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  1. Artikel ; Online: German translation, cross-cultural adaption and validation of the Venous Clinical Severity and Venous Disability Scores.

    Hofmann, Amun / Deinsberger, Julia / Kienzl, Philip / Rigler, Eva / Anzengruber, Florian / Weber, Benedikt

    Journal of patient-reported outcomes

    2023  Band 7, Heft 1, Seite(n) 28

    Abstract: Background: The Venous Clinical Severity Score (VCSS) and the Venous Disability Score (VDS) represent assessment tools for chronic venous disease (CVD) combining physician and patient reported outcomes. To date, German versions are not available. The ... ...

    Abstract Background: The Venous Clinical Severity Score (VCSS) and the Venous Disability Score (VDS) represent assessment tools for chronic venous disease (CVD) combining physician and patient reported outcomes. To date, German versions are not available. The present study aimed at translating the VCSS and VDS into German and validating the questionnaires.
    Methods: Translations of VCSS and VDS were compiled based on published guidelines considering potential differences in the use of German language in different countries. For validation, 33 patients with chronic venous disease and 5 healthy individuals were included in the pre-testing phase. Patients were examined twice by independent investigators to validate test-retest-validity culminating in 142 limb examinations. Internal consistency, inter-rater dependence and external reliability were subsequently evaluated.
    Results: All assessed metrics showed good internal consistency. Intra-class correlation coefficients were .75 for the VDS, .98 for the VCSS of the right leg and .90 for the VCSS of the left leg, indicating inter-rater independence. Furthermore, VCSS scores showed a modest positive correlation with CEAP C class and both VCSS and VDS showed a negative correlation with the physical component of the SF-12, indicating adequate external reliability.
    Conclusion: A pan-cultural German version of both the VCSS and VDS was established and validated as reliable tools to evaluate the severity of CVD in German speaking countries.
    Mesh-Begriff(e) Humans ; Reproducibility of Results ; Cross-Cultural Comparison ; Veins ; Vascular Diseases ; Translating ; Chronic Disease
    Sprache Englisch
    Erscheinungsdatum 2023-03-15
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2509-8020
    ISSN (online) 2509-8020
    DOI 10.1186/s41687-023-00569-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Maternal allergen-specific IgG might protect the child against allergic sensitization.

    Lupinek, Christian / Hochwallner, Heidrun / Johansson, Catharina / Mie, Axel / Rigler, Eva / Scheynius, Annika / Alm, Johan / Valenta, Rudolf

    The Journal of allergy and clinical immunology

    2019  Band 144, Heft 2, Seite(n) 536–548

    Abstract: Background: Analysis of allergen-specific IgE responses in birth cohorts with microarrayed allergens has provided detailed information regarding the evolution of specific IgE responses in children. High-resolution data regarding early development of ... ...

    Abstract Background: Analysis of allergen-specific IgE responses in birth cohorts with microarrayed allergens has provided detailed information regarding the evolution of specific IgE responses in children. High-resolution data regarding early development of allergen-specific IgG are needed.
    Objective: We sought to analyze IgG reactivity to microarrayed allergens in mothers during pregnancy, in cord blood samples, in breast milk, and in infants in the first years of life with the aim to investigate whether maternal allergen-specific IgG can protect against IgE sensitization in the offspring.
    Methods: Plasma samples from mothers during the third trimester, cord blood, breast milk collected 2 months after delivery, and plasma samples from children at 6, 12, and 60 months of age were analyzed for IgG reactivity to 164 microarrayed allergens (ImmunoCAP ISAC technology) in 99 families of the Swedish birth cohort Assessment of Lifestyle and Allergic Disease During Infancy (ALADDIN). IgE sensitizations to microarrayed allergens were determined at 5 years of age in the children.
    Results: Allergen-specific IgG reactivity profiles in mothers, cord blood, and breast milk were highly correlated. Maternal allergen-specific IgG persisted in some children at 6 months. Children's allergen-specific IgG production occurred at 6 months and reflected allergen exposure. Children who were IgE sensitized against an allergen at 5 years of age had significantly higher allergen-specific IgG levels than nonsensitized children. For all 164 tested allergens, children from mothers with increased (>30 ISAC standardized units) specific plasma IgG levels against an allergen had no IgE sensitizations against that allergen at 5 years of age.
    Conclusion: This is the first detailed analysis of the molecular IgG recognition profile in mothers and their children in early life. High allergen-specific IgG reactivity in the mother's plasma and breast milk and in cord blood seemed to protect against allergic sensitization at 5 years of age.
    Mesh-Begriff(e) Adult ; Allergens/immunology ; Child, Preschool ; Female ; Fetal Blood/immunology ; Humans ; Hypersensitivity/immunology ; Hypersensitivity/prevention & control ; Immunoglobulin G/immunology ; Infant ; Male ; Maternal-Fetal Exchange/immunology ; Middle Aged ; Milk, Human/immunology ; Pregnancy ; Pregnancy Trimester, Third/immunology ; Protein Array Analysis
    Chemische Substanzen Allergens ; Immunoglobulin G
    Sprache Englisch
    Erscheinungsdatum 2019-01-25
    Erscheinungsland United States
    Dokumenttyp Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2018.11.051
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Determination of IgE and IgG reactivity to more than 170 allergen molecules in paper-dried blood spots.

    Garib, Victoria / Rigler, Eva / Gastager, Felix / Campana, Raffaela / Dorofeeva, Yulia / Gattinger, Pia / Zhernov, Yury / Khaitov, Musa / Valenta, Rudolf

    The Journal of allergy and clinical immunology

    2018  Band 143, Heft 1, Seite(n) 437–440

    Mesh-Begriff(e) Allergens/chemistry ; Allergens/immunology ; Dried Blood Spot Testing/methods ; Female ; Humans ; Hypersensitivity/blood ; Hypersensitivity/immunology ; Immunoglobulin E/blood ; Immunoglobulin E/immunology ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Male ; Paper
    Chemische Substanzen Allergens ; Immunoglobulin G ; Immunoglobulin E (37341-29-0)
    Sprache Englisch
    Erscheinungsdatum 2018-11-01
    Erscheinungsland United States
    Dokumenttyp Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2018.08.047
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Vaccination of nonallergic individuals with recombinant hypoallergenic fragments of birch pollen allergen Bet v 1: Safety, effects, and mechanisms.

    Campana, Raffaela / Marth, Katharina / Zieglmayer, Petra / Weber, Milena / Lupinek, Christian / Zhernov, Yury / Elisyutina, Olga / Khaitov, Musa / Rigler, Eva / Westritschnig, Kerstin / Berger, Uwe / Wolkersdorfer, Martin / Horak, Fritz / Horak, Friedrich / Valenta, Rudolf

    The Journal of allergy and clinical immunology

    2018  Band 143, Heft 3, Seite(n) 1258–1261

    Mesh-Begriff(e) Adolescent ; Adult ; Allergens/administration & dosage ; Allergens/adverse effects ; Allergens/genetics ; Allergens/immunology ; Antigens, Plant/administration & dosage ; Antigens, Plant/adverse effects ; Antigens, Plant/genetics ; Antigens, Plant/immunology ; Betula/immunology ; Double-Blind Method ; Female ; Humans ; Immunoglobulin E/immunology ; Immunoglobulin G/immunology ; Male ; Pollen/immunology ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/adverse effects ; Rhinitis, Allergic, Seasonal/prevention & control ; Vaccination/adverse effects ; Young Adult
    Chemische Substanzen Allergens ; Antigens, Plant ; Immunoglobulin G ; Recombinant Proteins ; Bet v 1 allergen, Betula (126161-14-6) ; Immunoglobulin E (37341-29-0)
    Sprache Englisch
    Erscheinungsdatum 2018-11-22
    Erscheinungsland United States
    Dokumenttyp Letter ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2018.11.011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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