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  1. Artikel: Ongoing evolution of SARS-CoV-2 drives escape from mRNA vaccine-induced humoral immunity.

    Roederer, Alex L / Cao, Yi / Denis, Kerri St / Sheehan, Maegan L / Li, Chia Jung / Lam, Evan C / Gregory, David J / Poznansky, Mark C / Iafrate, A John / Canaday, David H / Gravenstein, Stefan / Garcia-Beltran, Wilfredo F / Balazs, Alejandro B

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: Since the COVID-19 pandemic began in 2020, viral sequencing has documented 131 individual mutations in the viral spike protein across 48 named variants. To determine the ability of vaccine-mediated humoral immunity to keep pace with continued SARS-CoV-2 ... ...

    Abstract Since the COVID-19 pandemic began in 2020, viral sequencing has documented 131 individual mutations in the viral spike protein across 48 named variants. To determine the ability of vaccine-mediated humoral immunity to keep pace with continued SARS-CoV-2 evolution, we assessed the neutralization potency of sera from 76 vaccine recipients collected after 2 to 6 immunizations against a comprehensive panel of mutations observed during the pandemic. Remarkably, while many individual mutations that emerged between 2020 and 2022 exhibit escape from sera following primary vaccination, few escape boosted sera. However, progressive loss of neutralization was observed across newer variants, irrespective of vaccine doses. Importantly, an updated XBB.1.5 booster significantly increased titers against newer variants but not JN.1. These findings demonstrate that seasonal boosters improve titers against contemporaneous strains, but novel variants continue to evade updated mRNA vaccines, demonstrating the need for novel approaches to adequately control SARS-CoV-2 transmission.
    Sprache Englisch
    Erscheinungsdatum 2024-03-07
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.03.05.24303815
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Ongoing evolution of SARS-CoV-2 drives escape from mRNA vaccine-induced humoral immunity

    Roederer, Alex L. / Cao, Yi / St. Denis, Kerri / Sheehan, Maegan L. / Li, Chia Jung / Lam, Evan C. / Gregory, David J. / Poznansky, Mark C. / Iafrate, A. John / Canaday, David H. / Gravenstein, Stefan / Garcia-Beltran, Wilfredo F. / Balazs, Alejandro B.

    medRxiv

    Abstract: Since the COVID-19 pandemic began in 2020, viral sequencing has documented 131 individual mutations in the viral spike protein across 48 named variants. To determine the ability of vaccine-mediated humoral immunity to keep pace with continued SARS-CoV-2 ... ...

    Abstract Since the COVID-19 pandemic began in 2020, viral sequencing has documented 131 individual mutations in the viral spike protein across 48 named variants. To determine the ability of vaccine-mediated humoral immunity to keep pace with continued SARS-CoV-2 evolution, we assessed the neutralization potency of sera from 76 vaccine recipients collected after 2 to 6 immunizations against a comprehensive panel of mutations observed during the pandemic. Remarkably, while many individual mutations that emerged between 2020 and 2022 exhibit escape from sera following primary vaccination, few escape boosted sera. However, progressive loss of neutralization was observed across newer variants, irrespective of vaccine doses. Importantly, an updated XBB.1.5 booster significantly increased titers against newer variants but not JN.1. These findings demonstrate that seasonal boosters improve titers against contemporaneous strains, but novel variants continue to evade updated mRNA vaccines, demonstrating the need for novel approaches to adequately control SARS-CoV-2 transmission.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2024-03-07
    Verlag Cold Spring Harbor Laboratory Press
    Dokumenttyp Artikel ; Online
    DOI 10.1101/2024.03.05.24303815
    Datenquelle COVID19

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  3. Artikel: mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant

    Garcia-Beltran, Wilfredo F. / St. Denis, Kerri J. / Hoelzemer, Angelique / Lam, Evan C. / Nitido, Adam D. / Sheehan, Maegan L. / Berrios, Cristhian / Ofoman, Onosereme / Chang, Christina C. / Hauser, Blake M. / Feldman, Jared / Roederer, Alex L. / Gregory, David J. / Poznansky, Mark C. / Schmidt, Aaron G. / Iafrate, A. John / Naranbhai, Vivek / Balazs, Alejandro B.

    Cell. 2022 Feb. 03, v. 185, no. 3

    2022  

    Abstract: Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.1/B.1.1.529) harboring up to 36 mutations in spike protein, the target of neutralizing antibodies. Given its potential to escape vaccine-induced humoral immunity, we ... ...

    Abstract Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.1/B.1.1.529) harboring up to 36 mutations in spike protein, the target of neutralizing antibodies. Given its potential to escape vaccine-induced humoral immunity, we measured the neutralization potency of sera from 88 mRNA-1273, 111 BNT162b, and 40 Ad26.COV2.S vaccine recipients against wild-type, Delta, and Omicron SARS-CoV-2 pseudoviruses. We included individuals that received their primary series recently (<3 months), distantly (6–12 months), or an additional “booster” dose, while accounting for prior SARS-CoV-2 infection. Remarkably, neutralization of Omicron was undetectable in most vaccinees. However, individuals boosted with mRNA vaccines exhibited potent neutralization of Omicron, only 4–6-fold lower than wild type, suggesting enhanced cross-reactivity of neutralizing antibody responses. In addition, we find that Omicron pseudovirus infects more efficiently than other variants tested. Overall, this study highlights the importance of additional mRNA doses to broaden neutralizing antibody responses against highly divergent SARS-CoV-2 variants.
    Schlagwörter COVID-19 infection ; Pseudovirus ; Severe acute respiratory syndrome coronavirus 2 ; cross reaction ; humoral immunity ; monitoring ; neutralization ; vaccines
    Sprache Englisch
    Erscheinungsverlauf 2022-0203
    Umfang p. 457-466.e4.
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2021.12.033
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel ; Online: mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant.

    Garcia-Beltran, Wilfredo F / St Denis, Kerri J / Hoelzemer, Angelique / Lam, Evan C / Nitido, Adam D / Sheehan, Maegan L / Berrios, Cristhian / Ofoman, Onosereme / Chang, Christina C / Hauser, Blake M / Feldman, Jared / Roederer, Alex L / Gregory, David J / Poznansky, Mark C / Schmidt, Aaron G / Iafrate, A John / Naranbhai, Vivek / Balazs, Alejandro B

    Cell

    2022  Band 185, Heft 3, Seite(n) 457–466.e4

    Abstract: Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.1/B.1.1.529) harboring up to 36 mutations in spike protein, the target of neutralizing antibodies. Given its potential to escape vaccine-induced humoral immunity, we ... ...

    Abstract Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.1/B.1.1.529) harboring up to 36 mutations in spike protein, the target of neutralizing antibodies. Given its potential to escape vaccine-induced humoral immunity, we measured the neutralization potency of sera from 88 mRNA-1273, 111 BNT162b, and 40 Ad26.COV2.S vaccine recipients against wild-type, Delta, and Omicron SARS-CoV-2 pseudoviruses. We included individuals that received their primary series recently (<3 months), distantly (6-12 months), or an additional "booster" dose, while accounting for prior SARS-CoV-2 infection. Remarkably, neutralization of Omicron was undetectable in most vaccinees. However, individuals boosted with mRNA vaccines exhibited potent neutralization of Omicron, only 4-6-fold lower than wild type, suggesting enhanced cross-reactivity of neutralizing antibody responses. In addition, we find that Omicron pseudovirus infects more efficiently than other variants tested. Overall, this study highlights the importance of additional mRNA doses to broaden neutralizing antibody responses against highly divergent SARS-CoV-2 variants.
    Sprache Englisch
    Erscheinungsdatum 2022-01-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2021.12.033
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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