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  1. Article ; Online: Efficacy and Freedom: Patient Experiences with the Transition from Daily Oral to Long-Acting Injectable Antiretroviral Therapy to Treat HIV in the Context of Phase 3 Trials.

    Mantsios, Andrea / Murray, Miranda / Karver, Tahilin S / Davis, Wendy / Margolis, David / Kumar, Princy / Swindells, Susan / Bredeek, U Fritz / García Del Toro, Miguel / Garcia Gasalla, Mercedes / Rubio García, Rafael / Antela, Antonio / Hudson, Krischan / Griffith, Sandy / Kerrigan, Deanna

    AIDS and behavior

    2020  Volume 24, Issue 12, Page(s) 3473–3481

    Abstract: Long-acting injectable antiretroviral therapy (LA ART) may be an alternative for people living with HIV (PLHIV) with adherence challenges or who prefer not to take pills. Using in-depth interviews, this study sought to understand the experiences of PLHIV ...

    Abstract Long-acting injectable antiretroviral therapy (LA ART) may be an alternative for people living with HIV (PLHIV) with adherence challenges or who prefer not to take pills. Using in-depth interviews, this study sought to understand the experiences of PLHIV (n = 53) participating in Phase 3 LA ART trials in the United States and Spain. The most salient consideration when contemplating LA ART was its clinical efficacy; many participants reported wanting to ensure that it worked as well as daily oral ART, including with less frequent dosing (every 8 versus 4 weeks). While injection side effects were often reported, most participants felt that regimen benefits outweighed such drawbacks. Participants described the main benefit of LA ART as the "freedom" it afforded both logistically and psychosocially, including through reduced HIV stigma. Findings highlight the importance of patient-provider communication related to weighing potential benefits and side effects and the continued need to address HIV stigma.
    MeSH term(s) Anti-Retroviral Agents/therapeutic use ; Freedom ; HIV Infections/drug therapy ; Humans ; Injections ; Social Stigma ; Spain ; United States
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2020-05-14
    Publishing country United States
    Document type Clinical Trial, Phase III ; Journal Article
    ZDB-ID 1339885-4
    ISSN 1573-3254 ; 1090-7165
    ISSN (online) 1573-3254
    ISSN 1090-7165
    DOI 10.1007/s10461-020-02918-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6451: Show issues Location:
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  2. Article: Acidosis láctica secundaria a tratamiento antirretroviral: se puede hacer algo más?

    Moreno-Cuerda, Víctor J / Rubio García, Rafael

    Medicina clinica

    2005  Volume 125, Issue 6, Page(s) 213–214

    Title translation Lactic acidosis following antiretroviral therapy.
    MeSH term(s) Acidosis, Lactic/chemically induced ; Acidosis, Lactic/therapy ; Anti-HIV Agents/adverse effects ; HIV Infections/blood ; HIV Infections/drug therapy ; Humans ; Lactic Acid/blood ; Reverse Transcriptase Inhibitors/adverse effects
    Chemical Substances Anti-HIV Agents ; Reverse Transcriptase Inhibitors ; Lactic Acid (33X04XA5AT)
    Language Spanish
    Publishing date 2005-07-11
    Publishing country Spain
    Document type Comment ; Editorial
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1157/13077381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Nuevas perspectivas en el del paciente con infección por el virus de la inmunodeficiencia humana politratado y en fracaso virológico.

    Moreno Cuerda, Víctor Julián / Rubio García, Rafael / Morales Conejo, Montserrat

    Medicina clinica

    2007  Volume 130, Issue 2, Page(s) 66–70

    Abstract: Once patients have a triple class virological failure, their treatment options are limited and there is an increased risk of death. In order to construct active treatment regimens, new potent antiretroviral agents are available for these patients. The ... ...

    Title translation New therapeutic options in protracted HIV-infected patients with virological failure.
    Abstract Once patients have a triple class virological failure, their treatment options are limited and there is an increased risk of death. In order to construct active treatment regimens, new potent antiretroviral agents are available for these patients. The virological target in patients with treatment failure is now plasma HIV RNA level below 50 copies/ml when 2 or more potent drugs are identified. If at least two active drugs cannot be identified, the current regimen should be maintained until new drugs become available, assuming that there is an immunological and clinical stability, in order to avoid the use of a single-active drug that usually leads to rapid development of resistance, further limiting the future treatment options. In this article, the current state of knowledge about these new agents available and the guidelines of main societies are reviewed.
    MeSH term(s) Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/pharmacology ; Anti-HIV Agents/therapeutic use ; Anti-Retroviral Agents/administration & dosage ; Anti-Retroviral Agents/pharmacology ; Anti-Retroviral Agents/therapeutic use ; Darunavir ; Drug Resistance, Viral ; Drug Therapy, Combination ; Enfuvirtide ; HIV/drug effects ; HIV/genetics ; HIV Envelope Protein gp41/administration & dosage ; HIV Envelope Protein gp41/pharmacology ; HIV Envelope Protein gp41/therapeutic use ; HIV Fusion Inhibitors/administration & dosage ; HIV Fusion Inhibitors/pharmacology ; HIV Fusion Inhibitors/therapeutic use ; HIV Infections/drug therapy ; HIV Infections/virology ; HIV Protease Inhibitors/administration & dosage ; HIV Protease Inhibitors/pharmacology ; HIV Protease Inhibitors/therapeutic use ; Humans ; Organic Chemicals/administration & dosage ; Organic Chemicals/pharmacology ; Organic Chemicals/therapeutic use ; Peptide Fragments/administration & dosage ; Peptide Fragments/pharmacology ; Peptide Fragments/therapeutic use ; Practice Guidelines as Topic ; Pyridines/administration & dosage ; Pyridines/pharmacology ; Pyridines/therapeutic use ; Pyrones/administration & dosage ; Pyrones/pharmacology ; Pyrones/therapeutic use ; Pyrrolidinones ; RNA, Viral/analysis ; Raltegravir Potassium ; Randomized Controlled Trials as Topic ; Sulfonamides/administration & dosage ; Sulfonamides/pharmacology ; Sulfonamides/therapeutic use
    Chemical Substances Anti-HIV Agents ; Anti-Retroviral Agents ; HIV Envelope Protein gp41 ; HIV Fusion Inhibitors ; HIV Protease Inhibitors ; Organic Chemicals ; Peptide Fragments ; Pyridines ; Pyrones ; Pyrrolidinones ; RNA, Viral ; Sulfonamides ; Enfuvirtide (19OWO1T3ZE) ; Raltegravir Potassium (43Y000U234) ; Darunavir (YO603Y8113) ; tipranavir (ZZT404XD09)
    Language Spanish
    Publishing date 2007-11-28
    Publishing country Spain
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1157/13115036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.279: Show issues Location:
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  4. Article ; Online: Clinical, epidemiological and treatment failure data among HIV-1 non-B-infected patients in the Spanish AIDS Research Network Cohort.

    Torrecilla García, Esther / Yebra Sanz, Gonzalo / Llácer-Delicado, Teresa / Rubio García, Rafael / González-García, Juan / García García, Federico / López-Aldeguer, José / Asensi Álvarez, Víctor / Holguín Fernández, África

    Enfermedades infecciosas y microbiologia clinica

    2016  Volume 34, Issue 6, Page(s) 353–360

    Abstract: Introduction: The prevalence of HIV-1 non-B variants is increasing in Spain, showing a higher number of transmitted drug resistance mutations (TDR) since 2002. This study presents the features of non-B-infected patients enrolled in the cohort of ... ...

    Abstract Introduction: The prevalence of HIV-1 non-B variants is increasing in Spain, showing a higher number of transmitted drug resistance mutations (TDR) since 2002. This study presents the features of non-B-infected patients enrolled in the cohort of antiretroviral treatment (ART) naïve HIV-infected patients included in the Research Network on HIV/AIDS (CoRIS).
    Methods: The study includes a selected group of HIV-1 non-B-infected subjects from 670 subjects with pol sequences collected from 2004 to 2008 in the CoRIS cohort. Epidemiological-clinical-virological data were analyzed since cohort entry until October 2011, considering the presence or absence of treatment failure (TF).
    Results: Eighty two non-B infected subjects with known HIV-1 variants were selected from 2004 to 2008 in the CoRIS cohort, being mainly female, immigrants, infected by recombinant viruses, and by heterosexual route. They had an intermediate TDR rate (9.4%), a high rate of TF (25.6%), of losses to follow-up (35%), of coinfections (32.9%), and baseline CD4+ counts ≥350cells/mm(3) (61.8%). Non-B subjects with TF showed higher rates of heterosexual infection (85.7% vs. 69.5%, p<0.05), tuberculosis (30.8% vs. 9.1%, p=0.10) and hepatitis C (23.8% vs. 13.9%, p=0.34) coinfections and lower rates of syphilis (0% vs. 21.9%, p<0.05), and had more frequently received first-line ART including protease inhibitors (PIs) than patients without TF (70% vs. 30%, p<0.05). Interestingly, infection with non-B variants reduced the risk of TDR to nucleoside reverse transcriptase inhibitors and increased the risk to PIs.
    Conclusion: HIV-1 non-B-infected patients in Spain had a particular epidemiological and clinical profile that should be considered during their clinical management.
    Language English
    Publishing date 2016-06
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1070941-1
    ISSN 1578-1852 ; 0213-005X
    ISSN (online) 1578-1852
    ISSN 0213-005X
    DOI 10.1016/j.eimc.2015.07.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3204: Show issues Location:
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  5. Article ; Online: Misindentification of Mycobacterium kumamotonense as M. tuberculosis.

    Rodríguez-Aranda, Almudena / Jimenez, María S / Yubero, Jesús / Chaves, Fernando / Rubio-Garcia, Rafael / Palenque, Elia / García, Maria J / Menendez, M Carmen

    Emerging infectious diseases

    2010  Volume 16, Issue 7, Page(s) 1178–1180

    MeSH term(s) Adult ; Diagnostic Errors ; Humans ; Male ; Mycobacterium/isolation & purification ; Mycobacterium tuberculosis/isolation & purification
    Language English
    Publishing date 2010-06-28
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid1607.091913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4778: Show issues Location:
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