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  1. Buch: Lymphocytes

    Rowland-Jones, Sarah L.

    a pracical approach

    (Practical approach series ; 220)

    2000  

    Verfasserangabe ed. by Sarah L. Rowland-Jones
    Serientitel Practical approach series ; 220
    The practical approach series
    Überordnung The practical approach series
    Schlagwörter Lymphocytes
    Sprache Englisch
    Umfang 320 S.
    Ausgabenhinweis 2. ed.
    Verlag Oxford Univ. Press
    Erscheinungsort Oxford u.a.
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch
    HBZ-ID HT012795728
    ISBN 0-19963-816-0 ; 978-0-19963-816-1
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  2. Artikel ; Online: Chikungunya: out of the tropical forests and heading our way ….

    Rowland-Jones, Sarah L

    Transactions of the Royal Society of Tropical Medicine and Hygiene

    2016  Band 110, Heft 2, Seite(n) 85–86

    Mesh-Begriff(e) Aedes/virology ; Animals ; Chikungunya Fever/epidemiology ; Chikungunya Fever/prevention & control ; Chikungunya Fever/transmission ; Chikungunya virus/pathogenicity ; Disease Outbreaks/prevention & control ; Drug Discovery ; Humans ; Insect Vectors ; Mosquito Control/organization & administration ; United States ; Viral Vaccines ; West Indies
    Chemische Substanzen Viral Vaccines
    Sprache Englisch
    Erscheinungsdatum 2016-02
    Erscheinungsland England
    Dokumenttyp Editorial
    ZDB-ID 441375-1
    ISSN 1878-3503 ; 0035-9203
    ISSN (online) 1878-3503
    ISSN 0035-9203
    DOI 10.1093/trstmh/trw002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design.

    Groves, Danielle C / Rowland-Jones, Sarah L / Angyal, Adrienn

    Biochemical and biophysical research communications

    2020  Band 538, Seite(n) 104–107

    Abstract: The development of the SARS-CoV-2 pandemic has prompted an extensive worldwide sequencing effort to characterise the geographical spread and molecular evolution of the virus. A point mutation in the spike protein, D614G, emerged as the virus spread from ... ...

    Abstract The development of the SARS-CoV-2 pandemic has prompted an extensive worldwide sequencing effort to characterise the geographical spread and molecular evolution of the virus. A point mutation in the spike protein, D614G, emerged as the virus spread from Asia into Europe and the USA, and has rapidly become the dominant form worldwide. Here we review how the D614G variant was identified and discuss recent evidence about the effect of the mutation on the characteristics of the virus, clinical outcome of infection and host immune response.
    Mesh-Begriff(e) Amino Acid Substitution ; Aspartic Acid/genetics ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/genetics ; COVID-19 Vaccines/immunology ; Evolution, Molecular ; Glycine/genetics ; Humans ; Immunogenicity, Vaccine ; SARS-CoV-2/genetics ; SARS-CoV-2/pathogenicity ; Severity of Illness Index ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology
    Chemische Substanzen COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Aspartic Acid (30KYC7MIAI) ; Glycine (TE7660XO1C)
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-11-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2020.10.109
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: IL-15 reprogramming compensates for NK cell mitochondrial dysfunction in HIV-1 infection.

    Moreno-Cubero, Elia / Alrubayyi, Aljawharah / Balint, Stefan / Ogbe, Ane / Gill, Upkar S / Matthews, Rebecca / Kinloch, Sabine / Burns, Fiona / Rowland-Jones, Sarah L / Borrow, Persephone / Schurich, Anna / Dustin, Michael / Peppa, Dimitra

    JCI insight

    2024  Band 9, Heft 4

    Abstract: Dynamic regulation of cellular metabolism is important for maintaining homeostasis and can directly influence immune cell function and differentiation, including NK cell responses. Persistent HIV-1 infection leads to a state of chronic immune activation, ...

    Abstract Dynamic regulation of cellular metabolism is important for maintaining homeostasis and can directly influence immune cell function and differentiation, including NK cell responses. Persistent HIV-1 infection leads to a state of chronic immune activation, NK cell subset redistribution, and progressive NK cell dysregulation. In this study, we examined the metabolic processes that characterize NK cell subsets in HIV-1 infection, including adaptive NK cell subpopulations expressing the activating receptor NKG2C, which expand during chronic infection. These adaptive NK cells exhibit an enhanced metabolic profile in HIV-1- individuals infected with human cytomegalovirus (HCMV). However, the bioenergetic advantage of adaptive CD57+NKG2C+ NK cells is diminished during chronic HIV-1 infection, where NK cells uniformly display reduced oxidative phosphorylation (OXPHOS). Defective OXPHOS was accompanied by increased mitochondrial depolarization, structural alterations, and increased DRP-1 levels promoting fission, suggesting that mitochondrial defects are restricting the metabolic plasticity of NK cell subsets in HIV-1 infection. The metabolic requirement for the NK cell response to receptor stimulation was alleviated upon IL-15 pretreatment, which enhanced mammalian target of rapamycin complex 1 (mTORC1) activity. IL-15 priming enhanced NK cell functionality to anti-CD16 stimulation in HIV-1 infection, representing an effective strategy for pharmacologically boosting NK cell responses.
    Mesh-Begriff(e) Humans ; Cytomegalovirus Infections ; HIV-1 ; Interleukin-15 ; HIV Infections ; Killer Cells, Natural ; Mitochondrial Diseases/complications
    Chemische Substanzen Interleukin-15
    Sprache Englisch
    Erscheinungsdatum 2024-01-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.173099
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: HLA-A*23 Is Associated With Lower Odds of Acute Retroviral Syndrome in Human Immunodeficiency Virus Type 1 Infection: A Multicenter Sub-Saharan African Study.

    Lindquist, Lovisa / Kilembe, William / Karita, Etienne / Price, Matt A / Kamali, Anatoli / Kaleebu, Pontiano / Tang, Jianming / Allen, Susan / Hunter, Eric / Gilmour, Jill / Rowland-Jones, Sarah L / Sanders, Eduard J / Hassan, Amin S / Esbjörnsson, Joakim

    Open forum infectious diseases

    2024  Band 11, Heft 4, Seite(n) ofae129

    Abstract: The role of human leukocyte antigen (HLA) class I and killer immunoglobulin-like receptor molecules in mediating acute retroviral syndrome (ARS) during human immunodeficiency virus type 1 (HIV-1) infection is unclear. Among 72 sub-Saharan African adults, ...

    Abstract The role of human leukocyte antigen (HLA) class I and killer immunoglobulin-like receptor molecules in mediating acute retroviral syndrome (ARS) during human immunodeficiency virus type 1 (HIV-1) infection is unclear. Among 72 sub-Saharan African adults, HLA-A*23 was associated with lower odds of ARS (adjusted odds ratio, 0.10 [95% confidence interval, .01-.48];
    Sprache Englisch
    Erscheinungsdatum 2024-03-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofae129
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design

    Groves, Danielle C / Rowland-Jones, Sarah L / Angyal, Adrienn

    Biochem. biophys. res. commun

    Abstract: The development of the SARS-CoV-2 pandemic has prompted an extensive worldwide sequencing effort to characterise the geographical spread and molecular evolution of the virus. A point mutation in the spike protein, D614G, emerged as the virus spread from ... ...

    Abstract The development of the SARS-CoV-2 pandemic has prompted an extensive worldwide sequencing effort to characterise the geographical spread and molecular evolution of the virus. A point mutation in the spike protein, D614G, emerged as the virus spread from Asia into Europe and the USA, and has rapidly become the dominant form worldwide. Here we review how the D614G variant was identified and discuss recent evidence about the effect of the mutation on the characteristics of the virus, clinical outcome of infection and host immune response.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #908990
    Datenquelle COVID19

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  7. Artikel ; Online: The D614G mutations in the SARS-CoV-2 spike protein

    Groves, Danielle C. / Rowland-Jones, Sarah L. / Angyal, Adrienn

    Biochemical and Biophysical Research Communications ; ISSN 0006-291X

    Implications for viral infectivity, disease severity and vaccine design

    2020  

    Schlagwörter Biophysics ; Cell Biology ; Biochemistry ; Molecular Biology ; covid19
    Sprache Englisch
    Verlag Elsevier BV
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    DOI 10.1016/j.bbrc.2020.10.109
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Higher HIV-1 evolutionary rate is associated with cytotoxic T lymphocyte escape mutations in infants.

    Nazziwa, Jamirah / Andrews, Sophie M / Hou, Mimi M / Bruhn, Christian A W / Garcia-Knight, Miguel A / Slyker, Jennifer / Hill, Sarah / Lohman Payne, Barbara / Moringas, Dorothy / Lemey, Philippe / John-Stewart, Grace / Rowland-Jones, Sarah L / Esbjörnsson, Joakim

    Journal of virology

    2024  , Seite(n) e0007224

    Abstract: Escape from cytotoxic T lymphocyte (CTL) responses toward HIV-1 Gag and Nef has been associated with reduced control of HIV-1 replication in adults. However, less is known about CTL-driven immune selection in infants as longitudinal studies of infants ... ...

    Abstract Escape from cytotoxic T lymphocyte (CTL) responses toward HIV-1 Gag and Nef has been associated with reduced control of HIV-1 replication in adults. However, less is known about CTL-driven immune selection in infants as longitudinal studies of infants are limited. Here, 1,210
    Sprache Englisch
    Erscheinungsdatum 2024-05-30
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.00072-24
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Editorial: Immune Mechanisms Underlying the Increased Morbidity and Mortality of HIV-Exposed Uninfected (HEU) Children.

    Goetghebuer, Tessa / Rowland-Jones, Sarah L / Kollmann, Tobias R

    Frontiers in immunology

    2017  Band 8, Seite(n) 1060

    Sprache Englisch
    Erscheinungsdatum 2017
    Erscheinungsland Switzerland
    Dokumenttyp Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2017.01060
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: A novel full-length two-domain KIR2DL5A allele isolated in Zimbabwean samples: KIR2DL5A*0010104.

    van Pul, Lisa / Majonga, Edith / Ferrand, Rashida / Rowland-Jones, Sarah L / Yindom, Louis-Marie

    HLA

    2020  Band 96, Heft 1, Seite(n) 135–136

    Abstract: The novel allele KIR2DL5A*0010104 differs from that of KIR2DL5A*0010101 with eight single intronic nucleotide changes. ...

    Abstract The novel allele KIR2DL5A*0010104 differs from that of KIR2DL5A*0010101 with eight single intronic nucleotide changes.
    Mesh-Begriff(e) Alleles ; Humans
    Sprache Englisch
    Erscheinungsdatum 2020-03-30
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.13875
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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