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  1. Artikel ; Online: Combinatorial blockade for cancer immunotherapy: targeting emerging immune checkpoint receptors.

    Roy, Dia / Gilmour, Cassandra / Patnaik, Sachin / Wang, Li Lily

    Frontiers in immunology

    2023  Band 14, Seite(n) 1264327

    Abstract: The differentiation, survival, and effector function of tumor-specific ... ...

    Abstract The differentiation, survival, and effector function of tumor-specific CD8
    Mesh-Begriff(e) Humans ; Hepatitis A Virus Cellular Receptor 2 ; Neoplasms/metabolism ; Immunotherapy ; Receptors, Immunologic/metabolism ; T-Lymphocytes, Cytotoxic
    Chemische Substanzen Hepatitis A Virus Cellular Receptor 2 ; Receptors, Immunologic
    Sprache Englisch
    Erscheinungsdatum 2023-10-19
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1264327
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: The Adroitness of Andrographolide as a Natural Weapon Against Colorectal Cancer.

    Paul, Silpita / Roy, Dia / Pati, Subhadip / Sa, Gaurisankar

    Frontiers in pharmacology

    2021  Band 12, Seite(n) 731492

    Abstract: The conventional carcinoma treatment generally encompasses the employment of radiotherapy, chemotherapy, surgery or use of cytotoxic drugs. However, recent advances in pharmacological research have divulged the importance of traditional treatments in ... ...

    Abstract The conventional carcinoma treatment generally encompasses the employment of radiotherapy, chemotherapy, surgery or use of cytotoxic drugs. However, recent advances in pharmacological research have divulged the importance of traditional treatments in cancer. The aim of the present review is to provide an overview of the importance of one such medicinal herb of Chinese and Indian origin:
    Sprache Englisch
    Erscheinungsdatum 2021-11-02
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.731492
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: LRIG1 engages ligand VISTA and impairs tumor-specific CD8

    Ta, Hieu Minh / Roy, Dia / Zhang, Keman / Alban, Tyler / Juric, Ivan / Dong, Juan / Parthasarathy, Prerana B / Patnaik, Sachin / Delaney, Elizabeth / Gilmour, Cassandra / Zakeri, Amin / Shukla, Nidhi / Rupani, Amit / Phoon, Yee Peng / Liu, Caini / Avril, Stefanie / Gastman, Brian / Chan, Timothy / Wang, Li Lily

    Science immunology

    2024  Band 9, Heft 95, Seite(n) eadi7418

    Abstract: Immune checkpoint blockade is a promising approach to activate antitumor immunity and improve the survival of patients with cancer. V-domain immunoglobulin suppressor of T cell activation (VISTA) is an immune checkpoint target; however, the downstream ... ...

    Abstract Immune checkpoint blockade is a promising approach to activate antitumor immunity and improve the survival of patients with cancer. V-domain immunoglobulin suppressor of T cell activation (VISTA) is an immune checkpoint target; however, the downstream signaling mechanisms are elusive. Here, we identify leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) as a VISTA binding partner, which acts as an inhibitory receptor by engaging VISTA and suppressing T cell receptor signaling pathways. Mice with T cell-specific LRIG1 deletion developed superior antitumor responses because of expansion of tumor-specific cytotoxic T lymphocytes (CTLs) with increased effector function and survival. Sustained tumor control was associated with a reduction of quiescent CTLs (TCF1
    Mesh-Begriff(e) Animals ; Mice ; CD8-Positive T-Lymphocytes/immunology ; Membrane Glycoproteins/immunology ; Membrane Glycoproteins/genetics ; Humans ; B7 Antigens/immunology ; B7 Antigens/genetics ; Mice, Inbred C57BL ; Mice, Knockout ; Cell Line, Tumor ; Female ; Membrane Proteins ; Nerve Tissue Proteins
    Chemische Substanzen Lrig1 protein, mouse ; VSIR protein, human ; Vsir protein, mouse ; LRIG1 protein, human
    Sprache Englisch
    Erscheinungsdatum 2024-05-17
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.adi7418
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Breast cancer stem cells generate immune-suppressive T regulatory cells by secreting TGFβ to evade immune-elimination.

    Mukherjee, Sumon / Chakraborty, Sourio / Basak, Udit / Pati, Subhadip / Dutta, Apratim / Dutta, Saikat / Roy, Dia / Banerjee, Shruti / Ray, Arpan / Sa, Gaurisankar / Das, Tanya

    Discover. Oncology

    2023  Band 14, Heft 1, Seite(n) 220

    Abstract: Cancer stem cells (CSCs), being the primary contributors in tumor initiation, metastasis, and relapse, ought to have seminal roles in evasion of immune surveillance. Tumor-promoting ... ...

    Abstract Cancer stem cells (CSCs), being the primary contributors in tumor initiation, metastasis, and relapse, ought to have seminal roles in evasion of immune surveillance. Tumor-promoting CD4
    Sprache Englisch
    Erscheinungsdatum 2023-12-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2730-6011
    ISSN (online) 2730-6011
    DOI 10.1007/s12672-023-00787-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Tumor-Associated CD19+CD39- B Regulatory Cells Deregulate Class-Switch Recombination to Suppress Antibody Responses.

    Pati, Subhadip / Mukherjee, Sumon / Dutta, Saikat / Guin, Aharna / Roy, Dia / Bose, Sayantan / Paul, Silpita / Saha, Sudipto / Bhattacharyya, Sankar / Datta, Pratyush / Chakraborty, Jayati / Sarkar, Diptendra K / Sa, Gaurisankar

    Cancer immunology research

    2022  Band 11, Heft 3, Seite(n) 364–380

    Abstract: B cells are an essential component of humoral immunity. Their primary function is to mount antigen-specific antibody responses to eliminate pathogens. Despite an increase in B-cell number, we found that serum-IgG levels were low in patients with breast ... ...

    Abstract B cells are an essential component of humoral immunity. Their primary function is to mount antigen-specific antibody responses to eliminate pathogens. Despite an increase in B-cell number, we found that serum-IgG levels were low in patients with breast cancer. To solve this conundrum, we used high-dimensional flow cytometry to analyze the heterogeneity of B-cell populations and identified a tumor-specific CD19+CD24hiCD38hi IL10-producing B regulatory (Breg)-cell subset. Although IL10 is a Breg-cell marker, being an intracellular protein, it is of limited value for Breg-cell isolation. Highly expressed Breg-cell surface proteins CD24 and CD38 also impede the isolation of viable Breg cells. These are hurdles that limit understanding of Breg-cell functions. Our transcriptomic analysis identified, CD39-negativity as an exclusive, sorting-friendly surface marker for tumor-associated Breg cells. We found that the identified CD19+CD39‒IL10+ B-cell population was suppressive in nature as it limited T helper-cell proliferation, type-1 cytokine production, and T effector-cell survival, and augmented CD4+FOXP3+ regulatory T-cell generation. These tumor-associated Breg cells were also found to restrict autologous T follicular helper-cell expansion and IL21 secretion, thereby inhibiting germinal transcript formation and activation-induced cytidine deaminase expression involved in H-chain class-switch recombination (CSR). This isotype-switching abnormality was shown to hinder B-cell differentiation into class-switched memory B cells and subsequent high-affinity antibody-producing plasma B cells, which collectively led to the dampening of IgG-mediated antibody responses in patients with cancer. As low IgG is associated with poor prognosis in patients with cancer, Breg-cell depletion could be a promising future therapy for boosting plasma B cell-mediated antibody responses.
    Mesh-Begriff(e) Humans ; Antibody Formation ; Antigens, CD19 ; CD4-Positive T-Lymphocytes ; Immunoglobulin G ; Interleukin-10 ; Neoplasms
    Chemische Substanzen Antigens, CD19 ; Immunoglobulin G ; Interleukin-10 (130068-27-8) ; ENTPD1 protein, human (EC 3.6.1.5) ; CD19 molecule, human
    Sprache Englisch
    Erscheinungsdatum 2022-12-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2732489-8
    ISSN 2326-6074 ; 2326-6066
    ISSN (online) 2326-6074
    ISSN 2326-6066
    DOI 10.1158/2326-6066.CIR-21-1073
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: GFI1/HDAC1-axis differentially regulates immunosuppressive CD73 in human tumor-associated FOXP3

    Roy, Dia / Bose, Sayantan / Pati, Subhadip / Guin, Aharna / Banerjee, Krishnendu / Saha, Sudipto / Singhal, Ayush K / Chakraborty, Jayati / Sarkar, Diptendra K / Sa, Gaurisankar

    European journal of immunology

    2021  Band 51, Heft 5, Seite(n) 1206–1217

    Abstract: Plasticity between Th17 and Treg cells is regarded as a crucial determinant of tumor-associated immunosuppression. Classically Th17 cells mediate inflammatory responses through production of cytokine IL17. Recently, Th17 cells have also been shown to ... ...

    Abstract Plasticity between Th17 and Treg cells is regarded as a crucial determinant of tumor-associated immunosuppression. Classically Th17 cells mediate inflammatory responses through production of cytokine IL17. Recently, Th17 cells have also been shown to acquire suppressive phenotypes in tumor microenvironment. However, the mechanism by which they acquire such immunosuppressive properties is still elusive. Here, we report that in tumor microenvironment Th17 cell acquires immunosuppressive properties by expressing Treg lineage-specific transcription factor FOXP3 and ectonucleotidase CD73. We designate this cell as Th17reg cell and perceive that such immunosuppressive property is dependent on CD73. It was observed that in classical Th17 cell, GFI1 recruits HDAC1 to change the euchromatin into tightly-packed heterochromatin at the proximal-promoter region of CD73 to repress its expression. Whereas in Th17reg cells GFI1 cannot get access to CD73-promoter due to heterochromatin state at its binding site and, thus, cannot recruit HDAC1, failing to suppress the expression of CD73.
    Mesh-Begriff(e) 5'-Nucleotidase/metabolism ; Cytokines/metabolism ; DNA-Binding Proteins/metabolism ; Forkhead Transcription Factors/metabolism ; Gene Expression Regulation, Neoplastic ; Histone Deacetylase 1/metabolism ; Humans ; Immunomodulation ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Promoter Regions, Genetic ; Signal Transduction ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Th17 Cells/immunology ; Th17 Cells/metabolism ; Transcription Factors/metabolism ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
    Chemische Substanzen Cytokines ; DNA-Binding Proteins ; FOXP3 protein, human ; Forkhead Transcription Factors ; GFI1 protein, human ; Transcription Factors ; 5'-Nucleotidase (EC 3.1.3.5) ; HDAC1 protein, human (EC 3.5.1.98) ; Histone Deacetylase 1 (EC 3.5.1.98)
    Sprache Englisch
    Erscheinungsdatum 2021-02-17
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202048892
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Transcriptional regulation of VEGFA expression in T-regulatory cells from breast cancer patients.

    Kajal, Kirti / Bose, Sayantan / Panda, Abir K / Chakraborty, Dwaipayan / Chakraborty, Sreeparna / Pati, Subhadip / Sarkar, Tania / Dhar, Subhanki / Roy, Dia / Saha, Shilpi / Sa, Gaurisankar

    Cancer immunology, immunotherapy : CII

    2021  Band 70, Heft 7, Seite(n) 1877–1891

    Abstract: The initiation of new blood vessel formation (neo-angiogenesis) is one of the primary requirements for the establishment of tumor. As the tumor grows beyond a certain size, a hypoxic-condition arises in the inner core of tumor, triggering the release of ... ...

    Abstract The initiation of new blood vessel formation (neo-angiogenesis) is one of the primary requirements for the establishment of tumor. As the tumor grows beyond a certain size, a hypoxic-condition arises in the inner core of tumor, triggering the release of chemokines, which attract T-regulatory (Treg) cells in the tumor-site. The presence of FOXP3, a lineage-specific transcription factor, expressing Treg cells in various types of tumor implements immunosuppressive and tumor-promoting strategies. One such strategy is the invitation of endothelial cells for neo-vascularization in the tumor site. Here we report that as the disease progresses, Treg cells from breast cancer patients are capable of secreting high-amount of VEGFA. The VEGFA promoter lacks Treg-specific transcription factor FOXP3 binding site. FOXP3 in association with locus-specific transcription factor STAT3 binds to VEGFA promoter to induce its transcription in Treg cells obtained from breast cancer patients. Treg cell-secreted VEGFA induces neo-angiogenesis from endothelial cells under in-vitro conditions. Targeting Tregs in mice with breast tumor reduces tumor growth as well as the level of neo-angiogenesis in the tumor tissue.
    Mesh-Begriff(e) Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/genetics ; Breast Neoplasms/immunology ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Case-Control Studies ; Cell Proliferation ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Mice, Inbred BALB C ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/immunology ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/pathology ; Prognosis ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Tumor Cells, Cultured ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism ; Xenograft Model Antitumor Assays
    Chemische Substanzen Biomarkers, Tumor ; STAT3 Transcription Factor ; VEGFA protein, human ; Vascular Endothelial Growth Factor A
    Sprache Englisch
    Erscheinungsdatum 2021-01-04
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 195342-4
    ISSN 1432-0851 ; 0340-7004
    ISSN (online) 1432-0851
    ISSN 0340-7004
    DOI 10.1007/s00262-020-02808-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1237: Hefte anzeigen Standort:
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  8. Artikel ; Online: Transcriptional regulation of FOXP3 requires integrated activation of both promoter and CNS regions in tumor-induced CD8

    Chakraborty, Sreeparna / Panda, Abir K / Bose, Sayantan / Roy, Dia / Kajal, Kirti / Guha, Deblina / Sa, Gaurisankar

    Scientific reports

    2017  Band 7, Heft 1, Seite(n) 1628

    Abstract: T-regulatory cells are an upsurge in the tumor microenvironment and induce immune-evasion. ... ...

    Abstract T-regulatory cells are an upsurge in the tumor microenvironment and induce immune-evasion. CD4
    Mesh-Begriff(e) Adolescent ; Adult ; Animals ; Base Sequence ; Breast Neoplasms/immunology ; Breast Neoplasms/pathology ; CD8-Positive T-Lymphocytes/metabolism ; Conserved Sequence/genetics ; Core Binding Factor Alpha 3 Subunit/metabolism ; DNA, Intergenic/genetics ; Female ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; GATA3 Transcription Factor/metabolism ; Gene Expression Regulation ; Humans ; Immunosuppression ; Interleukin-2 Receptor alpha Subunit/metabolism ; Mice, Inbred BALB C ; Middle Aged ; Models, Genetic ; Promoter Regions, Genetic ; Smad3 Protein/metabolism ; T-Lymphocytes, Regulatory/metabolism ; Transcription, Genetic ; Tumor Microenvironment ; Young Adult
    Chemische Substanzen Core Binding Factor Alpha 3 Subunit ; DNA, Intergenic ; FOXP3 protein, human ; Forkhead Transcription Factors ; GATA3 Transcription Factor ; Interleukin-2 Receptor alpha Subunit ; Smad3 Protein
    Sprache Englisch
    Erscheinungsdatum 2017-05-09
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-017-01788-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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