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  1. Artikel ; Online: Diagnostic and prognostic utility of WBC counts and cell population data in patients with COVID-19.

    Naoum, Flávio Augusto / Ruiz, Adriana Laridondo Zucareli / Martin, Fernando Henrique de Oliveira / Brito, Tayra Hostalacio Gomes / Hassem, Vitoria / Oliveira, Maria Gabriela de Lucca

    International journal of laboratory hematology

    2020  Band 43 Suppl 1, Seite(n) 124–128

    Abstract: Introduction: Early diagnosis and identification of potential critical cases for timely treatment are crucial for COVID-19 patients. The aim of this study was to analyze the diagnostic and prognostic implications of WBC and cell population data (CPD) ... ...

    Abstract Introduction: Early diagnosis and identification of potential critical cases for timely treatment are crucial for COVID-19 patients. The aim of this study was to analyze the diagnostic and prognostic implications of WBC and cell population data (CPD) abnormalities related to COVID-19 at disease onset.
    Methods: Baseline WBC counts and CPD data were analyzed in one hundred COVID-19 patients presenting to emergency department and subsequently discharged (n=49), admitted (n=51) or deceased (n=22), and in 47 healthy subjects.
    Results: Lymphopenia and eosinopenia were observed in all COVID-19 patients, with more intensity in the admitted and deceased groups, that also presented increased WBC and neutrophil counts. On CPD analysis, COVID-19 was associated with increased volume of neutrophils, lymphocytes, and monocytes, whereas conductivity was decreased for neutrophils and increased for lymphocytes. The ROC curve analysis showed good performance for lymphocyte counts in predicting COVID-19 diagnosis (AUC=0.858), for neutrophil counts in predicting admission for COVID-19 (AUC=0.744) and for monocytes volume in predicting COVID-19 diagnosis (AUC=0.837).
    Conclusion: WBC counts and CPD parameters at disease onset in COVID-19 patients can improve diagnostic characterization and aid in the discrimination between severe and nonsevere presentations.
    Mesh-Begriff(e) Adult ; Area Under Curve ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/mortality ; COVID-19 Testing ; Electric Conductivity ; Flow Cytometry ; Humans ; Inpatients ; Leukocyte Count ; Outpatients ; Pandemics ; Prognosis ; ROC Curve ; Retrospective Studies ; Risk ; SARS-CoV-2 ; Sensitivity and Specificity ; Survival Analysis
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-11-15
    Erscheinungsland England
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 2268590-X
    ISSN 1751-553X ; 1751-5521 ; 0141-9854
    ISSN (online) 1751-553X
    ISSN 1751-5521 ; 0141-9854
    DOI 10.1111/ijlh.13395
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Diagnostic and prognostic utility of WBC counts and cell population data in patients with COVID-19

    Naoum, Flávio Augusto / Ruiz, Adriana Laridondo Zucareli / Martin, Fernando Henrique de Oliveira / Brito, Tayra Hostalacio Gomes / Hassem, Vitoria / Oliveira, Maria Gabriela de Lucca

    Int. j. lab. hematol

    Abstract: INTRODUCTION: Early diagnosis and identification of potential critical cases for timely treatment are crucial for COVID-19 patients. The aim of this study was to analyze the diagnostic and prognostic implications of WBC and cell population data (CPD) ... ...

    Abstract INTRODUCTION: Early diagnosis and identification of potential critical cases for timely treatment are crucial for COVID-19 patients. The aim of this study was to analyze the diagnostic and prognostic implications of WBC and cell population data (CPD) abnormalities related to COVID-19 at disease onset. METHODS: Baseline WBC counts and CPD data were analyzed in one hundred COVID-19 patients presenting to emergency department and subsequently discharged (n = 49), admitted (n = 51) or deceased (n = 22), and in 47 healthy subjects. RESULTS: Lymphopenia and eosinopenia were observed in all COVID-19 patients, with more intensity in the admitted and deceased groups, that also presented increased WBC and neutrophil counts. On CPD analysis, COVID-19 was associated with increased volume of neutrophils, lymphocytes, and monocytes, whereas conductivity was decreased for neutrophils and increased for lymphocytes. The ROC curve analysis showed good performance for lymphocyte counts in predicting COVID-19 diagnosis (AUC = 0.858), for neutrophil counts in predicting admission for COVID-19 (AUC = 0.744) and for monocytes volume in predicting COVID-19 diagnosis (AUC = 0.837). CONCLUSION: WBC counts and CPD parameters at disease onset in COVID-19 patients can improve diagnostic characterization and aid in the discrimination between severe and nonsevere presentations.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #926858
    Datenquelle COVID19

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