Artikel ; Online: Perianal Abscesses in Infants Are Not Associated With Crohn's Disease in a Surgical Cohort.
2019 Band 14, Heft 6, Seite(n) 773–777
Abstract: Aims: The aim of this study is to search for an association between infantile perianal abscesses and [development of] Crohn's disease in a surgical population of children.: Methods: Patients who were surgically treated in the Amsterdam UMC between ... ...
Abstract | Aims: The aim of this study is to search for an association between infantile perianal abscesses and [development of] Crohn's disease in a surgical population of children. Methods: Patients who were surgically treated in the Amsterdam UMC between January 2000 and December 2014 were included in this retrospective cohort study. Data collected include: sex, date of birth, underlying conditions, age of onset, additional symptoms, pus cultures, endoscopic examination, histological examination, magnetic resonance imaging, faecal calprotectin levels, antibiotic treatment, surgical treatment strategy, and number of recurrences. Follow-up data were gathered from medical records and by contacting the patients and/or parents or the general practitioner. Results: The study consisted of 62 patients of whom 60 were boys. Median age was 5 months [range 0-17 months]; 92% were under 1 year of age at diagnosis. A minority of patients had accompanying symptoms. In total, 72 abscesses were treated, 19 fistulas and 23 abscesses with fistula-in-ano. Follow-up data of 46 patients [74%] were available; none of the patients developed Crohn's disease. Conclusions: We found no association between isolated perianal abscesses as presenting symptom in early childhood and [development of] Crohn's disease. In young infants with isolated perianal disease, risk for inflammatory bowel disease seems low. In this specific population there seems no place for routine performance of endoscopic investigations. One should always take the risk of very-early-onset inflammatory bowel disease into account. Further research with a larger cohort of children and a longer follow-up time is required. |
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Mesh-Begriff(e) | Abscess/diagnosis ; Abscess/drug therapy ; Abscess/surgery ; Anal Canal/pathology ; Anal Canal/surgery ; Anti-Bacterial Agents/therapeutic use ; Cohort Studies ; Correlation of Data ; Crohn Disease/diagnosis ; Crohn Disease/epidemiology ; Digestive System Surgical Procedures/methods ; Digestive System Surgical Procedures/statistics & numerical data ; Endoscopy/methods ; Female ; Humans ; Infant ; Male ; Netherlands/epidemiology ; Rectal Fistula/diagnosis ; Rectal Fistula/drug therapy ; Rectal Fistula/surgery ; Symptom Assessment/statistics & numerical data ; Unnecessary Procedures |
Chemische Substanzen | Anti-Bacterial Agents |
Sprache | Englisch |
Erscheinungsdatum | 2019-05-18 |
Erscheinungsland | England |
Dokumenttyp | Journal Article |
ZDB-ID | 2390120-2 |
ISSN | 1876-4479 ; 1873-9946 |
ISSN (online) | 1876-4479 |
ISSN | 1873-9946 |
DOI | 10.1093/ecco-jcc/jjz105 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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