Article: Comparative Genomic Hybridization and Transcriptome Sequencing Reveal Genes with Gain in Acute Lymphoblastic Leukemia:
Diagnostics (Basel, Switzerland)
2022 Volume 12, Issue 11
Abstract: Acute lymphoblastic leukemia (ALL) in children or adults is characterized by structural and numeric aberrations in chromosomes; these anomalies strongly correlate with prognosis and clinical outcome. Therefore, this work aimed to identify the genes ... ...
| Abstract | Acute lymphoblastic leukemia (ALL) in children or adults is characterized by structural and numeric aberrations in chromosomes; these anomalies strongly correlate with prognosis and clinical outcome. Therefore, this work aimed to identify the genes present in chromosomal gain regions found more frequently in patients with acute lymphoblastic leukemia (ALL) and ALL-derived cell lines using comparative genomic hybridization (CGH). In addition, validation of the genes found in these regions was performed utilizing RNAseq from JURKAT, CEM, and SUP-B15 cell lines, as well as expression microarrays derived from a MILE study. Chromosomes with common gain zones that were maintained in six or more samples were 14, 17, and 22, in which a total of 22 genes were identified. From them, |
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| Language | English |
| Publishing date | 2022-11-14 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2662336-5 |
| ISSN | 2075-4418 |
| ISSN | 2075-4418 |
| DOI | 10.3390/diagnostics12112788 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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