Artikel ; Online: The Role of Sphingolipids and Specialized Pro-Resolving Mediators in Alzheimer's Disease.
2021 Band 11, Seite(n) 620348
Abstract: Alzheimer's disease (AD) is the leading cause of dementia worldwide giving rise to devastating forms of cognitive decline, which impacts patients' lives and that of their proxies. Pathologically, AD is characterized by extracellular amyloid deposition, ... ...
Abstract | Alzheimer's disease (AD) is the leading cause of dementia worldwide giving rise to devastating forms of cognitive decline, which impacts patients' lives and that of their proxies. Pathologically, AD is characterized by extracellular amyloid deposition, neurofibrillary tangles and chronic neuroinflammation. To date, there is no cure that prevents progression of AD. In this review, we elaborate on how bioactive lipids, including sphingolipids (SL) and specialized pro-resolving lipid mediators (SPM), affect ongoing neuroinflammatory processes during AD and how we may exploit them for the development of new biomarker panels and/or therapies. In particular, we here describe how SPM and SL metabolism, ranging from ω-3/6 polyunsaturated fatty acids and their metabolites to ceramides and sphingosine-1-phosphate, initiates pro- and anti-inflammatory signaling cascades in the central nervous system (CNS) and what changes occur therein during AD pathology. Finally, we discuss novel therapeutic approaches to resolve chronic neuroinflammation in AD by modulating the SPM and SL pathways. |
---|---|
Mesh-Begriff(e) | Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Animals ; Central Nervous System/metabolism ; Ceramides/antagonists & inhibitors ; Ceramides/physiology ; Disease Models, Animal ; Fatty Acids, Omega-3/physiology ; Fatty Acids, Omega-6/physiology ; Fatty Acids, Unsaturated/metabolism ; Forecasting ; Humans ; Inflammation ; Lipoxygenases/metabolism ; Lysophospholipids/physiology ; Mice ; Microglia/pathology ; Models, Biological ; Prostaglandin-Endoperoxide Synthases/metabolism ; Receptors, Pattern Recognition/physiology ; Sphingolipids/physiology ; Sphingosine/analogs & derivatives ; Sphingosine/physiology ; Sphingosine 1 Phosphate Receptor Modulators/therapeutic use |
Chemische Substanzen | Ceramides ; Fatty Acids, Omega-3 ; Fatty Acids, Omega-6 ; Fatty Acids, Unsaturated ; Lysophospholipids ; Receptors, Pattern Recognition ; Sphingolipids ; Sphingosine 1 Phosphate Receptor Modulators ; sphingosine 1-phosphate (26993-30-6) ; Lipoxygenases (EC 1.13.11.-) ; Prostaglandin-Endoperoxide Synthases (EC 1.14.99.1) ; Sphingosine (NGZ37HRE42) |
Sprache | Englisch |
Erscheinungsdatum | 2021-01-29 |
Erscheinungsland | Switzerland |
Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
ZDB-ID | 2606827-8 |
ISSN | 1664-3224 ; 1664-3224 |
ISSN (online) | 1664-3224 |
ISSN | 1664-3224 |
DOI | 10.3389/fimmu.2020.620348 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Zusatzmaterialien
Kategorien
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.