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Artikel ; Online: Production of Toxins by the Gut Microbiota: The Role of Dietary Protein.

Alvarenga, Livia / Kemp, Julie A / Baptista, Beatriz G / Ribeiro, Marcia / Lima, Ligia Soares / Mafra, Denise

Current nutrition reports

2024 Band 13, Heft 2, Seite(n) 340–350

Abstract: Purpose of review: This narrative review will discuss how the intake of specific protein sources (animal and vegetable) providing specific amino acids can modulate the gut microbiota composition and generate toxins. A better understanding of these ... ...

Abstract	Purpose of review: This narrative review will discuss how the intake of specific protein sources (animal and vegetable) providing specific amino acids can modulate the gut microbiota composition and generate toxins. A better understanding of these interactions could lead to more appropriate dietary recommendations to improve gut health and mitigate the risk of complications promoted by the toxic metabolites formed by the gut microbiota. Recent findings: Gut microbiota is vital in maintaining human health by influencing immune function and key metabolic pathways. Under unfavorable conditions, the gut microbiota can produce excess toxins, which contribute to inflammation and the breakdown of the integrity of the intestinal barrier. Genetic and environmental factors influence gut microbiota diversity, with diet playing a crucial role. Emerging evidence indicates that the gut microbiota significantly metabolizes amino acids from dietary proteins, producing various metabolites with beneficial and harmful effects. Amino acids such as choline, betaine, l-carnitine, tyrosine, phenylalanine, and tryptophan can increase the production of uremic toxins when metabolized by intestinal bacteria. The type of food source that provides these amino acids affects the production of toxins. Plant-based diets and dietary fiber are associated with lower toxin formation than animal-based diets due to the high amino acid precursors in animal proteins.
Mesh-Begriff(e)	Humans ; Gastrointestinal Microbiome ; Dietary Proteins/metabolism ; Amino Acids/metabolism ; Diet ; Animals ; Uremic Toxins ; Dietary Fiber ; Plant Proteins, Dietary ; Toxins, Biological
Chemische Substanzen	Dietary Proteins ; Amino Acids ; Uremic Toxins ; Dietary Fiber ; Plant Proteins, Dietary ; Toxins, Biological
Sprache	Englisch
Erscheinungsdatum	2024-04-08
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ISSN	2161-3311
ISSN (online)	2161-3311
DOI	10.1007/s13668-024-00535-x
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Sulforaphane upregulates the mRNA expression of NRF2 and NQO1 in non-dialysis patients with chronic kidney disease.

Ribeiro, Marcia / Alvarenga, Livia / Coutinho-Wolino, Karen Salve / Nakao, Lia S / Cardozo, Ludmila Fmf / Mafra, Denise

Free radical biology & medicine

2024 Band 221, Seite(n) 181–187

Abstract: Sulforaphane (SFN), found in cruciferous vegetables, is a known activator of NRF2 (master regulator of cellular antioxidant responses). Patients with chronic kidney disease (CKD) present an imbalance in the redox state, presenting reduced expression of ... ...

Abstract	Sulforaphane (SFN), found in cruciferous vegetables, is a known activator of NRF2 (master regulator of cellular antioxidant responses). Patients with chronic kidney disease (CKD) present an imbalance in the redox state, presenting reduced expression of NRF2 and increased expression of NF-κB. Therefore, this study aimed to evaluate the effects of SFN on the mRNA expression of NRF2, NF-κB and markers of oxidative stress in patients with CKD. Here, we observed a significant increase in the mRNA expression of NRF2 (p = 0.02) and NQO1 (p = 0.04) in the group that received 400 μg/day of SFN for 1 month. Furthermore, we observed an improvement in the levels of phosphate (p = 0.02), glucose (p = 0.05) and triglycerides (p = 0.02) also in this group. On the other hand, plasma levels of LDL-c (p = 0.04) and total cholesterol (p = 0.03) increased in the placebo group during the study period. In conclusion, 400 μg/day of SFN for one month improves the antioxidant system and serum glucose and phosphate levels in non-dialysis CKD patients.
Sprache	Englisch
Erscheinungsdatum	2024-05-19
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2024.05.034
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Behavioral Assessment of Central Auditory Processing in Turner Syndrome.

Santos, Adriana Fernandes Duarte Dos / Bazilio, Martha Marcela Matos / Frota, Silvana / Guimarães, Marilia / Ribeiro, Marcia Gonçalves

International archives of otorhinolaryngology

2023 Band 28, Heft 1, Seite(n) e50–e56

Abstract: ... ...

Abstract	Introduction
Sprache	Englisch
Erscheinungsdatum	2023-10-06
Erscheinungsland	Brazil
Dokumenttyp	Journal Article
ZDB-ID	2578584-9
ISSN	1809-4864 ; 1809-9777
ISSN (online)	1809-4864
ISSN	1809-9777
DOI	10.1055/s-0043-1768141
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: From recurrent rhabdomyolysis in a young adult to carnitine palmitoyltransferase II deficiency.

Marques, Cristina / Silva, Catarina / Silva, Carina / Abreu, João Pedro / Ribeiro, Márcia / Guimas, Arlindo

Archive of clinical cases

2023 Band 10, Heft 1, Seite(n) 42–46

Abstract: Metabolic myopathies are a diverse group of rare genetic disorders associated with recurrent episodes of rhabdomyolysis, induced by triggers such as fever or exercise. In these disorders, the energetic metabolism is compromised resulting in damage of the ...

Abstract	Metabolic myopathies are a diverse group of rare genetic disorders associated with recurrent episodes of rhabdomyolysis, induced by triggers such as fever or exercise. In these disorders, the energetic metabolism is compromised resulting in damage of the muscle cells. The diagnosis can be challenging but is essential for the correct treatment. Carnitine palmitoytransferase II (CPT-II) deficiency is the most common long-chain fatty acid oxidation defect, with the adulthood form requiring additional external triggers. The authors present a case of a young-male adult with recurrent episodes of rhabdomyolysis, one of them presented with acute renal failure and acute hepatitis. The diagnostic is demanding, which requires a high level of suspicion. The adequate treatment of these patients improves the muscle function and prevents other episodes of severe rhabdomyolysis.
Sprache	Englisch
Erscheinungsdatum	2023-03-27
Erscheinungsland	Romania
Dokumenttyp	Case Reports
ZDB-ID	2788093-X
ISSN	2360-6975 ; 2360-6975
ISSN (online)	2360-6975
ISSN	2360-6975
DOI	10.22551/2023.38.1001.10238
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Investigation of possible relationship between atopic dermatitis and salivary biomarkers, stress, and sleep disorders.

Estefan, Juliany / Ferreira, Dennis de Carvalho / Cavalcante, Fernanda Sampaio / Dos Santos, Kátia Regina Netto / Ribeiro, Marcia

World journal of clinical cases

2023 Band 11, Heft 17, Seite(n) 3958–3966

Abstract: Atopic dermatitis (AD) is a chronic, relapsing, multifactorial inflammatory disease with genetic, environmental, and immunological characteristics. The quality of life and sleep of patients and their families are affected by AD, which triggers stress, ... ...

Abstract	Atopic dermatitis (AD) is a chronic, relapsing, multifactorial inflammatory disease with genetic, environmental, and immunological characteristics. The quality of life and sleep of patients and their families are affected by AD, which triggers stress, described as one of the factors that worsens AD. Salivary biomarkers such as cortisol, alpha-amylase, chromogranin A, and melatonin have been associated with stress and sleep disturbances. Therefore, the evaluation of stress and sleep disorders using salivary biomarkers in AD patients is important. This review aims to describe the possible relationship between atopic dermatitis and stress, sleep disorders, and salivary biomarkers, seeking to contribute to better understanding and clinical management of AD. This descriptive study is characterized as a narrative literature review. A literature search was conducted of studies published in English and Portuguese between January 2012 and October 2022 that are available in electronic media from various databases, such as Scientific Electronic Library Online, Latin American and Caribbean Literature on Health Sciences, and PubMed. AD is associated with different degrees of impact on the lives of individuals who present with the disease. Psychological stress may induce changes in saliva composition and worsen AD; at the same time, the severity of the disease may be associated with emotional impact. Further studies are needed to assess and correlate AD severity, stress, and sleep disturbances with salivary biomarkers in order to better understand this association.
Sprache	Englisch
Erscheinungsdatum	2023-06-14
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i17.3958
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Protect the Kidneys and Save the Heart Using the Concept of Food as Medicine.

Cardozo, Ludmila F M F / Borges, Natália A / Ribeiro, Marcia / Yee-Moon Wang, Angela / Mafra, Denise

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation

2023 Band 33, Heft 6S, Seite(n) S110–S117

Abstract: Chronic kidney disease is a significant risk factor for cardiovascular disease. In addition to traditional risk factors, such as hypertension, dyslipidemia, diabetes and smoking, patients with chronic kidney disease have a uremic phenotype marked by ... ...

Abstract	Chronic kidney disease is a significant risk factor for cardiovascular disease. In addition to traditional risk factors, such as hypertension, dyslipidemia, diabetes and smoking, patients with chronic kidney disease have a uremic phenotype marked by premature aging, mitochondrial dysfunction, persistent low-grade inflammation, gut dysbiosis and oxidative stress. These complications contribute to abnormal vascular and myocardial remodeling processes, resulting in accelerated vascular calcification, cellular and organ senescence and a high risk of cardiovascular disease. Nonpharmacological strategies, such as increasing physical activity and a healthy diet, may slow the progression of kidney disease and consequently protect the heart. Thus, a deep promotion and advocacy of nutritional guidance based on scientific data is needed. This narrative review discusses how nutritional interventions may delay progressive organ damage in the kidney-heart axis.
Mesh-Begriff(e)	Humans ; Cardiovascular Diseases/complications ; Kidney ; Renal Insufficiency, Chronic/complications ; Risk Factors ; Hypertension
Sprache	Englisch
Erscheinungsdatum	2023-08-25
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ZDB-ID	1080003-7
ISSN	1532-8503 ; 1051-2276
ISSN (online)	1532-8503
ISSN	1051-2276
DOI	10.1053/j.jrn.2023.08.002
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Nutritional benefits of ginger for patients with non-communicable diseases.

Baptista, Beatriz G / Ribeiro, Marcia / Cardozo, Ludmila Fmf / Leal, Viviane de O / Regis, Bruna / Mafra, Denise

Clinical nutrition ESPEN

2022 Band 49, Seite(n) 1–16

Abstract: Ginger (Zingiber officinale) is a famous dietary spice rich in bioactive components like gingerols, and it has been used for a long time as food and medicine. Indeed, clinical studies have confirmed the anti-inflammatory and antioxidant properties of ... ...

Abstract	Ginger (Zingiber officinale) is a famous dietary spice rich in bioactive components like gingerols, and it has been used for a long time as food and medicine. Indeed, clinical studies have confirmed the anti-inflammatory and antioxidant properties of ginger. Thus, ginger seems to be an excellent complementary nutritional strategy for non-communicable diseases (NCD) such as obesity, diabetes, cardiovascular disease and chronic kidney disease. This narrative review aims to discuss the possible effects of ginger on the mitigation of common complications such as inflammation, oxidative stress, and gut dysbiosis in NCD.
Mesh-Begriff(e)	Anti-Inflammatory Agents ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Zingiber officinale ; Humans ; Noncommunicable Diseases/prevention & control ; Plant Extracts/pharmacology
Chemische Substanzen	Anti-Inflammatory Agents ; Antioxidants ; Plant Extracts
Sprache	Englisch
Erscheinungsdatum	2022-04-23
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ISSN	2405-4577
ISSN (online)	2405-4577
DOI	10.1016/j.clnesp.2022.04.017
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Nutritional benefits of ginger for patients with non-communicable diseases

Baptista, Beatriz G. / Ribeiro, Marcia / Cardozo, Ludmila FMF / Leal, Viviane de O. / Regis, Bruna / Mafra, Denise

European Society for Clinical Nutrition and Metabolism Clinical Nutrition ESPEN. 2022 June, v. 49 p.1-16

2022

Abstract	Ginger (Zingiber officinale) is a famous dietary spice rich in bioactive components like gingerols, and it has been used for a long time as food and medicine. Indeed, clinical studies have confirmed the anti-inflammatory and antioxidant properties of ginger. Thus, ginger seems to be an excellent complementary nutritional strategy for non-communicable diseases (NCD) such as obesity, diabetes, cardiovascular disease and chronic kidney disease. This narrative review aims to discuss the possible effects of ginger on the mitigation of common complications such as inflammation, oxidative stress, and gut dysbiosis in NCD.
Schlagwörter	Zingiber officinale ; antioxidants ; cardiovascular diseases ; clinical nutrition ; diabetes ; digestive system ; dysbiosis ; ginger ; inflammation ; kidney diseases ; medicine ; obesity ; oxidative stress ; Non-communicable diseases ; Gut microbiota
Sprache	Englisch
Erscheinungsverlauf	2022-06
Umfang	p. 1-16.
Erscheinungsort	Elsevier Ltd
Dokumenttyp	Artikel ; Online
ISSN	2405-4577
DOI	10.1016/j.clnesp.2022.04.017
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: The magical smell and taste: Can coffee be good to patients with cardiometabolic disease?

Ribeiro, Marcia / Alvarenga, Livia / Cardozo, Ludmila F. M. F. / Kemp, Julie A. / Lima, Ligia S. / Almeida, Jonatas S. de / Leal, Viviane de O. / Stenvinkel, Peter / Shiels, Paul G. / Mafra, Denise

Critical Reviews in Food Science and Nutrition. 2024 Jan. 13, v. 64, no. 2 p.562-583

2024

Abstract: Coffee is a beverage consumed globally. Although few studies have indicated adverse effects, it is typically a beneficial health-promoting agent in a range of diseases, including depression, diabetes, cardiovascular disease, and obesity. Coffee is rich ... ...

Abstract	Coffee is a beverage consumed globally. Although few studies have indicated adverse effects, it is typically a beneficial health-promoting agent in a range of diseases, including depression, diabetes, cardiovascular disease, and obesity. Coffee is rich in caffeine, antioxidants, and phenolic compounds, which can modulate the composition of the gut microbiota and mitigate both inflammation and oxidative stress, common features of the burden of lifestyle diseases. This review will discuss the possible benefits of coffee on complications present in patients with diabetes, cardiovascular disease and chronic kidney disease, outwith the social and emotional benefits attributed to caffeine consumption.
Schlagwörter	beverages ; caffeine ; cardiovascular diseases ; diabetes ; food science ; health promotion ; inflammation ; intestinal microorganisms ; kidney diseases ; lifestyle ; nutrition ; obesity ; oxidative stress ; smell ; taste ; burden of lifestyle diseases ; coffee ; coffee phytochemicals structure ; gut microbiota
Sprache	Englisch
Erscheinungsverlauf	2024-0113
Umfang	p. 562-583.
Erscheinungsort	Taylor & Francis
Dokumenttyp	Artikel ; Online
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2022.2106938
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel: Behavioral Assessment of Central Auditory Processing in Turner Syndrome

Santos, Adriana Fernandes Duarte dos / Bazilio, Martha Marcela Matos / Frota, Silvana / Guimarães, Marilia / Ribeiro, Marcia Gonçalves

International Archives of Otorhinolaryngology

2023 Band 28, Heft 01, Seite(n) e50–e56

Abstract: Introduction: Turner syndrome (TS) affects ∼ 1 in 2,500 live births. The presence of hearing alterations is one of the comorbidities found in this syndrome.: Objective: The present study aimed to evaluate the central auditory abilities in TS and to ... ...

Abstract	Introduction: Turner syndrome (TS) affects ∼ 1 in 2,500 live births. The presence of hearing alterations is one of the comorbidities found in this syndrome. Objective: The present study aimed to evaluate the central auditory abilities in TS and to associate the alterations found with the cytogenetic pattern of the syndrome. Methods: We included children and adults aged 9 to 39 years old, diagnosed with TS, with numerical or structural alterations of sex chromosomes in their karyotype. A battery of behavioral tests of central auditory processing (CAP) was performed, including a test within the modalities: monoaural low-redundancy, dichotic listening, binaural interaction, and temporal processing (resolution and ordering). We studied auditory skills in the total sample and in the sample stratified by age, divided into groups: G1 (9 to 13 years old), G2 (14 to 19 years old), and G3 (20 to 31 years old). For the association of the cytogenetic pattern, the division was T1 (chromosome monosomy X), and T2 (other TS cytogenetic patterns). Statistical analysis presented data expressed as median and interquartile range for numerical data and as frequency and percentage for categorical data. Results: We found alterations in four auditory skills in the three age groups, but there was a statistically significant difference between the age groups only in the Gaps in Noise Test (GIN) ( p -value = 0.009). Regarding karyotype, a greater number of alterations in the T1 cytogenetic pattern (chromosome monosomy X) was observed in four auditory skills, but without a statistically significant difference. Conclusion: The alterations found point to an impairment in CAP in TS.
Schlagwörter	turner syndrome ; gonadal dysgenesis, 45, X ; hearing ; auditory processing
Sprache	Englisch
Erscheinungsdatum	2023-10-06
Verlag	Thieme Revinter Publicações Ltda.
Erscheinungsort	Stuttgart ; New York
Dokumenttyp	Artikel
ZDB-ID	2578584-9
ISSN	1809-4864 ; 1809-9777 ; 1809-4864
ISSN (online)	1809-4864
ISSN	1809-9777 ; 1809-4864
DOI	10.1055/s-0043-1768141
Datenquelle	Thieme Verlag

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