction from mint oils. The aim of the present study was to investigate menthol levels in selected menthol-producing species ...

    Abstract Menthol is an organic compound with diverse medicinal and commercial applications, and is made either synthetically or through extraction from mint oils. The aim of the present study was to investigate menthol levels in selected menthol-producing species belonging to the Lamiaceae family, and to determine phylogenetic relationships of menthol dehydrogenase gene sequence among these species. Three genus of Lamiaceae, namely Mentha, Salvia, and Micromeria, were selected for phytochemical and phylogenetic analyses. After identification of each species based on menthol dehydrogenase gene in NCBI, BLAST software was used for the sequence alignment. MEGA4 software was used to draw phylogenetic tree for various species. Phytochemical analysis revealed that the highest and lowest amounts of both essential oil and menthol belonged to Mentha spicata and Micromeria hyssopifolia, respectively. The species Mentha spicata and Mentha piperita, which were assigned to one cluster in the dendrogram, contained the highest amounts of essential oil and menthol while Micromeria species, which was in the distinct cluster and placed in the farther evolutionary distance, contained the lowest amount of essential oil and menthol. Phylogenetic and phytochemistry analyses showed that essential oil and menthol contents of menthol-producing species are associated with menthol dehydrogenase gene sequence.
    Mesh-Begriff(e) Genes, Plant ; Lamiaceae/chemistry ; Lamiaceae/classification ; Lamiaceae/genetics ; Lamiaceae/metabolism ; Menthol/chemistry ; Menthol/metabolism ; Oils, Volatile/chemistry ; Oils, Volatile/metabolism ; Phylogeny
    Chemische Substanzen Oils, Volatile ; Menthol (1490-04-6)
    Sprache Englisch
    Erscheinungsdatum 2015
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2008956-9
    ISSN 1532-2335 ; 1525-7770
    ISSN (online) 1532-2335
    ISSN 1525-7770
    DOI 10.1080/15257770.2015.1047030
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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